LOCUS       BGC0001859             23175 bp    DNA     linear   BCT 25-JUL-2012
DEFINITION  Pseudomonas syringae strain PB-5123 fosfomycin biosynthetic gene
            cluster, complete sequence.
ACCESSION   BGC0001859
VERSION     BGC0001859
KEYWORDS    .
SOURCE      Pseudomonas syringae
  ORGANISM  Pseudomonas syringae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
            Pseudomonadaceae; Pseudomonas.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 16:26:43
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..23175
                     /db_xref="taxon:317"
                     /mol_type="genomic DNA"
                     /organism="Pseudomonas syringae"
                     /strain="PB-5123"
     subregion       1..23175
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001859"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..23175
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             complement(6610..7518)
                     /codon_start=1
                     /note="Psf6"
                     /product="F1 5,10-methylene-tetrahydrofolate
                     dehydrogenase/cyclohydrolase"
                     /protein_id="AFM38982.1"
                     /transl_table=11
                     /translation="MRECSLLHVSFSMVNHASMTAHLIDGKAIAANLRKQIAQRVAERR
                     QQGLRTPGLAVILVGTDPASQVYVSHKRKDCEEVGFISQAFDLPSETTQQTLTELIDRL
                     NDDPAVDGILLQLPLPAHLDASLLLERIRPDKDVDGFHPYNIGRLAQRIPLLRPCTPKG
                     IITLLESTGQDLYGMNAVIVGASNIVGRPMAMELLLAGCTVTVCHRFTKDLAGHVGRAD
                     LLVVAAGKPGLVKGEWVKEGAIVIDVGINRQEDGKLVGDVVYETALPRAGWITPVPGGV
                     GPMTRACLLENTLYAAEELHK"
     misc_feature    6610..19144
                     /note="fosfomycin biosynthetic gene cluster"
     protocluster    6790..23003
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[11789:18003]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      11790..18003
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    6790..23003
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     CDS             complement(8404..9615)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020:major
                     facilitator transporter (Score: 119.9; E-value: 2.2e-36)"
                     /gene_kind="transport"
                     /note="Psf9"
                     /product="MFS family transporter"
                     /protein_id="AFM38983.1"
                     /transl_table=11
                     /translation="MSKPYSLHLLISAFGIEIFCTQVLFIYTPLHFIFNGGDSVIGSFL
                     RALAYIGPVLFGYYIGVLVDRFEKRRLGYIISVVLGATAACYSIRLPDQTLAETFLFLG
                     AVSVGTYFLNNLRSSVLPSVALASQLPRMNAMLLVTENVALIVAPLIASLLLSLSSPRM
                     GFLGIAALFCSSSLLYALALPRRPTQPGQTQRKTGSFAQNLGTLTSNKPLLHLVFVVMG
                     NNAFTGVYLLYVIINAVETGLFDTRNAPNILVSFAVGAIISGLTAEKAIAFFGNRNLAL
                     LCCAFMAISGALPLIAPSHAAFFTSAFLVGFFESYVVIAAWTLRQTVVPAEVLGRVTGI
                     TSALFKVSMVVAIPIAGLLGEHLNSKMAILFGICAALLGTAPMALRMVRDHSGANRVDT
                     PSPD"
     CDS             complement(9608..10627)
                     /codon_start=1
                     /note="Psf10"
                     /product="hypothetical protein"
                     /protein_id="AFM38984.1"
                     /transl_table=11
                     /translation="MANPESLLSILPGLIDSIARNQPVIIRDLDDEQLISMLPALTRHK
                     LESIALLSMAETAGMSTFYLQTYHAQFAAIRAHLAHRLKALDCMFLQGFPRCLDFSSFY
                     TPGMRTDIDIYVPAASHTAVRDFARNAGFDYYGFDSENIFVVDAEQSNALTAHNWADKD
                     VALTLLREVELPADLPIEIVDCYLPYVLRNGKTYLFISLEVHHLYTDHSDIGVLEANRE
                     PWQEMGVDRCNAEATLYFNLIRLHRGVLAGEARMRLLLDTACLLASRHRPLDMQRFAQL
                     VVDSPGRVAITSVCSTLATLHPLFEALLPALTDQLDNRVEQSWFQQLQHSLRIEPEHV"
     CDS             complement(10614..11354)
                     /codon_start=1
                     /note="Psf11"
                     /product="hypothetical protein"
                     /protein_id="AFM38985.1"
                     /transl_table=11
                     /translation="MDDAIEFYRGWPETPLPTPARIDLSGHIPTRAHQYCEPFLVANSM
                     GYLLYPPIDFNLYWDGTQTLIQFEGSSEWIIVDKIFLPNSMNHWQDSIEAELVDTLPVF
                     LESFPERGVLQLWSGYFASTAPGSSLWIRGPVNQTLSNAYTIIEGIVETDWWAGPLFTN
                     IEISKTDVPIAFRKDKPFLQVFEIPRRSHQRDARPTLSVSDLGPSTPSAFLERMKETAA
                     RRNTQRPGSYRKCAKQMRKNDGQP"
     CDS             11790..12665
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) phosphonates-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 273.4;
                     E-value: 3.8e-83)"
                     /gene_kind="biosynthetic"
                     /note="Psf1"
                     /product="phosphoenolpyruvate phosphomutase"
                     /protein_id="AFM38986.1"
                     /sec_met_domain="phosphonates (E-value: 7.7e-132, bitscore:
                     428.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates-like (E-value: 6.4e-113,
                     bitscore: 366.1, seeds: 13, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.8e-66, bitscore:
