LOCUS       BGC0001869             11792 bp    DNA     linear   BCT 23-OCT-2017
DEFINITION  Xenorhabdus szentirmaii DSM 16338 Xsze_2, whole genome shotgun
            sequence.
ACCESSION   BGC0001869
VERSION     BGC0001869
KEYWORDS    .
SOURCE      Xenorhabdus szentirmaii DSM 16338
  ORGANISM  Xenorhabdus szentirmaii DSM 16338
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Morganellaceae; Xenorhabdus.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 16:28:01
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     subregion       1..11792
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001869"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..11792
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phenazine"
                     /region_number="1"
                     /rules="phzB"
                     /subregion_numbers="1"
                     /tool="antismash"
     protocluster    1..11311
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[825:1311]"
                     /cutoff="20000"
                     /detection_rule="phzB"
                     /neighbourhood="10000"
                     /product="phenazine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      826..1311
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="phzB"
                     /neighbourhood="10000"
                     /product="phenazine"
                     /protocluster_number="1"
     cand_cluster    1..11311
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="phzB"
                     /kind="single"
                     /product="phenazine"
                     /protoclusters="1"
                     /tool="antismash"
     gene            2..391
                     /locus_tag="Xsze_03174"
     CDS             2..391
                     /codon_start=1
                     /locus_tag="Xsze_03174"
                     /product="glyoxalase"
                     /protein_id="PHM32428.1"
                     /transl_table=11
                     /translation="MSSATSGPMAANLQLVYVSDVERSTTFYKSLFKTDPIFITPRYVA
                     FRASSSGDALFALWSGGETPDLQVQRFNEIGIMLPTSDDVEQLFQEWQGNSDIEIVKEL
                     YTEVFGRTFLVKDPDGHIIRVCPLD"
     gene            826..1311
                     /locus_tag="Xsze_03175"
     CDS             826..1311
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phenazine: phzB"
                     /gene_kind="biosynthetic"
                     /locus_tag="Xsze_03175"
                     /product="phenazine biosynthesis protein PhzB"
                     /protein_id="PHM32429.1"
                     /sec_met_domain="phzB (E-value: 2.2e-66, bitscore: 213.7,
                     seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKHNDNFDQLREKNRKTVEKYLELTKGEARLKRHELFAEDAEDA
                     EGGLWTTETGEPIVIRGIENLERHAHWSLQCFPDWEWYNIKIFTTDDPDHIWVECDGHG
                     IIRLPNYPESYYENHFIHSFELRDGLIIRNREFMNPINQLKALDIVVTKINRQGIPS"
     gene            1666..2307
                     /locus_tag="Xsze_03176"
     CDS             1666..2307
                     /codon_start=1
                     /locus_tag="Xsze_03176"
                     /product="putative pyrodoxamine 5'-phosphate oxidase"
                     /protein_id="PHM32430.1"
                     /transl_table=11
                     /translation="MKKLKSLTGLLDVPFPHYDNPSPSPETVIKAWLARARNDDVCEHD
                     AYTLATRNADGDISMCTVFPVRFDGDVLLFATHRSSRKGQDIDSTGSAGCHIYWRELGR
                     RLSLSGSAILASDLASGEVAEAVWYAQDPAYDPVSTVSYQSTPHTNIPALFHEAAKYDG
                     KSKLPRPERFVVYQLIIACCEFWAVDAFRMHKRLVYKRTEKGWKNERLQP"
     gene            2288..3385
                     /locus_tag="Xsze_03177"
     CDS             2288..3385
                     /NRPS_PKS="Domain: AMP-binding (91-316). E-value: 9.3e-12.
                     Score: 36.0. Matches aSDomain:
                     nrpspksdomains_Xsze_03177_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="Xsze_03177"
