BGC0001854: tricholignan A biosynthetic gene cluster from Trichoderma harzianum
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Location: 22,313 - 56,389 nt. (total: 34,077 nt).
This entry is originally from NCBI GenBank JOKZ01000220.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001854
Short description tricholignan A biosynthetic gene cluster from Trichoderma harzianum
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Aryl polyene)
Loci NCBI GenBank: JOKZ01000220.1
Compounds
  • tricholignan A
Species Trichoderma harzianum [taxonomy]
References
Chemical products information
tricholignan A
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • THAR02_06934
  • KKP00962.1
 22314 - 27104 (+) hypothetical protein
  • Transport
Sequence-based prediction
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  • THAR02_06935
  • KKP00963.1
 27636 - 35087 (-) fatty acid synthase S-acetyltransferase
  • Scaffold biosynthesis
Activity assay
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  • THAR02_06936
  • KKP00964.1
 35624 - 36801 (+) hypothetical protein
  • Scaffold biosynthesis
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  • THAR02_06937
  • KKP00965.1
 37809 - 39569 (+) FAD dependent oxidoreductase
  • Tailoring (Decarboxylation)
Activity assay
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  • THAR02_06938
  • KKP00966.1
 40313 - 45618 (+) RADS2 nonreducing polyketide synthase
  • Scaffold biosynthesis
Activity assay
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  • THAR02_06939
  • KKP00967.1
 48945 - 50038 (-) hypothetical protein
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  • THAR02_06940
  • KKP00968.1
 50520 - 51461 (+) hypothetical protein
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  • THAR02_06941
  • KKP00969.1
 52440 - 53897 (-) methyltransferase domain-containing protein
  • Scaffold biosynthesis
Activity assay
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  • THAR02_06942
  • KKP00970.1
 54904 - 56388 (+) hypothetical protein
  • Tailoring (Methylation)
Activity assay
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Polyketide-specific information
Subclass Aryl polyene
Cyclic? yes
Release type
  • Hydrolysis
Polyketide-synthases
Genes Properties Modules
THAR02_06938
+
THAR02_06938 		Synthase subclass: Iterative type I
Iterative PKS type: Non-reducing, C2-C7 first
Iteration counts: 3
Annotation changelog
MIBiG version Submitter Notes
2.0
  • Hidden contributor (ID: AK5NYVRLOZHRMH3OHIPC6VPO, no GDPR consent given).
  • Submitted
3.0
  • Hidden contributor (ID: 3UOU7PODQJXIM6BEPUHHRRA5, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Remove negative molecular mass
  • Extended locus to include KKP00962.1 and removed the gene as an additional 'extra'
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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