LOCUS       BGC0001860             16387 bp    DNA     linear   BCT 11-DEC-2013
DEFINITION  Thermobispora bispora DSM 43833, complete genome.
ACCESSION   BGC0001860
VERSION     BGC0001860
KEYWORDS    .
SOURCE      Thermobispora bispora DSM 43833
  ORGANISM  Thermobispora bispora DSM 43833
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Streptosporangiaceae; Thermobispora.
COMMENT     URL -- http://www.jgi.doe.gov
            JGI Project ID: 4082801
            Source DNA and organism available from Hans-Peter Klenk at the
            German Collection of Microorganisms and Cell Cultures (DSMZ)
            (hans-peter.klenk@dsmz.de)
            Contacts: Jonathan A. Eisen (jaeisen@ucdavis.edu)
            David Bruce (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Finishing done by JGI-LANL
            Annotation by JGI-ORNL and JGI-PGF
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376).
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 16:26:59
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16387
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16387
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[9824:15047]"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      9825..15047
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
     protocluster    1..16387
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[0:15047]"
                     /cutoff="20000"
                     /detection_rule="((YcaO or TIGR03604) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /neighbourhood="10000"
                     /product="thiopeptide"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      1..15047
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((YcaO or TIGR03604) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /neighbourhood="10000"
                     /product="thiopeptide"
                     /protocluster_number="2"
     cand_cluster    1..16387
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((YcaO or TIGR03604) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /detection_rules="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /kind="chemical_hybrid"
                     /product="thiopeptide"
                     /product="LAP"
                     /protoclusters="2"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..16387
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001860"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..16387
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="thiopeptide"
                     /product="LAP"
                     /region_number="1"
                     /rules="((YcaO or TIGR03604) and ((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or PF07366 or PF06968 or PF04055) or thiostrepton)"
                     /rules="((((goadsporin_like or PF00881 or TIGR03605) and
                     (YcaO or TIGR03604)) or TIGR03882 or TIGR03603 or
                     TIGR03602) and not cyanobactin_synth)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1..1215)
                     /locus_tag="Tbis_0545"
     CDS             complement(1..1215)
                     /EC_number="1.3.99.22"
                     /codon_start=1
                     /db_xref="InterPro:IPR006638"
                     /db_xref="InterPro:IPR007197"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: PF04055"
                     /gene_functions="other (smcogs) SMCOG1277:Radical SAM
                     domain protein (Score: 62.7; E-value: 4.4e-19)"
                     /gene_kind="biosynthetic"
                     /inference="protein motif:PRIAM:1.3.99.22"
                     /locus_tag="Tbis_0545"
                     /note="KEGG: gsu:GSU0030 oxygen-independent
                     coproporphyrinogen III oxidase, putative; PFAM: Radical SAM
                     domain protein; SMART: Elongator protein 3/MiaB/NifB"
                     /product="Coproporphyrinogen dehydrogenase"
                     /protein_id="ADG87272.1"
                     /sec_met_domain="PF04055 (E-value: 4.1e-24, bitscore: 75.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRPLLLYVNIPFCNSKCHFCDWVVQIPVRDLRLDQQAPGRIAYL
                     DAVRAQIRGQAPVLREHYQPAIIYWGGGTASILGESEIESLYTCLRSEFDLSHVRETTI
                     EGSPESLTPQKLRRLRELGFDRISIGVQSFDDQRLRRLGRAHSAEQAVEVVKNAHAAGF
                     RNINIDLIVGFPGQTDAEVAESVRTALTLPINHFSIYPYRASPGTILRKQVERGGHLDL
                     NRQLAAYYITRDLLEEAGFPEYAMSYFGAPRCEADQAYYRLTMDWIGFGSGANSLLGHR
                     YLAFRKGRLHAYNQNPLRFDVNAPASSPQLTLHWLSQALTTVEGMDARVYQERTGTPLR
                     VACEEPEVQAYLRRMSEHGRLIIDRNGIRIHREDIARVIIALNWIDTPGGDQKVTRLTP
                     VSATS"
     misc_feature    complement(1039..1041)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(1434..2606)
                     /locus_tag="Tbis_0546"
     CDS             complement(1434..2606)
                     /codon_start=1
                     /db_xref="InterPro:IPR001128"
                     /db_xref="InterPro:IPR002397"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 397.2; E-value:
                     1.3e-120)"
                     /gene_kind="biosynthetic-additional"
                     /inference="protein motif:PFAM:PF00067"
                     /locus_tag="Tbis_0546"
                     /note="PFAM: cytochrome P450; KEGG: scl:sce8913 cytochrome
                     P450 CYP109C2"
                     /product="cytochrome P450"
                     /protein_id="ADG87273.1"
                     /sec_met_domain="p450 (E-value: 4.8e-31, bitscore: 97.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMELPGQPSLTDGGAALFAWLRTMRNEHPVWRDQFGIYHVFRYDD
                     VRQILGDYQTFSSDRTRLMPTAQGFGKGGITMIDPPEHRHQRRLITHAFTPQSISAMEP
                     RIRQIADHLLDELPGPEFDLVEHFAYPLPVIVIAELLGVPPGDRHLFRTWSDRLMSLQV
                     ENYADPELARTVAAAMTEMNDYLREHCRSRRTHPRDDLLTRLVQAEVEGKRLDLEEVVN
                     TASLLLLAGHLTTTVLIGNTMLCLWDHPEAEKAVRADPSLIPAALEESLRLRSPFLQAG
                     RVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDPERFDLHRQTTGHIAFGHGVHFC
                     LGAQLGRLEGRIALERLLGRFTEIHPWPREGISFYQSAIFGASRMPVRCG"
     gene            complement(2607..3827)
                     /locus_tag="Tbis_0547"
     CDS             complement(2607..3827)
                     /codon_start=1
                     /db_xref="InterPro:IPR001128"
                     /db_xref="InterPro:IPR002397"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 389; E-value: 3.8e-118)"
                     /gene_kind="biosynthetic-additional"
                     /inference="protein motif:PFAM:PF00067"
                     /locus_tag="Tbis_0547"
                     /note="PFAM: cytochrome P450; KEGG: scl:sce8913 cytochrome
                     P450 CYP109C2"
                     /product="cytochrome P450"
                     /protein_id="ADG87274.1"
                     /sec_met_domain="p450 (E-value: 5.5e-32, bitscore: 100.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEPLTAQGTPTMTMPAAQRPRISHGGQALLKWLDEMRESQPVWR
                     DGFGIFHVFRHADVQRVMADYATFSSDINRLRPGGDPFSAGSLMLTDPPEHRKLRRLIS
                     QAFSPKMSADMKPRIAELTEELLDDIEEDEFDLVEKFAHPLPIMVIAELLGIPIHDRGL
                     FRTWADRLIALHVDDPTDVEIGRMVGEAMREMGEYVQTHVRKRRADPQDDLVSKLIAAE
                     VDGERLTDAEIVNTSCLLLLAGQITSTMALGNTFLCFRDAPDAERAVRADFSLLGPAFE
                     EVLRLRPPLTQAARLTTTDVEVAGTLIPAGSLVINWLLSANYDERQFPNPYRFDLTRSP
                     NRHFAFGHGIHHCLGAPLARVEGRVALELLLRRFSEITIDPDAELSYYEDPMFGVKSLP
                     VRVRRAA"
     misc_feature    complement(3600..3602)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(3813..3815)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(3848..4537)
                     /locus_tag="Tbis_0548"
     CDS             complement(3848..4537)
                     /codon_start=1
                     /db_xref="InterPro:IPR001647"
                     /inference="protein motif:PFAM:PF00440"
                     /locus_tag="Tbis_0548"
                     /note="PFAM: regulatory protein TetR; KEGG: bha:BH2145
                     TetR/AcrR family transcriptional regulator"
                     /product="transcriptional regulator, TetR family"
                     /protein_id="ADG87275.1"
                     /transl_table=11
                     /translation="MDITRALLLQSGYKRTTIDEIARKADIGKGTVYLSWDTKDDLIRS
                     LVIHDIIDVCDDVSNWAGTESDAPTLPSLSRRMFTLIFKYPLFRALYTRDRYILGRTCD
                     DPSLNFQSYRITTFTPFRKYLGMLADNRALDGTTGRDSQYFSLDALMWGFIKLHLLSST
                     EASINDSAANLAELVRRSFGPWRTPAAATLKTISRKTAEIFKAAADEYRAMLGVPFFGT
                     RTATASA"
     gene            5049..5198
                     /locus_tag="Tbis_0549"
     CDS             5049..5198
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (thiopeptides)
                     predicted thiopeptide"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:Prodigal:1.4"
                     /locus_tag="Tbis_0549"
                     /product="hypothetical protein"
                     /protein_id="ADG87276.1"
                     /transl_table=11
                     /translation="MDLNDLPMDVFELADSGVAVESLTAGHGMTEVGASCNCFCYICCS
                     CSSA"
     CDS_motif       5049..5150
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence:
                     MDLNDLPMDVFELADSGVAVESLTAGHGMTEVGA"
                     /locus_tag="Tbis_0549_thiopeptide"
                     /aSTool="thiopeptides"
                     /tool="antismash"
     CDS_motif       5151..5195
                     /prepeptide="core"
                     /locus_tag="Tbis_0549_thiopeptide"
                     /peptide="thiopeptide"
                     /predicted_class="Type II"
                     /score="27.60"
                     /molecular_weight="1522.8"
                     /monoisotopic_mass="1521.5"
                     /core_sequence="SCNCFCYICCSCSS"
                     /aSTool="thiopeptides"
                     /tool="antismash"
                     /leader_sequence="MDLNDLPMDVFELADSGVAVESLTAGHGMTEVGA"
                     /leader_location="[5048:5150](+)"
                     /tail_sequence="A"
                     /tail_location="[5195:5198](+)"
                     /alternative_weights="1540.8"
                     /alternative_weights="1558.8"
                     /alternative_weights="1576.8"
                     /alternative_weights="1594.9"
     CDS_motif       5196..5198
                     /locus_tag="Tbis_0549_thiopeptide"
                     /note="tail peptide"
                     /note="thiopeptide"
                     /prepeptide="tail"
                     /aSTool="thiopeptides"
                     /tool="antismash"
     gene            5283..7859
                     /locus_tag="Tbis_0550"
     CDS             5283..7859
                     /codon_start=1
                     /db_xref="InterPro:IPR006826"
                     /db_xref="InterPro:IPR006827"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     63.4; E-value: 1.6e-19)"
                     /gene_kind="biosynthetic"
                     /inference="protein motif:PFAM:PF04737"
                     /locus_tag="Tbis_0550"
                     /note="PFAM: Lantibiotic dehydratase domain protein; KEGG:
                     scl:sce9070 hypothetical protein"
                     /product="Lantibiotic dehydratase domain protein"
                     /protein_id="ADG87277.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 4.2e-47, bitscore:
                     150.1, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLVERRFPVAMTSTAPKVAVRECGLPVSAIESLCCTDSFALIRR
                     QVRETAWLKGEGKRLAVDLGLLIGERGDGDDGLRPVLVGLRRALHTGRLPDAREWTPRV
                     ASALPAELAARVADWVTRMRALTRARRELPELFAAEARVKEKVLAQVAADPGFRRALSL
                     ASPELAADLDRWLAEPARRPKTQKLLRLAKYVARAAVKTSPYSTFTSMGVAVWENGEDW
                     ADGAIVRFAPREPPSVILEPSGEWLHGALRAWLARPENLVRSRLRLNPSLVIRADKAEF
                     LGFPPREPIIRMGLTPVVATVLRLAEPAADADGWIDPMGFRDRLARDLPAEPEQVDRLL
                     RSLIEAGVLEAHPLTRAGLPETGEWAEIRAALRHDPHGEDPEAYRVRLARLKRAMTMMW
                     PQGDTTALLHETAVVTRPVASLNPTAWGRGLSDLDVVRRWLSVFDGKLPIRIVVAEYLR
                     ARYGEHARVPFLTFHRHVQEEIAGDAPSGADLRTFVGRSAAIWAPPLAHSRLPRLRELA
                     KLREAARELALGRPEHDGIQRVDPEELIKQMATWPEWIVVPRSCACYVQPAPEGRLVLN
                     VVHGGHGRGLRRLSHLIGRVRGEAVDHPMVADEPEGTVYAELSGSLGSTLNVHVPGTRY
                     EIDYPFSPGDRSRDRRLPLSDLEVVLAPETGLAELRSRRLGFRVIPLHLGMAAEFQLPP
                     AARFLERAFGVTYLLHPSAPPLLRIGEVPPPQEVTRYPRVEVGRVVVQRRRWLAPAGTL
                     PIRAKGEDDASYLLRLVAWTDANGIPTRSFVRAWQERMVQAGQDKARKPLFLDLANPFL
                     VKVFERQIRDCAFVLFEEALPDPADAPPREGSDLPRVIEFLVELGE"
     misc_feature    7356..7358
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7856..8752
                     /locus_tag="Tbis_0551"
     CDS             7856..8752
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="ab initio prediction:Prodigal:1.4"
                     /locus_tag="Tbis_0551"
                     /note="KEGG: bce:BC5083 lantibiotic biosynthesis protein"
                     /product="hypothetical protein"
                     /protein_id="ADG87278.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 5.8e-50, bitscore:
                     160.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPHEAEVIWVSAHIFHQGPLDRLVTEVAGPLFVELAAAGLSTQG
                     FFLRYWEGGPHLRFRVRLLPGADAAETRRLIRERACAYLRRYPSQDVLDREEYARLAEV
                     LAAREGLTGHARELYPNDSVQFISYRPEHHRYGRGPSLEAVERHFAESSRIALELLHAG
                     LTIPQRGAVWLTMLMATWLLAGSRGEDAFRPWPDARKEQAFDRERERLTGLARHARQLT
                     LRPPDPEAQGVLAAWHGSVARLADALAASGFTATRTATVLDLCAHLLANRLGIRIQDEA
                     RLRYLASRALDEAEVTV"
     gene            8752..9828
                     /locus_tag="Tbis_0552"
     CDS             8752..9828
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="ab initio prediction:Prodigal:1.4"
                     /locus_tag="Tbis_0552"
                     /note="KEGG: bce:BC5082 hypothetical protein"
                     /product="hypothetical protein"
                     /protein_id="ADG87279.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.5e-82, bitscore:
                     267.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAGERWWRFRVDYHAGPMDDLILDGVRPAFAAFAAQAPMAYFLR
                     HWRRGPHLRIYVSTTREALEAVVRPAIEHVVGGYLRARPSPGMADPSAFLPLHERLAEL
                     EGEDGPLMPWSPDNTIHAEGERPEPLTVRDVLLADFYADTTPSVYHALERVRSGASLPT
                     IAFDLVVATAHALSTGGLPVARTSLRSHAEAYLARRSDGVRLRELWRDHYARNREAFTE
                     RLIAVASSAESAENGAHLPHVREWVRRLRPIRERARALLESGELTLEYASPAEGARDLP
                     SLAEVSAFHRELESRPEWARLRDSPAFGAYRLVINCTYLHLTRLGLTPHQRFLVCHLAA
                     DAAADVYGIAAHEEVATR"
     gene            9825..11201
                     /locus_tag="Tbis_0553"
     CDS             9825..11201
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     PF00881"
                     /gene_kind="biosynthetic"
                     /inference="similar to AA sequence:KEGG:M446_3966"
                     /locus_tag="Tbis_0553"
                     /note="KEGG: met:M446_3966 hypothetical protein"
                     /product="conserved hypothetical protein"
                     /protein_id="ADG87280.1"
                     /sec_met_domain="PF00881 (E-value: 2.4e-16, bitscore: 49.9,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIPPGLTERYALRAGVHSAVLPDGVMRLFAWPHAESIGALSADE
                     TTLLKELAEGPREIADPALRPFVERLFRGGWLKRTLSRGEHDLYTLDPLRRPGSRPAPP
                     DDPVLSRFAAVRRRPSGFVIESPLAWCDVHVHDPALLPDLLEPAGGRAGRSSLAPQIRR
                     QALADLAWAGLVVPRGAEDGALRTRQWAPHELDFHQRSRLYHRGYLGDGFGGTFWARGT
                     FDPPQARPQRYPGDPIPLHRPDLNALRAADPPLTAVLEDRRSVREYDDDAPMTVEQLGE
                     LLYRSARIRDVKVIDGVEYVRKPYPSGGSVYELEIYPVVRHVAGLAPGMYHYDAYEHVL
                     RPVRPAGHPAVRRMLTVASHGSAVGIRPQLLLVVSARVGRVMWKYEGMGYALILKHVGV
                     LYQTLYCVATAMGLAPCAIGSGDSAAFSEATGRDPLEECAVGDFLLGSRPASGSTVEES
                     "
     misc_feature    10566..10568
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            11198..13081
                     /locus_tag="Tbis_0554"
     CDS             11198..13081
                     /codon_start=1
                     /db_xref="InterPro:IPR003776"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     YcaO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thiopeptide_F_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Heterocycloanthracin_C_RRE"
                     /gene_kind="biosynthetic"
                     /inference="protein motif:PFAM:PF02624"
                     /locus_tag="Tbis_0554"
                     /note="PFAM: protein of unknown function DUF181; KEGG:
                     acp:A2cp1_3940 TPR repeat-containing protein"
                     /product="protein of unknown function DUF181"
                     /protein_id="ADG87281.1"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 6.5e-28,
                     bitscore: 86.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     3.8e-11, bitscore: 32.5, seeds: 5, tool:
                     rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 2.7e-11, bitscore: 33.3,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIPARPVLTPGVRYAPTSDGVAFLTRDGIVSITGVSIHRWIDRIA
                     PHLTGERSVAELTDGLAPERRAFVLRLLQALADRGLIIDAAGGREPRLERGTACALHVT
                     ETCGPYRESLPKLARSLADALTRAGLDVRLASASEPCDPERCHALVHLTAADEVGLAAA
                     ERLDRLSERWGVPIAHVVVWGGEIWRTEAGTVGEDGLPLAAGWRRLTALRPDTEERVPI
                     SPTAAVVVAGQVAADVRDRLTTATRAGRRPRLHVVEPARLTCRAHHFIPHFHTMPLTGD
                     APLAEELTEEEFSRRAAALMDDRTGVFTEIAEGDFGQLPLHVAVTTVADPVGLLGPAGD
                     RPRVIGVGPDFATARYRTARAAIALYGLLAVDPRRLVDADGEPLAGPRTSAAELEDLLG
                     RIRAGGLPAFVRAEDVRGGPPRLLPASSVFPFATARALLAGTVPTGTAVGYSEEGALRA
                     ALLDHCRERTLADLASRRVARLTPDTAPSDPVTARYLAFLRAIGLPFDVLDATGPLGVP
                     VYVGVLDGRVVAAEAGASPGEAFRSVLEGILRGLQGIPAARSLPDTLPPVLPEAMAVPD
                     GSPLSAEALAAALARAGLSVSVVRLDHDRRVHALIPHCVRVMVTGEESAHV"
     gene            13074..15047
                     /locus_tag="Tbis_0555"
     CDS             13074..15047
                     /codon_start=1
                     /db_xref="InterPro:IPR003776"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     YcaO"
                     /gene_kind="biosynthetic"
                     /inference="protein motif:PFAM:PF02624"
                     /locus_tag="Tbis_0555"
                     /note="PFAM: protein of unknown function DUF181; KEGG:
                     bcy:Bcer98_0958 hypothetical protein"
                     /product="protein of unknown function DUF181"
                     /protein_id="ADG87282.1"
                     /sec_met_domain="YcaO (E-value: 1.2e-76, bitscore: 248.2,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 2.5e-109, bitscore:
                     355.1, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDALAAAIIGAGLLADELAAAFRPYGEVIRLDEVERAETEAHRL
                     RALVMACDGWDTSIYRETRERCRRLGIPWLPVRTEHGIAVIGPLERPGEPGCAHCFELR
                     RERARPDAAAYRAILNHHGPELAKRPSPYLDELAAATIAALGVRMIDQGSGCHVWYVRL
                     NGLTVERHAFLPEPLCPECGSLPMDDRDSAVIVLRSQPKRAPDDYRTRDIVDELDALVA
                     DYVDGESGLIRPLVRDTQGGLVIAGAMLPLRFAGGSEPGVGRTRGYRTSEVTAILEALE
                     RWGGVEPGGKRTVIRAAFRDIAADALDPRTLGVHSPEAYAAEDFPFRPFTEDEETEWVW
                     GYSFARRSPILVPETVAYYYVHRDRPRQERPFLYEISNGCALGSGMEEAILYGILEVVE
                     RDAFLMTWYGRLGVPRIDLDSAKNRMVPLQAAAISAETGYRIEVYDTTMEHGIPSVWAL
                     AIRGGEEPTAAPRPRMVCAAAAHLDPEQAVLSALSELGPLLADLLRRYPDEAERARRMV
                     DDPGLVTTMHDHSTLYGADEAFGRLEFLTGTASTRDLAAMRESTVAFRSADLRDDLLEV
                     IGRILAEGMDVIVVDQTTPEHRVHGFTCVKVLIPGMIPMTFGHRNRRLDGLTRPLVIPY
                     RLGYRPAPLTPEALNPHPHPFP"
     gene            15059..16387
                     /locus_tag="Tbis_0556"
     CDS             15059..16387
                     /codon_start=1
                     /db_xref="InterPro:IPR002933"
                     /db_xref="InterPro:IPR010168"
                     /db_xref="InterPro:IPR011650"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1244:amidohydrolase (Score: 329.1; E-value: 5.3e-100)"
                     /gene_kind="biosynthetic-additional"
                     /inference="protein motif:TFAM:TIGR01891"
                     /locus_tag="Tbis_0556"
                     /note="TIGRFAM: amidohydrolase; PFAM: peptidase M20;
                     peptidase dimerisation domain protein; KEGG: nmu:Nmul_A0853
                     peptidase M20D, amidohydrolase"
                     /product="amidohydrolase"
                     /protein_id="ADG87283.1"
                     /transl_table=11
                     /translation="MTSRQRSAPASILQGVEALLRPLAVFRADLHRNPELSGQERRTAE
                     RLARWLGHAGCEVFTGVGGHGVVARLRNGEGPLVLLRAELDALPVREETGLSYASTVTA
                     ARPDGRVVPVAHACGHDIHMTCLAGTAELLAANRASWRGTVLLVGQPAEETLTGAAAML
                     DDGLYQRFGVPDVALAQHVAPLPAGVVAHAPPGEPLTAAGAELRIVIRGRGGHGGMPHL
                     AVDPVVVAASVVLRLRAMAVQERRPGEHVVVTVGALHAGERANVIPDSAVLEAIVRAPS
                     LAAVDRVVEVARRVVEDECLAARCPDPPEFTVVTRVPAGISDPVAAARVRRAHLAVFGA
                     GRVVEVPQGQASEDFPLFGADGRVPTVYWYVGSVPPAVWDRAPGAGPLEKLHSLPAAHS
                     PKFSPDPVATLRAGITALAAGALAWLGTGPLGNGEIMSFGSLP"
ORIGIN
        1 ctaagaggta gcggacaccg gtgtgagccg ggtgactttt tgatcgcccc cgggagtatc
       61 gatccagttc agggcgataa tgactcgcgc gatgtcctcg cggtggatac ggatgccgtt
      121 ccggtcgatg atgagacggc cgtgctcgct catccgcctc aggtaggcct gcacctcagg
      181 ttcctcacag gcgacccgga ggggtgtgcc cgtacgctcc tggtagaccc gcgcatccat
      241 gccctccacc gtggtcagcg cctgggagag ccagtgcagc gtgagctgcg gtgacgacgc
      301 gggcgcgttg acgtcgaagc ggaggggatt ctggttatac gcgtgcagcc tcccttttcg
      361 gaaggcgagg taacggtggc cgagcaatga gttggccccg gacccgaatc cgatccagtc
      421 catggtcagc cggtagtagg cctggtccgc ttcgcaccgg ggtgcgccga agtacgacat
      481 ggcgtactcg gggaacccgg cctcctcgag cagatcacgg gtgatgtagt aggccgccag
      541 ttgccggttg aggtcgaggt gccctccccg ttccacctgc ttgcggagga tggtccccgg
      601 gctggcgcga tagggataga tcgagaagtg attgatgggc agggtcagcg ccgtgcgcac
      661 tgactcggcg acctcggcgt ccgtctgacc gggaaagccg acgatgaggt cgatgttgat
      721 gttgcggaac cctgccgcgt gggcgttctt cacgacctca acggcctgct cggcgctgtg
      781 cgcccggccg agccgtcgca gccgctgatc gtcgaacgac tggaccccga tgctgatccg
      841 atcgaatccg agctcgcgca atcggcggag cttctgcggg gtgagcgact cggggctgcc
      901 ctcgatcgtg gtctcccgga cgtgactgag atcgaactcg ctccgcaggc acgtgtacag
      961 agactcgatc tctgactcgc cgaggatgct ggccgtgccg cctccccaat agatgatcgc
     1021 cggctgatag tgttcccgta acaccggcgc ctgaccccgg atctgagcgc gcaccgcgtc
     1081 gagatacgcg atccggccgg gtgcctgctg gtcgagccgc aggtccctca cggggatctg
     1141 gacgacccag tcgcaaaagt ggcatttgga attgcagaac gggatgttga cgtaaagcag
     1201 cagcggcctg gtcatcagca acctccgacc ggtcgtgtct tcgacggtgc ttcactggca
     1261 acggtgggaa gaacgcggaa tcgatccggt gaacccgtca tcatccggta ccggtgccgc
     1321 cggggagacg ccgtagcgct ccagccatgc caggccgttc cggtcggtcg ggcggagctc
     1381 ggcgaggcgg tacggcgacg cgggacgccg tatcgagggc gcggagcgcg ggatcaaccg
     1441 cagcggacgg gcattctcga cgccccgaat atggcgctct ggtagaacga gatcccctcc
     1501 cgaggccacg ggtggatctc ggtgaagcgg ccgagcagcc gttccagcgc gatcctgcct
     1561 tccagccggc ccagctgcgc cccgaggcag aagtgaacgc catggccgaa cgcgatgtgt
     1621 ccggtggtct gccggtggag gtcgaagcgc tcgggatcgg gaaaccggcg gtcgtcgtgg
     1681 tttgccgaca ggatccaggc catcacgaac cggttggccg ggatggtctc gccggctatg
     1741 gtcacatcac gcgtggtcac ccggcctgcc tgcaggaacg gggaacgcag ccggagactc
     1801 tcctccagag cggcggggat cagcgacggg tcggcgcgca cggccttctc ggcctccgga
     1861 tggtcccaaa ggcagagcat ggtgttcccg atcaggacgg tggtcgtcag gtggccggcg
     1921 agcagcagga ggctcgccgt gttgacgact tcctccaggt cgagccgctt cccctcgacc
     1981 tctgcctgaa ccaaccgggt gagcagatcg tcccgggggt gggtgcgccg gctccggcaa
     2041 tgctcccgca ggtagtcgtt catctccgtc atggccgcgg cgaccgtcct ggccagttcc
     2101 ggatcggcgt agttctccac ctgcagggac atcagccggt cggaccaggt gcggaacaga
     2161 tgcctgtctc cgggcggcac accgaggagc tccgcgatga cgatgaccgg caggggatag
     2221 gcgaagtgtt cgacgaggtc gaactcaggg ccggggagct cgtcgagcag gtggtcggcg
     2281 atctgcctga tgcggggctc catcgccgaa atcgactgcg gtgtgaacgc gtgggtgatc
     2341 agtcggcgct gatgccggtg ctcaggggga tcgatcattg tgatcccgcc cttgccgaag
     2401 ccctgcgcgg tcggcatgag cctggtccga tcagaagaga acgtctgata atcgcccagg
     2461 atctgccgta cgtcgtcgta gcggaacacg tggtaaatgc cgaactggtc acgccagacg
     2521 ggatgttcgt tccgcatcgt gcggagccag gcgaacagcg ccgctccgcc gtcggtaaga
     2581 gagggctgtc ccggtagttc catcatctag gcggccctcc tgactcggac ggggaggctc
     2641 ttcaccccga acatcgggtc ctcgtagtac gaaagctcgg cgtcggggtc gatggtgatc
     2701 tcagagaagc ggcggagcag cagctcgagc gccactcttc cctcgaccct ggcgagcggc
     2761 gctccgaggc agtgatggat gccgtgtccg aacgcgaagt gccggttagg ggagcgggtg
     2821 aggtcgaagc ggtacgggtt agggaactga cgctcgtcgt agttcgcgga gagcagccag
     2881 ttgatcacca aggacccggc ggggatcagc gtgccggcaa cctcaacgtc ggtcgtggtg
     2941 agccgggccg cctgagtgag cggcggccgg agccggagca cctcctcgaa ggcggggccg
     3001 aggagcgaga agtccgcgcg caccgcccgc tccgcatccg gggcgtcgcg gaagcacagg
     3061 aaggtgttgc cgagcgccat cgtgctcgtg atctgcccgg cgagcagcag caggcaggag
     3121 gtgttgacga tctcggcgtc ggtgagccgt tcgccgtcga cctccgcggc gatgagcttg
     3181 ctgaccaggt cgtcctgggg gtcggcacga cgcttgcgga catgggtctg cacgtactcg
     3241 cccatctccc gcatcgcctc gccgaccatc cgcccgattt cgacgtcggt cggatcgtcg
     3301 acgtggaggg cgatgagccg gtcagcccag gtgcggaaga ggcctcgatc gtggatcggg
     3361 atgccgagca gctccgcaat gaccatgatc ggcagagggt gggcgaactt ctcgaccagg
     3421 tcgaactcgt cttcctcgat gtcatcgagg agttcctcgg tgagctcggc gatgcgcggc
     3481 ttcatgtcgg ccgacatctt cgggctgaac gcctgactga tcagccgtcg cagtttgcgg
     3541 tgttcgggcg ggtcggtcag catcaggctt ccggcgctga acgggtcacc accaggccgt
     3601 aagcgattga tgtccgaaga gaaggtggcg tagtccgcca tcacccgttg tacgtccgcg
     3661 tggcggaaga cgtggaagat cccgaagccg tcccgccaca ccggctggct ttcccgcatc
     3721 tcgtccagcc acttcagcag cgcctggccg ccgtgcgaaa tcctcggccg ctgagcggcc
     3781 ggcatcgtca tcgtcggagt tccctgggct gttaacggct cgttcatgga tcgcctcctt
