LOCUS       BGC0001896              8329 bp    DNA     linear   BCT 25-DEC-2018
DEFINITION  Streptomyces luteoverticillatus strain CGMCC 15060 chromosome,
            complete genome.
ACCESSION   BGC0001896
VERSION     BGC0001896
KEYWORDS    .
SOURCE      Streptomyces luteoverticillatus
  ORGANISM  Streptomyces luteoverticillatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 16:31:14
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     subregion       1..8329
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001896"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..8329
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1..999)
                     /locus_tag="EKH77_31960"
     CDS             complement(1..999)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 218.4; E-value:
                     2.6e-66)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018726311.1"
                     /locus_tag="EKH77_31960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase"
                     /protein_id="AZQ75928.1"
                     /transl_table=11
                     /translation="MAIADGFRVAKVLAVALDFDLFTKLSGGEGTTPEEFGSAEGLAPR
                     PATLLLTACASLGLLDKRDGRYVNSELSEEFLVRGKRYFFGDLVTFTDRREYDAWGKLD
                     VALRTDRPNTWDPDTEQTLFDPQDEHMAELFPKAAHSGAVFTARAMALSHDFGAYRRLL
                     DVGGGLGSFCGELCAHHPNLRATVYDLPFVSGMAEKRLAETEVGDRVDALGGDFFADGL
                     PTGYDAILLTNILHDWSDEESARILAKCHDALGSGGEVIIGEAFLDDDGTGPVAGAVAG
                     LNMLVETAAGTNRSRAAYTEMLNRAGFTDVRRLGLVVDAPLINGALVARKA"
     gene            complement(1112..1935)
                     /locus_tag="EKH77_31965"
                     /pseudo=""
     CDS             complement(1112..1935)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199:NmrA family
                     protein (Score: 85; E-value: 1e-25)"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174521.1"
                     /locus_tag="EKH77_31965"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVLGATGKTGRRVADRLREAGKTVRAASRSGETRFDWQDESTWAA
                     ALDGVHAVYLVAPTVPSQAWAVVPPFVRQAVAAGVRRLVLLSARGIDAAGDEKFLTSER
                     AVRDSGRSGRSCARRGSRRTSARRSSSRRSWRASSRCPPVRARSPSSTSRTSPTWPWPR
                     SPRTTTRARSTSCPGRRR"
     gene            complement(2074..3072)
                     /locus_tag="EKH77_31970"
     CDS             complement(2074..3072)
                     /NRPS_PKS="Domain: Aminotran_1_2 (7-304). E-value: 3e-49.
                     Score: 159.9. Matches aSDomain:
                     nrpspksdomains_EKH77_31970_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 135.5; E-value:
                     3.9e-41)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:PRK03321.1"
                     /locus_tag="EKH77_31970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="AZQ75154.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 4e-50, bitscore:
                     159.8, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 1.2e-08, bitscore:
                     23.1, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 7.1e-09,
                     bitscore: 24.2, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRLHELRLHLNENPYPPLPEVREALAAQLDAVNRYPEFTPVTLV
                     GMIADWLGVAREAVAVGNGSVGIALQVLDLCTGPGDEVVYGWRSFDAYPIITRMAGAEA
                     VQVPLTAAGEQDLDGMLAAVTPRTRVVVLCNPHNPTGTVFDRIALKSFLAALPERVTVV
                     LDEAYHEFARDPGIPDGLDHLADHPNLLVLRTFSKAYGLAALRVGYCVAAPELAGRLRE
                     ASLPYGISPLAQVGVAASLGAREQLTARVDAIVGERDRLREGLARLGWHSFPSHGNFLW
                     LGAGDASERLAAALGGAGALVRCYPGEGVRLTVGLPEANDLVLRAAGPAAA"
     aSDomain        complement(2161..3051)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EKH77_31970_Aminotran_1_2.1"
                     /evalue="3.00E-49"
                     /label="EKH77_31970_Aminotran_1_2.1"
                     /locus_tag="EKH77_31970"
                     /protein_end="304"
                     /protein_start="7"
                     /score="159.9"
                     /tool="antismash"
                     /translation="RLHLNENPYPPLPEVREALAAQLDAVNRYPEFTPVTLVGMIADWL
                     GVAREAVAVGNGSVGIALQVLDLCTGPGDEVVYGWRSFDAYPIITRMAGAEAVQVPLTA
                     AGEQDLDGMLAAVTPRTRVVVLCNPHNPTGTVFDRIALKSFLAALPERVTVVLDEAYHE
                     FARDPGIPDGLDHLADHPNLLVLRTFSKAYGLAALRVGYCVAAPELAGRLREASLPYGI
                     SPLAQVGVAASLGAREQLTARVDAIVGERDRLREGLARLGWHSFPSHGNFLWLGAGDAS
                     ERLAAALGGAGALVRC"
     misc_feature    complement(3061..3063)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(3085..4685)
                     /locus_tag="EKH77_31975"
                     /pseudo=""
     CDS             complement(3085..4685)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138:FAD linked oxidase domain protein (Score: 357.5;
                     E-value: 2.7e-108)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894814.1"
                     /locus_tag="EKH77_31975"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="FAD-binding oxidoreductase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MEQDTRRVVDTGEAAVGGVALGTAPPAAVLDDAARAGAVAVAPGD
                     ARYADLRRGYNQRWISNAESIRLVHTRRQVEDAVREAFAADKKIAIRSGGHCYEGFGID
                     AKLLLDLSHMNAVYFDERRGAFAIEPGATLGEVYRALYKAWGVTIPGGACPSVGIGGHI
                     AGGGHGPLSRLHGLTVDYLHAVEVVTVNAAGKVVTLVATREDWEEGRPKGALWWAHTGG
                     GGGNFGVATRYWFRAPGVQGNDPATLLPKPPGEVFLSTVTWQWAEVTEESFTRLVRNYS
                     TWCENNSAADSPYAALYSQFMPTPRAAGSFSMIAQFDATRPDSEQLLNDFLAAVSAGTG
