BGC0001865 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001865 (Parastagonospora nodorum SN15)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	52,193	High	elsinochrome C	PKS:Iterative type I

BGC0001865 - Region 1 - T1PKS

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Location: 1 - 52,193 nt. (total: 52,193 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 52,194
Label		BGC0001865

Tailoring functions

Oxidoreductases: dehydrogenase oxidase

SNOG_08602: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

SNOG_08605: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

SNOG_08608: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

Transferases: methyltransferase

SNOG_08610: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Ligases: synthase

SNOG_08614: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001865.4	0.94	PKS	elsinochrome C	Parastagonospora nodorum SN15
BGC0002175.3	0.77	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.77	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001258.3	0.77	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001257.3	0.77	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.77	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001284.4	0.76	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001276.3	0.62	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.62	PKS	asperlactone	Aspergillus ochraceus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001865.4	1.00	PKS	elsinochrome C	Parastagonospora nodorum SN15
BGC0002175.3	0.77	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.77	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001258.3	0.77	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001257.3	0.77	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.77	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001284.4	0.76	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001276.3	0.62	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.62	PKS	asperlactone	Aspergillus ochraceus

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 6043 - 52193:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

SNOG_08614: mal

PKS_AT (706..995): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 58.3%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 80.5
Methylmalonyl-CoA: 48.3
inactive: 48.0
Methoxymalonyl-CoA: 44.3
fatty_acid: 28.4
Isobutyryl-CoA: 16.8
Ethylmalonyl-CoA: 16.2
Acetyl-CoA: 15.9
2-Methylbutyryl-CoA: 15.4
CHC-CoA: 15.0
3-Methylbutyryl-CoA: 14.9
Propionyl-CoA: 13.2
trans-1,2-CPDA: 8.4
Benzoyl-CoA: -1.8

Link to PARAS substrate predictor