BGC0001854 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001854 (Trichoderma harzianum)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	49,530	High	tricholignan A	PKS:Iterative type I

BGC0001854 - Region 1 - T1PKS

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Location: 1 - 49,530 nt. (total: 49,530 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 49,531
Label		BGC0001854

Tailoring functions

Transferases: methyltransferase

THAR02_06942: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Hydrolases: hydrolase

THAR02_06940: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

Ligases: synthase

THAR02_06935: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

THAR02_06938: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001854.4	1.00	PKS	tricholignan A	Trichoderma harzianum
BGC0000107.3	0.76	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002154.2	0.76	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001258.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002175.3	0.76	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001284.4	0.75	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001275.3	0.66	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001854.4	1.00	PKS	tricholignan A	Trichoderma harzianum
BGC0000107.3	0.76	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002154.2	0.76	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001258.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002175.3	0.76	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001284.4	0.75	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001275.3	0.66	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 49530:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (pk)
Non-colinear ordering:: THAR02_06938 + THAR02_06935

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

THAR02_06935: pk

PKS_AT (566..887): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; Methylmalonyl-CoA: 66.7%; Ethylmalonyl-CoA: 58.3%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 76.1
Methylmalonyl-CoA: 74.0
Malonyl-CoA: 67.1
Isobutyryl-CoA: 43.0
Propionyl-CoA: 27.6
trans-1,2-CPDA: 24.9
fatty_acid: 23.9
Benzoyl-CoA: 22.0
2-Methylbutyryl-CoA: 21.5
inactive: 19.0
Acetyl-CoA: 18.0
CHC-CoA: 16.9
3-Methylbutyryl-CoA: 7.5
Ethylmalonyl-CoA: -3.0

THAR02_06938: mal

PKS_AT (901..1202): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; inactive: 54.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 107.0
Methoxymalonyl-CoA: 55.8
Methylmalonyl-CoA: 48.1
inactive: 42.6
Propionyl-CoA: 27.7
2-Methylbutyryl-CoA: 22.0
Isobutyryl-CoA: 21.8
Ethylmalonyl-CoA: 17.7
fatty_acid: 16.5
CHC-CoA: 14.8
Benzoyl-CoA: 11.6
Acetyl-CoA: 9.5
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor