BGC0001852: komodoquinone B biosynthetic gene cluster from Streptomyces sp. NRRL S-378
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Location: 170,734 - 243,231 nt. (total: 72,498 nt).
This entry is originally from NCBI GenBank NZ_JOBX01000002.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001852
Short description komodoquinone B biosynthetic gene cluster from Streptomyces sp. NRRL S-378
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type II)
  • saccharide (hybrid/tailoring)
Loci
NZ_JOBX01000002.1
186402 - 230564
via Enzymatic assays
Compounds
  • komodoquinone B
Species Streptomyces sp. NRRL S-378 [taxonomy]
References
Chemical products information
komodoquinone B Evidence: NMR [1]
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C19H16O7
Chemical database entries
ChemSpider
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • IH80_RS0102665
  • WP_030957320.1
 186402 - 187364 (-) 3-ketoreductase
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    • IH80_RS0102670
    • WP_030957322.1
    		 187412 - 188521 (-) DegT/DnrJ/EryC1/StrS family aminotransferase
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      • IH80_RS0102675
      • WP_030957324.1
      		 188570 - 189280 (-) class I SAM-dependent methyltransferase
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        • IH80_RS0102680
        • WP_030957326.1
        		 189337 - 190116 (-) cyclase family protein
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          • IH80_RS45245
          • WP_199819204.1
          		 190126 - 190374 (-) hypothetical protein
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            • IH80_RS0102685
            • WP_234432093.1
            		 190375 - 190743 (+) nuclear transport factor 2 family protein
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              • IH80_RS0102690
              • WP_199819199.1
              		 190802 - 191740 (+) NAD(P)-dependent oxidoreductase
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                • IH80_RS0102695
                • WP_030957330.1
                		 191822 - 192079 (+) phosphopantetheine-binding protein
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                  • IH80_RS0102700
                  • WP_030957332.1
                  		 192117 - 192836 (-) class I SAM-dependent methyltransferase
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                    • IH80_RS0102705
                    • WP_078906285.1
                    		 193068 - 194276 (+) aromatic ring-hydroxylating dioxygenase subunit alpha
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                      • IH80_RS0102710
                      • WP_030957336.1
                      		 194390 - 195607 (+) class I SAM-dependent methyltransferase
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                        • IH80_RS0102715
                        • WP_030957338.1
                        		 195659 - 197023 (+) activator-dependent family glycosyltransferase
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                          • IH80_RS0102720
                          • WP_030957340.1
                          		 197020 - 198654 (+) FAD-binding protein
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                            • IH80_RS0102725
                            • WP_030957341.1
                            		 198694 - 199812 (-) DUF1205 domain-containing protein
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                              • IH80_RS0102730
                              • WP_030957343.1
                              		 199974 - 200753 (+) NAD-dependent epimerase/dehydratase family protein
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                                • IH80_RS0102735
                                • WP_030957345.1
                                		 200750 - 201955 (+) acyl-CoA dehydrogenase family protein
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                                  • IH80_RS0102740
                                  • WP_030957347.1
                                  		 201952 - 203013 (+) methyltransferase
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                                    • IH80_RS0102745
                                    • WP_030957349.1
                                    		 203090 - 203983 (+) alpha/beta hydrolase
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                                      • IH80_RS0102750
                                      • WP_030957350.1
                                      		 204038 - 204658 (-) DSBA oxidoreductase
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                                        • IH80_RS0102755
                                        • WP_030957351.1
                                        		 204700 - 205134 (-) ester cyclase
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                                          • IH80_RS0102760
                                          • WP_030957352.1
                                          		 205384 - 205734 (+) antibiotic biosynthesis monooxygenase family protein
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                                            • IH80_RS0102765
                                            • WP_030957354.1
                                            		 205734 - 207014 (+) beta-ketoacyl-[acyl-carrier-protein] synthase family protein
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                                              • IH80_RS0102770
                                              • WP_030957356.1
                                              		 207011 - 208231 (+) ketosynthase chain-length factor
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                                                • IH80_RS0102775
                                                • WP_030957358.1
                                                		 208246 - 209031 (+) SDR family NAD(P)-dependent oxidoreductase
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                                                  • IH80_RS0102780
                                                  • WP_030957360.1
                                                  		 209064 - 210017 (+) aromatase/cyclase
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                                                    • IH80_RS0102785
                                                    • WP_030957361.1
                                                    		 210017 - 211354 (+) activator-dependent family glycosyltransferase
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                                                      • IH80_RS0102790
                                                      • WP_051808697.1
                                                      		 211347 - 212138 (+) SDR family oxidoreductase
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                                                        • IH80_RS0102795
                                                        • WP_030957364.1
                                                        		 212203 - 213489 (+) P450-derived glycosyltransferase activator
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                                                          • IH80_RS0102800
                                                          • WP_107056739.1
                                                          		 213692 - 214576 (+) ABC transporter ATP-binding protein
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                                                            • IH80_RS0102805
                                                            • WP_030957368.1
                                                            		 214573 - 215427 (+) ABC transporter permease
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                                                              • IH80_RS45655
                                                              • WP_037631637.1