                     213.9, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSITHAEQFRRSLFNGKLDLILEAHNGLSARIVEEAGFSAIWAS
                     GLSISSALGLRDCNEASWSQVVEVTQSIHDAVTIPILFDGDSGFGNFNNVRHIVKRLSH
                     YGIAGISLEDKLFPKMNSFITGAHALSPVEEFCGKIKAAQDSKCDRHFTVIARTEALIA
                     GLGVEAALERAQHYHDAGADGIFIHSKTGDGLDILEFGRRWERRSPLVVAPTTYINTPL
                     ALLEEVGVSIYICANHLMRASIQAMRKAAGQIRKDNSISTINSDISSLTEVFSLLNYDE
                     LQAAERLYAR"
     CDS             12628..13221
                     /codon_start=1
                     /note="Psf12"
                     /product="hypothetical protein"
                     /protein_id="AFM38987.1"
                     /transl_table=11
                     /translation="MSCKRLSVCMHGNPVDVPLAMQTLRTAMDGCGQVRLSDGTNVLEH
                     ALWAAHQAVMASCDNTLIVAALFHDIGHYLCAGDPELAEYYKDREHAALGARWLSRWFG
                     RAVCAPIELHIEAKRYLATIDTDYRRQLGAGSLQSLEHQGGLMSAEEVRAFRQVEHFES
                     ALLVRQFDDTPFKGETLPPYSWYERIVASVMGSL"
     CDS             13179..13955
                     /codon_start=1
                     /note="Psf13"
                     /product="hypothetical protein"
                     /protein_id="AFM38988.1"
                     /transl_table=11
                     /translation="MVRAHCRISDGVIMNRKVVDTHVHLLLSKKQRVPDWAAIKRMLDV
                     AKVDELDALCVTEHIEADGYQTLMEGLFVENRLPGGDQHAGRLTYQGVAIFPGAELELA
                     NRTNVGVHTDLEGLLALDRAPGAYTLERLHAVLEQRGRPFKLVAHHIFWPGKTCDDLQA
                     LGRYVNAIEVPAKDLANAQNYVALAETLALDTTGGSDAHTFIQVGACRTAFELPGSVRD
                     CTAQDWISSRQTSHLFTAQSPRLVVMSNIYRQSLMG"
     CDS             13972..14544
                     /codon_start=1
                     /note="Psf4"
                     /product="epoxidase"
                     /protein_id="AFM38989.1"
                     /transl_table=11
                     /translation="MDVRTLAVGKAHLEALLATRKMTLEHLQDVRHDATQVYFDGLEHL
                     QNVAQYLAIPLSEFFVGQTQSDLDDGVKIARRNGGFKREEIRGGVHYYTYEHLVTTNQD
                     PGLMALRLDLHSDDEQPLRLNGGHGSREIVYVTRGAVRVRWVGDNDELKEDVLNEGDSI
                     FILPNVPHSFTNHVGGAKSEIIAINYG"
     CDS             14572..15357
                     /codon_start=1
                     /note="Psf7"
                     /product="phosphotransferase"
                     /protein_id="AFM38990.1"
                     /transl_table=11
                     /translation="MKPACYVIKLGGSVTTYKQGRYALRHDAIALVARVLKARQALIGL
                     PVILIFGGGSFGNVAPTEYRIFERQHGLPSANLPMMTSIMFSMLSDITRIFVEQGLRVY
                     PFQSSALLGVDEEGRVTLHARQLATAMASGYMPLLTGDLLLRGEQEAQVFSSDNIAPLL
                     AADFEVRRVLYYSDVAGVYDQGNALVPWVGNANAACMEACVGASSMTDLTGGMRNKFMQ
                     QRQLARLGVVSEVLSFECFDRVHLSLCGLRQFGTVFLSE"
     CDS             15363..15992
                     /codon_start=1
                     /note="Psf8"
                     /product="hypothetical protein"
                     /protein_id="AFM38991.1"
                     /transl_table=11
                     /translation="MLITLAGIDGAGKSTQCRHLERWLVSKNIPVNVIDKWDVLKPEVF
                     PECRFIQPDLDQLRVCIAQMEGASRALFLIWSIATVMKQYERDPHQVYILDGYWMKHLA
                     SEILYGNDEQWLLGLVSVLPPADTVLYFDVDVARTGVRKQAYTPYECGRNEVSRQAFDK
                     HQLALKGLMDRWSSSMGWTVIDANQPEALVSAALQEVLTPLLQGRP"
     CDS             15989..16876
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1100:3-hydroxyisobutyrate dehydrogenase (Score: 187.4;
                     E-value: 6.4e-57)"
                     /gene_kind="biosynthetic"
                     /note="Psf3"
                     /product="6-phosphogluconate dehydrogenase"
                     /protein_id="AFM38992.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 1.1e-09, bitscore:
                     27.7, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRVVGFIGLGRMGQAICRRLLASQMPVHVHNRSREKADDLIRQG
                     AVWAPDIVALTRAARVLFVCTAGSEAVQDFYHAPDRGLLACLEVGDIVVDLSTIAPETA
                     EGLHAAFAQQGADYIECPVSGGVEGALAGILSAIVSGRPEAYGLIRPLLEVFCATVTYV
                     PEPGKAQRLKILNNLAESINLAGAIEVISQGLSQGLDLKSMADVFTSCRGRSAYMDVAL
                     GYALSGGASSNVSLGVRCKDLELARRRLPQDQSYPFSTLAMTTFDTVRQACGEESDQCQ
                     YFSVLSHNKAWKAS"
     CDS             16861..18003
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271:2-isopropylmalate synthase (Score: 312.8;
                     E-value: 7e-95)"
                     /gene_kind="biosynthetic"
                     /note="Psf2"
                     /product="trans-homoaconitate synthase"
                     /protein_id="AFM38993.1"
                     /sec_met_domain="HMGL-like (E-value: 1.8e-73, bitscore:
                     237.2, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEGVMNIRTDVIIEDTTLRDGEQAPGVSFDRQTKLKIFDALVDAG
                     VRWIEGGINAMGGSERSTLREMLERTEGTDIRLIGWNRGVKDDIKSTLDLGYRHVHIGL
                     PTSDIHLKDSINKSKAWLIEQACELIDYAKQRGAFVSISAEDVGRSDLSFVVEYAGHVK
                     EAGADRLRLSDTVGLLTPEQYHRVVKEVSMATSIDTQCHAHNDFGYAVSNTISGLLAGA