                     LTPKTQVLRLPWLHATMWPSLTGPNTPTFSFKAKSAYQRACLPDEQLRAMYRHLGGEVA
                     YGNPAARLLMITFGGKINTRPREATAYPHRDSVMELHYVTTWVPGTDEAPT"
     gene            complement(4730..6496)
                     /locus_tag="EKH77_31980"
     CDS             complement(4730..6496)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 399.7;
                     E-value: 3.6e-121)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012233848.1"
                     /locus_tag="EKH77_31980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiamine pyrophosphate-binding protein"
                     /protein_id="AZQ75155.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.2e-45, bitscore:
                     144.1, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 6.6e-28, bitscore:
                     86.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLDDALVSTLRDWDVRYVFGVSGANIEHVHDAIHRLGGDRLRSV
                     MARREDGAAFMADGRARVHRTLGVCCATSGGGMVNLLAGLAESYAESVPVLALIGQPPL
                     HLEGRGAFQDSSGIGRTVDAVGLLRATTKRVAKIEDPADFWPELHAAAVAALTGRPGPV
                     ALLLPRDVFERAVGPRPEDFPAELSALLAPAEAAPHTVRPLFDALRSAERPALLIGHGV
                     RRGGASDVVTEFARRAGVPVVATMAARGEFPNDDPLFLGVAGVVGHPSAHRYLKESDLV
                     VAVGTGLGVMTRGPLGPLDPARLAVVNIDPGEAERATAPGLVVARDAGAVFRTLLELLD
                     AEPFTAAPPDGYELLRYRPRLAPDAGGEPSPRTARDTLRQSQAIRALEPYLPRDGHIVL
                     DAGNCASAAIHLAHVPEGASSTIALGMGGMGYSIAAAIGAQLGSAPGTRSVVLCGDGAF
                     LMNGFEVHTAVAERLPVLYVVFNNNMHGMCVTRQQTFFDSRLEAVRYPPLDVATVAYGL
                     GGPDRLWVGTAGTLDELHVRLADYHDAHAHLPGVLELRLPVEEVPPFAAFLPEDEPTYA
                     VGRRTDSRVLAG"
     gene            complement(6552..7088)
                     /locus_tag="EKH77_31985"
                     /pseudo=""
     CDS             complement(6552..7088)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011874385.1"
                     /locus_tag="EKH77_31985"
                     /note="incomplete; partial on complete genome; missing
                     stop; Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLGMTKETYSHEEIFGPYCTLGEHIDVPFDVVFDYLADIRSLEEW
                     SYSMRELRHIGGGLYRGREAIQPNTEIFIRAEVTKGPQHGQVVWPCAWDQGQELWMRYY
                     FTIIDAWPTLRRPGTVIIWTNCRHPYYDREVTDVPEYIAAGRARTDRYWVGDIWPQFDA
                     IHKVEMANLKRILEHR"
     gene            complement(7313..8329)
                     /locus_tag="EKH77_31990"
     CDS             complement(7313..8329)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084:3-oxoacyl-(acyl carrier protein) synthase III
                     (Score: 202.1; E-value: 1.9e-61)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012233847.1"
                     /locus_tag="EKH77_31990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="3-oxoacyl-ACP synthase"
