BGC0001872 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001872 (Xenorhabdus bovienii SS-2004)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	PUFA,T1PKS,hglE-KS	1	51,335	High	fabclavine-polyamine	PKS

BGC0001872 - Region 1 - PUFA,T1PKS,hglE-KS

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Location: 1 - 51,335 nt. (total: 51,335 nt) Show pHMM detection rules used

Region on contig edge.

PUFA: PUFA_KS
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
hglE-KS: (hglE or hglD)

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 51,336
Label		BGC0001872

Tailoring functions

Oxidoreductases: dehydrogenase

XBJ1_2950: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acylase

XBJ1_2951: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Lyases: dehydratase hydratase

XBJ1_2948: Nitrilase/cyanide hydratase and apolipoprotein

smcogs: SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

XBJ1_2949: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase synthase

XBJ1_2946: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

XBJ1_2952: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

XBJ1_2953: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001872.3	3.00	PKS	fabclavine-polyamine	Xenorhabdus bovienii SS-2004
BGC0001284.4	0.96	PKS	alternariol	Parastagonospora nodorum SN15
BGC0000863.3	0.89	other (other)	eicosapentaenoic acid	Pseudoalteromonas sp. DS-12
BGC0000107.3	0.87	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002175.3	0.86	PKS	YWA1	Aspergillus oryzae RIB40
BGC0002154.2	0.85	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001268.4	0.83	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001166.5	0.79	NRPS	HC-toxin	Alternaria jesenskae
BGC0001164.3	0.79	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002648.2	0.76	PKS	eicosapentaenoic acid	Shewanella sp. N2AIL

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001872.3	1.00	PKS	fabclavine-polyamine	Xenorhabdus bovienii SS-2004
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0000863.3	0.63	other (other)	eicosapentaenoic acid	Pseudoalteromonas sp. DS-12
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002175.3	0.62	PKS	YWA1	Aspergillus oryzae RIB40
BGC0002154.2	0.62	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001268.4	0.61	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001166.5	0.60	NRPS	HC-toxin	Alternaria jesenskae
BGC0001164.3	0.60	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002648.2	0.59	PKS	eicosapentaenoic acid	Shewanella sp. N2AIL

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 51335:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 44365:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 4510 - 51335:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

XBJ1_2946: X

AMP-binding (35..212): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DELICDP-DK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

XBJ1_2953: mal

PKS_AT (593..896): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 41.5
Methoxymalonyl-CoA: 26.3
Methylmalonyl-CoA: 19.9
Acetyl-CoA: 19.1
fatty_acid: 10.8
Benzoyl-CoA: 9.0
inactive: 8.2
trans-1,2-CPDA: 0.0
Propionyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor