LOCUS       BGC0001849              6950 bp    DNA     linear   BCT 02-JUL-2014
DEFINITION  Streptomyces varsoviensis strain NRRL ISP-5346 contig11.1, whole
            genome shotgun sequence.
ACCESSION   BGC0001849
VERSION     BGC0001849
KEYWORDS    .
SOURCE      Streptomyces varsoviensis
  ORGANISM  Streptomyces varsoviensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     Bacteria available from NRRL.
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 16:25:24
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..1452)
                     /gene_functions="transport (smcogs) SMCOG1020:major
                     facilitator transporter (Score: 36.3; E-value: 5.1e-11)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_1"
                     /transl_table=1
                     /translation="MIRTYRSLLQVPGAARFSAAAFVGRLPVPMLGLGVVLLVSARSGS
                     YGTAGVVAAVTMLGYALTAPLAGRFVDRFGQRRVLLVSAAVHGAGLVTLMSATTATVWL
                     LCLAGIVTGASRPSTGTMVRTRWAYVLPTAAPEPPAAPPVGEPSTPPGHDNHRTDSGER
                     AASWERAARRGAPPAVTLETAFSFEAVLDEVTFIAGPVLVTALATRLSPWAGLLCCLVL
                     TVGGATALALQRATEPPPLRSHEHRGSALTVPGMPVITAVAFSNLLGVGVLDLAIVARA
                     DSLGSRALSGPLLAMLAVGSMLGGLWYGSRAWRAAPRVLWLRCLGVQVVGLVPLALSPG
                     LPALVVAMLVAGLTVAPIGVSGLVLMERLLPPHLLTEGMAAETAAMALGAAVGGWLSGT
                     VVEALGAARALALPAAAAALAFLIAVCCSRSIASPTADADAVAATVAEECPPPPPPGRG
                     RESGREKASGPGKESDRERESGQPL"
     protocluster    1..6950
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[1448:3727]"
                     /cutoff="20000"
                     /detection_rule="((YcaO or TIGR03604) and TfuA)"
                     /neighbourhood="10000"
                     /product="thioamitides"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1449..3727
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((YcaO or TIGR03604) and TfuA)"
                     /neighbourhood="10000"
                     /product="thioamitides"
                     /protocluster_number="1"
     cand_cluster    1..6950
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((YcaO or TIGR03604) and TfuA)"
                     /kind="single"
                     /product="thioamitides"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..6950
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001849"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..6950
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="thioamitides"
                     /region_number="1"
                     /rules="((YcaO or TIGR03604) and TfuA)"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             complement(1449..2264)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thioamitides: TfuA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2"
                     /sec_met_domain="TfuA (E-value: 3.2e-40, bitscore: 125.4,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MDPVVFLGPSLDRAVAARTLDAEFLPPIVRGDIDALLARPHPPCV