                     /protein_id="AZQ75156.1"
                     /sec_met_domain="fabH (E-value: 7.3e-43, bitscore: 135.8,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNNRANFAQIIDVVNFLPERIVTNGSQSAGDELGDDPFFRGVAE
                     RRFASPDHSSAELGALAVEKLLNRTGVAATDVDLIIYNCVFNDTFWPGIGPAVQKAVGA
                     DRAMILQVDTSCCSWLSGVRTAAAFIESGQHRNVVVLTVTNFVSRLPEFQKSSRSRVLG
                     DGATATLLAPGEQTILSTYERSHGENYGLLRFEPDEVDGQFRQFWERGCGPITVNFTRE
                     RIDALRENAMRLVPEAVGISLDRAGLESRDVSLLITHQPNDEYLAEWRRRCGIEPPRTH
                     DTLAKYGNLFAGSIPVTLADALDNSLVKPGDILALGTFSNGGDMVSAMTLRWPAARA"
ORIGIN
        1 tcaggccttg cgcgccacca gcgccccgtt gatcagcggg gcgtcgacga cgagcccgag
       61 ccggcggacg tccgtgaagc ccgcccggtt cagcatttcg gtgtaggcgg cacggctgcg
      121 gttggtgccg gcggccgtct cgacgagcat gttgaggccc gccacggcac ccgcgaccgg
      181 accggtgccg tcgtcgtcga ggaacgcctc gccgatgatg acctcgcccc cggagccgag
      241 cgcgtcgtgg cacttcgcca ggatccgcgc gctctcctcg tcgctccagt cgtggaggat
      301 gttggtcagc aggatggcgt cgtagccggt gggcaggccg tcggcgaaga agtccccgcc
      361 cagcgcgtcc acccggtcgc ccacctccgt ctccgccagc cgcttctcgg ccatcccgct
      421 gacgaacggc aggtcgtaga cggtggcccg caggttcggg tggtgcgcgc acaactcgcc
      481 gcagaaggag cccagcccgc cgccgacgtc cagcagcctc cggtaggcgc cgaagtcgtg
      541 cgacagggcc atcgcccggg cggtgaacac cgcaccggag tgcgccgcct tggggaagag
      601 ctccgccatg tgctcgtcct gcgggtcgaa cagcgtctgc tcggtgtccg ggtcccaggt
      661 gttgggccgg tcggtgcgca gggcgacgtc gagcttgccc cacgcgtcgt actcgcgccg
      721 gtcggtgaag gtgaccaggt cgccgaagaa gtagcgcttg ccgcgcacca ggaattcctc
      781 ggacagctcc gagttgacgt accgtccgtc ccgtttgtcg agcagcccga gcgaggcgca
      841 cgcggtcagc agcagcgtcg cggggcgcgg ggcgagcccc tcggcgctgc cgaactcctc
      901 gggcgtggtg ccctcgccgc cgctgagctt ggtgaacagg tcgaagtcga gcgcgaccgc
      961 gagcaccttg gcgacgcgga agccgtccgc gatcgccatc aggggcgccg gggtcagcgg
     1021 ctggacgccg gtgtacgagt gggtgttcat acgacctcct ccccgggtgg ccggcacccg
     1081 ccggtgccgg ccaccgcgtg tgtggacgtg atcagcgggc ctggccggcc caggcgcccg
     1141 ctccggcggc cgcgcgcgcg tacgcgtcga agctccgggg ctcacggccc agcgcgtccc
     1201 ggacaccggt gctcaggtgc gcgtcgaagc cgttgcggat ggccgtgaac aggcccagca
     1261 acaccccggc gtgctcctcc gggacaccgg cctcgaccga gcccttgagg aaggcctcgc
     1321 cgtcgaggtc cacgaagcgg atctcccggc ccagcaccgc cgcgatcttc ccggcggcct
     1381 cgccgaaggt cagcgcctcc ggcccggaca gctcgtagac cttgctcgcg tggtggtcct
     1441 cggtgagcgc ggccacggcc acgtcggcga tgtcctcgac gtcgatgaag ggctccttgc
     1501 cctcaccggt gggcaccgcg aggacgccct ccaggatctg cgggaggaag aacgcctcgc
     1561 tgaagttctg cgcgaaccac gtcgggcgca ggatcgtcca ctccgccccg agtcccgcac
     1621 cgcgcgctcg gaggtcagga acttctcgtc gcccgccgcg tcgatgccgc gcgccgacag