     3841 tctggtccta tgccgacgcg gtcgcggtac gggtgccaaa gaacgggacg ccgagcatgg
     3901 cccgatattc gtcggcagcc gctttgaaga tctcggcggt cttccggctg atggttttca
     3961 aggtggccgc cgcaggtgtt cgccacgggc cgaacgaccg ccggaccaac tcggcgagat
     4021 tggcggcgct gtcattgatg ctcgcctccg tgctggaaag caggtggagc ttgatgaagc
     4081 cccacatcag cgcatccaag gagaagtact gagaatcacg gcccgtggtg ccgtcgaggg
     4141 cacgattatc ggcgagcatc ccaaggtact tgcgaaacgg ggtgaacgtg gtgatccgat
     4201 aggactggaa attcagcgac ggatcatcgc atgttcgccc caggatatac ctgtcccggg
     4261 tatagagcgc ccggaagagc ggatacttga aaataagggt gaacatgcgg cgggacagtg
     4321 agggcaatgt gggcgcatcg gattcggttc ccgcccaatt cgacacgtca tcgcagacgt
     4381 cgatgatgtc gtgaatgacc agcgacctga tcaggtcgtc cttggtatcc cagctgagat
     4441 agaccgtgcc cttaccgatg tcggcctttc tggcgatctc atcgatcgtc gtccgtttgt
     4501 acccggactg cagcagcaaa gcccgggtga tgtccatgat gcgccgaact cgatcccctt
     4561 gcgacccgga catcggccgg cacgtcggca ttgcttgcct attcgacatc gtttccttcc
     4621 ccccggtgcg gacgattcgg cacttacgac ggccgcggga ccggatgcgt gcggcccata
     4681 atccgctgcc ggtgccggga acggcaccca gcggcatttt cgctggtcgt cgtgatggtg
     4741 acggcggtgt gaatctcccc gtacgtccta cgcccccctc ttaggccggc cgatcgcctc
     4801 taatggcacg aaacgccgtg attgtcaacc ctcagaggcg gcttccctgt tgtacgccgg
     4861 ttctactgac tggttttcaa tttcagtcat cgggttcgaa ctgttgactc ttcctatatc
     4921 tacacctagc gtaagcgatg ccgcaagggt gaggttagcg ccttttgcgg tgatatggcg
     4981 tgtaacgcac ttgaaacacg tgcgcttaca caccgccgtc caccgaaaat cgcaggaagg
     5041 aggatctcgt ggacctgaac gacctgccca tggacgtttt cgagctcgcc gacagcggcg
     5101 tcgcggtcga gtccctgacc gcgggccacg gcatgaccga ggtcggcgcc tcgtgcaact
     5161 gcttctgcta catctgctgc tcctgctcga gcgcttgatg tggcagcgtg ggcgcctccc
     5221 cgaatggggc ggcgcccacg cccctctcgc gccggccaag cgatattaag gagcctttct
     5281 taatgagact tgtggagcgc cgttttccgg tcgccatgac gtccactgcg cccaaagtcg
     5341 ccgttcgaga atgcggtctt ccggtatccg ccatcgaatc actatgctgt accgattcgt
     5401 tcgccctgat ccgtcgtcag gtcagggaga ccgcgtggct taagggcgaa ggaaaacggc
     5461 tcgcggtcga tttgggcctg ctcatcggtg agcgggggga tggcgacgac gggctacggc
     5521 ccgttctggt cggcctgcgc cgggctctgc acaccggccg cctgcccgat gcacgtgagt
     5581 ggactccgcg cgtcgcctcc gcacttccgg ccgagctggc cgcgcgcgtg gccgactggg
     5641 tgacgcggat gcgcgcgctc accagagcgc gacgggaact gcccgagctg ttcgccgccg
     5701 aggcccgggt caaggagaag gtgctggccc aggtcgcggc cgacccgggc ttccgccggg
     5761 cgctttcgct ggcgagccct gagctcgccg ctgacctcga ccgctggctc gccgaaccgg
     5821 cccgccgtcc caagacgcag aagctgctcc ggctggccaa gtacgtcgcc cgggccgccg
     5881 tcaagacgag cccgtacagc acgttcacca gcatgggagt ggccgtctgg gagaacgggg
     5941 aggattgggc ggacggcgcg atcgtccgct tcgcgccgcg cgagccccca tcggtcatcc
     6001 tcgaacccag cggcgagtgg ctgcacggtg cgctgcgcgc ctggctcgct cggcccgaga
     6061 acctcgtccg ttccaggttg cggctcaacc cttcactggt gatccgggct gacaaggcgg
     6121 agttccttgg attcccgcca cgcgagccga tcatccggat gggcctcact ccggtcgtcg
     6181 ccactgtcct gcgtttggcc gaaccggcag cggacgctga cggctggatc gatccgatgg
     6241 ggttccgcga tcggctcgcg cgcgacctgc cggccgagcc ggaacaggtc gatcggctcc
     6301 ttcgctcgct gatcgaggcc ggggtgctgg aggcgcaccc cctcaccagg gccgggctgc
     6361 cggaaaccgg cgagtgggcc gagatccgcg ccgcactccg gcacgatccc catggcgagg
     6421 atccggaggc gtatcgcgta cggctcgcgc ggttgaagcg ggccatgacc atgatgtggc
     6481 cgcagggcga cacgaccgcc ctgctccacg agaccgcggt ggtcacccgg ccggtcgcct
     6541 ccctgaatcc caccgcctgg ggccgcgggc tgagcgacct cgacgtggtc aggcgatggc
     6601 tctcggtctt cgacgggaag ctaccgatcc ggatcgtggt cgccgaatac ctgcgcgcac
     6661 ggtacggcga gcacgcccgg gtaccgttcc tcaccttcca ccggcacgtg caggaggaga
     6721 tcgccgggga cgcgccctcc ggcgccgacc tgcggacgtt cgtcggccgt tccgccgcga
     6781 tatgggcgcc tccactggcg cactcccggc ttccgaggct gcgtgagctg gccaagctcc
     6841 gggaggccgc acgtgagctc gctctggggc gaccggagca cgacggcatc caacgggtcg
     6901 acccggagga gctcatcaag cagatggcca cgtggccgga gtggatcgtg gtgccccgct
     6961 cctgtgcctg ttacgtgcag ccggctccgg agggccgtct ggtgctcaac gtcgttcacg
     7021 gcgggcacgg gcgcgggctg cgccggctca gccatctcat cggcagggtg cgcggcgagg
     7081 cggtcgatca tccgatggtc gcggacgaac cggaggggac ggtctatgcg gaactctccg
     7141 gatccctcgg ctcgacgctc aacgtccacg tgcccggtac ccgatacgag atcgactacc
     7201 cgttctcgcc aggcgaccgg tcccgcgatc gccggctgcc gctgtcggat ctcgaggtgg
     7261 tgctcgctcc cgagaccggg ctggccgagc tgcgctcccg gcggctcggt ttccgggtga
     7321 tccccctgca tctcggcatg gcggccgagt tccagttacc gcccgccgct cgctttctgg
     7381 aacgcgcgtt cggcgtcacc tacctcctgc acccgagtgc accaccgctg ctgcgcatcg
     7441 gtgaggtacc gccgccccag gaggtcaccc gctatccccg cgtggaggtg ggccgagtgg
     7501 tggtgcagcg ccgcaggtgg ctggctcccg caggcaccct cccgatccgg gcgaaggggg
     7561 aggacgacgc ctcgtacctg ctgaggctgg tggcgtggac cgatgcgaac ggcataccga
     7621 ccagatcgtt cgtccgcgcc tggcaggagc ggatggtgca agcggggcag gacaaggcgc
     7681 gtaagcccct cttcctcgat ctggcgaacc cgttcctggt caaggtcttc gaacgccaga
     7741 tccgtgattg cgcgttcgtg ctcttcgaag aggcgctgcc ggacccggcc gacgcgccgc
     7801 caagagaggg ctccgacctg ccccgtgtga tcgagttcct cgtggagctg ggcgaatgac
     7861 gccgcatgaa gccgaagtga tctgggtgag cgcccacata ttccatcaag gcccgctcga
     7921 tcggctcgtc accgaggtgg ccggtccgct cttcgttgag ctggcggccg ccgggctgag
     7981 cacccagggc ttcttcttgc gctactggga gggcggcccg cacctccggt tccgggtccg