                     IGIVDGRFLDSLAVSPKEVLRAVDAGIPVYGSSSMGALRAAECAPFGVTGVGRIYDAYA
                     SGAVDADDEVAIVYDPDTLCATSEPLINLRFAIEDGVAEGEFGAAVGERFLAVAKSLHF
                     PDRTVANVLRGLAAEGLAAETGTVAETAAERDRIAAYFADRAPDTKAEDALALLGTLRD
                     HIAAAGAPAPPEPTITKAPEKTPDSGRATATDSDTVTHTPPGRFERARS"
     CDS             complement(2381..3727)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thioamitides: YcaO"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_3"
                     /sec_met_domain="YcaO (E-value: 1.9e-83, bitscore: 269.5,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MRAHAPKAAGPGVHREVTTQETWERIAPHLRRAGITRLADITGLD
                     YLGIPVYSAVIPRSNDSISVYSGKGATPIDAKVSAAMEAIERFSAWLPVRPDLVASYDE
                     LAAAGETVMHPAEYTLELAPGYRDDNPISWLRGWDLLSEEPVLVPQDGAVYQARLHEEP
                     CYRIATTTGLASGNSVEEAICHALCELIERDSMTLAELVSNYLPQVLAGEERDPRTLPA
                     TIDRLRGRHPHLRLETAPPAAQAMLARFHAAGIDVRAIDVTSPLGIPTVFAATSEDIGP
                     ATSQGHCGYGAHPDPEVALTRALSECAQARAVDIQAMREDISLPGAEVTKYELHVRRSA
                     AVDKSTWAWQPASRTVGMADLPAFPSDDVRADIDLMLGRLREAGIPRAVMVDLSPPQIP
                     VNVVRVIAPGLESWATDYCRIGPRAAHAWRTAVQELLAPPPDVSATRTT"
     CDS             complement(3988..4329)
                     /locus_tag="ctg1_4"
                     /transl_table=1
                     /translation="MRKDSDLRLDDLAHVNPEQLQGFLEERSTAAVHGATDAYFSGPRA
                     QTVRGATDAHFSAPRAQTVRGATDAHFSAPRAQTVRGATDAHFSAPRAQTVRGATDSYF
                     SAPRAQNVR"
     CDS             5049..6182
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) pgm_amidino"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_5"
                     /sec_met_domain="pgm_amidino (E-value: 8.3e-200, bitscore:
                     651.8, seeds: 95, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MRLNSYDEWSPLREVVVGSASNYTSHERELSFELFFHENFAESTW
                     YYPRLTTGGGSPAAPGRSLIKQRYVDELNEDIEGIVKALEDLAVTVLRPMELDARTTEV
                     RTPAWSAAVVPPLNLRDNTLIVGDEIIETPPMIRSRYFETQFLTPVFADYFRQGARWTV
                     MPRPLMTDASFDRSYAERTATAEPVDEARPSPYDVGHEMMFDAAQCLRLGRDIVANIST
                     ANHALGVDWLERHLHGRFRIHRVYGISDSHIDSMVLALRPGTLLVRSPEVADVLPEWLR
                     SWDLIVAPPPQSDSFPAYDDDDLILTSPFIDLNVLSVSPDTVLVNDACPDLVRTLERHG
                     FTAVPVRHRHRRLFGGGFHCFTLDTVRDGGAEDYFHG"
     CDS             6261..6950
                     /locus_tag="ctg1_6"
                     /transl_table=1
                     /translation="MTESLDRAKLENLALELTERQFEAVPRLREWHEGTWTDREFYKRY
                     MIEVVLQIRLNNVADAYALYKASYGDYRLAGKLARYLADEIGHEGMFVKDLAGLGVTLE
                     QIDATKVLPATAKTMGYLRLATDERGPAPVALWDWYLEWWSDRYMQAITDAAAKEFGIA
                     CTRGAQAHLDLDDSHGHDDMMFQTTAQAVETYGSAADAYADLEIYVDLGTEQYRQLFAA
                     AVDSHGA"
ORIGIN
