BGC0001857: burnettramic acid A biosynthetic gene cluster from Aspergillus sp. CLMG-2019a
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Location: 1 - 28,117 nt. (total: 28,117 nt).
This entry is originally from NCBI GenBank MK425157.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001857
Short description burnettramic acid A biosynthetic gene cluster from Aspergillus sp. CLMG-2019a
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Alkaloid (Pyrrolizidine)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: MK425157.1
Compounds
  • burnettramic acid A
Species Aspergillus sp. CLMG-2019a [taxonomy]
References
Chemical products information
burnettramic acid A [synonyms: bolaamphiphilic pyrrolizidinediones]
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C41H71N1O12
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QBE85641.1
 282 - 1893 (-) BuaB
  • Other enzymatic
Other in vivo study
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  • QBE85642.1
 2263 - 3414 (+) BuaC
  • Scaffold biosynthesis
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  • QBE85643.1
 3894 - 5678 (+) BuaD
  • Tailoring (Hydroxylation)
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  • QBE85644.1
 5884 - 7072 (-) hypothetical protein
  • Unknown
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  • QBE85645.1
 7860 - 8959 (-) BuaE
  • Precursor biosynthesis
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  • QBE85646.1
 9656 - 11184 (+) BuaF
  • Unknown
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  • QBE85647.1
 11815 - 13459 (+) BuaG
  • Tailoring (Hydroxylation)
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  • QBE85648.1
 14044 - 14641 (-) hypothetical protein
  • Unknown
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  • QBE85649.1
 15342 - 27878 (+) BuaA
  • Scaffold biosynthesis
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? no
Release type
  • Claisen condensation
Polyketide-synthases
Genes Properties Modules
QBE85649.1 Synthase subclass: Iterative type I
Iterative PKS type: Highly reducing, Unknown
Iteration counts: 14
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
QBE85649.1
Module ?
Specificity: 4R-hydroxyproline
Evidence for specificity:
  • Heterologous expression
Annotation changelog
MIBiG version Submitter Notes
2.0
  • Hidden contributor (ID: VI2SAJFMVVIEGOHMYZDSD4C4, no GDPR consent given).
  • Submitted
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed gene names of 'No gene ID'
  • Fixed biosynthetic classes
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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