BGC0001848: diazaquinomycin H biosynthetic gene cluster from Micromonospora sp. B006
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Location: 3,038,865 - 3,097,062 nt. (total: 58,198 nt).
This entry is originally from NCBI GenBank CP030865.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001848
Short description diazaquinomycin H biosynthetic gene cluster from Micromonospora sp. B006
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "key publication containing the BGC:Braesel et al. (2019) Diazaquinomycin biosynthetic gene clusters from marine and freshwater actionmycetes. J. Nat. Prod., in revision"
Biosynthetic class(es)
  • other (other)
Loci
CP030865.1
3038865 - 3097062
via Knock-out studies
Compounds
  • diazaquinomycin H
  • diazaquinomycin J
Species Micromonospora sp. B006 [taxonomy]
References
Chemical products information
diazaquinomycin H Evidence: NMR, Mass spectrometry
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C22H26N2O4
Chemical database entries
PubCHEM
diazaquinomycin J Evidence: NMR, Mass spectrometry
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C23H28N2O4
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • MicB006_2892
  • AXO35173.1
 3038865 - 3040082 (-) 2-keto-3-deoxy-D-arabino-heptulosonate-7- phosphate synthase II
  • Precursor biosynthesis
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  • MicB006_2893
  • AXO35174.1
 3040216 - 3041814 (-) hypothetical protein
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    • MicB006_2894
    • AXO35175.1
    		 3041874 - 3043553 (-) SSS sodium solute transporter superfamily
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      • MicB006_2895
      • AXO35176.1
      		 3043550 - 3043885 (-) putative membrane protein
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        • MicB006_2896
        • AXO35177.1
        		 3044080 - 3044820 (+) hypothetical protein
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          • MicB006_2897
          • AXO35178.1
          		 3044813 - 3045514 (-) short-chain dehydrogenase/reductase SDR
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            • MicB006_2898
            • AXO35179.1
            		 3045526 - 3046200 (-) isochorismatase
            • Precursor biosynthesis
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            • MicB006_2899
            • AXO35180.1
            		 3046233 - 3047018 (-) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
            • Precursor biosynthesis
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            • MicB006_2900
            • AXO35181.1
            		 3047018 - 3048187 (-) putative n-hydroxybenzoate hydroxylase
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              • MicB006_2901
              • AXO35182.1
              		 3048219 - 3049535 (-) phenylacetate-coenzyme A ligase
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                • MicB006_2902
                • AXO35183.1
                		 3049532 - 3050293 (-) hypothetical protein
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                  • MicB006_2903
                  • AXO35184.1
                  		 3050319 - 3051422 (-) 37-dideoxy-D-threo-hepto-2 6-diulosonate synthase
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                    • MicB006_2904
                    • AXO35185.1
                    		 3051454 - 3052278 (-) 2-amino-37-dideoxy-D-threo-hept-6-ulosonate synthase
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                      • MicB006_2905
                      • AXO35186.1
                      		 3052294 - 3053577 (-) aspartokinase
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                        • MicB006_2906
                        • AXO35187.1
                        		 3053813 - 3055777 (+) anthranilate synthase
                        • Precursor biosynthesis
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                        • MicB006_2907
                        • AXO35188.1
                        		 3055937 - 3056335 (+) hypothetical protein
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                          • MicB006_2908
                          • AXO35189.1
                          		 3056436 - 3056825 (-) glyoxalase/bleomycin resistance protein/dioxygenase
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                            • MicB006_2909
                            • AXO35190.1
                            		 3056836 - 3058797 (-) multicopper oxidase
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                              • MicB006_2910
                              • AXO35191.1
                              		 3058818 - 3059273 (-) hypothetical protein
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                                • MicB006_2911
                                • AXO35192.1
                                		 3059338 - 3059733 (-) hypothetical protein
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                                  • MicB006_2912
                                  • AXO35193.1
                                  		 3059926 - 3060588 (-) DNA-binding response regulator LuxR family
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                                    • MicB006_2913
                                    • AXO35194.1
                                    		 3060585 - 3061697 (-) putative two-component system sensor kinase
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                                      • MicB006_2914
                                      • AXO35195.1
                                      		 3061811 - 3062683 (-) hypothetical protein
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                                        • MicB006_2915
                                        • AXO35196.1
                                        		 3062752 - 3063927 (-) hydroxymethylglutaryl-CoA synthase
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                                          • MicB006_2916
                                          • AXO35197.1
                                          		 3063930 - 3064922 (-) hydroxymethylglutaryl-CoA reductase
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                                            • MicB006_2917
                                            • AXO35198.1
                                            		 3064982 - 3066064 (-) isopentenyl-diphosphate delta-isomerase
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                                              • MicB006_2918
                                              • AXO35199.1
                                              		 3066061 - 3067170 (-) phosphomevalonate kinase
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                                                • MicB006_2919
                                                • AXO35200.1
                                                		 3067167 - 3068207 (-) diphosphomevalonate decarboxylase
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                                                  • MicB006_2920
                                                  • AXO35201.1
                                                  		 3068197 - 3069246 (-) mevalonate kinase
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                                                    • MicB006_2921
                                                    • AXO35202.1
                                                    		 3069261 - 3070349 (-) geranylgeranyl pyrophosphate synthetase
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                                                      • MicB006_2922
                                                      • AXO35203.1
                                                      		 3070800 - 3073439 (+) regulatory protein LuxR family
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                                                        • MicB006_2923
                                                        • AXO35204.1
                                                        		 3073494 - 3075563 (-) transcriptional activator
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                                                          • MicB006_2924