        1 tcacagcggc tgcccggact ccctctcgcg atcggactcc tttccggggc cggacgcttt
       61 ctcgcgcccg gactccctcc ctcggccggg cggcggaggc ggcggacact cctccgccac
      121 ggtcgccgcc acggcgtcgg cgtcagcggt cggcgaggcg atcgaccggg aacagcagac
      181 ggcgatcagg aaggcgaggg ccgccgcggc ggcgggcagg gcgagggcgc gggcggcgcc
      241 cagggcctcg accacggttc cggagagcca gccgccgacc gccgcgccga gcgccatggc
      301 cgcggtttcc gccgccatgc cctcggtgag caggtgcggg ggcagcagcc gttccatcag
      361 tacgaggccg gagacgccga tcggggccac ggtcaggccg gcgacgagca tcgcgacgac
      421 cagcgcgggc aggccggggg agagggcgag ggggaccaga ccgacgactt ggacgcccag
      481 acagcgcagc cacagtacgc gcggggcggc gcgccaggcg cggctgccgt accagagccc
      541 gcccagcatg ctcccgacgg cgagcatcgc cagcaggggg ccggacaggg cgcgcgagcc
      601 caggctgtcg gcgcgggcga cgatggcgag gtcgaggacg ccgacgccga ggaggttgga
      661 gaaggccacg gcggtgatga cgggcatgcc gggcacggtg agcgcggaac cccggtgctc
      721 gtggctccgc aacggcgggg gttcggtggc gcgttgcagc gccagcgccg tggcgccgcc
      781 gacggtcagc accagacagc acagcagccc ggcccaaggg ctcaggcgcg tggccaacgc
      841 ggtgacgagg acgggacccg cgatgaaggt cacctcgtcc agcaccgcct cgaaggagaa
      901 cgcggtctcc agcgtgacgg ctgggggcgc cccccgccgg gctgctctct cccaggaggc
      961 cgctctctcc ccggagtccg tccggtggtt gtcgtgcccc gggggggtgc tgggttctcc
     1021 tacgggcggg gccgcgggcg gctcgggggc ggccgtcggg agtacgtacg cccatcgcgt
     1081 acgtaccatc gtgcccgtcg atggccggga cgcacccgtc acgatccccg ccaggcacag
     1141 cagccacacc gtggcggtcg tggcggacat gagcgtcacc agccccgcgc cgtggacggc
     1201 ggcggagacg agcagcaccc ggcgttgccc gaaacggtcc acgaaccggc cggccagcgg
     1261 cgccgtcagc gcgtaaccga gcatggtcac ggccgcgacg acaccggccg tcccgtacga
     1321 gcccgaccgc gcggagacca gcaggacgac gccgagcccg agcatgggta cgggcagccg
     1381 gccgacgaac gcggcggcgc tgaagcgggc ggcgccgggg acttggagga gtgaccggta
     1441 ggtacggatc aagaacgggc cctttcgaag cggcccggcg gcgtgtgcgt gaccgtgtcg
     1501 gaatccgtgg ccgtggccct gccgctgtcc ggagtcttct ccggggcctt tgtgatcgta
     1561 ggctccggcg gcgcgggggc ccccgccgcc gcgatgtggt cgcggagggt gccaaggagc
     1621 gcgagggcgt cctccgcctt ggtgtcgggc gcgcggtcgg cgaagtaggc ggcgatcctg
     1681 tccctttccg ccgccgtctc cgccactgtc cccgtctctg ccgccaagcc ttcggccgcc
     1741 agcccgcgga ggacgttcgc caccgtccga tcgggaaagt gcagcgactt ggcgacggcc
     1801 aggaaccgct cgccgacggc ggcgccgaac tcgccctcgg cgactccgtc ctcgatggcg
     1861 aaccggaggt tgatcagcgg ttcggaggtg gcgcacaggg tgtcggggtc gtagacgatg
     1921 gccacttcgt cgtcggcgtc gacggccccg gaggcgtagg cgtcgtagat gcggccgacg
     1981 cccgtcaccc cgaacggggc gcattcggcg gcgcggagcg cccccatgct ggacgagccg
     2041 tagaccggga tgcccgcgtc gacggctcgc agcacctcct tgggggagac ggccaggctg
     2101 tccaggaacc ggccgtccac gatgccgatc acgcagggcg gatggggccg ggcgagcagc
     2161 gcgtcgatgt cgccacggac gatgggcggc aggaattcgg cgtcgagcgt ccgggccgcg
     2221 acggcgcggt cgaggctcgg gccgaggaag accaccgggt ccatggagaa cgctcccaga
     2281 tgctaggcag gcccggaggc cgggccgaaa gaggacggtg aggcgagggg actgagagag