     1681 cagcaccagc cggcggacgc ccgccgccac ggcctgccgc acgaacggcg ggaccacggc
     1741 ccacgcctgg ctcggcacgg tcggtgccac caggtagacg gcgtggacgc cgtccagcgc
     1801 cgccgcccag gtcgactcgt cctgccagtc gaagcgcgtc tcaccgctcc ggctcgcggc
     1861 acgtaccgtc ttccctgcct cccgcagccg gtccgccacc cggcggccgg tcttgccggt
     1921 ggcgcccagc accaagaatg tctcgctcat ctcgtccttc ccgtgctccg cgatcggttg
     1981 cccgatcgat gggtttttcc ttcagtggtg cagccggccc gaggttcggc cggacgcggt
     2041 gggacccctc cccgtgaagg gaggggcctt tcgtcaggcg gccgccggtc cggcggcgcg
     2101 caggacgagg tcgttggcct cgggcaggcc cacggtcagc cgcacgcctt cgcccgggta
     2161 gcagcgcacc agcgccccgg ccccgcccag cgccgccgcg aggcgctcgc tcgcgtcccc
     2221 ggccccgagc cacaggaagt tgccgtggct cgggaagctg tgccagccga gacgggcgag
     2281 cccctcgcgc agccggtcgc gctcgccgac gatcgcgtcg acgcgcgccg tgagctgctc
     2341 ccgcgccccc agcgacgccg ccaccccgac ctgggcgagc gggctgatgc cgtacggcag
     2401 cgacgcctcc cgcagccgcc ccgcgagctc cggcgccgcg acgcagtagc cgacgcgcag
     2461 cgcggccagc ccgtaggcct tggagaaggt gcgcaggacc aggaggttgg ggtggtccgc
     2521 gaggtggtcc agcccgtcgg ggatcccggg gtcgcgggcg aactcgtggt acgcctcgtc
     2581 caggacgacc gtgacgcgct ccggcagggc cgcgaggaag gacttcagcg cgatgcggtc
     2641 gaagaccgtg cccgtcgggt tgtgcgggtt gcacagcacc acgaccctgg tccgcggtgt
     2701 gaccgcggcg agcattccgt cgaggtcctg ctcaccggcg gccgtcagcg gcacctgcac
     2761 ggcctcggcc ccggccatcc gcgtgatgat gggatacgcg tcgaacgacc gccacccgta
     2821 caccacctcg tcgcccggtc ccgtgcacag gtcgaggacc tggagcgcga tcccgaccga
     2881 accgttgccg accgccaccg cctcacgggc gacccccagc cagtcggcga tcatcccgac
     2941 gagcgtgacc ggggtgaact ccggatagcg gttgaccgcg tccagctgcg ccgcgagggc
     3001 ctcgcggacc tcgggcagtg gcgggtaggg gttctcgttg aggtgcagcc ggagctcgtg
     3061 taatcgcgtc atccttctcc gacctcactt caccggtatg gactgggcgt ggcggaagac
     3121 gtcgtgcggg tcgaaggcct gcttggccgc gaccagggcc tcgaggttgg cggcgtagta
     3181 gagctggtgg gccgacaggc ccgagctgtt gtacgccggg tcgtcgaggt cggtgtccgg
     3241 gtagttgacg tagcagccgt tggtgacgtc attgggcacg ggcacgccgc cggtcggcgc
     3301 gtacacgtcc gcgtagaagt cccggagcca cttcaggtgg gggcctcgtc cgtgccgggc
     3361 acccaggtgg tgacgtagtg gagctccatc accgagtcgc ggtgcgggta ggccgtggcc
     3421 tcccgggggc gggtgttgat ctttcccccg aaggtgatca tgaggaggcg ggcggccggg
     3481 ttgccgtagg cgacctcacc cccgaggtgc cggtacatgg cccgcagctg ctcgtccggc
     3541 aggcaggcgc gctggtaggc cgacttggcc ttgaaactga acgtgggggt gttcggcccc
     3601 gtcaggctcg gccacatcgt ggcgtggagc cacggcagtc gcaggacctg cgtcttgggc
     3661 gtcaggccgg tgcccgcgct caccgccgcg aggaagtcgt tcagcaactg ttcggagtcc
     3721 ggccgcgtgg cgtcgaactg cgcgatcatg gagaacgagc ccgccgcgcg cggcgtcggc
     3781 atgaactggc tgtagagggc ggcgtacggc gagtccgcgg cgctgttgtt ctcgcaccag
     3841 gtgctgtagt tgcgcaccag ccgggtgaag ctctcctccg tcacctcggc ccactgccag