                     /product="hypothetical protein"
                     /protein_id="PHM32431.1"
                     /sec_met_domain="AMP-binding (E-value: 4.9e-13, bitscore:
                     38.0, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDYSHEIEQITAAQACQDPNRFVQAVMKWHFSEETGTDFWLAMR
                     QELPFNPLSDINTFDDLRKFPDISARLRTTPVQSLQPRGLQHDRQVSVYESGGTTGTPK
                     YVVAYDAWIEALIDWRMSSYKDRPGRPTGNTLAAVPSGPHLVGAINRVRAQKLGGLCFM
                     IDIDPRWVKRSIREGNMAYARRYSSHLADQIENTLLNQDIRFLVTTPPILRELVKRTEL
                     VTHMKRSLAQITLGGTELNLDEVKFIAREILPECEFSASYGSTSALGVSRSRLITADSV
                     RVEYNSFAPFITYDVVDRDTQATVDYGQRGTVVVSHLSRYAFYPRILERDTAIRLPGGG
                     QIGDNLADIAAEVTFSGLKVIEGVY"
     aSDomain        2561..3235
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Xsze_03177_AMP-binding.1"
                     /evalue="9.30E-12"
                     /label="Xsze_03177_AMP-binding.1"
                     /locus_tag="Xsze_03177"
                     /protein_end="316"
                     /protein_start="91"
                     /score="36.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="SVYESGGTTGTPKYVVAYDAWIEALIDWRMSSYKDRPGRPTGNTL
                     AAVPSGPHLVGAINRVRAQKLGGLCFMIDIDPRWVKRSIREGNMAYARRYSSHLADQIE
                     NTLLNQDIRFLVTTPPILRELVKRTELVTHMKRSLAQITLGGTELNLDEVKFIAREILP
                     ECEFSASYGSTSALGVSRSRLITADSVRVEYNSFAPFITYDVVDRDTQATVDYGQRGTV
                     VVS"
     gene            3385..4782
                     /locus_tag="Xsze_03178"
     CDS             3385..4782
                     /EC_number="1.2.1.8"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="Xsze_03178"
                     /product="5-carboxymethyl-2-hydroxymuconate semialdehyde
                     dehydrogenase"
                     /protein_id="PHM32432.1"
                     /sec_met_domain="Aldedh (E-value: 2.1e-12, bitscore: 35.9,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLELDEKTPELPLIEAITPITQKRFIQQKVINNIQGTPVGKITQV
                     PAIYAHYTVNCLRQGESLSIEKRDEALQKAAELFMNGKLCGLTVEDYVAKVVSVTGLPE
                     HIIKNAVRSIAYATASGVHLAKLGIPQGVPEDNTGRVLENGCAQSVRRGDVLAVIAPGN
                     GPGVHAIWPQAIALGYRVILRPSDREPYTAQRLIQAMSESGLGNYAAMLPSDHSLVDEL
                     LEFADLSVIYGGKALVDRFAYRSDVLVQGPGLSKIVIGADYPRNAALELVFESVMGLGG
                     AACVCTSSVLVEGDAVAFAHEFYAYASERLKNESEQHHYLPQLSAERYSWWSEQVTQYA
                     DFLVQPPDVFDTLSGVKRVMPLIMLAESFDSPLIQSEFPVAAVTFVPFRCDDDLDVIAP
                     ALVVTVASKKPSLISRISDIPAIRNLYIGQVPTVWMQPHVPHDAFIAEFLMTTRGYRVA
                     YPASMSG"
     gene            4848..5537
                     /locus_tag="Xsze_03179"
     CDS             4848..5537
                     /codon_start=1
                     /locus_tag="Xsze_03179"
                     /product="tellurite resistance protein TehB"
                     /protein_id="PHM32433.1"
                     /transl_table=11
                     /translation="MSNVKNNEYDRADFQGVYQGKSLIESAEIKTVPWEIGRAQPVVCD
                     LLKKGARGKLLDVGCGLGRNAEAAAEMGYDVTAIDNAPTAIESCQDRQMTNHIRFKVAN
                     ACATGLNETFDTILDSATYHAIPSNDRAAYMGEMRRLANEATEYHLITFAPSVRGMPKP
                     LAIELSEIVDTAEKSGWQIESVSRVEYKGNAEAIADFCKKKNLTILLDEEGLTRLPSWH
                     IILKTVL"
     gene            5564..6997
                     /locus_tag="Xsze_03180"
     CDS             5564..6997
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 220; E-value:
                     6.8e-67)"
                     /gene_kind="transport"
                     /locus_tag="Xsze_03180"
                     /product="MFS family major facilitator transporter"
                     /protein_id="PHM32434.1"
                     /transl_table=11
                     /translation="MNQRKMAFFGLCVGFFIAMMDITTVPLIYTSLIAEFKVTPVMAAW