     2341 acggggctga gggggactgg gctgaggcga gagacgcgtg tcaggtcgtg cgggtggcgg
     2401 agacgtcggg cgggggcgcg agcagttcct gtacggccgt ccgccacgcg tgcgcggcgc
     2461 gcggcccgat ccggcagtag tcggtcgccc aggattcgag cccgggtgcg atcacccgta
     2521 ccacgttgac cggtatctga gggggcgaca ggtcgaccat gaccgcccgg gggatgcccg
     2581 cttcgcgcaa tcggccgagc atgaggtcga tgtccgcccg gacgtcgtcg gaggggaagg
     2641 cggggaggtc cgccatgccg accgtacggc tcgccggctg ccaggcccac gtgctcttgt
     2701 ccacggcggc cgaacgccgt acgtgcagct cgtacttggt gacctccgcg ccgggcaggc
     2761 tgatgtcctc gcgcatggcc tggatgtcga cggccctggc ctgcgcgcat tcgctgagcg
     2821 cgcgcgtcag cgccacctct gggtcggggt gggccccgta accgcagtgc ccctgcgagg
     2881 tggcgggccc gatgtcctcg ctcgtcgccg cgaagacggt ggggatgccc aggggagagg
     2941 tgacgtcgat ggcgcggacg tcgataccgg ccgcgtggaa gcgggcgagc atggcctgcg
     3001 cggcgggcgg cgcggtctcc agccgcaggt gcggatggcg gccgcggagc cggtcgatgg
     3061 tggcgggcag ggtgcgcggg tcccgctcct cgccggccag cacctgcggg aggtagttgc
     3121 tcaccagctc ggccagcgtc atcgagtccc gctcgatcag ctcgcacagg gcgtggcaga
     3181 tcgcctcctc gacgctgttg cccgaggcca ggcccgtggt ggtggcgatg cggtagcacg
     3241 gctcctcgtg cagccgggcc tggtagaccg cgccgtcctg cggaaccagt acgggctctt
     3301 cggagagcag gtcccagccg cggagccacg agatggggtt gtcgtcgcgg tagccggggg
     3361 cgagttcgag ggtgtattcg gcggggtgca tgaccgtctc gcctgccgcg gccagctcgt
     3421 cgtacgaggc gacgaggtcg gggcgtacgg gcagccaggc cgagaagcgc tcgatcgcct
     3481 ccatcgcggc gctgaccttc gcgtcgatgg gggtggcccc tttgccgctg tagaccgaga
     3541 tgctgtcgtt ggatctcggg atgacggcgc tgtatacggg gatgccgagg tagtcgaggc
     3601 cggtgatgtc ggcgagccgc gtgatgccgg cccggcgcag gtggggcgcg atgcgctccc
     3661 aggtctcctg ggtggtgacc tcgcggtgga cgccggggcc ggcggccttg ggggcgtgag
     3721 cccgcatctt cacgctgtct ccgtctccat ctccgtgtct gtgcctgtgc ctgtctgtct
     3781 tcgtatttct ctgtatgtct ccgtatgtgc ggacgatcgc gagcccctgc ccgtcttccg
     3841 gcggacaggg actcgacttg gccgcggtca cgaccttccg cggctctctg cggctttccg
     3901 tgaccttccg cggtcttccg cggtcttccg cggtctttcc gtggtctttc cgtggtcttt
     3961 ccgtggtctt ccgtggtctt cgggggctca gcggacgttc tgggcccgcg gtgcggagaa
     4021 gtaggagtcc gtggcgccgc gtacggtctg ggcgcgcggt gccgagaagt gggcgtccgt
     4081 ggcgccgcgt acggtctggg cccgcggtgc cgagaagtgg gcgtccgtgg cgccgcgtac
     4141 ggtctgggcg cgcggcgcgg agaagtgggc gtccgtcgcg ccgcgcaccg tctgggcccg
     4201 cgggcccgag aagtacgcgt ccgtcgcgcc gtggacggcg gcggtggagc gctcctccag
     4261 gaagccttgc aactgctccg ggttcacgtg cgcgagatcg tcgagcctga gatccgagtc
     4321 tttcctcatg agggcctttt cctttcctta cgggtttgga ggccgggcac ggtcgacagc
     4381 gtcggcaacc ggtaaccagt aaccggtaac cagtgaccgg taatacgcac tgtcccgcac
     4441 aggaacgtcg ttccgactcc gcctctgccg agttgtgcgc gagttctcac gccgctgttt
     4501 gtcctattgt cggccgggcg cacatggaga ccgaacggaa cgcgcaatta ctcggtcgcc
     4561 ccggatgacg gaaggggaga tattccctcc ggtcattccc cccgacagga ggccatttcg
