BGC0001858 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001858 (Parastagonospora nodorum SN15)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	46,939	High	alternapyrone B/alternapyrone C/alternapyrone D/alternapyrone E/alternapyrone F	PKS

BGC0001858 - Region 1 - T1PKS

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Location: 1 - 46,939 nt. (total: 46,939 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 46,940
Label		BGC0001858

Tailoring functions

Oxidoreductases: oxidase oxygenase

SNOG_05793: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

SNOG_05795: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Transferases: acylase sulfotransferase

SNOG_05791: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

SNOG_05797: Sulfotransferase domain

extras: Sulfotransfer_4: Sulfotransferase domain

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001858.2	0.99	PKS	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001244.3	0.65	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001254.3	0.63	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.63	PKS	FR901512	fungal sp. No.14919
BGC0001268.4	0.60	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0000012.3	0.55	PKS	alternapyrone	Alternaria solani
BGC0002240.3	0.50	PKS	BAB, BAA	Metarhizium anisopliae
BGC0002245.2	0.48	terpene	terpestacin, preterpestacin 3, preterpestacin 2, preterpestacin 1	Bipolaris maydis C5
BGC0001264.3	0.46	PKS	betaenone A, betaenone B, betaenone C	Phoma betae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001858.2	0.99	PKS	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001244.3	0.65	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001254.3	0.63	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.63	PKS	FR901512	fungal sp. No.14919
BGC0001268.4	0.60	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0000012.3	0.55	PKS	alternapyrone	Alternaria solani
BGC0002240.3	0.50	PKS	BAB, BAA	Metarhizium anisopliae
BGC0002245.2	0.48	terpene	terpestacin, preterpestacin 3, preterpestacin 2, preterpestacin 1	Bipolaris maydis C5
BGC0001264.3	0.46	PKS	betaenone A, betaenone B, betaenone C	Phoma betae

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 46939:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

SNOG_05791: pk

PKS_AT (249..556): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; Methylmalonyl-CoA: 70.8%; Ethylmalonyl-CoA: 66.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 92.7
Methoxymalonyl-CoA: 78.2
Malonyl-CoA: 75.4
Ethylmalonyl-CoA: 59.1
Isobutyryl-CoA: 40.8
Benzoyl-CoA: 36.0
2-Methylbutyryl-CoA: 23.8
trans-1,2-CPDA: 20.7
Propionyl-CoA: 20.4
fatty_acid: 20.2
inactive: 18.6
3-Methylbutyryl-CoA: 17.1
CHC-CoA: 10.3
Acetyl-CoA: 0.0

Link to PARAS substrate predictor