BGC0001867 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001867 (Prochlorococcus marinus str. MIT 9313)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	lanthipeptide-class-ii	1	23,207	High	prochlorosins	ribosomal:RiPP:Lanthipeptide

BGC0001867 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 23,207 nt. (total: 23,207 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 23,208
Label		BGC0001867

Tailoring functions

Lyases: cyclase

PMT_0250: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001867.2	1.00	ribosomal	prochlorosins	Prochlorococcus marinus str. MIT 9313
BGC0002404.2	0.46	other (other)	falcarindiol	Solanum lycopersicum
BGC0002699.2	0.42	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0002698.2	0.39	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002110.3	0.36	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000022.3	0.31	PKS	asperfuranone	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001867.2	1.00	ribosomal	prochlorosins	Prochlorococcus marinus str. MIT 9313
BGC0002404.2	0.46	other (other)	falcarindiol	Solanum lycopersicum
BGC0002699.2	0.42	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0002698.2	0.39	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002110.3	0.36	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000022.3	0.31	PKS	asperfuranone	Aspergillus nidulans FGSC A4

Similar known clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for PMT_0250

PMT_2325

Leader:

MANNELTIDQLKTITGS

Core:

GPLRGLGGVVAEGSRDRYMRDTVDSCNAGRASWNNISNPWNHRRYNIRGRLDFDGLWI

Core with dehydrations:

GPLRGLGGVVAEGDhaRDRYMRDDhbVDDhaCysNAGRADhaWNNIDhaNPWNHRRYNIRGRLDFDGLWI

antiSMASH-DB 4.0 matches for PMT_2325

100.0%

NC_005071.1:

Lanthipeptides: AKG35_RS12665_lanthipeptide

GPLRGLGGVVAEGSRDRYMRDTVDSCNAGRASWNNISNPWNHRRYNIRGRLDFDGLWI

22.4%

NZ_CP022961.1:

Lanthipeptides: allorf_3798315_3798509_lanthipeptide

RGLGGVV---AEGSRDRYMRDTVDSCNAGRASWNNI

R LG V A G R R +R C GR+ W++

RRLGAAVSGRASGERRRRLRSV---CALGRSHWSHF

11.9%

NZ_RDBM01000037.1and 1 other:

NZ_RDBM01000037.1 Lanthipeptides: allorf_1268916_1269122_lanthipeptide

Lanthipeptides: allorf_1268916_1269122_lanthipeptide

PWNHRRYNIRGRL

PW HRR RL

PWTHRRARSTSRL

MIBiG 4.0 matches for PMT_2325

10.3%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

VAEGSRDRYMRDTVDS

VAE D + + +DS

VAESGYDDFDLNIIDS

6.9%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

ASWNNIS

+W NIS

CAWYNIS

allorf_00489_00569

Leader:

MADALSLVSLDGS

Core:

PLWVWLHCLANES

Core with dehydrations:

PLWVWLHCysLANEDha

antiSMASH-DB 4.0 matches for allorf_00489_00569

18.2%

NZ_CP058255.1:

Lanthipeptides: HW369_RS18860_lanthipeptide

PLWVWLHCLA

PL WL C+A

PLTYWLICIA

allorf_00554_00667

Leader:

MLDRQAAA

Core:

SSSLVARRAACLCLGPMLLLFGKQLWLML

Core with dehydrations:

DhaDhaDhaLVARRAACysLCysLGPMLLLFGKQLWLML

antiSMASH-DB 4.0 matches for allorf_00554_00667

27.6%

NZ_FOGO01000004.1:

Lassopeptides: BMX65_RS32050_lassopeptide

GPMLLLFGKQL

GP LL GKQL

GPKDLLGGKQL

27.6%

NZ_PGGW01000066.1:

Lassopeptides: CUT44_RS34240_lassopeptide

GPMLLLFGKQL

GP LL GKQL

GPRDLLGGKQL

24.1%

NZ_JAJQQQ010000018.1:

Lassopeptides: LUZ28_RS25695_lassopeptide

GPMLLLFGKQL

GP +L GKQL

GPKDILGGKQL

with 2 more sequence matches

24.1%

NZ_JAMTCF010000005.1:

Lassopeptides: LV78_RS12115_lassopeptide

LVARRAACLCLG

LVAR+AA + G

LVARKAADVITG

10.9%

NZ_FNGC01000009.1:

Lanthipeptides: allorf_101916_102134_lanthipeptide

ARRAACLCLGPMLLL

+RR AC GP L

SRRGACRGFGPAFWL

MIBiG 4.0 matches for allorf_00554_00667

20.7%

BGC0000563.4 (AEA03263.1):

Lanthipeptide: venezuelin

AACLCLGPMLLL

A C C+G + LL

ATCECVGLLTLL

allorf_00795_00944

Leader:

MVDPLYLLLIPLSHSSSISSVISGS

Core:

KASACFRCCSCCQISVASCSSQIW

Core with dehydrations:

KADhaACysFRCysCysDhaCysCysQIDhaVADhaCysDhaDhaQIW

MIBiG 4.0 matches for allorf_00795_00944

20.8%

BGC0001155.5 (AGY49587.1):

Thiopeptide: GE2270

ACFRCCSC

C CCSC

VCGFCCSC

allorf_01329_01442

Leader:

MSRHVLISLSSEGS

Core:

CIKDGGSLARFARSFTARSAIGS

Core with dehydrations:

CysIKDGGDhaLARFARDhaFDhbARDhaAIGDha

antiSMASH-DB 4.0 matches for allorf_01329_01442

100.0%

NC_005071.1:

Lanthipeptides: allorf_0271463_0271561_lanthipeptide

CIKDGGSLARFARSFTARSAIGS

allorf_02157_02291

Leader:

MLITTATAYTLKALALAGA

Core:

FYFFNDCPICLKRHPIPGTTLRSRS

Core with dehydrations:

FYFFNDCysPICysLKRHPIPGDhbDhbLRDhaRDha

antiSMASH-DB 4.0 matches for allorf_02157_02291

100.0%

NC_005071.1:

Lanthipeptides: allorf_0272291_0272425_lanthipeptide

FYFFNDCPICLKRHPIPGTTLRSRS

32.0%

NZ_AKXV01000031.1:

Lanthipeptides: allorf_115346_115471_lanthipeptide

CPICLKRHPIPGTTLRSR

CP ++R PGT +R+R

CPPSIRRTHRPGTLVRTR

13.0%

NZ_BIFH01000022.1:

Lanthipeptides: allorf_294958_295173_lanthipeptide

KRHPIPGTTL

+RH IPGTT+

RRHFIPGTTV

with 1 more sequence matches

11.3%

NZ_AP014940.1:

Lanthipeptides: allorf_3261946_3262173_lanthipeptide

YFFNDCPICLKRHPIPGTTLRSR

Y + R P PG R+R

YGMRRFEVVFARKPRPGRNARAR

allorf_15209_15337

Leader:

MKQILGG

Core:

LRSGRRQSQVKTKGKDNFFCINILSPGGQEKEVRS

Core with dehydrations:

LRDhaGRRQDhaQVKDhbKGKDNFFCysINILDhaPGGQEKEVRDha

antiSMASH-DB 4.0 matches for allorf_15209_15337

100.0%

NC_005071.1:

Lanthipeptides: allorf_0285343_0285471_lanthipeptide

LRSGRRQSQVKTKGKDNFFCINILSPGGQEKEVRS

allorf_15362_15445

Leader:

MQKRTELKMLLHQLMFS

Core:

SRSVMTSCQT

Core with dehydrations:

DhaRDhaVMDhbDhaCysQDhb

allorf_16026_16097

Leader:

MPVDDAKDNRHYG

Core:

KQNKSCDLRD

Core with dehydrations:

KQNKDhaCysDLRD

allorf_16362_16577

Leader:

MIIPVNNKVLLENRIFQSDQFGM

Core:

SANLLNVLKKFSNTPKKTFGYIWKHNSGAFNLLIEVCDEKQTLENRVP

Core with dehydrations:

DhaANLLNVLKKFDhaNDhbPKKDhbFGYIWKHNDhaGAFNLLIEVCysDEKQDhbLENRVP

allorf_17155_17229

Leader:

MDLSSLGG

Core:

SLITLPAGVLSSCGRL

Core with dehydrations:

DhaLIDhbLPAGVLDhaDhaCysGRL

antiSMASH-DB 4.0 matches for allorf_17155_17229

20.0%

NZ_CP050504.1and 3 others:

NZ_CP050504.1 Lanthipeptides: allorf_8953271_8953453_lanthipeptideNZ_CP050504.1 Lanthipeptides: allorf_8953271_8953453_lanthipeptideNZ_CP050504.1 Lanthipeptides: allorf_8953271_8953453_lanthipeptide

Lanthipeptides: allorf_8953271_8953453_lanthipeptide

TLPAGVLSSCGR

T PA SCGR

TSPAASDKSCGR

allorf_17251_17400

Leader:

MPALFSAALLSRPGA

Core:

CKRSTINKLSSGSSSCSRAAKVALIIPAPTSTAS

Core with dehydrations:

CysKRDhaDhbINKLDhaDhaGDhaDhaDhaCysDhaRAAKVALIIPAPDhbDhaDhbADha

antiSMASH-DB 4.0 matches for allorf_17251_17400

23.5%

NZ_JACHJN010000006.1:

Lanthipeptides: FHS29_RS22065_lanthipeptide

AAKVALIIPAPTSTAS

A+ V+L++P STAS

ASNVSLLLPCSHSTAS

21.6%

NZ_CP013666.1and 2 others:

NZ_CP013666.1 Lanthipeptides: AXO1947_RS23410_lanthipeptideNZ_CP036255.1 Lanthipeptides: EYC56_RS24020_lanthipeptide

Lanthipeptides: AXO1947_RS23955_lanthipeptide

CKRSTINKLSSGSSSCSR

C T N+ S+GS C+R

CAGVTNNQWSTGSHGCAR

20.5%

NC_017267.2:

Lanthipeptides: XOC_RS24555_lanthipeptide

CKRSTINKLSSGSSSCSR

C T N+ S+GS C R

CAGVTNNQWSTGSHGCER

with 1 more sequence matches

17.6%

NZ_CP023701.1:

Thiopeptides: CP968_RS31560_thiopeptide

GSSSCSRAAKVALIIP

GSSSC++ + + +P

GSSSCAQPDQTGVPVP

allorf_22280_22369

Leader:

MAVIVGA

Core:

GRRVFIAVTIFSARVIIVFICI

Core with dehydrations:

GRRVFIAVDhbIFDhaARVIIVFICysI

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

PMT_2325 - Class II

Cleavage pHMM score: -2.50

RODEO score: 0

Monoisotopic mass: 6525.3 Da

Molecular weight: 6529.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 6547.2 Da N = 1; 6565.2 Da N = 2; 6583.2 Da N = 3; 6601.2 Da N = 4

allorf_00489_00569 - Class II

Cleavage pHMM score: -6.00

RODEO score: 0

Monoisotopic mass: 1548.8 Da

Molecular weight: 1549.8 Da

Number of bridges: 1

allorf_00554_00667 - Class II

Cleavage pHMM score: -6.90

RODEO score: 0

Monoisotopic mass: 3135.7 Da

Molecular weight: 3137.9 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3155.9 Da N = 1

allorf_00795_00944 - Class II

Cleavage pHMM score: -6.10

RODEO score: 0

Monoisotopic mass: 2462.1 Da

Molecular weight: 2463.9 Da

Number of bridges: 6

allorf_01329_01442 - Class II

Cleavage pHMM score: -6.40

RODEO score: 0

Monoisotopic mass: 2280.2 Da

Molecular weight: 2281.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2299.6 Da N = 1; 2317.6 Da N = 2; 2335.6 Da N = 3; 2353.7 Da N = 4

allorf_02157_02291 - Class II

Cleavage pHMM score: -2.60

RODEO score: 0

Monoisotopic mass: 2895.5 Da

Molecular weight: 2897.4 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2915.4 Da N = 1; 2933.4 Da N = 2

allorf_15209_15337 - Class II

Cleavage pHMM score: -4.00

RODEO score: 0

Monoisotopic mass: 3872.1 Da

Molecular weight: 3874.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3892.4 Da N = 1; 3910.4 Da N = 2; 3928.4 Da N = 3; 3946.5 Da N = 4

allorf_15362_15445 - Class II

Cleavage pHMM score: -6.90

RODEO score: 0

Monoisotopic mass: 1008.5 Da

Molecular weight: 1009.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1027.2 Da N = 1; 1045.2 Da N = 2; 1063.2 Da N = 3; 1081.2 Da N = 4

allorf_16026_16097 - Class II

Cleavage pHMM score: -7.10

RODEO score: 0

Monoisotopic mass: 1187.6 Da

Molecular weight: 1188.3 Da

Number of bridges: 1

allorf_16362_16577 - Class II

Cleavage pHMM score: -4.80

RODEO score: 0

Monoisotopic mass: 5395.9 Da

Molecular weight: 5399.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 5417.2 Da N = 1; 5435.2 Da N = 2; 5453.2 Da N = 3; 5471.2 Da N = 4; 5489.3 Da N = 5

allorf_17155_17229 - Class II

Cleavage pHMM score: -4.50

RODEO score: 0

Monoisotopic mass: 1513.9 Da

Molecular weight: 1514.8 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1532.8 Da N = 1; 1550.9 Da N = 2; 1568.9 Da N = 3

allorf_17251_17400 - Class II

Cleavage pHMM score: -6.40

RODEO score: 0

Monoisotopic mass: 3175.8 Da

Molecular weight: 3177.6 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3195.7 Da N = 1; 3213.7 Da N = 2; 3231.7 Da N = 3; 3249.7 Da N = 4; 3267.7 Da N = 5; 3285.8 Da N = 6; 3303.8 Da N = 7; 3321.8 Da N = 8; 3339.8 Da N = 9; 3357.8 Da N = 10

allorf_22280_22369 - Class II

Cleavage pHMM score: -4.90

RODEO score: 0

Monoisotopic mass: 2456.5 Da

Molecular weight: 2458.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2476.1 Da N = 1