BGC0001902 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001902 (Myxococcus virescens)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS	1	37,175	bengamide	NRPS:Type I+PKS	100%

BGC0001902 - Region 1 - NRPS,T1PKS

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Location: 1 - 37,175 nt. (total: 37,175 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 37,176
Label		BGC0001902

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001902	1.89	NRP, Polyketide	bengamide	Myxococcus virescens
BGC0000131	0.61	Polyketide	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000041	0.58	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001615	0.53	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0000999	0.51	NRP, Polyketide	heat-stable antifungal factor	Lysobacter enzymogenes
BGC0001185	0.50	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001132	0.50	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001876	0.49	NRP	thalassospiramide A	Thalassospira sp. CNJ-328
BGC0001128	0.49	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002359	0.48	NRP	dudomycin A	Streptomyces albus subsp. chlorinus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001902	1.00	NRP, Polyketide	bengamide	Myxococcus virescens
BGC0000131	0.66	Polyketide	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000041	0.62	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001615	0.60	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0002284	0.59	Other	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000999	0.59	NRP, Polyketide	heat-stable antifungal factor	Lysobacter enzymogenes
BGC0002689	0.59	NRP	2,3-dihydroxybenzoylserine	Stenotrophomonas maltophilia K279a
BGC0002359	0.59	NRP	dudomycin A	Streptomyces albus subsp. chlorinus
BGC0001726	0.58	NRP, Polyketide	pactamides	Streptomyces pactum
BGC0001185	0.58	NRP	bacillibactin	Bacillus velezensis FZB42

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 37175:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-ccmal) + (ohmal) + (ohmal) + (Lys)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 9373 - 37175:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-ccmal) + (ohmal) + (ohmal) + (Lys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

benA

PKS_AT (541..825): mmal

ATSignature: Ethylmalonyl-CoA, Malonyl-CoA, Methylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 58.3%; Malonyl-CoA: 58.3%; Methylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 89.9
Isobutyryl-CoA: 85.7
Malonyl-CoA: 84.1
Methoxymalonyl-CoA: 80.2
Propionyl-CoA: 61.6
Ethylmalonyl-CoA: 56.6
3-Methylbutyryl-CoA: 49.5
inactive: 48.3
2-Methylbutyryl-CoA: 43.0
Benzoyl-CoA: 41.1
trans-1,2-CPDA: 40.6
Acetyl-CoA: 34.3
CHC-CoA: 23.9
fatty_acid: 7.1

benB

PKS_AT (564..868): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 62.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 123.9
inactive: 70.3
Methoxymalonyl-CoA: 62.7
Methylmalonyl-CoA: 48.4
Ethylmalonyl-CoA: 43.5
Propionyl-CoA: 30.6
Isobutyryl-CoA: 18.3
trans-1,2-CPDA: 15.5
Benzoyl-CoA: 14.4
2-Methylbutyryl-CoA: 13.0
Acetyl-CoA: 12.4
CHC-CoA: 12.2
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

benC

PKS_AT (537..744): mal

ATSignature: (unknown)

No matches above 50%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 20.8
inactive: 17.9
Methoxymalonyl-CoA: 4.9
Propionyl-CoA: 4.0
Methylmalonyl-CoA: 3.3
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

benD

Search NORINE for peptide: strict or relaxed

AMP-binding (503..906): Lys

nrpys: Lys

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DNESGGTVAK
Nearest Stachelhaus code(s):: Lys DNESGGTVAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)