                                                              		 215594 - 215818 (+) helix-turn-helix transcriptional regulator
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                                                                • IH80_RS0102815
                                                                • WP_030957371.1
                                                                		 215876 - 217162 (-) activator-dependent family glycosyltransferase
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                                                                  • IH80_RS0102820
                                                                  • WP_030957372.1
                                                                  		 217330 - 218937 (+) FAD-dependent monooxygenase
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                                                                    • IH80_RS0102825
                                                                    • WP_030957374.1
                                                                    		 218985 - 219782 (+) phytanoyl-CoA dioxygenase family protein
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                                                                      • IH80_RS0102830
                                                                      • WP_051808699.1
                                                                      		 219824 - 221002 (+) P450-derived glycosyltransferase activator
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                                                                        • IH80_RS0102835
                                                                        • WP_030957378.1
                                                                        		 221030 - 222313 (+) activator-dependent family glycosyltransferase
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                                                                          • IH80_RS0102840
                                                                          • WP_030957379.1
                                                                          		 222391 - 223200 (+) FkbM family methyltransferase
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                                                                            • IH80_RS0102845
                                                                            • WP_051808700.1
                                                                            		 223222 - 224463 (+) DUF418 domain-containing protein
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                                                                              • IH80_RS0102850
                                                                              • WP_030957381.1
                                                                              		 224441 - 225301 (-) class I SAM-dependent methyltransferase
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                                                                                • IH80_RS0102855
                                                                                • WP_158943267.1
                                                                                		 225590 - 226198 (+) dTDP-4-dehydrorhamnose 3,5-epimerase
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                                                                                  • IH80_RS0102860
                                                                                  • WP_234432094.1
                                                                                  		 226287 - 227759 (-) NDP-hexose 2,3-dehydratase family protein
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                                                                                    • IH80_RS0102865
                                                                                    • WP_199819203.1
                                                                                    		 228666 - 230564 (+) BTAD domain-containing putative transcriptional regulator
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                                                                                      Biosynthesis information

                                                                                      No biosynthesis information available for this record.

                                                                                      Annotation changelog

                                                                                      Entry version: 4

                                                                                      Date
                                                                                      Changes
                                                                                      Submitters
                                                                                      Reviewers
                                                                                      2024-03-22
                                                                                      MIBiG v4 annotathon
                                                                                      • (ID: K5UBFDWZSYOHS4HI42NVQMJK)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                      Entry version: 3

                                                                                      Date
                                                                                      Changes
                                                                                      Submitters
                                                                                      Reviewers
                                                                                      2022-10-07
                                                                                      Update chemical activity to schema version 2.11
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                      Entry version: 2

                                                                                      Date
                                                                                      Changes
                                                                                      Submitters
                                                                                      Reviewers
                                                                                      2022-09-15
                                                                                      Removed gene names of 'No gene ID'
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      2022-09-15
                                                                                      Removed gene annotation with no information
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      2022-09-15
                                                                                      Updated bioactivity data
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                      Entry version: 1

                                                                                      Date
                                                                                      Changes
                                                                                      Submitters
                                                                                      Reviewers
                                                                                      2019-10-16
                                                                                      Submitted
                                                                                      • (ID: K5UBFDWZSYOHS4HI42NVQMJK)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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