                     VNNSYLITYAGFLLLGGRLGDAYNRKNLIVSALIILSIGALVSGCGQTLMQVIVGRALM
                     GVGAALLTPQSMAYISILFAQGGRGTALGIWGAVAGIATATGPVVTQFFLQVADWRWIM
                     WINIPIALLGLVIITMYLPAAPGKGLKGREFLINGAFGFSLAAIILGLQLIHGAGGINP
                     ITVLLLVLGSVIVVWLLRYELRHRAECILPVKIWQDRVFLRTCLVSGLLGFGVTAFYLP
                     LAFLIEIRMNFGPFAISMIMITIALANALTGPIAGHFSDKIVPEVIIRYGLSTFALAVL
                     LLGGIGIFATGGSIAFIAMIIAMALAGAGAGLAFAPLANLALSRAVPTAIGRAAAFFNG
                     SRQLMSALGSVIVAVLFDYVVNQSPLEGASSISEKLQPYSPVVASAALVCFLLIALCLV
                     TGAWLSHSHSSNDKNISQS"
     gene            7015..7806
                     /locus_tag="Xsze_03181"
     CDS             7015..7806
                     /NRPS_PKS="Domain: PKS_KR (2-161). E-value: 1.5e-07. Score:
                     23.3. Matches aSDomain: nrpspksdomains_Xsze_03181_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     116.4; E-value: 2.5e-35)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="Xsze_03181"
                     /product="3-ketoacyl-ACP-reductase CylG"
                     /protein_id="PHM32435.1"
                     /transl_table=11
                     /translation="MNTWVVSGCSNGLGRCWTNSIIRERHDRVIGITRSEDIAHEMVEL
                     YQDSFIPCIADIRDEQILAEKLPALIRKVGIPNRIVTAAGYAQFGTLEDLSTQQLREQF
                     ETNVEGTLNVIKPLLPFMRKLPEARILVVSSMSGVACWPLLGAYQISKYAIEAIGETLR
                     LELDNTPIQVGIIEPGPYKTGWATTSARREKISDAYDEDMLRKRAACGFTVEEPTASLP
                     FFWKMFDTPVMPVRIATSAPFVDLVCAQAEEKVQAWRKFFE"
     aSDomain        7021..7497
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Xsze_03181_PKS_KR.1"
                     /evalue="1.50E-07"
                     /label="Xsze_03181_PKS_KR.1"
                     /locus_tag="Xsze_03181"
                     /protein_end="161"
                     /protein_start="2"
                     /score="23.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TWVVSGCSNGLGRCWTNSIIRERHDRVIGITRSEDIAHEMVELYQ
                     DSFIPCIADIRDEQILAEKLPALIRKVGIPNRIVTAAGYAQFGTLEDLSTQQLREQFET
                     NVEGTLNVIKPLLPFMRKLPEARILVVSSMSGVACWPLLGAYQISKYAIEAIGET"
     gene            7799..8956
                     /locus_tag="Xsze_03182"
     CDS             7799..8956
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1191:acyl-CoA dehydrogenase type 2 (Score: 154;
                     E-value: 7.8e-47)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="Xsze_03182"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="PHM32436.1"
                     /transl_table=11
                     /translation="MNSHMINEQAIWHSEIGAIIAAYSLEEKTETPSAHTMSVLQDKTV
                     LKILDETSPTGPGKLSDVVAVCCELGKVDASLAWLVGVANAAWSMRANFSLSESVCAAM
                     NKNAMLSMVLGRPATLKPAPKGEGWILNGEWKYASGYPWSSYFFGLAMSDDGHVRVVVV
                     PSDDLHIIAPWQSTGLIGTQSVTIRAQDVYVPEMHTVEYQSILSGKSRHHHDKPSYSSY
                     FTGVLMNCLVGSMLGATEGAINYVIGNIQRPIAGSTYAAMDHSDPIRYELGRLSSAFDL
                     LIRAAEYNASVIDDAVYNRIVLTNRQRVEIRARATQIMRGCTETVQSLLWLYGSSGLET
                     SCPLEKIWRDINVGTRHGGFAKLVPEELAGITLLGGDPTTLSHMF"
     gene            9039..10535
                     /locus_tag="Xsze_03183"
     CDS             9039..10535
                     /NRPS_PKS="Domain: AMP-binding (24-396). E-value: 1.1e-62.
                     Score: 203.7. Matches aSDomain:
                     nrpspksdomains_Xsze_03183_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     224.3; E-value: 3.9e-68)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="Xsze_03183"
                     /product="Amino acid adenylation"
                     /protein_id="PHM32437.1"
                     /sec_met_domain="AMP-binding (E-value: 2.1e-66, bitscore:
                     213.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNHISPWKINTGIKVLDDVLTSALEEQPDAKALINAERVYSYHQ