     3901 gtgaccgtcg agaggaagac ttccccgggc ggcttgggca gcagcgtggc cgggtcgttc
     3961 ccctgcacac ccggggcgcg gaaccagtag cgggtggcga cgccgaagtt gccgccgcca
     4021 ccgccggtgt gggcccacca cagcgcgccc ttgggccggc cctcctccca gtcctcgcgg
     4081 gtggccacga gggtgacgac cttgcccgcg gcgttgacgg tgacgacctc gacggcgtgg
     4141 aggtagtcga cggtcaggcc gtgcagccgc gacagcggac cgtggccgcc gcccgcgatg
     4201 tgcccgccga tgcccaccga cgggcaggcg ccgccgggga tggtgacgcc ccaggccttg
     4261 tacagcgccc ggtacacctc gccgagcgtc gcgcccggct cgatggcgaa ggcgccgcgc
     4321 cgctcgtcga agtagacggc gttcatgtgc gacagatcga ggaggagctt ggcgtcgatg
     4381 ccgaagccct cgtagcagtg ccccccgcta cggatcgcga tcttcttgtc ggccgcgaac
     4441 gcctcgcgga ccgcgtcctc cacctggcgc cgggtgtgga ccagacgaat ggactccgcg
     4501 ttcgagatcc accgctggtt gtacccgcgc cgcaggtccg cgtagcgggc gtcgccgggc
     4561 gcgacggcta ccgccccggc ccgcgcggcg tcgtccagga ccgcggcggg cggtgccgta
     4621 ccgagcgcga cgccgccgac ggcggcctcc ccggtgtcga cgacacggcg agtgtcctgc
     4681 tccatctttc tccccctgat tgttttccgg tggcggtgtt tcctggtgct cagccggcga
     4741 gtacccggct gtcggtgcgg cggccgacgg cgtacgtcgg ctcgtcctcc gggaggaagg
     4801 ccgcgaaggg cggcacctcc tcgaccggga gccgcagttc gaggacgccc ggcagatgcg
     4861 cgtgggcgtc gtggtagtcg gcgagccgga cgtggagctc gtcgagggtg ccggcggtgc
     4921 cgacccagag ccggtctggg ccgcccagcc cgtacgccac cgtggccacg tccagcggcg
     4981 ggtagcgcac ggcctccagc cgcgagtcga agaacgtctg ctgccgggtg acgcacatgc
     5041 cgtgcatgtt gttgttgaag accacgtaca gcacgggcag ccgctcggcc acggcggtgt
     5101 gcacctcgaa gccgttcatc aggaacgccc cgtccccgca gaggaccacc gaccgggtgc
     5161 ccggcgccga gcccagctgg gcgccgatgg ccgcggcgat gctgtagccc atgccgccca
     5221 tgcccagcgc gatggtcgac gaggcgccct ccggcacgtg cgccagatgg atcgcggccg
     5281 aggcgcagtt gcccgcgtcc agcacgatgt ggccgtcgcg cggcaggtag ggctcgaggg
     5341 cccggatcgc ctgactctgc cgcagggtgt cgcgggcggt gcgcggcgag ggctccccgc
     5401 ccgcgtcggg cgccagccgc ggacggtagc ggagcagctc gtagccgtcg ggcggcgccg
     5461 ccgtgaacgg ctcggcgtcg agcagctcca gcagcgtacg gaagacggcg ccggcgtccc
     5521 gcgcgacgac caggccgggc gcggtggccc gctccgcctc cccggggtcg atgttgacca
     5581 cggccaggcg cgccgggtcc agcgggccca gcggcccccg ggtcatcaca ccgagcccgg
     5641 tgccgaccgc gacgaccagg tccgactcct tcaggtagcg gtgcgcggaa gggtgcccca
     5701 ccacgcccgc cacgcccagg aacagcgggt cgtcattggg gaactcgccg cgcgccgcca
     5761 tggtggcgac caccgggacg cccgcgcggc gggcgaactc ggtgacgacg tcagaggcgc
     5821 cgccgcgacg caccccgtgc ccgatgagca gcgccgggcg ctcggccgag cgcagcgcgt
     5881 cgaacagcgg gcggacggtg tgcggggcgg cctcggcggg cgcgagcagc gcggacagct
     5941 cggccgggaa gtcctcgggg cgtggcccca cggccctctc gaagacgtcc cggggcagca
     6001 gcagcgccac cgggccgggc cggccggtga gcgccgcgac cgcggcggcg tggagctcgg
     6061 gccagaagtc ggccgggtcc tcgatcttgg cgacgcgctt ggtggtggcc cgcagcagcc