     4621 ccacgatggc acagcgggca agactagtca acagtcgggc agcatggtgt agttggcgcc
     4681 cggggtgtcg tctcaagggt cgcctaaggg gtcacgcaag gaccctccaa ggggtgtcga
     4741 tcccggggcg caatatttca gccatgttgc acggtcggcg gtttccgccg tgtgccgtcc
     4801 tttggcggag gaatccgaac ggccgacggt cgaagatcaa aaggaggcgg cgggatgaca
     4861 gggggggcgt accggggagt tgtgatcttc ggatcgggca ttgccgaacg tcccacgcgt
     4921 tctgtataaa gaaaaatccg ccattcttcg gcgcgtcatc ggcccatcat tcgcccggcc
     4981 ctcacccccc gtcccgtccc cgatgctgct gccccggtcc tttcgaagcc ccagaggaga
     5041 gcccatcgat gcggctgaac agctacgacg aatggtcgcc actgcgcgag gtcgtggtcg
     5101 gatcggcgtc gaactacacc tcccacgagc gcgagctgtc gttcgagctg ttcttccacg
     5161 agaacttcgc cgaatccacc tggtattacc cccggctcac cacgggcggc ggatcgcccg
     5221 ccgcgcccgg ccgctcactg atcaagcagc ggtacgtcga cgagctgaac gaggacatcg
     5281 aagggatcgt caaggccctt gaggacctgg cggtgacggt gctccggccg atggaactgg
     5341 acgcccgcac caccgaagta cggacccccg cctggtcggc ggcggtcgtg ccgcccctga
     5401 acctgcggga caacacgctc atagtcggcg acgaaatcat cgagacgccc ccgatgatcc
     5461 ggtcccgcta tttcgaaacc cagttcctca ccccggtctt cgccgactat ttccgccagg
     5521 gcgcccggtg gaccgtgatg ccccggccgc tgatgaccga cgcctctttc gaccgttcct
     5581 acgccgagcg caccgccacg gccgaaccgg tcgacgaagc gcggccgtcc ccgtacgacg
     5641 tcggccacga gatgatgttc gacgccgcgc agtgcctgcg cctcggccgg gacatcgtcg
     5701 ccaacatctc gaccgccaac cacgccctgg gcgtcgactg gctggaacgc catttgcacg
     5761 gccggttccg tatccaccgg gtgtacggaa tcagcgacag ccatatcgac agcatggtcc
     5821 tcgccctgcg cccggggacc ctgctggtgc gctccccgga ggtcgccgac gtgctgcccg
     5881 agtggctgcg ctcctgggac ctcatcgtcg ccccgccgcc ccagtcggac agcttccccg
     5941 cgtacgacga tgacgacctc atcctgacca gcccgttcat cgacctgaac gtcctgtccg
     6001 tgagccccga caccgtgctg gtcaacgacg cgtgcccgga tctcgtacgg acgctggagc
     6061 ggcacggctt caccgccgtg cccgtacgcc accggcaccg gcggctgttc ggcgggggct
     6121 tccactgctt caccctcgac accgtccggg acggcggggc ggaggactac ttccacggct
     6181 gaccgccggg cgcgggccac gggcgcggcc gccataggga aagcgacgaa caacgacgga
     6241 aagcgagtgg tgggcgagcg atgacggaga gtctggaccg ggcgaagctg gagaacctcg
     6301 cccttgaact cacggagcgt cagttcgagg ccgtaccgag gctccgcgag tggcacgagg
     6361 ggacgtggac cgaccgcgag ttctacaagc ggtacatgat cgaggtcgtt ctgcagatcc
     6421 ggctcaacaa cgtggccgac gcctacgccc tctacaaggc gagctacggc gactaccggc
     6481 tcgcggggaa actcgcgcgg tacctcgcgg acgaaatcgg tcacgagggc atgttcgtca
     6541 aggacttggc ggggctcggc gtgaccctgg agcagatcga cgcgaccaag gtcctcccgg
     6601 cgacggcgaa gaccatgggc tatctgcgcc tggccaccga cgagcgcggg cccgcgccgg
     6661 tcgccctgtg ggactggtac ctggagtggt ggtcggaccg ctatatgcag gccatcaccg
     6721 acgccgcggc gaaggagttc ggcatcgcct gcaccagagg cgcccaggcc cacctcgacc
     6781 tcgacgactc ccacggccac gacgacatga tgttccagac gacggcacag gccgtcgaga
     6841 cctatggttc ggcggcggac gcgtacgcgg acctggagat ctacgtcgac ctggggaccg
     6901 agcagtaccg ccagctcttc gccgccgcgg tcgacagcca cggcgcgtga
//