                     RYFHVTVNGIGERAGMPDLAQVVMSLKVQYGVDLGIRLDKLQALSELVAQASATRIHPW
                     QPVVGANVFAHESGIHAKGTINNGNAFEPFAPELLGRDRQIVVGKHSGRASLKYALDHL
                     QVDYAEDDLAGLLQLVREVSMIKSHALSFEDVAMLHATLK"
     CDS             18014..18589
                     /codon_start=1
                     /note="Psf5"
                     /product="non-heme Fe-binding protein"
                     /protein_id="AFM38994.1"
                     /transl_table=11
                     /translation="MPDTLIASRQALTRLLQSRKMALENIRGLYQEVGDAIHLDLGQLT
                     GLAARLDFPLAYVIDCFDDAGSDLRHRVKICRKQGQFERLRVVGSHKQPAYLYRHVMKT
                     TADKHLMVLRTSPLFTRAEDAPLNGGHQVREIVYVLSGRVGVNWAGKSGKRRSEVLAAG
                     DSIFIESWVPHSFHALEADAQILAVDYA"
     CDS             18779..19144
                     /codon_start=1
                     /note="Psf14"
                     /product="hypothetical protein"
                     /protein_id="AFM38995.1"
                     /transl_table=11
                     /translation="MKADRFQPVECLAEGAGRGIPLMIAKEARQALALQRFAEANPQLL
                     EEIRELDAREQAQQIEWAFEDAADEQGIQPWELALQLIAETPEQLQAMRLETHREVAEA
                     LGMEWGEYCQFNEIDPQ"
ORIGIN
        1 agcgtgcgcc gggggtgaag gcgtgctgct ggcgcgggtc gacgaagcgc cgggtccccc
       61 aggcgccgag caggcagccg ctggcgtcgc cgagcatcac caggtggctg gcgttgccca
      121 gcaggtgcgc gtattgcggc agcacgtcgt catgggtgag gcgcaggagg acttggttgc
      181 gttcgagcag ggcatcgagc tcggcaccgg tcaggcaatc gaagtcgggc gcgtgctggg
      241 gctgcaggcc gtgctcgcgg cagcgcgccc aggaggcctg gatcagttgg gcgtgggtcg
      301 aagcggagtg ggccatgggc ctgtcctgtg gggtgttgtt tttattggcg accgcgattg
      361 agtgtcgttc agtgctgttc aatgtcaaac ccgagggtgt tcagttgttc agcgaaactg
      421 ttcacatctg tacaggccgc gtgccgcgcc cgggcgcgag atgccggtat agagcggttg
      481 tgccgggctg gcacggaact ggctgaggtg gctggacaac catcacaaga aggccacgcc
      541 atgtccctgg tgctggagca ggtacgccgc agtgtcgaca accagctgtg gatcgacgac
      601 gccagcctgc gcttcgagcc tggctcgttc aacgtgctgc tgggccgcac cctggccggt
      661 aagaccagcc tgatgcgcct gatggccggc ctcgaccgcc cggacagcgg ccgggtgctg
      721 atggatggcg aggatgtcac cgggcggccg gtgcgcagcc gcaacgtatc gatggtctat
      781 caacagttca tcaactaccc cacgctcacg gtgttcgaga acatcgcctc gccgttgcgc
      841 caggcgcgca tggccgaacc ggacatccag cggcgggtgc gcgaaaccgc cgagatgttg
      901 cgcatcgagc cctttctcgg gcgcctgccg ctggaattgt cgggtggcca gcagcagcgc
      961 accgccatgg cccgggcatt ggtcaaggac gcctcgctga tcctgttcga cgagcccttg
     1021 gtcaacctcg actacaagct gcgcgagggc ttgcgccagg agctgcgcag cctgttcgcc
     1081 gagcgcaact gcatcgccgt gtatgccacc accgagccca acgaggcgct ggccttgggt
     1141 ggcaccacca ccttgctgca cgagggccgg gtgatccaga gcggccgcac caccgaggtg
     1201 tatcaacggc ccgccagcgt gctggccgcc gagctgttct gcgagccgcc gatcaacctg
     1261 gtgcccgggc gcatcgtcgg caacgaggtg agcctggccg gtgccgtgca ctttgcccgc
     1321 acggccgatc tgcgtgagct ggcggacggc gagtatcgtt tcggcatccg ccccggccac
     1381 ctgaccctgg tgccctcgcg cgacgatgac ctggaactgg cggtgctggt ggagctggcc
     1441 gagatcagtg gctcggaaac cttcctgcat gtgcgcaacg agcactggcg catgaccctg
     1501 catctgccgg gcgtgcacga atatcaggtg gacacgccga tccgcgtgtt cgtccccacc
     1561 cacaagctgt tcatcttcga cagcgccgac accctggcgc aggcgccacg cctgcgcgac
     1621 gcgaggagcg cctgatggcc gagatccgcc tgcaccagct ggcccacagt tacagccgct
     1681 cgcccgcaag cgccgacgac tacgccttgc atgagctgga acatgtgtgg gctcagggcg
     1741 gtgcctatgc cttgctcggg ccgtcgggct gcggcaagtc gaccttgctc aacatcattt
     1801 ccggcctgct cgcgccctcc catggcgagg tgttgttcga cggcaaggtg gtcaacgcct
     1861 tgaccccgca gcagcgcaac atcgcccagg tgttccagtt cccggtggtg tacgacacca
     1921 tgacggtgtt cgacaacctg gccttccctc tgcgcaacca gggcttggac gaggcgcggg
     1981 taggtgcgcg ggtcgaggaa atcgccgagg tgctggaact gaccgcggtg ctgcacaagc
     2041 gcgcgcgcaa cctcagtgcc gacgaaaagc agaaggtttc catgggccgc gggctggtgc
     2101 gcgacgacgt ttcggcgatc cttttcgacg agccgctgac ggtgatcgac ccgcacctga
     2161 aatggaagct gcggcgcaag ctcaagcaga tccacgaaca gttcaacatc accatgatct
     2221 acgtcaccca cgatcagctg gaggcctcga ccttcgccga caagatcgcg gtgatgcacg
     2281 ccgggcgcat cgtccagttc ggcaccccgc gcgagctgtt cgaacggccc cggcatacct
     2341 ttgtcggcta tttcatcggc agccccggga tgaacctgat cgatgtgcgc gccgaggccg
     2401 acggcgtgag ctttggcgag gttcatctgg tgttgcacga gggggtgcgt gagcgcctgg
     2461 caacctccga aggcgggcgt ttgcaggtgg gcatccgccc ggagttcgtg caggtgtggg
     2521 agcacccctt cgacaacgcg ttcgagacgc gggtggtgga cgtggaggac ctgggcacct
     2581 accgcatcct cacgctggtg ctggcggggg tgaccctcaa ggcgcgcctg ggcgaggacc
     2641 gggtggtgcc ccatggccgg gcctgggtaa gcctgccgcc gcaatggctg atgctctacc
     2701 tggacgatgt gctggtggag gccgaggcat gaacaaggtg ccgaacaaca aggcctggtg
     2761 gctggtgctg ccggtgttcc tgctggtggc gttcagcgcc gtgatcccga tgatgaccgt
     2821 ggtcaactac tcggtgcagg acatcttcga tgcttccaac cgttacttcg tcggtgccga
     2881 ctggtaccgc caagtgctgc gcgacccagc gctgcatgat gcgctgctgc gccagttcat
     2941 ctattccggg tgcgtgctgg ctatcgaaat cccgctgggt atcgccatcg ccctgaccat
     3001 gccgacccgt gggcgcatgg cgtcggtgtg cctgatcctc atggccatcc ccttgctgat
