BGC0001850: diazaquinomycin A biosynthetic gene cluster from Streptomyces sp. F001
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Location: 257,859 - 281,361 nt. (total: 23,503 nt).
This entry is originally from NCBI GenBank QZWF01000007.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001850
Short description diazaquinomycin A biosynthetic gene cluster from Streptomyces sp. F001
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "additional key publication:Braesel, J., Lee, J.-H., Arnould, B., Murphy, B.T., Eustaquio, A.S. (2019) Diazaquinomycin biosynthetic gene clusters from marine and freshwater actinomycetes. J. Nat. Prod., in revisionBraesel, J.; Clark, C. M., Kunstman, K. J., Green, S. J., Maienschein-Cline, M., Murphy, B. T., Eustáquio, A. S. (2019) Genome sequence of marine-derived Streptomyces sp. F001, a producer of akashin A and diazaquinomycins. submitted to Microbiology Resource Announcement"
Biosynthetic class(es)
  • other (shikimate-derived)
Loci
QZWF01000007.1
257859 - 281361
via
Compounds
  • diazaquinomycin A
  • diazaquinomycin E
  • diazaquinomycin F
  • diazaquinomycin G
Species Streptomyces sp. F001 [taxonomy]
References
Chemical products information
diazaquinomycin A Evidence:
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C20H22N2O4
Chemical database entries
PubCHEM
diazaquinomycin E Evidence: NMR, Mass spectrometry
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C22H26N2O4
Chemical database entries
PubCHEM
diazaquinomycin F Evidence: NMR, Mass spectrometry
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C21H24N2O4
diazaquinomycin G Evidence: NMR, Mass spectrometry
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C21H24N2O4
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • StrepF001_25885
  • RZB16697.1
 258927 - 259739 (-) acetyltransferase
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    • StrepF001_25890
    • RZB16698.1
    		 259770 - 260582 (-) acetyltransferase
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      • StrepF001_25895
      • RZB16699.1
      		 260589 - 261650 (-) amidohydrolase
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        • StrepF001_25900
        • RZB16700.1
        		 261660 - 262064 (-) nuclear transport factor 2 family protein
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          • StrepF001_25905
          • RZB16701.1
          		 262283 - 262963 (+) NAD(P)H dehydrogenase
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            • StrepF001_25910
            • RZB16702.1
            		 263163 - 263867 (+) SDR family oxidoreductase
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              • StrepF001_25915
              • RZB16703.1
              		 263936 - 264940 (-) ketoacyl-ACP synthase III
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                • StrepF001_25920
                • RZB16704.1
                		 265176 - 265937 (-) TetR family transcriptional regulator
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                  • StrepF001_25925
                  • RZB16705.1
                  		 266116 - 266763 (+) NAD-dependent epimerase/dehydratase family protein
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                    • StrepF001_25930
                    • RZB16796.1
                    		 267417 - 268547 (+) transposase
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                      • StrepF001_25935
                      • RZB16706.1
                      		 268436 - 270079 (+) phospho-2-dehydro-3-deoxyheptonate aldolase
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                        • StrepF001_25940
                        • RZB16707.1
                        		 270145 - 270915 (+) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
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                          • StrepF001_25945
                          • RZB16708.1
                          		 270948 - 271613 (+) isochorismatase family protein
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                            • StrepF001_25950
                            • RZB16709.1
                            		 271610 - 273475 (+) phenazine-specific anthranilate synthase component I
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                              • StrepF001_25955
                              • RZB16710.1
                              • pcaB
                              		 273538 - 274920 (-) 3-carboxy-cis,cis-muconate cycloisomerase
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                                • StrepF001_25960
                                • RZB16711.1
                                		 274917 - 276866 (-) FAD-binding protein
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                                  • StrepF001_25965
                                  • RZB16712.1
                                  		 276863 - 278053 (-) FAD-binding protein
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                                    • StrepF001_25970
                                    • RZB16713.1
                                    		 278062 - 279633 (-) acyl-CoA synthetase
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                                      • StrepF001_25975
                                      • RZB16714.1
                                      		 279712 - 280290 (-) SRPBCC family protein
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                                        • StrepF001_25980
                                        • RZB16715.1
                                        		 280365 - 281351 (-) NADPH:quinone reductase
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                                          Biosynthesis information
                                          Annotation changelog

                                          Entry version: 3

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2022-10-07
                                          Update chemical activity to schema version 2.11
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 2

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2022-09-15
                                          Cleaned up synonym list
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          2022-09-15
                                          Fetch compound properties from PubChem
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          2022-09-15
                                          Updated bioactivity data
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 1

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2019-10-16
                                          Submitted
                                          • (ID: GMXWAML5TKYYBXKHYBMH2DDT)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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