                     LISAADTLAKQFNNMGINEGDRIALDAPRSCELFIATMACLLSSISFIFVPRSIKKEQK
                     MKFAVQTGCAAIFSLSDEFVELKAQSLDMGNVLILPDAPLSRAPHQLSGKEIYCVRTSG
                     TTGEPKIVPIHARQLQAFLSNVRSVFAIPQGRRWLWMHDLSFDLSIWETLGCLVHRGSL
                     VVLEEEDKRDPGLIWQVLEREKINQIMMTPSEFRYIFSKNYLSYFPRLSLNEMLLGGEK
                     LSVEMLKPFFSAFQSQKMKLVNVYGPSETTVFCSSHIVTENDLQAGSIPIGKPFPNMYF
                     SLENRESDGSGDLLLEGNQVFEGYEGRLLERKGYLTGDICRCDDQGEYHFIGRKMGFYK
                     INGFRVDPMEIEEFLKSIPGVGEAVVWVDETSENLSLLYACVNVMAGVTLSTRDLRMEC
                     TQLATWLRPARYLIVPQNEWPMNTTGKTDRAELKRRIYEK"
     aSDomain        9111..10226
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Xsze_03183_AMP-binding.1"
                     /evalue="1.10E-62"
                     /label="Xsze_03183_AMP-binding.1"
                     /locus_tag="Xsze_03183"
                     /protein_end="396"
                     /protein_start="24"
                     /score="203.7"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LEEQPDAKALINAERVYSYHQLISAADTLAKQFNNMGINEGDRIA
                     LDAPRSCELFIATMACLLSSISFIFVPRSIKKEQKMKFAVQTGCAAIFSLSDEFVELKA
                     QSLDMGNVLILPDAPLSRAPHQLSGKEIYCVRTSGTTGEPKIVPIHARQLQAFLSNVRS
                     VFAIPQGRRWLWMHDLSFDLSIWETLGCLVHRGSLVVLEEEDKRDPGLIWQVLEREKIN
                     QIMMTPSEFRYIFSKNYLSYFPRLSLNEMLLGGEKLSVEMLKPFFSAFQSQKMKLVNVY
                     GPSETTVFCSSHIVTENDLQAGSIPIGKPFPNMYFSLENRESDGSGDLLLEGNQVFEGY
                     EGRLLERKGYLTGDICRCDDQGEYHFIGRKMG"
     CDS_motif       9507..9557
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Xsze_03183_0001"
                     /evalue="2.60E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="Xsze_03183"
                     /protein_end="173"
                     /protein_start="156"
                     /score="14.0"
                     /tool="antismash"
                     /translation="YCVRTSGTTGEPKIVPI"
     CDS_motif       10206..10271
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Xsze_03183_0002"
                     /evalue="4.90E-05"
                     /label="NRPS-A_a8"
                     /locus_tag="Xsze_03183"
                     /protein_end="411"
                     /protein_start="389"
                     /score="16.0"
                     /tool="antismash"
                     /translation="FIGRKMGFYKINGFRVDPMEIE"
     gene            10525..10770
                     /locus_tag="Xsze_03184"
     CDS             10525..10770
                     /NRPS_PKS="Domain: PCP (10-64). E-value: 9.8e-11. Score:
                     33.6. Matches aSDomain: nrpspksdomains_Xsze_03184_PCP.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="Xsze_03184"
                     /product="hypothetical protein"
                     /protein_id="PHM32438.1"
                     /sec_met_domain="PP-binding (E-value: 1.5e-09, bitscore:
                     28.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNNEQMLSILLHEVQIMLNEPDVREDDNFTELGGNSIMAMQIVE
                     TLKIRDGILVSSAQLLGARIAHIELKRMDEGNGEQK"
     aSDomain        10555..10716
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Xsze_03184_PCP.1"
                     /evalue="9.80E-11"
                     /label="Xsze_03184_PCP.1"
                     /locus_tag="Xsze_03184"
                     /protein_end="64"
                     /protein_start="10"
                     /score="33.6"
                     /tool="antismash"
                     /translation="LLHEVQIMLNEPDVREDDNFTELGGNSIMAMQIVETLKIRDGILV
                     SSAQLLGAR"
     gene            10767..11792
                     /locus_tag="Xsze_03185"
     CDS             10767..11792
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084:3-oxoacyl-(acyl carrier protein) synthase III
                     (Score: 89.1; E-value: 4.7e-27)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="Xsze_03185"
                     /product="3-oxoacyl-ACP synthase"
                     /protein_id="PHM32439.1"
                     /transl_table=11
                     /translation="MKILSIDYQLTRPVCIKEVEHPNKMQIETIQYAGYNQFWIEPNST
                     REMASVAVQKALSSSGIQAKDIHFIVAGQSGMPDYIGIDFSCQVGAELQCSDIRTVNLV
                     EGCGSGISTWFHAESLARKLPLGKVGLVVVAQRVSEVHQDRFGTMNAILSDGAAVAVVA
                     SDDWQTSTPTLHYLSGDDMSDCRYVDMMRVEYGGGCQPVLPEGYDVRYDKLGRERIMDI
                     YQFTPDDLKEFLALRQDNTIKIIKRVMAQIDRPLNSPFLLQTLEGVQSIKELCRKMDIL
                     PERSNLNLISELGHVGCTDLLISLKILIDRGDIQPGDDIIMSTISSGLKWGAAIFHYGK
                     G"
ORIGIN
        1 tatgagtagt gcgacttctg gtccaatggc ggccaatttg caactagttt atgtttctga
       61 tgttgagcgc tcaaccactt tctacaaatc tctattcaag acagatccta tttttattac
      121 cccgcgttat gtggcttttc gtgcctcttc ttctggtgat gctctttttg ctctttggtc
      181 tggtggtgaa acacctgatc tgcaagttca acgttttaat gaaattggta tcatgctgcc
      241 aacaagtgat gatgttgagc aactattcca agaatggcaa ggtaattcag atattgaaat
      301 tgtaaaagaa ctatatacag aagtatttgg gcgaaccttc cttgtaaaag atcctgatgg
      361 tcacattatt cgagtttgcc cgttggatta ataagatgta gaaactatta gatattcatc
      421 cggggttccg tattgattcg ggaattttgt ttaatcggga atatctacat gtcagtaaca
      481 aatttctact tttgggcttc tttggaaaag tgaattttta aaaattattc atagcgccaa
      541 agaagcttat attagttcta tcgtgaaaat atattgtgtt actgatttta atgacaaaga
      601 atttaatcaa tcattaatat tataaagtaa ttctgattta tattgtttaa ttatctattg
      661 ttggtattac aacaattaaa ttgtaaagca aaaaattcaa tgaaatcaat aaatactcga
      721 cggtattaat ttttcaccta taaaaggtta aataatatat tatcttctgt ttttagtggg
      781 aataaagaaa aactatttaa aaataactat ttcaataggt tttttatgac taaacataat
      841 gataattttg atcagcttcg tgaaaaaaat cgtaagactg tagagaaata tttagaactg
      901 accaaaggcg aagctcgctt aaaaagacat gagctttttg cggaagatgc ggaagatgca
      961 gaaggcggat tatggaccac agaaacaggt gagccaatag ttatacgtgg tattgagaac
     1021 ttagagcgcc atgctcactg gtcacttcaa tgttttcctg attgggagtg gtacaatatc
     1081 aaaatcttca caactgatga ccctgatcat atttgggttg aatgtgatgg tcacggtatt
     1141 attcgcttac ctaattaccc tgaaagttac tatgaaaatc attttattca ttctttcgag
     1201 ttacgtgatg ggctaatcat acgtaaccgg gaattcatga atcctatcaa tcaacttaaa
     1261 gcccttgata ttgttgttac gaaaataaat cgacaaggta tacctagtta attgttactt
     1321 aaaaatcatt tggtaataag tattttattc atcattcaat attcgttttt atgttgtgga
     1381 tgattggcgt taaattaact ttctgaataa ataattcaat tcaataattt aataaaataa
     1441 taaaatgagc agaaaattaa aatataagtc ttatgattta ggcaatattc gtattccttc
     1501 ccaccaaccg ttaaaccgga aaataaaaaa ggatcatgtg cattattaat tcataatatg
     1561 caacgttact ttgtgcacgc tttactggat aaaccggcaa attattgatg cgctttttta
     1621 atcaatgtgc ccgctccgat taaaggggat gaaagaaaga gaaaaatgaa gaaactcaaa
     1681 tcattaaccg gactgctgga tgtgcctttt ccgcactatg ataatccgtc tccctcaccg
     1741 gagacagtga taaaagcgtg gttagcacgg gcacggaatg acgatgtctg tgagcacgat
     1801 gcctatacgc tggctacgcg caatgctgat ggtgatattt caatgtgcac ggtgtttcct
     1861 gtccgttttg atggtgatgt cttgttattt gcgacgcacc gctccagtcg caaaggtcag
     1921 gatattgact caacaggctc tgccggttgc catatctatt ggcgtgagct ggggcgccgg
     1981 ttaagtcttt ccgggtcagc gatattggct tctgatttgg cttccggtga agtggctgag
     2041 gcggtttggt atgcacagga ccctgcatat gatccggtgt caacggtgtc ttatcaaagt
     2101 accccacaca cgaatattcc ggccttattc catgaagccg ctaaatatga cgggaaaagt
     2161 aaattgccgc gccctgagcg ttttgttgtc tatcagctca tcatcgcgtg ctgtgaattc
     2221 tgggcagtcg atgcattccg tatgcataag agactggttt ataaacgaac cgaaaaggga
     2281 tggaaaaatg aacgattaca gccatgaaat tgagcagata acggcagcgc aggcctgtca
     2341 ggatcctaac cgttttgttc aggctgtcat gaaatggcat ttttctgaag aaacgggaac
     2401 cgatttttgg ctggcgatgc gtcaggaatt gccgtttaac ccgttgagtg acattaatac
     2461 atttgatgat ttgcggaaat tccccgatat ttcggcacgc cttcgcacaa cgccggttca
     2521 gtctcttcag ccacggggat tgcagcatga tcgacaggtt tctgtgtatg aaagtggcgg
     2581 aacaaccgga acgccaaaat atgttgtcgc ctatgatgcc tggattgaag cgctgattga
     2641 ctggcgcatg tcatcgtata aagatcgccc gggcaggcca accggcaata cactggcggc
     2701 cgtcccttct gggccgcatc tcgtcggggc gataaataga gtgcgtgcac aaaagctggg
     2761 tggcctttgt tttatgattg atattgaccc acgctgggtt aagcgttcaa tccgtgaagg
     2821 caatatggct tatgctcgcc gttattcttc ccatctggct gatcaaattg aaaatacact
     2881 gcttaatcag gatatccgtt ttcttgtaac aacgccgccc atattgcgtg aattggtgaa
     2941 acgaacggag ctggttacgc atatgaaacg ttctttagcg caaattacat taggcggaac
     3001 agaactcaat ctggatgaag tgaagtttat tgctcgtgaa attctgcctg aatgtgaatt
     3061 cagtgcgagc tacggcagca cttctgcatt aggtgtatca cggtcacggc tgattacggc
     3121 agacagtgtt cgggtggaat ataacagctt tgcgcccttt attacctatg atgtggttga
     3181 tcgcgatacg caggcaacgg ttgattatgg tcaacgggga actgttgtcg tttctcacct
     3241 cagccgttat gccttttacc cccggatctt ggaaagagac acggcaattc gcttacccgg
     3301 gggcgggcaa attggggaca atctggcaga tattgctgct gaggtaacgt ttagtggcct
     3361 taaagtcatt gaaggggtct actaatgtta gagctggatg agaagactcc ggaattacca
     3421 ctaatagaag caattacacc gattacgcag aaacgtttta ttcagcaaaa agtgattaac
     3481 aatattcagg gaacgcctgt gggaaagata acacaggtac ctgcaatata tgcgcattat
     3541 accgtgaatt gtctacgcca aggagaatcg ctttctatcg agaagcggga tgaagcatta
     3601 caaaaagcgg ctgaactctt tatgaatggc aaattgtgtg gcttaacggt agaggattat
     3661 gttgcaaagg ttgtttcagt gactggcctt cctgagcata ttattaaaaa tgcggtcaga
     3721 agtattgctt atgcgacagc atctggggtg catttagcta aattgggcat tccacaaggt
     3781 gtaccggaag ataatacagg ccgggtttta gaaaacggat gtgcgcaaag tgttcggcga
     3841 ggagatgtac tcgcagtgat tgcaccgggt aatgggccgg gtgtccatgc gatttggcca
     3901 caggcaatag cgcttggcta tagagttata ttacgtcctt ctgatcgtga gccttatacg
     3961 gcacagcgtc tgattcaggc aatgtctgaa tcaggtttgg ggaattatgc agcaatgctg
     4021 ccttctgatc atagcttggt tgacgaattg cttgaatttg ctgatctcag tgtaatttat
     4081 ggcggaaaag cacttgttga tcgtttcgcc tatcgttcgg atgtcttggt acaaggccct
     4141 gggctatcaa aaattgtgat tggtgctgat tatccccgga atgctgcatt agaactggtt
     4201 tttgaatcgg ttatgggatt agggggagcc gcctgtgttt gtacgagcag tgtacttgtg
     4261 gagggtgatg ctgttgcttt tgcacacgaa ttttatgctt atgcatccga gagattgaaa
     4321 aatgagtcgg aacaacatca ttatcttccc caactttcag ctgaacgcta ttcatggtgg
     4381 tcagaacaag tcacacagta tgccgatttt ttagtacaac caccggatgt gtttgacacg
     4441 ctatcaggcg taaaacgtgt aatgccattg attatgttgg ctgaatcgtt tgacagcccg
     4501 ttaattcagt cagaatttcc ggttgcggca gtgacttttg tcccttttcg ctgtgacgat
     4561 gaccttgatg ttattgctcc tgcgttagtg gtgactgtag cgtcaaaaaa accatcttta
     4621 atttcccgta tttctgatat tccggctatt cgtaatttgt atatcggtca ggttcctact
     4681 gtttggatgc agcctcatgt tccccatgat gcttttattg ctgagttctt aatgacaaca
     4741 cgaggttatc gtgtggctta tcctgcatca atgagtgggt aaatgatctc tatgttcagt
     4801 aatgaaaaac taacaattgt ttatggaaat aggtttaggt gaaagtcatg agtaatgtaa
     4861 aaaataatga atatgacaga gcagattttc aaggggtata ccaaggaaaa tcacttatag
     4921 aaagtgctga aattaaaaca gttccttggg aaatagggcg tgcccaacct gttgtttgtg
     4981 accttttgaa aaagggggca cgcgggaaat tattggatgt cggttgtggt ttagggcgca
     5041 atgctgaggc agccgcggaa atgggttatg atgttaccgc tatcgataat gcccctactg
     5101 ccattgagag ttgccaagac agacaaatga cgaaccatat cagattcaaa gttgctaatg
     5161 cttgtgcaac agggctgaat gagacatttg acacaatttt ggactctgct acctatcacg
     5221 ctattccttc taatgatcgt gccgcttaca tgggtgaaat gcgccgctta gcgaatgagg
     5281 cgactgaata tcacttgatt acgtttgctc cttcagttcg cggaatgccc aagcctctgg
     5341 ctattgagct atctgaaatt gtagatacgg cagaaaaaag tggttggcaa attgaatcag
     5401 tttctcgtgt tgaatacaaa ggtaatgcgg aggcaattgc tgatttttgt aagaagaaaa
     5461 acttaactat tttgctggat gaagaaggac ttactcgttt accaagctgg cacatcatac
     5521 tgaaaactgt tctttaataa aaatttgtcg gtcaggggta gcgatgaacc agcggaaaat
     5581 ggcatttttc ggactctgtg ttggcttttt tattgcgatg atggatatca caacagtacc
