BGC0001866 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001866 (Paecilomyces variotii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	55,807	High	viriditoxin	PKS

BGC0001866 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 55,807 nt. (total: 55,807 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 55,808
Label		BGC0001866

Tailoring functions

Oxidoreductases: dehydrogenase

C8Q69DRAFT_480057: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: methyltransferase

C8Q69DRAFT_488617: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Ligases: synthase

C8Q69DRAFT_480069: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

C8Q69DRAFT_515060: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001866.4	1.00	PKS	viriditoxin	Byssochlamys spectabilis
BGC0002175.3	0.78	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.78	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002154.2	0.77	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.77	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001258.3	0.77	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001284.4	0.76	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.76	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001866.4	1.00	PKS	viriditoxin	Byssochlamys spectabilis
BGC0002175.3	0.78	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.78	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002154.2	0.77	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.77	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001258.3	0.77	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001284.4	0.76	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.76	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus

Similar known clusters from MIBiG 4.0

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 55807:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-pk) + (mal)
Non-colinear ordering:: C8Q69DRAFT_515060 + C8Q69DRAFT_480069

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

C8Q69DRAFT_515060: pk

PKS_AT (512..808): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Isobutyryl-CoA: 66.7%; Methylmalonyl-CoA: 66.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 73.4
Methoxymalonyl-CoA: 65.4
Ethylmalonyl-CoA: 43.8
Isobutyryl-CoA: 29.6
trans-1,2-CPDA: 27.4
Benzoyl-CoA: 23.3
Propionyl-CoA: 22.7
Malonyl-CoA: 18.0
Acetyl-CoA: 11.5
fatty_acid: 10.1
2-Methylbutyryl-CoA: 4.8
CHC-CoA: 4.2
inactive: 0.0
3-Methylbutyryl-CoA: 0.0

C8Q69DRAFT_480069: mal

PKS_AT (906..1205): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 58.3%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 120.6
Methoxymalonyl-CoA: 78.2
Methylmalonyl-CoA: 72.6
inactive: 53.4
Propionyl-CoA: 35.2
2-Methylbutyryl-CoA: 30.8
Isobutyryl-CoA: 26.6
Ethylmalonyl-CoA: 25.1
fatty_acid: 19.9
3-Methylbutyryl-CoA: 19.2
CHC-CoA: 16.6
Benzoyl-CoA: 13.0
trans-1,2-CPDA: 10.9
Acetyl-CoA: 9.6

Link to PARAS substrate predictor