     8041 gctgcttccc ggggcggatg ccgccgagac ccgccggctg atcagggaac gcgcctgcgc
     8101 ttacctgcgg cggtatccgt cgcaggatgt cctcgatcgc gaggagtacg ccaggctggc
     8161 ggaggtgctc gccgcccggg aggggctgac cggccacgcc cgtgagctct atccgaacga
     8221 ctcggtgcag ttcatttcct accggccgga acaccacaga tacggccgcg gaccatcgct
     8281 cgaggccgtg gaacggcatt tcgcggagtc cagccggatc gcgctggagc tgctccacgc
     8341 cgggctgacg atcccgcagc gaggggcggt atggctgacc atgctcatgg ccacctggct
     8401 gctcgcgggc tcacgaggcg aggacgcgtt ccgcccgtgg ccggacgccc gcaaagagca
     8461 ggcgttcgac cgtgagcggg aacggttgac cggccttgcc cggcatgccc ggcagctcac
     8521 cctgcggccg ccggatccgg aggcgcaggg cgtgctagcg gcgtggcacg gttccgtggc
     8581 ccggctcgcc gacgcgctgg ccgcgtccgg cttcaccgcg acgcggaccg cgaccgtgct
     8641 ggacctgtgc gcgcacctgc tcgccaaccg tctgggcatc cggatccagg acgaggcgag
     8701 gctgcgctat ctggcgtccc gggcgctcga tgaggcggag gtgaccgtgt gatggccgcc
     8761 ggcgagcggt ggtggcggtt ccgggtggac taccacgcgg gcccgatgga cgacctgatc
     8821 ctcgacggtg tgcgaccggc gttcgccgcc ttcgccgcgc aagcacccat ggcctacttt
     8881 ctccgccact ggcggcgagg tccgcacctg cggatctatg tcagcaccac gcgggaggct
     8941 ctggaggccg tggtacgccc ggccatcgag cacgtcgtgg gcggttacct gcgggcccgg
     9001 ccttcccccg ggatggccga cccgtcggcc tttctcccgc tgcacgagcg gcttgccgag
     9061 ctggagggtg aggacggccc gctcatgccg tggtctccgg acaacacgat ccacgcagag
     9121 ggggagagac cggagccctt gacggtgcgg gacgtgctcc tagccgactt ctatgcggac
     9181 accaccccct ccgtctatca cgcgctcgaa cgggtgagat ccggggcctc gctgcccacg
     9241 atcgccttcg acctggtggt cgcgaccgcc cacgcccttt ccaccggggg acttccggtg
     9301 gcacggacct cactccgctc acatgccgag gcgtacctgg cccggcgatc ggacggcgtt
     9361 cggctgcgcg agctgtggcg cgaccattac gcgcgcaacc gtgaggcctt caccgaacgg
     9421 ctgatcgcgg tggcgtcgtc agcggagagc gcggagaacg gggcgcactt gccgcatgtc
     9481 cgggagtggg tgcggcgctt gcgcccgatc cgggagcggg cccgggcgct cctggagtcg
     9541 ggtgagctga cgctggagta cgcatccccg gcagagggcg cacgggacct gccgtcgctc
     9601 gccgaggtgt ccgcgttcca ccgggagctc gagtcgcgtc ccgagtgggc gagactgcgc
     9661 gactcccctg ccttcggcgc ttaccgattg gtgatcaact gtacgtacct gcacctcacc
     9721 cggctggggc tgacgccgca tcagcggttc ctggtatgcc atctcgccgc cgatgccgcc
     9781 gccgacgtct atgggatcgc cgcgcacgag gaggttgcca cccgatgacc atccccccag
     9841 ggctcacgga gcggtatgcg ctgcgggcgg gcgtgcacag cgccgtgctg ccggacggcg
     9901 tgatgcggct gttcgcctgg ccccacgctg agtcgatcgg cgccctcagc gcggatgaga
     9961 ccacgctgct gaaggagctg gcggaaggac cgcgggagat cgccgatccc gcgctgcggc
    10021 ctttcgtgga gcggttgttc cggggcggct ggctcaagcg gaccctcagc cggggagaac
    10081 acgacctgta cacgctcgat ccgctgcgcc gaccgggatc gcggcccgcc ccacccgacg
    10141 atccggtgct ctcccggttc gccgcagtac gccggcgtcc gtccgggttc gtcattgaat
    10201 cgccattggc ctggtgcgac gtgcacgtcc acgaccccgc gctgctgcct gacctactcg
    10261 agccggcagg cgggcgggcg ggccggtcct cgctggcccc gcagatccgc cgccaggcgc
    10321 ttgcggacct tgcatgggcg ggcctggtcg taccccgggg cgcggaggac ggcgctctgc
    10381 ggacccggca gtgggcgccg cacgagctcg acttccatca gcgcagcagg ctctaccacc
    10441 ggggctacct gggtgacggg ttcggcggca cgttctgggc tcggggcacc ttcgacccgc
    10501 cccaggctcg gccgcagcgg tatcccgggg atccgatccc gctccaccgg ccggatctga
    10561 acgcgttacg cgcggccgat ccaccgctca ccgcggtcct cgaggaccgc cggtcggtgc
    10621 gggagtacga cgacgacgcc cccatgaccg tggagcagct cggggagctg ctgtaccggt
    10681 cggccaggat ccgggacgtc aaggtgatcg atggcgtgga gtacgtcaga aagccgtacc
    10741 cgtccggtgg ctccgtctac gagctggaaa tctacccggt ggtgcggcac gtggccggtc
    10801 tggcgcccgg catgtaccac tacgacgcct acgagcatgt gctccggccg gtccgcccgg
    10861 ccggccaccc agcggtgcgc cggatgctca ccgtggcatc gcacggatcc gcggtcggca
    10921 tccgcccgca gctcctgctc gtcgtgtccg cccgggtcgg ccgggtgatg tggaagtacg
    10981 agggcatggg ttatgccctg atcctcaaac acgtgggcgt gctgtaccag acgctgtact
    11041 gcgtggcgac cgcgatggga ctcgccccgt gcgccatcgg cagcggcgac tccgccgcct
    11101 tcagcgaggc gaccgggcgt gacccgctgg aggagtgcgc ggtgggcgac ttcctcctcg
    11161 gtagccgtcc ggcatccggc tccaccgtgg aggaatcgtg atcccggcgc ggcccgtgct
    11221 gacccccggc gtccggtacg cgccgacctc ggacggggtg gcattcctca cccgcgacgg
    11281 catcgtgtcg atcaccggag tctcgatcca ccggtggatc gaccggatcg ccccgcattt
    11341 gaccggtgag cggagcgtgg cggagctgac ggacgggctg gcaccggagc gcagggcctt
    11401 cgtgctccgc ctgctccagg cgctggccga tcgcggcctg atcatcgacg ccgcgggcgg
    11461 ccgggagcca cgcctcgagc gtggcaccgc ctgtgcactg cacgtcaccg aaacctgcgg
    11521 accgtaccgt gagtcgctgc cgaagctcgc ccgttccctc gccgacgccc tcacgagggc
    11581 gggcttggac gtgcggctgg cgtcggcgag cgaaccgtgc gatccggagc ggtgccatgc
    11641 gctcgtccac ctgactgcag ccgatgaggt ggggctggcc gcggcggagc ggctcgaccg
    11701 actgagcgag cgatgggggg tgccgatcgc ccatgtcgtg gtgtggggcg gggagatatg
    11761 gcggaccgag gcgggcacgg tgggggagga cggcctgccg ctcgccgcgg gatggcgccg
    11821 gctgacggcc ctccgtcctg acacggagga gcgcgtcccg atctccccta ccgcggcggt
    11881 cgtggtcgcc ggtcaggtgg ccgctgatgt ccgcgaccgc ctcacgaccg ccacacgggc
    11941 cgggcgccgg ccccggttgc acgtggtgga gccggcgcgg ctcacgtgcc gcgcccacca
    12001 tttcatcccg cactttcaca ccatgccgct caccggggac gcgccgctgg ccgaagagct
    12061 gaccgaggag gagttctccc ggcgggcggc cgcgctgatg gacgaccgca ccggggtgtt
    12121 caccgagatc gccgaaggtg acttcggcca gctcccgctg cacgtcgcgg tgaccaccgt
    12181 cgccgatccg gtgggactgc tcggcccggc cggggatcgg ccgcgcgtga tcggggtggg
