BGC0001875: nargenicin A1 biosynthetic gene cluster from Nocardia arthritidis AUSMDU00012717 Unclassified.
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Location: 1 - 64,883 nt. (total: 64,883 nt).
This entry is originally from NCBI GenBank MN095516.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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TTA codons
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Gene details
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General
Compounds
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Biosynthesis
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001875
Short description nargenicin A1 biosynthetic gene cluster from Nocardia arthritidis AUSMDU00012717 Unclassified.
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
MN095516.1
1 - 64883
via Knock-out studies
Compounds
  • nargenicin A1
Species Nocardia arthritidis AUSMDU00012717 Unclassified. [taxonomy]
References
Chemical products information
nargenicin A1 [synonyms: cp-47444, nargenicin] Evidence:
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C28H37N1O8
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QHZ99318.1
  • narR
 1 - 3561 (-) DNA polymerase III subunit alpha
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    • QHZ99319.1
    • narE
    		 3665 - 4468 (-) thioesterase
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      • QHZ99320.1
      • narD
      		 4540 - 4998 (-) putative cyclase
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        • QHZ99321.1
        • narC
        		 4995 - 15944 (-) polyketide synthaase
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          • QHZ99322.1
          • narB
          		 15960 - 30167 (-) nargenicin biosynthesis PKS
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            • QHZ99323.1
            • narA
            		 30215 - 48058 (-) nargenicin PKS
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              • QHZ99324.1
              • narF
              		 48357 - 49403 (-) aldo/keto reductase
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                • QHZ99325.1
                • narG
                		 49595 - 50857 (+) cytochrome P450 monooxygenase
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                  • QHZ99326.1
                  • narH
                  		 50877 - 52142 (+) flavin utilizing monoxidase
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                    • QHZ99327.1
                    • narI
                    		 52139 - 53110 (+) flavin utilizing monooxoidase
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                      • QHZ99328.1
                      • narJ
                      		 53148 - 53969 (+) short chain dehydrogenase
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                        • QHZ99329.1
                        • narK
                        		 54065 - 54901 (-) O-methyltransferase
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                          • QHZ99330.1
                          • narL
                          		 54901 - 55131 (-) ferredoxin
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                            • QHZ99331.1
                            • narM
                            		 55140 - 56240 (-) cytochrome P450
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                              • QHZ99332.1
                              • narN
                              		 56515 - 57321 (+) Ether bridge forming dioxygenase
                              • Tailoring
                              • Knock-out
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                              • QHZ99333.1
                              • narO
                              		 57350 - 58276 (+) short chain dehydrogenase
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                                • QHZ99334.1
                                • narP
                                		 58384 - 59235 (-) HTH-type transcriptional regulator
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                                  • QHZ99335.1
                                  • ngnN5
                                  		 60391 - 60666 (-) proline carrier protein
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                                    • QHZ99336.1
                                    • ngnN4
                                    		 60663 - 62159 (-) proline adenyltransferase
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                                      • QHZ99337.1
                                      • ngnN3
                                      		 62156 - 63283 (-) prolyl carrier protein dehydrogenase
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                                        • QHZ99338.1
                                        • ngnN2
                                        		 63565 - 64536 (+) keto-acyl ACP-synthase
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                                          Biosynthesis information
                                          Annotation changelog

                                          Entry version: next

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2024-03-19
                                          MIBiG v4 annotathon
                                          • (ID: YO3TP6VWB5CBNPZKNYNQSKUW)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 3

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2022-10-07
                                          Update chemical activity to schema version 2.11
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 2

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2022-09-15
                                          Un-retire entry
                                          • (ID: 3UOU7PODQJXIM6BEPUHHRRA5)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 1

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2019-10-16
                                          Submitted
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          Detailed domain annotation
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