     5641 gttgatttat acctcattaa ttgcagagtt taaagtcaca ccagtaatgg cagcatgggt
     5701 taataatagt tatctaatta cctatgcggg ctttctttta ttggggggac ggttaggtga
     5761 tgcttataat cgaaaaaacc ttattgtcag tgcattgatt attctctcta ttggcgcatt
     5821 ggtaagtggt tgtggccaaa cacttatgca ggttatcgtt ggtcgggcat tgatgggagt
     5881 tggtgctgcc ctgttgacgc cgcaaagtat ggcttatatc tctatccttt ttgcacaagg
     5941 gggacgtggt acagctttgg gtatttgggg tgcagttgct ggtattgcta ctgcgacagg
     6001 gcctgtagtg actcagtttt ttctacaagt tgctgattgg cgctggatca tgtggataaa
     6061 cattcctatt gcgctgctag gattagtcat tatcacgatg tatttacctg ctgcgcctgg
     6121 taaagggtta aaagggagag agtttcttat taatggggct tttggtttct ctctggcagc
     6181 tattattctg ggtttgcagt taattcatgg cgcaggaggt atcaatccca taacggtact
     6241 tctgttggtg ttgggaagtg taattgttgt ttggttattg cgttatgaac tgcgtcatcg
     6301 ggcagagtgt attttacctg tcaagatttg gcaggatagg gtcttcttac ggacttgttt
     6361 agtctccggt cttcttggtt ttggtgtgac agcattctat ctaccattag ctttcttgat
     6421 cgaaattcgc atgaattttg ggccattcgc aatcagtatg attatgatta cgattgcact
     6481 tgctaatgcg ttaactgggc caatagcagg tcatttttca gataaaatag ttcctgaagt
     6541 tatcattcgt tatggtttgt ctacttttgc tctggcagta ctactgttgg gcggtatagg
     6601 gatatttgcc acaggaggtt caattgcatt tatcgctatg ataatcgcga tggcactggc
     6661 gggtgcaggg gctggattag catttgcacc tctggctaat cttgcattaa gtcgggctgt
     6721 accaacagca ataggcagag cagcggcatt tttcaacggc tcacggcagt tgatgagtgc
     6781 cttaggcagc gttatcgttg ctgtactgtt tgattatgtt gtcaatcaat cccctctgga
     6841 aggcgcatca agtatctcag agaagttgca accgtattct cctgtggttg cttctgcggc
     6901 actcgtttgt ttcttattaa ttgcactgtg tttagttaca ggagcatggt tatctcacag
     6961 tcattcctca aatgataaaa atatttctca gagttaatca aaggaattag aaatatgaat
     7021 acttgggttg ttagcggttg ttcaaatggt ttaggtcgat gctggacgaa ttctattatt
     7081 agggaacgcc atgatcgcgt tattggtatc acgcgttctg aggatattgc tcatgaaatg
     7141 gtagaacttt atcaagatag ttttattcct tgtattgctg atattcgaga tgagcaaata
     7201 cttgcagaaa agcttcctgc attaatacga aaagtgggta ttccaaatcg gatcgtaact
     7261 gctgcgggtt atgctcagtt tggtacgtta gaggatctgt ctacacagca attgcgtgag
     7321 cagtttgaaa caaatgttga agggacgctt aacgttatta aaccgctatt gccgtttatg
     7381 cggaagttgc cagaagcaag gatccttgtg gtatcaagca tgagtggagt tgcttgttgg
     7441 ccacttttag gggcttatca aataagcaaa tacgcgattg aagcgattgg ggaaacgttg
     7501 agattggaac ttgataatac accgatccag gttgggatta ttgagccagg tccttataaa
     7561 acggggtggg caacaacttc agcacgccga gaaaaaataa gtgatgctta tgatgaagat
     7621 atgctgagaa agcgggctgc ttgcggtttt actgttgaag agcctacagc gagcttgcca
     7681 tttttctgga agatgtttga tacacccgtc atgcctgttc gtatagcaac gtctgcccca
     7741 tttgtagatt tagtttgtgc gcaagctgaa gaaaaagtac aggcatggag gaaattcttt
     7801 gaatagccat atgataaatg agcaagcaat ctggcatagc gagattgggg ctatcattgc
     7861 tgcttattcc ctggaggaaa aaacagaaac tccatctgct cacactatgt cggtattgca
     7921 agacaaaacc gtactgaaaa tattggatga aacttcacca acaggcccgg gtaaattatc
     7981 ggatgttgtg gcagtgtgct gtgaattagg caaagttgat gcttcattag cttggttagt
     8041 tggtgttgct aatgcggcgt ggtcgatgag agccaatttt tctttgtctg aatcggtttg
     8101 tgctgccatg aataaaaatg ccatgttgtc tatggtgctg gggcgaccag ccacgcttaa
     8161 accagcacca aaaggtgaag gatggatttt aaacggcgaa tggaaatatg cttcaggata
     8221 cccttggtca tcgtattttt tcggcctggc tatgtctgat gatggtcatg tccgtgttgt
     8281 tgttgtgcca tctgatgatt tacatatcat cgccccatgg caatcaacgg gattgattgg
     8341 aactcaaagt gtcactattc gagcacaaga tgtgtatgtt cctgaaatgc atactgtaga
     8401 gtatcaatcc attctttcag gtaaatcccg ccatcatcat gataagcctt cttattcgag
     8461 ttatttcacc ggggttttaa tgaactgcct ggttggttcg atgttaggtg caacggaagg
     8521 tgccataaat tatgtgatag gaaatataca acgccctata gctggcagta cgtatgcagc
     8581 tatggatcat tctgatccca ttcggtatga attagggcgg ttaagtagtg cctttgacct
     8641 attgatacgt gctgctgagt ataacgcgag tgtcatagat gatgctgtgt acaacagaat