    12241 gccggacttc gccaccgccc ggtatcggac ggcgcgtgcc gcgatcgccc tctacggtct
    12301 gctcgcggtg gatccgcgcc gcctggtcga tgcggacggt gaaccgctgg ccgggccacg
    12361 gacctccgcg gcggagctgg aggatctgct gggcaggatc cgcgcgggcg ggctgccggc
    12421 cttcgtgcgc gccgaggacg tgcgcggcgg cccgcctcgg ctcctccccg cgtcctcggt
    12481 cttccccttt gctacggcgc gtgccctcct cgccggaacc gtccccacgg gcaccgccgt
    12541 cggctactcg gaggagggcg ccctccgggc cgcactgctc gatcactgcc gcgagcgcac
    12601 gctcgccgat cttgccagcc gtcgggtcgc ccggctcact cccgataccg ctccatcgga
    12661 tccggtcacc gcccgctacc tggcgttcct gcgcgcgatc ggcctgccgt tcgacgtgct
    12721 ggacgcgacg ggtccgctgg gcgtcccggt gtacgtcggg gtgctcgacg gccgggtggt
    12781 ggcggccgag gccggcgcct cgcccgggga ggcgttccgt tcggtgctgg aaggcatcct
    12841 ccgcggtctc cagggcattc cagcggcccg ttcgctcccg gacacgctcc cgccggtgct
    12901 ccccgaggcg atggccgtgc ccgacggctc cccgttgagc gcggaagcgc tcgccgccgc
    12961 cttggcgcgg gccgggctgt cggtgtcggt cgtccggctc gaccacgatc ggcgggtgca
    13021 cgccctgatc ccgcattgtg tccgcgtcat ggtgaccggt gaggagagcg cacatgtctg
    13081 atgccctggc cgcggcgatc atcggggccg gcctgctcgc cgatgagctc gccgccgcgt
    13141 tccggccgta cggcgaggtg atcaggctgg acgaggtgga gcgggccgaa acggaggcgc
    13201 accggttgcg ggcgctcgtg atggcgtgcg acggatggga tacctctatt tatagggaga
    13261 cccgcgaacg ctgccggagg ctcggcatcc cgtggctgcc cgtccggacc gaacacggga
    13321 ttgccgtgat cggcccgctc gaacggcccg gggagcccgg gtgcgcgcac tgcttcgagc
    13381 tgcgcaggga acgggcgcgc cctgacgcgg cggcctaccg ggcgattctc aaccaccacg
    13441 gaccggagct cgccaagcgg ccgtcgccct atctcgacga gctggcggcc gcaaccatcg
    13501 cggcgctggg cgtacggatg atcgatcaag gctccgggtg tcacgtctgg tacgtgaggc
    13561 tcaacggtct gaccgtggaa cgccacgcct tcctgcccga gcccctctgc cctgaatgcg
    13621 ggtcactgcc gatggacgat cgggactcgg cggtgatcgt ccttcggtcc cagccgaagc
    13681 gcgccccgga cgactaccgc accagggaca tcgtcgatga gctcgacgcg ctcgtggcgg
    13741 attacgtcga cggcgagtcg ggattgatcc ggccgctggt ccgcgacacg cagggcggcc
    13801 tggtgatagc cggggcgatg ctgccgttgc ggttcgccgg cggctcggag ccaggggtcg
    13861 gccggacccg cggctaccgc accagcgagg tgaccgccat cttggaggcg ctggagcggt
    13921 ggggcggggt cgagcccgga ggcaagcgca ccgtaatccg ggcggccttc cgcgacatcg
    13981 ccgcggacgc gctcgacccg cggacgctcg gcgtgcattc ccccgaggcc tacgcggccg
    14041 aggatttccc gttccggccc ttcaccgagg acgaggagac cgagtgggtc tggggatact
    14101 ccttcgcccg tcgttccccg atcctcgtcc cggagacggt ggcctattac tacgtgcacc
    14161 gcgaccggcc acgacaggag cggccgttcc tgtacgagat ctccaacgga tgtgcactgg
    14221 gcagcggcat ggaggaggcg atcctctacg ggatcctgga ggtcgtggag cgcgacgcct
    14281 ttctcatgac ctggtacggc cggctcggtg tgccacggat cgatctcgat tcggcgaaga
    14341 acaggatggt cccgctgcag gccgccgcga tcagcgcgga aaccggctac cggatcgagg
    14401 tctacgacac cacgatggag cacgggatcc catcggtgtg ggcgctcgcg atacgaggcg
    14461 gcgaggagcc cacggcggcc ccgcggccgc gcatggtgtg cgcggccgcg gctcacctcg
    14521 atcccgagca ggcggtgctc agcgcactca gcgaactggg accactgctc gccgacttgc
    14581 ttcgccgtta ccccgacgag gccgagcggg cccggcgcat ggtggacgac cccggcctcg
    14641 tcaccacgat gcacgaccac tcgaccctgt acggcgccga cgaggcgttc ggccggctcg
    14701 agttcctcac cggcacggcc tcgaccaggg atctcgccgc catgcgggag tccaccgtgg
    14761 cgttccggtc ggcggacctc cgtgacgatc tcctcgaggt gatcggccgc atcctggccg
    14821 agggaatgga cgtcatagtc gtcgaccaga ccactcccga gcaccgggtg cacggcttca
    14881 cctgcgtcaa ggtcctgatc cccgggatga tccccatgac cttcggccac cgtaatcgca
    14941 ggctcgacgg cctcacccgg ccgctggtga tcccgtaccg gctcgggtat cgcccggcgc
    15001 cgctcacccc cgaggcgctc aatccgcacc cgcacccttt cccgtgagga gcgccgcggt
    15061 gacatcacgg caaagatctg cgccggcttc gatcctccag ggggtggaag cgctgctgag
    15121 gccgctcgcg gtgttccggg cagacctgca ccggaatcca gagctgtccg gccaggagcg
    15181 gcgcaccgcc gagcggctcg cccggtggct tgggcacgcc gggtgcgagg tcttcaccgg
    15241 ggtgggcggc catggtgtcg tggcacgcct gcgaaacggc gaggggccgc tcgtcctgct
    15301 ccgcgctgaa ttggacgcgc tcccggtccg ggaggagacc ggtctgtcct acgccagcac
    15361 ggtcaccgcg gcgcggccgg acggccgggt cgttcccgtc gcgcacgcct gcggacatga
    15421 catccacatg acctgcctcg cagggaccgc cgagctgctc gccgccaacc gcgcatcctg
    15481 gcgggggacc gtgctactgg tggggcagcc tgcagaggag acgctgacag gggcggcggc
    15541 gatgctcgac gatggcctct accagcggtt cggcgtgccg gacgtggcgc tcgcgcagca
    15601 tgtggcgccc ctgcccgcgg gcgtggtggc ccatgcgcca cccggggaac cgctcaccgc
    15661 cgccggggcg gagctgcgca tcgtgatacg cggccggggc gggcacggcg ggatgccgca
    15721 cctcgccgtg gatccggtgg tggtggccgc ctcggtggtg ctgcggttgc gggccatggc
    15781 cgtccaggag cgcaggcccg gtgagcacgt ggtcgtgacg gtcggggcgc tgcatgcggg
    15841 agagcgggcg aatgtgatcc cggactccgc cgtgctcgag gcgatcgtcc gcgctccgtc
    15901 gctggcggcc gtggatcggg tggtggaggt ggcacgccgg gtggtggagg atgagtgcct
    15961 ggccgcgagg tgccccgatc cgcccgagtt caccgtggtc accagggttc ccgcggggat
    16021 atccgatccg gtcgcggccg cgcgggtacg gcgggcgcac ctcgccgtgt tcggcgcggg
    16081 ccgggtggtg gaggtgccgc agggccaggc cagcgaggac ttccccctgt tcggggcgga
    16141 tgggcgtgtg cccaccgtct actggtatgt gggctcggtg ccacccgccg tctgggaccg
    16201 cgcgcctgga gcggggccgc tggagaagct gcattctctt ccggccgcgc attctccgaa
    16261 gttcagtcct gaccccgtgg ccacgctgcg ggcgggcatc accgcgctgg cggccggcgc
    16321 gctcgcctgg ctcggcaccg gaccgctggg aaatggtgag atcatgtcct tcggctcgct
    16381 accatga
//
