BGC0001881: pyrichalasin H biosynthetic gene cluster from Pyricularia grisea
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Location: 1 - 43,279 nt. (total: 43,279 nt).
This entry is originally from NCBI GenBank MK801691.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001881
Short description pyrichalasin H biosynthetic gene cluster from Pyricularia grisea
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Iterative type I)
Loci
MK801691.1
via Knock-out studies
Compounds
  • pyrichalasin H
Species Pyricularia grisea [taxonomy]
References
Chemical products information
pyrichalasin H Evidence:
Copy SMILES
C31H41N1O6
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QCS37511.1
  • pyiA
 245 - 2095 (-) pyiA
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    • QCS37512.1
    • pyiE
    		 3572 - 5188 (+) pyiE
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      • QCS37513.1
      • pyiT
      		 5775 - 7783 (-) PyiT
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        • QCS37514.1
        • pyiG
        		 9576 - 11250 (-) PyiG
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          • QCS37515.1
          • pyiC
          		 11673 - 12867 (-) PyiC
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            • QCS37516.1
            • pyiF
            		 13188 - 14543 (+) PyiF
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              • QCS37517.1
              • pyiD
              		 16787 - 18621 (+) PyiD
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                • QCS37518.1
                • pyiR
                		 19597 - 21432 (-) PyiR
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                  • QCS37519.1
                  • pyiB
                  		 22657 - 24298 (+) PyiB
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                    • QCS37520.1
                    • pyiH
                    		 26197 - 27596 (+) PyiH
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                      • QCS37521.1
                      • pyiS
                      		 30235 - 42858 (+) PyiS
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                        Biosynthesis information

                        Biosynthetic modules

                        Name
                        2
                        Type
                        nrps-type1
                        Genes
                        pyiS
                        Substrates
                        O-methyltyrosine (evidence: Feeding study)
                        Integrated Monomers
                        Domains
                        condensation (LCL), adenylation
                        Name
                        1
                        Type
                        pks-modular
                        Genes
                        pyiS
                        Substrates
                        Integrated Monomers
                        Domains
                        acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, methyltransferase
                        Annotation changelog

                        Entry version: next

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2024-05-19
                        MIBiG v4 annotathon
                        • (ID: 6D5LMAPEWCC7D4XUWEJ6ZULO)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 3

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-10-07
                        Update chemical activity to schema version 2.11
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 2

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-09-15
                        Fetch compound properties from PubChem
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2022-09-15
                        Add publication
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2022-09-15
                        Corrected NRP module activity
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2022-09-15
                        Cleaned up synonym list
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 1

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2019-10-16
                        Submitted
                        • (ID: EKAHUWDWTQK5IEHDAR2BGQHT)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        Detailed domain annotation
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