     3061 cccgtggaac gtggtgggca ccatctggca gatcttcggc cgcgccgaca tcggtctgct
     3121 cggcgcgacg ttggccaagc ttggggtcaa ctacaactat gccggcgacc cgttcgacgc
     3181 ctgggtcacc gtgctggtga tggacgtgtg gcactggacg tcgctggtgg cgctgctgtg
     3241 ctactcgggt ttgcgcgcca tccccgacgt gtactaccag gccgcgcgca tcgaccgggc
     3301 atcgggctgg gcggtgtttc gccatatcca gctgccgaag ctcaagaatg tgctgctgat
     3361 cgcggtgatg ctgcggttca tggacagctt catgatctac accgagccgt tcgtgctcac
     3421 tggcggcggg ccgggcaacg ccaccacctt cctcagccag accctcacgc gcatggcggt
     3481 cgggcagttc gacctggggc cggcggcggc gttctcgctg gtgtacttcc tgatcatcct
     3541 gctggtgtcg tggctgttct acacagccat gacccacgcc gacaaggagt aggccatgag
     3601 caagcgcaaa acgctggccc tattgttgta cttcttcttc ctgctggtgc cgatctactg
     3661 gctgctgaac atgtcgttca agagcaacag cgagatcctc ggtgggctga cgttgtggcc
     3721 gcaagtgttc accttcgata actaccgggt gatcttcacc gatgccagct ggtacagcgg
     3781 ctatatcaac tcgctgtact acgtgtgcct gaacacggtc atctcgctga cggtggcctt
     3841 gccggcggcc tatgcctttt cgcgctaccg ctttcttggc gaccggcacc tgttcttctg
     3901 gctgctgacc aaccgcatgg cgccgccggc ggtgttcctg ctgccgtttt ttcagctgta
     3961 ttcgtcgatc ggcctgttcg acacgcacat tgccgtggcc ctggcccact gcctgttcaa
     4021 cgtgccgctg gcggtgtgga tcctggaggg tttcatgagc ggggtgccga aggaaatcga
     4081 tgaaaccgcc tacatcgatg ggtacagctt cccgcggttc ttcgtgaaga tcttcatccc
     4141 gctgatcggt tcggggatcg gcgtgacagc cttcttctgc ttcatgttct cttgggtcga
     4201 gctgctgctg gcacgcaccc tcacttcggt gaacgccaag ccgatcgcgg cggtgatgac
     4261 ccgcacggtg tccgcctcgg gtatcgactg gggcgtgctg gcggccgccg gggtgctgac
     4321 catcctgccg ggcatgctgg tgatctggtt cgtgcgcaac catgtggcca agggcttcgc
     4381 cctgggccgg gtgtgaggag ggcggatgat ggagtggatg gcctggaccc tgccgaccgc
     4441 gctgttcttc tcggcgatcg gcctgttgtt gatgtgcatg accctgtttg aactgcgccg
     4501 cccgtgcctt gagcgtcgcg gttttctgcc gattgccacg acccgtggcg accggctgtt
     4561 catcggcttg ttggtcagcg cctacctgca tctgctggtg gtgggggtga gcgactggcc
     4621 gttgtgggtg gcctcgctgc tgtcgctggc gtggctggtg gtggtgctgc gctggggttg
     4681 agcctggggc aaggatcctt ctgcaatctg gagatcataa tgttcgataa cgacaacaaa
     4741 cggcgacatt tgaccctggc cgcattgctg gtgctggccg gcctgcacgg cacggcctgg
     4801 gcagaccagt acgaagacgc ggcgaaaaaa tggatcggca gcgagttcaa gccttcgacc
     4861 ctgaccccgg agcagcaact cgaagaactc aagtggttca tcaaggccgc cgagccgttc
     4921 cgggggatga agatcaacgt ggtgtcggaa accatcacca cccacgaata cgagtccaag
     4981 gtgctggcca aggccttcac cgagatcacc ggcatccagt tgacccacga cctgctgcag
     5041 gaaggcgacg tggtggagaa gctgcagacg cagatgcagt cggacaagaa catctatgac
     5101 ggctgggtca atgattccga tctgatcggt acgcactttc gctatggcaa ggtggaatcc
     5161 atcaccgacc tgatggccaa tgagggcaag aactacacct cgccaaccct ggacctgaag
     5221 gacttcatcg gcatttcctt caccaccgcg ccggacggca agatctacca gttgcctgac
     5281 cagcaattcg ccaacctcta ctggttccgc gccgactggt tcgagcgccc ggacctgaaa
     5341 gccaagttca aagagaagta cggctacgag ctgggcgtgc cggtgaactg gtcggcctac
     5401 gaggacatcg ccaagttctt cagcgaggac gtcaaggaga tcgacggcaa gcgggtctat
     5461 ggtcacatgg actatggcaa gaaggaccct tcgctgggct ggcgtttcac cgacgcctgg
     5521 ttttccatgg ccggcggtgg cgacaagggg ctgcccaacg gcctgccggt ggacgagtgg
     5581 ggcattcgcg tggaggactg ccacccggtg ggctccagtg tgacccgcgg cggcgacacc
     5641 aatggcccgg cggcggtgtt tgccacgcag aagtacgtgg actggatgcg cgcctacgcc
     5701 cccaaggaag cccagggcat gaccttctcc gaggcgggcc cggtgccggc gcagggcaac
     5761 atcgcccagc agatcttctg gtacaccgcc ttcaccgccg acatgaccaa gcccgggctg
     5821 ccggtggtca acgccgacgg cacgccgaag tggcgcatgg cgccctcgcc caaggggccg
     5881 tactgggagg aggggatgaa actcggttac caggacaccg gctcctggac cttcttcaaa
     5941 tccaccccgg agaaacagcg tctggctgct tggctgtatg cccagttcgt cacctccaag
     6001 actgtgtcgc tgaagaagac cgtcgtcggc ctgacgccga tccgcgagtc ggacatcaac
     6061 tcccaggcca tgaccgacct cgcgcccaag ctgggcgggc tggtggagtt ctacagaagc
     6121 ccggcgcggg tgcagtggac gccgaccggc accaacgtgc cggattatcc acgcctggcg
     6181 cagctgtggt ggagccatat cgccgaggtg gccagtggcg agaaaacgcc gcaagaggcg
     6241 ctggacggcc tggcgcggga tcaggaccgc atgatggagc ggctgcagcg ctccaacgcg
     6301 caggccacct gtgcacccaa gctcaacccc gagaaggatg cccagtactg gttcgaccag
     6361 ccgggggcgc cgaagccgaa actggccaac gagaaaccca agggcgaaac ggtcagctac
     6421 aacgaactgc tcaagtcgtg ggaggcggcg cgcaagtgat cggttagctt caagggcctc
     6481 atcgcggggc aagcccgctc ccacgctgca tggcgtggga gcgggcttgc cccgcgatgg
     6541 ggtttttaca aaaacgccag gcaaaaaaaa cggcacctgc cagaggtgcc gttttcgctt
     6601 cacgccaact tacttgtgca gctcttcagc ggcatacagc gtattttcca gcaggcatgc
     6661 gcgggtcatc gggccgacgc cgccgggtac cggggtgatc cagccagcgc ggggcagggc
     6721 ggtctcgtag accacgtcgc cgaccagctt gccgtcttcc tggcggttga tgccgacgtc
     6781 gatgacgatc gcgccttcct tgacccactc acccttgacc aggcccggct tgccagcggc
     6841 aaccaccagc aggtcggcac ggccgacgtg gccggccagg tccttggtga agcggtggca
     6901 gacggtgacg gtgcagccgg ccagcagcag ttccatggcc atcgggcgac cgacgatgtt
     6961 ggaagcaccg acgatgaccg cgttcatgcc gtacaggtcc tggccggtgc tttccagcag
     7021 ggtgatgatg ccctttgggg tgcacgggcg cagcagcggg atgcgctgcg cgaggcggcc
     7081 gatgttgtac gggtggaaac cgtcgacgtc cttgtctggg cggatgcgct cgagcagcag
     7141 cgaggcgtcc aggtgcgcgg gcagcggcaa ctgcagcagg atgccatcga cggccgggtc
     7201 gtcgttgagg cggtcgatca gctcggtcag ggtctgctgg gtggtctcgc tgggcaggtc
     7261 gaaggcctgc gagatgaagc cgacttcttc gcagtccttg cgcttgtgcg agacatagac
     7321 ttgggaggcc gggtcggtac cgaccaggat cactgccagg cctggcgtac gcaggccctg
     7381 ctggcggcgc tccgcgacac gttgcgcgat ctgcttgcgc aggttggcgg cgatcgcctt
     7441 gccatcgata aggtgtgcag tcatagacgc gtgattaacc atcgagaagg aaacatgaag
     7501 aagcgagcat tctcgcacga cacggcgcaa gggcaaaggc gggtggtcgg gcaaatcccc
     7561 taaccccttc aataatttaa atttttttca gaaacatgtt gacgactttg agggtcggct
     7621 ataagattcg ccgcacttgt cgggcactgc ctggcacggg ttggcaaagt cagacagaat
     7681 gagcggtttg ttggcttgtt aagttggact gaaagcttaa gcgcccgtag ctcagctgga
     7741 tagagcatcc gccttctaag cggatggtcg caggttcgag tcctgccggg tgcgccatta
     7801 ggcctgggca agtaagcagt aacgcaatat ggtgggcgta gctcagttgg tagagcgccg
     7861 gattgtgatt ccggttgtcg tgggttcgat tcccatcgtc caccccagat tcggcagagg
     7921 cgccaggatt gaatgatcag gcgcctttgt tttaagcgct tcatgcggac gtggtgaaat
     7981 tggtagacac actggattta ggttccagcg gcgcaagctg taagagttcg agtctcttcg
     8041 tccgcaccat gtttctgtaa ggctgtaccg caacactgca ttatggtggg cgtagctcag
     8101 ttggtagagc gccggattgt gattccggtt gtcgtgggtt cgattcccat cgtccacccc
     8161 atattttatg aaggcgcctt gatcgaaaga tcgggcgcct ttgttgtttt agccctacgc
     8221 gaacttgatc aaatgggtga gcatgctgga ccgcagcttc ctgcggcgcc agctgtaggc
     8281 gttcgagtca ctgcgcccgc gccttcttat gctctcgtcg cgctcctgtg cagttgcatg
     8341 tgtgagcgct tggaacaatg ccgctgaatg cggcattttt tgtttttgct gggcgggtgg
     8401 gcttcagtcg ggcgagggcg tgtcgacacg attcgcgcct gaatggtcgc ggaccatgcg
     8461 gagggccatg ggggctgtgc ccaggagtgc ggcgcagatg ccgaagagta tcgccatctt
     8521 gctgttgagg tgctcgccaa gcaggccggc gatgggtatg gcgacgacca tcgagacctt
     8581 gaacagcgcg ctggttatac ccgttacccg gcccagcact tctgcgggga cgacggtttg
     8641 gcgaagggtc catgctgcaa tcacgacata ggactcgaaa aaaccgacga ggaaggccga
     8701 ggtgaaaaat gcagcgtggc ttggcgcgat cagcggcagg gcgccggaga tggccatgaa
     8761 tgcgcagcag agtagcgcaa ggttgcggtt gccgaaaaat gcaatggctt tctctgccgt
     8821 gaggcctgaa atgatcgcgc caacagcgaa ggacaccagg atgttggggg cgttgcgggt
     8881 atcgaacagg ccggtttcca ctgcattgat gatgacgtac agcaggtata cgccggtgaa
     8941 ggcgttgttg cccatgacca caaacacgag atggagcaat ggtttgttgc tggtcaaggt
     9001 gcccagattt tgtgcaaagg agcctgtctt gcgctgcgtc tggccgggct gagttggccg
     9061 gcggggtagt gccaaggcgt acagcaggct tgaactgcag aacagagcgg cgatacccag
     9121 gaagcccatc cgcgggctgc tcagtgacag cagcagcgaa gcgatcagcg gcgcgacgat
     9181 cagcgcgaca ttctcggtga ccagcagcat ggcgttcatg cgcggcaact gcgacgctag
     9241 ggcgacgctg ggcagtacag acgagcgcaa gttgttgagg aagtaagtgc cgaccgatac
     9301 cgcgcccagg aatagaaacg tctcggccag cgtctggtcg ggcaatcgaa tgctgtagca
     9361 ggctgctgtc gcgcccagaa ccaccgagat gatatagccc aggcggcgct tctcgaagcg
     9421 gtccaccagc acgccgatgt aatagccaaa cagcacgggc ccgatatagg cgagggctcg
     9481 gagaaatgat ccgattacgc tatcgccgcc gttgaagatg aaatgcagcg gcgtatagat
     9541 gaagagcacc tgggtgcaga agatctcgat gccaaatgcc gagatcagaa ggtgcaggga
     9601 atagggttta gacatgttca ggctcaatcc gcaagctgtg ctggagctgc tggaaccacg
     9661 actgctcaac cctgttgtcg agctggtctg ttagcgctgg cagcagcgct tcgaacagcg
     9721 ggtgaagcgt tgccagcgtg ctgcaaaccg atgtgatagc tactctgccg ggtgagtcga
     9781 cgaccagttg tgcgaaacgc tgcatgtcga gtgggcgatg ccggctggct aacaggcagg
     9841 ccgtgtccag cagcaggcgc attcgcgctt cgccagcaag caccccgcgg tgcagtcgga
     9901 tcaggttgaa gtacagcgtg gcttcggcat tgcaccggtc gacacccatc tcttgccagg
     9961 gctctcggtt cgcttccagt acgccgatgt cggagtgatc ggtatacagg tgatggacct
    10021 caagggagat gaacaggtag gtcttgccgt tgcgaagcac atagggcagg tagcaatcca
    10081 cgatctcgat gggtaggtcg gcggggagtt cgacttccct gagcagggtc agcgcgacgt
    10141 ccttgtcggc ccagttgtgt gcggtaagtg cgttggactg ttcggcgtcg acgacgaaga
    10201 tgttctcgct gtcgaagccg tagtaatcga agccggcgtt gcgcgcaaaa tcgcgcactg
    10261 cggtgtgaga cgccgccggc acatagatgt ctatgtcggt acgcataccg ggcgtataga
    10321 aactcgagaa gtccaggcac cttgggaaac cttgcaggaa catgcagtcc agagccttga
    10381 gcctgtgcgc gagatgagcg cgaatggccg cgaattgtgc atgataggtc tgcagataga
    10441 aggtgctcat tcccgcggtt tcggccatcg acaacagcgc gatgctttcc agtttgtggc
    10501 gagtgagtgc cggcagcatc gaaatgagtt gctcatcatc caggtcgcgg atgatgacgg
    10561 gctggttgcg tgcgatcgaa tcgatcaggc ctggcaggat gctcaacagg ctttcagggt
    10621 tggccatcgt tttttctcat ctgcttggcg cacttgcgat acgatccagg cctttgcgtg
    10681 ttgcgccggg cggccgtttc cttcattcgc tcgagaaagg cgcttggcgt acttgggccc
    10741 aggtcgctga ccgagagggt ggggcgcgca tcgcgttggt ggctgcgccg aggtatctcg
    10801 aagacttgca ggaacggttt gtctttgcgg aatgcaatcg gtacgtcggt cttgctgatc
    10861 tcgatgttgg tgaacagtgg gccggcccac caatcggtct ccacgatccc ttcgatgatc
    10921 gtgtaggcat tggagagtgt ctggttgacg gggcctcgaa tccacaggct ggagccggga
    10981 gcggtactgg caaaatagcc ggaccacagt tgcagtacgc cccgctccgg gaatgactca
    11041 agaaacaccg gcagggtatc gaccagctcg gcctcgatgc tgtcttgcca gtggttcatc
