BGC0001881: pyrichalasin H biosynthetic gene cluster from Pyricularia grisea
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Location: 1 - 43,279 nt. (total: 43,279 nt).
This entry is originally from NCBI GenBank MK801691.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001881
Short description pyrichalasin H biosynthetic gene cluster from Pyricularia grisea
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Polyene)
Loci NCBI GenBank: MK801691.1
Compounds
  • pyrichalasin H
Species Pyricularia grisea [taxonomy]
References
Chemical products information
pyrichalasin H
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C31H41N1O6
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QCS37511.1
  • pyiA
 245 - 2095 (-) pyiA
  • Precursor biosynthesis
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  • QCS37512.1
  • pyiE
 3572 - 5188 (+) pyiE
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  • QCS37513.1
  • pyiT
 5775 - 7783 (-) pyiT
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  • QCS37514.1
  • pyiG
 9576 - 11250 (-) pyiG
  • Tailoring (Monooxygenation)
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  • QCS37515.1
  • pyiC
 11673 - 12867 (-) pyiC
  • Scaffold biosynthesis
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  • QCS37516.1
  • pyiF
 13188 - 14543 (+) pyiF
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  • QCS37517.1
  • pyiD
 16787 - 18621 (+) pyiD
  • Tailoring (Monooxygenation)
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  • QCS37518.1
  • pyiR
 19597 - 21432 (-) pyiR
  • Regulation
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  • QCS37519.1
  • pyiB
 22657 - 24298 (+) pyiB
  • Tailoring (Acetylation)
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  • QCS37520.1
  • pyiH
 26197 - 27596 (+) pyiH
  • Tailoring (Reduction)
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  • QCS37521.1
  • pyiS
 30235 - 42858 (+) pyiS
  • Scaffold biosynthesis
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Polyketide-specific information
Subclass Polyene
Starter unit Acetyl-CoA
Cyclic? no
Release type
  • Macrolactamization
Polyketide-synthases
Genes Properties Modules
pyiS Synthase subclass: Iterative type I
Iterative PKS type: Highly reducing, Unknown
Iteration counts: 8
Module 1
Specificity: Malonyl-CoA
Genes: pyiS
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
NRP-specific information
Subclass N/A
Cyclic? no
Release type
  • Reductive release
NRP-synthases
Gene Modules
pyiS
Module 2
Specificity: O-methyltyrosine
Evidence for specificity:
  • Feeding study
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
2.0
  • Hidden contributor (ID: EKAHUWDWTQK5IEHDAR2BGQHT, no GDPR consent given).
  • Submitted
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Fetch compound properties from PubChem
  • Add publication
  • Corrected NRP module activity
  • Cleaned up synonym list
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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