     6121 cgaccgcgtc gacggtgcgg ccgatcccgg acgagtcctg gaacgcgccg cgcccctcca
     6181 gatggagcgg cggctgcccg atgagggcga gcaccgggac cgactccgcg taggactcgg
     6241 cgagcccggc cagcaggttg accatgccgc caccggaggt ggcgcagcag acgccgaggg
     6301 tgcggtggac ccgcgcccgg ccgtcggcca tgaacgcggc gccgtcctcg cgccgcgcca
     6361 tcaccgaccg cagccggtcg ccgccgaggc ggtggatggc gtcgtggacg tgctcgatgt
     6421 tggccccgct gaccccgaag acatagcgga cgtcccagtc gcggagcgtg ctgaccagcg
     6481 cgtcatccag tcgcatcgtt cggtcccgac acgctggggg aaccggccgg gccgacggcg
     6541 ccgaccgaga accggtgctc gaggatgcgc ttgaggttgg ccatctccac cttgtggatc
     6601 gcgtcgaact gcggccagat gtcaccgacc cagtaccggt cggtgcgcgc ccggccggcg
     6661 gcgatgtact ccggcacgtc cgtgacctca cggtcgtagt aggggtggcg gcagttggtc
     6721 cagatgatca ccgtgccggg acggcgcagg gtcggccagg cgtcgatgat ggtgaagtag
     6781 tagcgcatcc agagctcctg cccctggtcc caggcgcagg gccagaccac ctggccgtgc
     6841 tgcgggccct tggtgacctc cgcccggatg aagatctcgg tgttgggctg gatggcctcc
     6901 cggccccggt agagcccgcc gccgatgtgc ctcagctccc gcatgctgta cgaccattcc
     6961 tccagggaac ggatgtcggc gagatagtcg aagaccacgt cgaaggggac gtctatgtgc
     7021 tcgccgagcg tgcagtaggg gccgaatatc tcctcgtgcg aataggtttc cttggtcatg
     7081 ccgagcatca gtttgtggat ctcttccgcg tcggtgttct cacagcgaat gagatcgagc
     7141 cgggccaggt cggaatcgtc ggcgggcgcg gcgggattcg gttcaggcgt catgacgcct
     7201 ccttgaatac tgtggtccgg aaaggttgtg ggaacggtgt ttcaacggcc gtcaagaagc
     7261 cgtatgtgaa ttcccggaaa tcagcggagc ggcacaccgt atccggtggt gctcacgcgc
     7321 gggcggcggg ccagcgcagc gtcatggcgc tgaccatgtc cccgccgttg gagaaggtgc
     7381 cgagggcaag gatgtcaccc ggcttgacca gggagttgtc cagcgcgtcg gccagggtca
     7441 ccgggatcga tcccgcgaag agattcccgt acttggccag cgtgtcgtgc gtgcgcggtg
     7501 gttcgatgcc acagcgtcgg cgccactcgg cgagatattc gtcgttcggc tggtgggtga
     7561 tgaggagcga gacgtcccgg ctctccagcc cggcccggtc gaggctgatc cccacggcct
     7621 ccggcaccag gcgcatcgcg ttctcacgca gcgcgtcgat gcgctcacgc gtgaagttga
     7681 ccgtgatggg gccgcagccg cgctcccaga attgccggaa ctgcccgtcg acctcatcgg
     7741 gttcgaagcg cagcagcccg tagttctccc cgtgcgaccg ctcgtacgtg gagagaatcg
     7801 tttgctctcc gggtgccagc aaggtcgcgg tggcaccgtc gcccaggacg cgcgagcgcg
     7861 aggacttctg gaactccggc aggcgggaga cgaagttggt gacggtgagc accacgacgt
     7921 tgcggtgctg cccggactcg atgaaggcgg cggccgtccg caccccggac agccaggagc
     7981 agcagctcgt gtccacctgg aggatcatcg cgcggtccgc gccgacggcc ttctgcaccg
     8041 ccgggccgat gcccggccag aaggtgtcgt tgaagacgca gttgtagatg atgagatcca
     8101 cgtccgtggc ggccacaccc gtacggttca gcagcttctc cacggcgagc gcgccgagtt
     8161 cggcggagct gtggtccggg gaggcgaagc ggcgctccgc caccccccga aaaaacgggt
     8221 cgtccccgag ctcgtcaccg gccgactgcg acccattggt gacgattcgc tcggggagga
     8281 agttgacgac atcgatgatc tgggcaaagt tcgcccggtt gttgcgcac
//