    11101 gaattgggca ggaagatctt gtcaacgatg atccattcgc tgctgccttc gaactggatc
    11161 agggtctggg tgccatccca gtacaggttg aagtcgatgg gcgggtaaag caggtagccc
    11221 atgctgttgg cgaccagaaa cggttcgcaa tactggtgtg cgcgggttgg aatatggccg
    11281 ctcaggtcaa tccgggccgg ggtgggtaat ggggtctcgg gccagccgcg atagaactcg
    11341 atggcgtcat ccatatatag gtcattgcct tcctggtagg gagattacga cggggtagac
    11401 cccgtcgtaa gtttcagcct attgccgatt acttggcagg cgccgaaccg ccgccagcac
    11461 tgcgaacttg tacgccattg ctggtaacgg ctggaacgct gctcgagatt acgattttca
    11521 taagttctcc ataactctaa gtgtgcctgg aattaggcag ggttgagggt agaagtgggc
    11581 ttggaatgct gtcaaggcgt gatggggtaa ttttgtcacg ggttggtgac attactcatc
    11641 tgtttggggg tgtctataag atagcggttg agtatctgtt tgggtgtaat tgttaaaaaa
    11701 cgtaaaagtt gggttgaaat ttaataggtc gttggctaac actggtggga cggggcgtgg
    11761 tggggcaata acaaggacgg tgaaacgaca tgtcatcaat aacgcatgca gagcaatttc
    11821 ggcgaagtct gttcaatgga aagttggatt taattctcga ggcgcacaat ggcttgtccg
    11881 cgcgtattgt cgaagaggct ggcttctcgg caatatgggc ttcgggtttg tctatttcct
    11941 ctgcgctggg cttgagggat tgcaatgaag cgtcctggag ccaggttgtt gaagtcacgc
    12001 agtcgattca tgatgcggtg actattccta ttctgttcga tggcgattcg gggtttggga
    12061 acttcaacaa tgttcggcat atcgtcaagc gtctgtcgca ttacgggatt gcgggtatct
    12121 cgcttgaaga caaactattt cccaagatga actccttcat tactggtgcg catgcgctga
    12181 gcccggtaga ggagttttgc ggaaaaataa aggccgcgca ggactccaag tgcgatcgac
    12241 acttcacggt catcgcccgc actgaggctt tgatcgccgg actgggggtg gaagccgcgc
    12301 tggaaagggc gcagcactac cacgatgctg gcgcagatgg gatattcatc cattccaaga
    12361 ccggggatgg tctggatatc ctcgagtttg gcaggcgctg ggagcggcgc tcacccttgg
    12421 tcgtggcgcc gacgacctat ataaacacac cgttggcgtt attggaggag gtcggggtct
    12481 ccatttatat ctgcgctaac catttgatgc gagcgtccat acaggcgatg cgcaaggcgg
    12541 ctgggcagat cagaaaagac aacagcatca gtacgataaa ttcggacatc tcttcgctga
    12601 ccgaagtgtt ttcgctgctt aattatgatg agttgcaagc ggctgagcgt ttgtatgcac
    12661 ggtaatccgg tggatgtgcc attggcgatg cagacactgc gtacggcaat ggacggctgc
    12721 ggccaggtaa gattgagtga tggcaccaat gtgcttgagc acgctttatg ggccgcacac
    12781 caggcggtga tggcgagctg tgataatacc ttgatcgtgg ctgcgctatt tcatgatata
    12841 ggccattact tgtgcgccgg cgatccggag ttggcggaat attacaagga tcgcgagcac
    12901 gctgcactgg gtgcgcggtg gttgtctcgt tggttcgggc gtgcggtgtg tgcgcccatt
    12961 gaattacata tcgaagccaa gcgttatctc gcgacaatcg atacggatta tcgccggcaa
    13021 ctgggtgcgg ggtcgttgca aagtttggaa catcaaggtg gattgatgtc cgcggaagaa
    13081 gtgcgcgcct ttcgtcaggt cgaacatttc gaaagtgcac tgcttgtcag gcagtttgat
    13141 gatacgcctt tcaagggtga aaccctgccg ccttattcat ggtacgagcg cattgtcgca
    13201 tcagtgatgg ggtcattatg aacaggaaag tcgtggacac gcatgttcac ttgttgttga
    13261 gcaaaaaaca gcgcgtgccc gattgggcgg cgatcaagcg gatgctcgat gtggcgaagg
    13321 ttgatgaact ggatgcgcta tgcgttaccg agcacatcga ggccgatggc tatcaaacct
    13381 tgatggaagg gctgttcgtg gaaaacaggc tgccgggtgg cgatcagcac gctgggcggc
    13441 tcacttacca gggtgtcgcc atttttccgg gagcggagct tgagttggcc aacaggacca
    13501 acgtgggcgt gcacacggac ctggagggcc tgttggccct ggaccgagcg ccgggcgcct
    13561 acaccctgga gcgtctgcat gccgtcctgg agcagcgggg caggcctttc aagctggtgg
    13621 ctcatcacat tttctggccg ggcaagacct gtgacgactt gcaggcgctg ggtcgctatg
    13681 tgaacgccat cgaagtgccg gcgaaggacc tggcaaatgc gcagaattat gttgcgctcg
    13741 ccgaaacgct cgcgcttgac accacgggtg gctccgatgc gcataccttc attcaggtgg
    13801 gggcctgccg taccgccttc gagttgccgg gttcggtgcg cgattgcacg gcgcaggact
    13861 ggatctcaag caggcagaca agccacctgt tcaccgcgca gtcgccgcgt ctggtggtca
    13921 tgtccaatat ctatcgtcaa tcactgatgg gctaactggg agtgggttga aatggacgtt
    13981 cgcactttag ctgttggcaa agcgcacctg gaagcgttgc tggccacaag aaagatgacc
    14041 ctggagcatc tgcaggatgt caggcatgac gcgacgcagg tctacttcga tggtctcgaa
    14101 catctgcaga atgtggcgca gtacctggca attccgttga gcgaattctt tgtcggacag
    14161 acacagagtg atctcgacga cggggtgaag atcgctcggc gcaacggtgg ctttaaacgc
    14221 gaagaaatca gagggggtgt gcactattac acctacgaac acctggtcac gacgaaccag
    14281 gatcccggat tgatggcgct tcgccttgac ctgcacagtg atgacgagca gccattgcgt
    14341 ctgaacggtg gtcacggttc cagggagatc gtctatgtca cccgtggcgc cgtccgtgtg
    14401 cgatgggtcg gtgacaatga tgagctcaag gaagatgtgt tgaatgaagg tgactccatt
    14461 ttcattctgc cgaatgtccc acacagtttt accaaccatg ttggcggggc aaagtccgag
    14521 atcattgcca tcaattatgg ttgagtgccc gttcacgcca ggagtcgaga tatgaaaccg
    14581 gcctgctatg tcatcaagct gggtggcagt gtcacgactt acaagcaggg ccgttatgcc
    14641 ttgcggcacg atgcgatcgc gctggttgcg cgcgtgctta aggctcggca ggcgctcatc
    14701 gggttaccgg tgatcctgat attcggtggg ggttctttcg ggaatgtggc gcccacggaa
    14761 tatcgcatct tcgagcgcca gcacggcttg ccgtcagcca acttgccgat gatgacatcg
    14821 atcatgtttt cgatgttgtc ggacatcacg cggatttttg tcgagcaggg gctacgggtc
    14881 tatccctttc aaagcagtgc cttgctgggc gtcgatgaag aggggcgtgt cacgcttcat
    14941 gcgcgccagc tggcaacggc catggcatcg ggttacatgc ccttgctcac tggggatctg
    15001 ctgctgcgcg gcgagcagga ggcgcaggtc ttttcaagtg acaatatcgc cccgttgctc
    15061 gctgcggact tcgaagtgcg tcgggtcttg tattactccg atgtggccgg tgtctacgac
    15121 cagggcaatg ccttggtccc ttgggttggc aatgccaacg ccgcgtgcat ggaggcttgt
    15181 gtgggggcgt cgtcgatgac ggacctgacc ggtggcatgc gcaacaagtt catgcagcag
    15241 cgccagttgg cacgcctggg cgtggtttcg gaggtcttgt cattcgagtg cttcgacagg
    15301 gtgcatctgt cgttgtgcgg gttgcgtcaa tttggaaccg tgttcttgag cgagtgataa
    15361 ctatgctaat tacgcttgcc ggtatcgatg gggcgggaaa atccacccag tgccgtcacc
    15421 tggaacgttg gctggtatcg aaaaacatac cggtcaatgt gatcgataaa tgggatgtgc
    15481 tgaaaccgga ggtctttccg gagtgcaggt tcatacagcc tgatctcgac caattgaggg
    15541 tctgcattgc gcaaatggag ggcgcctcgc gcgccttgtt tctgatctgg tccatcgcga
    15601 cggtcatgaa gcagtacgag cgagatcccc atcaggtcta catccttgat ggatactgga
    15661 tgaagcacct ggccagcgag attctgtacg gcaacgatga gcagtggctg ctgggcctgg
    15721 tctcggtgct gccgcctgcg gatacggtgc tttactttga tgtcgatgtt gcccgaaccg
    15781 gtgttcgcaa gcaggcctac acgccgtacg agtgcgggcg caacgaagtg agcaggcagg
    15841 ctttcgacaa gcatcagctg gcgctcaagg gcctgatgga ccgatggtcg agcagcatgg
    15901 gctggaccgt catcgacgcg aaccagccag aagccctggt gtccgcggcc ttgcaggagg
    15961 tcctgacacc cttgctgcag gggcgcccat gaaccgcgtg gtggggttca tcgggctggg
    16021 gcgcatgggt caggccattt gccggcgttt gctggccagt cagatgccgg tgcatgtcca
    16081 taaccgctcg agggaaaagg cagacgacct gatccggcag ggtgcggtct gggcgccgga
    16141 tatcgttgcg ctgacgagag cagcgcgggt cctgttcgtc tgtaccgccg gcagcgaagc
    16201 ggtgcaggac ttctatcatg cgccggatcg aggcctgctg gcttgcctgg aagtaggcga
    16261 catagtggtt gacctgagca ccatagcccc ggaaacggcc gaagggcttc atgccgcgtt
    16321 tgcccagcaa ggcgccgact atatcgagtg ccctgtttca ggcggcgttg aaggcgctct
    16381 tgcaggtatc ttgagcgcga tcgtgtcggg caggcccgag gcctacgggt tgatacgccc
    16441 gctgcttgag gttttttgcg cgacggtgac ctacgtgcct gaaccaggca aggcgcagcg
    16501 tctgaaaatt ctcaacaacc tggctgaaag catcaacttg gcgggcgcga tcgaggtcat
    16561 cagtcagggc ctgtcccaag ggctggacct caagtcgatg gcagatgtct tcacgtcctg
    16621 tcgagggcgc tcggcctata tggatgtggc actgggctac gcgctctcgg gcggcgcaag
    16681 cagcaacgtc agccttggcg tgcgctgcaa ggatctcgaa ctggcgcgcc ggcgcttgcc
    16741 gcaagatcag tcatacccct tctcgacctt ggcgatgacg accttcgaca cggtcaggca
    16801 ggcctgcgga gaagagagtg accaatgtca gtatttttct gttctgtccc ataacaaagc
    16861 atggaaggcg tcatgaatat tcgcactgat gtgatcatcg aagacaccac gttgcgcgat
    16921 ggcgaacagg ctccaggtgt ttctttcgac aggcagacca agctgaagat cttcgatgcg
    16981 ctggtggatg caggtgtcag gtggatcgaa ggcggtatca atgccatggg cgggagcgag
    17041 cggagtacct tgcgtgagat gctcgagcgc accgagggta ccgatatcag gctgatcggc
    17101 tggaaccgcg gtgtgaagga cgatatcaag agcaccctgg atctaggtta caggcacgtg
    17161 cacatcggcc tgccgacttc ggacatccat ctcaaggaca gcatcaacaa gtcgaaggcg
    17221 tggttgatcg agcaggcctg tgagctgatc gattatgcaa agcagcgggg cgctttcgtc
    17281 tcaatcagcg ccgaggacgt cgggcgctcc gatctttcct tcgtggtcga atatgccggc
    17341 cacgtaaagg aagcgggggc cgatcgactg cgtttgtccg acaccgtggg cctgctgacc
    17401 ccggagcaat accaccgagt ggtcaaggaa gtgtcgatgg cgacgtccat tgatacgcaa
    17461 tgtcatgcac acaacgactt cggctatgca gtcagcaata ccatctccgg tttgctggcg
    17521 ggggcgcgtt acttccacgt caccgtcaac ggtatcggcg agcgggccgg catgcctgac
    17581 ctggcgcagg tagtgatgtc cctgaaggtc cagtatggcg ttgacttggg tatcaggctc
    17641 gacaagcttc aggcattgag cgaactggtg gcgcaggcca gtgccacgcg catccacccc
    17701 tggcagcccg tggtcggcgc caatgtcttc gcccatgagt ccggcattca tgccaagggt
    17761 acgatcaaca acggcaatgc attcgagcct tttgccccgg agttgctggg gcgagacagg
    17821 cagatcgtgg tgggcaagca ctccgggcgt gcatcattga aatatgcgct ggatcacttg
    17881 caggtcgact acgcggaaga cgatctggcc gggctgctgc agctggtgcg ggaggtctcg
    17941 atgatcaagt cgcacgcctt gagtttcgag gatgtggcga tgctgcatgc gacgctgaaa
    18001 tgaaggaggc ccgatgccag acactttgat cgccagcagg caggcgctga cacgcctgct
    18061 gcaatcgcgc aagatggccc tggagaacat tcgtgggttg tatcaggagg taggtgatgc
    18121 cattcacctg gacctgggtc agctcactgg gcttgcggca aggctcgatt ttcccttggc
    18181 gtatgtcatc gactgcttcg atgatgcggg cagcgatctt cggcaccggg tgaagatctg
    18241 tcgcaagcag gggcagttcg agcgcctgag ggtcgttggc agccataagc agccagctta
    18301 tctgtaccgg catgtgatga agaccacggc cgacaagcat ctcatggtgc tcagaacctc
    18361 gcccttgttc acgcgggccg aggatgcgcc gctcaatggc ggccaccagg tcagggagat
    18421 cgtgtacgtc ttgtcgggca gggttggcgt gaactgggcc ggcaagtcgg ggaagcggcg
    18481 ttccgaagtg ctggcggcag gggactccat cttcatagag tcgtgggtac ctcattcttt
    18541 ccacgcgctg gaggccgacg cgcagattct ggcagtcgat tacgcttgat gcgcaccgag
    18601 cgcgtcgggc tcgctacctg gcggcgctgt gccgccaggt aacatccagc agggtttcac
    18661 accgctgacg ctgggccata cttctttctc cccaacctga tgccgtcatt tgctccgttc
    18721 ctgcgatcca tgcagcgctt gggctgcacg gctgtcgccg ccctctggtg acaacgtcat
    18781 gaaagctgat agatttcagc cggttgaatg tctggccgaa ggggctggca gaggaatacc
    18841 tttgatgatt gcaaaagaag cgcgccaggc tctggcgctg caacgtttcg ccgaggccaa
    18901 cccacaactg ctcgaagaga tccgcgagct ggatgcgcgc gagcaggcgc aacagataga
    18961 gtgggcgttc gaggatgccg ctgacgagca aggcatccag ccctgggagc tggctctgca
    19021 actgatcgct gaaacccccg agcagctgca ggcgatgcgc ttggaaaccc atcgcgaggt
    19081 tgccgaagcg ctgggcatgg aatggggcga gtattgccag ttcaatgaga tcgatccgca