     8701 agtgcttacg aatcggcaac gtgtagaaat ccgggcacgg gccacacaaa ttatgcgcgg
     8761 gtgtacagaa acagttcagt ccttgttgtg gctttatggc tcatcaggat tggagacaag
     8821 ctgtcctcta gaaaaaattt ggcgtgatat caatgtggga acacgccatg gaggttttgc
     8881 gaagcttgtc ccagaagaat tggcaggaat tacgttgtta gggggtgatc caacaacgct
     8941 ttcacacatg ttctgagtga ttcgtttttt cattcgttgc tgcatcagtg atgtgtagca
     9001 atgcggtgga aaatggtgct gttgatgaag gataagctat gaaaaatcat attagcccat
     9061 ggaaaataaa cacgggaata aaagtccttg atgatgtact cacaagtgcc cttgaagagc
     9121 aacctgatgc aaaagcattg attaatgcag aaagagtcta tagctatcat cagttaattt
     9181 ctgctgccga tacgttagcc aagcaattca acaacatggg aatcaatgaa ggagacagaa
     9241 ttgcactgga tgcaccgaga agttgtgagt tatttatcgc tacgatggcc tgcctattat
     9301 ctagcatctc atttattttt gtacctagat caataaaaaa agagcaaaaa atgaaatttg
     9361 ctgtgcagac gggctgtgcg gcgatttttt ctctttctga tgagtttgtt gaattgaagg
     9421 cacaatctct tgatatgggt aatgtattga tattacctga tgctcctctt tcgagagcgc
     9481 ctcatcaatt atccggaaaa gagatctatt gtgtacgtac ttctggaaca acaggagaac
     9541 ctaaaattgt tcctattcat gctcggcaac ttcaggcatt tttaagcaat gtccgtagtg
     9601 tatttgctat cccacaagga aggcgctggt tgtggatgca tgatctttca tttgatttat
     9661 ctatatggga aaccttaggc tgcttggttc atcgtggttc tttggtggta ttggaagaag
     9721 aggataaacg tgatcctggc ctgatttggc aggtgttaga gcgagaaaaa ataaaccaaa
     9781 ttatgatgac accctctgag tttcgttaca ttttcagtaa gaattattta tcatattttc
     9841 cccgtctatc attaaacgaa atgcttcttg gcggtgaaaa gttgtctgtc gaaatgctga
     9901 aacccttttt ctccgctttc caatcccaaa aaatgaaatt agtcaatgtt tatggtccat
     9961 cagaaacaac cgtattttgc tcttcacata ttgtgaccga aaatgatctt caagcgggtt
    10021 ctattcctat tggtaagcca tttcccaata tgtatttttc tttggaaaac cgggagagtg
    10081 atggtagtgg ggatttatta ttggaaggga accaggtttt tgaaggatat gaaggacgct
    10141 tgcttgaacg aaagggctat ctgacggggg atatttgtcg gtgtgacgac caaggtgagt
    10201 atcactttat tggccgaaaa atggggttct ataagatcaa cggattccgt gttgacccca
    10261 tggaaattga ggagttcttg aaatctattc ctggtgttgg tgaagcggtg gtctgggtcg
    10321 atgaaacttc agaaaatctg tctttattat atgcctgcgt aaatgtgatg gctggtgtga
    10381 ctttgtcaac tcgagatttg agaatggaat gtacacaact tgcaacatgg ttacgacctg
    10441 cccgttattt aattgttcct cagaatgagt ggccgatgaa tacaacagga aaaacggaca
    10501 gagctgaatt gaaaaggagg atatatgaaa aataacgaac agatgctcag tatcttgtta
    10561 catgaagtac aaattatgct caatgaacca gatgtaagag aagatgataa tttcactgaa
    10621 ttgggcggta attcaattat ggccatgcaa attgttgaaa ccttgaaaat acgagacggt
    10681 attttggtga gttcggccca attactgggt gcccgcatcg ctcatattga attaaagcga
    10741 atggatgaag gaaacgggga gcaaaaatga aaattttaag tatagattat cagctaaccc
    10801 ggcctgtatg tataaaagag gttgagcacc ctaataaaat gcagatagaa accattcaat
    10861 atgcgggcta taaccaattt tggattgaac cgaacagtac tcgggaaatg gcgtcagtgg
    10921 ctgtacaaaa agcactttct agttcaggga ttcaggctaa agatattcat tttattgtcg
    10981 cggggcaatc aggtatgcca gattacattg gcattgattt ctcctgtcag gttggagcag
    11041 aactgcaatg ttctgatatt cgcactgtga atttggttga aggatgtggg agtggcatta
    11101 gtacttggtt tcacgctgaa tcgctggcta gaaagctgcc tttggggaaa gtgggcttag
    11161 ttgttgttgc tcaacgtgtc agtgaggtgc accaagatag atttggcacg atgaatgcga
    11221 tcttaagcga tggggcagct gttgctgttg ttgcttctga tgactggcaa acatctacgc
    11281 cgacattaca ttacctttcc ggtgatgata tgtccgattg ccgttatgtt gacatgatgc
    11341 gcgttgagta tggtggtggt tgtcaacctg tgctaccaga aggctatgat gttcgttatg
    11401 ataaattagg ccgtgaacga atcatggata tttatcagtt cacgcctgat gatctaaaag
    11461 aatttctagc attacgccaa gataacacta tcaagattat taaaagggtt atggctcaaa
    11521 ttgatcgtcc cctaaattca ccattcttat tacaaacatt ggaaggtgta caaagtatta
    11581 aggagctttg tagaaaaatg gatattttac cagaaagaag taatctgaat ttaatttctg
    11641 agttggggca tgttggatgc accgatttgc tcatttcgtt gaaaattttg attgatagag
    11701 gagatattca gcccggtgat gatattatca tgagtacgat ttctagtggg ttaaaatggg
    11761 gagctgctat tttccactac ggtaagggat aa
//
