BGC0001895 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001895 (Streptomyces sp. CB09001)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	72,447	High	huanglongmycin A/huanglongmycin B/huanglongmycin C	PKS

BGC0001895 - Region 1 - T2PKS

Download region GenBank file

Download region SVG

Location: 1 - 72,447 nt. (total: 72,447 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 72,448
Label		BGC0001895

Tailoring functions

Oxidoreductases: dehydrogenase

C4J65_11105: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: hydrolase

C4J65_11135: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

C4J65_11160: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Lyases: cyclase

C4J65_11100: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: ligase synthase

C4J65_11115: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

C4J65_11120: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

C4J65_11165: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001895.4	0.98	PKS	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0000231.5	0.82	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.73	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.68	PKS	oviedomycin	Streptomyces antibioticus
BGC0002000.4	0.66	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0002514.3	0.64	PKS	julichrome Q6.6	Streptomyces sampsonii
BGC0002276.2	0.60	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002274.2	0.59	NRPS	aspulvinone H, aspulvinone B1	Aspergillus terreus NIH2624
BGC0002012.4	0.58	PKS	julichrome Q3-3, julichrome Q3-5	Streptomyces afghaniensis 772
BGC0001833.4	0.58	NRPS	icosalide A, icosalide B	Burkholderia gladioli

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001895.4	0.98	PKS	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0000231.5	0.82	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.73	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.68	PKS	oviedomycin	Streptomyces antibioticus
BGC0002000.4	0.66	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0002514.3	0.64	PKS	julichrome Q6.6	Streptomyces sampsonii
BGC0002276.2	0.60	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002274.2	0.59	NRPS	aspulvinone H, aspulvinone B1	Aspergillus terreus NIH2624
BGC0002012.4	0.58	PKS	julichrome Q3-3, julichrome Q3-5	Streptomyces afghaniensis 772
BGC0001833.4	0.58	NRPS	icosalide A, icosalide B	Burkholderia gladioli

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

C4J65_11165: X

AMP-binding (43..441): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: IVMYAGGHLK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 0 to 72447
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 674.1; E-value: 1.4e-205)
Product molecular weight(s):: acetyl-CoA_8: 349 Da
acetyl-CoA_9: 391 Da

C4J65_11100: CYC C7-C12 (Score: 426.2; E-value: 1.4e-130)
C4J65_11105: KR C9 (Score: 461.2; E-value: 2.1e-141)
C4J65_11110: ACP (Score: 123.9; E-value: 4.5e-39)
C4J65_11115: CLF 8|9 (Score: 674.1; E-value: 1.4e-205)
C4J65_11120: KS (Score: 768.2; E-value: 4.5e-234)
C4J65_11135: CYC C5-C14 (Score: 424.7; E-value: 3.9e-130)