    19141 ataagagcag cgatctttct ggctgttgat tatttgacaa ggttttgcag tcggacggca
    19201 tccagccggc catccgaccc tgtatgagtg aggctcgacg ccacgtcgcg cgggccttgc
    19261 aaggaaatcg accggtgtga ggcgccgaca tcccgagtgg ggtgacttct ggtgcgtgag
    19321 tcactagaat gcttgccctt gattctggag tcgggctatc gccggctaat gtctgtgcaa
    19381 cgaggaatat ccatgcaagt ttctgttgaa aacacttccg ctctcgagcg ccgcatgacc
    19441 atcgccgttc cggccgagcg cgtcgagaac gaagtcaaca agcgtctgca gcagactgcc
    19501 cgtcgcgcca aggttgcagg cttccgtcct ggcaaggtgc cgatgagcgt cattcgccag
    19561 cgtttcgaag ccgatgcccg tcaggaagct ttcggtgacc tggtccaggc ctccttctac
    19621 gaagccatcg tcgagcagaa gctgaacccg gccggcgctc ctgccgttga gccgaagtcg
    19681 ttcgaaaagg gcaaggacct cgagttcgtc gctatcttcg aagtcttccc tgagttcacc
    19741 gttggcggtt tcgagtcgat cactgtcgag cgcctgaacg ccgaagtggc cgataccgac
    19801 ctggacaaga tgctggacgt gctgcgcaag cagaacaccc gtttcgaggc cgtcgagcgc
    19861 gccgcgcaga acgacgatca agtcaacatc gacttcgttg gcaagatcga cggtgaagcc
    19921 ttcgccggtg gttcggccaa aggcactcag ctggtgctgg gttccggccg catgatccca
    19981 ggcttcgaag aaggcctggt cggcgccaag gctggtgaag agcgcgttgt cagcgtgacc
    20041 ttcccagagg actaccagaa cctcgacctg gctggcaaag ccgccgagtt caccatcacc
    20101 gtcaacagcg tttcggcgcc acagctgcca gaactgaacg aagagttctt cgctcaattc
    20161 ggtatcaaag agtcgaccct ggaaggcttc cgcgccgaag ttcgcaagaa catggagcgt
    20221 gaactgcgtc aggccaccaa gaccaaggtc aagaaccagg tcatggacgg tctgctggcc
    20281 gccaacccga tcgaagtgcc aaaagccctg ctggaaaacg aagtcaaccg tctgcgcgtg
    20341 caggctgtcc agcagttcgg tggcaacatc aagcctgacc aactgccggc cgagctgttc
    20401 gaagagcaag ccaagcgtcg cgtggtgctg ggcctgatcg tcgccgaagt ggtcaagcag
    20461 ttcgacctga agccggacga cgccaaagtg cgtcaggtga tcgaagaaat ggcttcggcc
    20521 taccagcagc cagagcaggt tatcgcctgg tactacaaga acgacgaaca actgaacgaa
    20581 gtgcgttcgg ttgtactgga agagcaagtt gtagatactg tcctgcagaa agcgactgtg
    20641 accgacaaaa cggtctcgta cgaagaagct gtaaaaccag tacaggctca agccgacgct
    20701 gagtaacagg ctactctcgt aggaaacccc cacaagccag ccttcgcgct ggcttgtgcg
    20761 tattcaagcc atgactattt gggagtgagt gcaggacatg tcccgcaatt cttatattca
    20821 gcagagctct gacatccagg ccgcaggcgg cctggtcccg atggttatcg agcagtccgc
    20881 ccgtggcgaa cgcgcctatg acatctactc gcgccttttg aaggagcggg tgatcttcct
    20941 ggtcggcccc gtagaagact acatggccaa cctggtggtg gcgcagctgc tgttcctgga
    21001 agcggaaaac ccggacaagg atatccatct gtacatcaac tcgccgggcg gttcggtgac
    21061 tgccggcatg tcgatctacg acaccatgca gttcatcaag ccggacgtct cgaccatctg
    21121 catcggccag gcctgcagca tgggcgcctt cctgctggcg gccggtgccg ctggcaagcg
    21181 ccactgcctg ccgaactcgc gagtgatgat tcaccagcca ctcggcggtt tccagggcca
    21241 ggcgactgac atcgagatcc acgcccagga aatcctcaac atcaagtcgc gcctgaacga
    21301 gctgctggcc catcacaccg gccagtcgct cgagaccatc aagcgcgata ccgagcgtga
    21361 caacttcatg agcgctgcgc gcgcggccga gtacggcctg atcgactcgg tctacgacaa
    21421 gcggcaactg gcatcctgaa gcaaagcgcc agagcggtcg ggtgcacagt gtgcccgacc
    21481 gcggacttga aaaagcctgc gattgccttc atcttgtgtt tcaagcctac cggattggat
    21541 cgatcgaatg actgacaccc gtaacggcga ggacaacggc aaattgctct attgctcctt
    21601 ctgcggcaaa agccagcacg aagtgcgcaa gttgattgcc ggcccctcgg tatttatctg
    21661 cgacgagtgc gtcgacctgt gcaacgacat catccgtgag gaggtgcagg aagcccaggc
    21721 cgagagcaac gcgcacaagt taccctcgcc gaaagaaatc agcggcatcc tggaccagta
    21781 cgtcattggt caggagcgcg ccaagaaggt gcttgccgta gcggtgtaca accactacaa
    21841 gcgcctgaac cagcgtgaca agaagggcga cgaagtcgaa ctcggcaaaa gcaacatcct
    21901 gctgatcggg ccaaccggct cgggcaagac gctgctcgcc gaaaccctcg cacgcctgct
    21961 gaacgtaccg ttcaccattg ccgacgccac caccctgacc gaagccggtt atgtgggtga
    22021 ggacgtcgag aacatcattc agaaactgct gcaaaagtgc gactacgacg tggaaaaggc
    22081 ccagatgggc attgtctaca tcgacgagat cgacaagatt tcgcgcaagt cggacaaccc
    22141 gtccattacc cgtgatgttt cgggtgaggg cgtgcagcag gcactgctga aactgatcga
    22201 aggcactgtc gcttccgtgc cgccgcaagg tggtcgcaag cacccgcaac aggaattcct
    22261 gcaggttgat acccgcaata tcctgttcat ctgcggtggc gccttctctg gcctggaaaa
    22321 ggtcatccag aaccgttcca ctaaaggtgg tatcggtttc agtgcagaag tgcgcagcaa
    22381 ggaagaaggc aagaaagtcg gcgagtctct gcgtgaggtc gagccggacg atctggtcaa
    22441 gtttggtctc atccccgagt tcgtcggtcg tttgccggta ctggcgacgc tggacgagct
    22501 ggacgaggct gcgctgatgc agattctgac cgagccgaag aacgcgctga ccaagcaata
    22561 cgccaagctg ttcgaaatgg aaagcgttga cctcgagttc cgcagcgatg cgctcaaggc
    22621 cgttgcccgc aaggcgctgg aacgcaagac cggtgcccgt ggcctgcgtt cgatcctgga
    22681 gggcgtgctg ctcgacacca tgtacgagat tccttcgcag aaggaagtca gcaaggtggt
    22741 gatcgacgaa agcgtcatcg agggtacttc gaagccgctg ctgatctacg aaaacagcga
    22801 gccgcaagcc aaggccgccc ccgacgcctg atcgggcaag gggcagcatg cagaaagggg
    22861 ccttcgggcc cctttttgca tttcctggta tcgacgcttg taatttcaaa gggctgcccc
    22921 cacattagct ccaagcacca tttccaacgg tttccggcca caaggccgct gtagaggcga
    22981 aatcatgaag accaccctcg acttgcctct tttgccattg cgcgacgttg tcgtctatcc
    23041 gcacatggtc atcccactgt tcgtggggcg tgagaagtcc atcgaagccc tcgaggcggc
    23101 gatgacgggc gaaaagcaga tcctcctgct ggcccagaaa aaccctgccg acgatgatcc
    23161 gggtgaggat gccct
//