                                                          • AXO35205.1
                                                          		 3076156 - 3078288 (+) putative integral membrane export protein
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                                                            • MicB006_2925
                                                            • AXO35206.1
                                                            		 3078372 - 3079376 (+) enoyl-[acyl-carrier-protein] reductase
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                                                              • MicB006_2926
                                                              • AXO35207.1
                                                              		 3079510 - 3079926 (-) nuclear transport factor 2 family protein
                                                              • Scaffold biosynthesis
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                                                              • MicB006_2927
                                                              • AXO35208.1
                                                              		 3080117 - 3080785 (+) flavoprotein WrbA
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                                                                • MicB006_2928
                                                                • AXO35209.1
                                                                		 3080837 - 3081514 (-) transcriptional regulator TetR family
                                                                • Regulation
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                                                                • MicB006_2929
                                                                • AXO35210.1
                                                                		 3081642 - 3082337 (+) NAD-dependent epimerase
                                                                • Precursor biosynthesis
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                                                                • MicB006_2930
                                                                • AXO35211.1
                                                                		 3082482 - 3083576 (+) mobile element protein/transposase
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                                                                  • MicB006_2931
                                                                  • AXO35212.1
                                                                  		 3083622 - 3084590 (-) 3-oxoacyl-[acyl-carrier-protein] synthase KASIII
                                                                  • Precursor biosynthesis
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                                                                  • MicB006_2932
                                                                  • AXO35213.1
                                                                  		 3085008 - 3085832 (+) amidohydrolase
                                                                  • Precursor biosynthesis
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                                                                  • MicB006_2933
                                                                  • AXO35214.1
                                                                  		 3085837 - 3086646 (+) arylamine N-acetyltransferase 1
                                                                  • Scaffold biosynthesis
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                                                                  • MicB006_2934
                                                                  • AXO35215.1
                                                                  		 3086650 - 3087489 (+) arylamine N-acetyltransferase 1
                                                                  • Scaffold biosynthesis
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                                                                  • MicB006_2935
                                                                  • AXO35216.1
                                                                  		 3087486 - 3088538 (+) NADPH:quinone reductase
                                                                  • Precursor biosynthesis
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                                                                  • MicB006_2936
                                                                  • AXO35217.1
                                                                  		 3088479 - 3090176 (-) transcriptional regulator
                                                                  • Regulation
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                                                                  • MicB006_2937
                                                                  • AXO35218.1
                                                                  		 3090343 - 3090885 (+) SRPBCC family protein
                                                                  • Scaffold biosynthesis
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                                                                  • MicB006_2938
                                                                  • AXO35219.1
                                                                  		 3090895 - 3092466 (+) long-chain acyl-CoA synthetase
                                                                  • Precursor biosynthesis
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                                                                  • MicB006_2939
                                                                  • AXO35220.1
                                                                  		 3092463 - 3093671 (+) FAD-dependent oxidoreductase
                                                                  • Precursor biosynthesis
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                                                                  • MicB006_2940
                                                                  • AXO35221.1
                                                                  		 3093668 - 3095641 (+) FAD-binding protein
                                                                  • Precursor biosynthesis
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                                                                  • MicB006_2941
                                                                  • AXO35222.1
                                                                  		 3095638 - 3097062 (+) 3-carboxy-ciscis-muconate cycloisomerase
                                                                  • Precursor biosynthesis
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                                                                  Biosynthesis information
                                                                  Annotation changelog

                                                                  Entry version: 3

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2022-10-07
                                                                  Update chemical activity to schema version 2.11
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 2

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2022-09-15
                                                                  Fetch compound properties from PubChem
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  2022-09-15
                                                                  Cleaned up synonym list
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 1

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2019-10-16
                                                                  Submitted
                                                                  • (ID: GMXWAML5TKYYBXKHYBMH2DDT)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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