BGC0001873 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001873 (Xenorhabdus szentirmaii DSM 16338)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	8,606	pyrrolizixenamide A	NRPS:Type I	100%

BGC0001873 - Region 1 - NRPS

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Location: 1 - 8,606 nt. (total: 8,606 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 8,607
Label		BGC0001873

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001873	1.00	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0001149	0.27	NRP, Saccharide	brabantamide A	Pseudomonas sp. SHC52
BGC0001833	0.24	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0002518	0.24	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0002135	0.23	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001825	0.23	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001135	0.23	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132	0.22	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286	0.22	NRP	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002037	0.22	NRP	azetidomonamide A, azetidomonamide B	Pseudomonas aeruginosa PAO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001873	1.00	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0001149	0.60	NRP, Saccharide	brabantamide A	Pseudomonas sp. SHC52
BGC0001833	0.57	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0002518	0.57	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0002135	0.57	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001825	0.56	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001135	0.56	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132	0.55	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286	0.55	NRP	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002037	0.54	NRP	azetidomonamide A, azetidomonamide B	Pseudomonas aeruginosa PAO1

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 8606:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ser - Pro)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

Xsze_RS17115

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AMP-binding (466..874): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLVDK
Nearest Stachelhaus code(s):: Ser DVWHFSLVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1571..1985): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVQYISGVIK
Nearest Stachelhaus code(s):: Pro DVQYISGVIK (100% 8Å match)
Stachelhaus code match:: 100% (strong)