LOCUS       BGC0001903             10870 bp    DNA     linear   BCT 31-DEC-2015
DEFINITION  Streptomyces sp. MA37 cytochrome c oxidase subunit I gene, partial
            cds; cytochrome c oxidase polypeptide 4, lipoprotein,
            L,D-transpeptidase, two-component system response regulator,
            cytochrome c oxidase subunit III, cytochrome C heme-binding subunit,
            ubiquinol-cytochrome C reductase iron-sulfur subunit,
            ubiquinol-cytochrome c reductase cytochrome b subunit, and
            cytochrome P450 monooxygenase genes, complete cds; neocarazostatin A
            biosynthesis gene cluster, complete sequence; and transcriptional
            regulator and putative integral membrane protein genes, complete
            cds.
ACCESSION   BGC0001903
VERSION     BGC0001903
KEYWORDS    .
SOURCE      Streptomyces sp. MA37
  ORGANISM  Streptomyces sp. MA37
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-08 05:19:37
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 8904
            Orig. end    :: 19774
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1068
                     /codon_start=1
                     /gene="nzsA"
                     /product="anthranilate phosphoribosyltransferase"
                     /protein_id="ALL53315.1"
                     /transl_table=11
                     /translation="MNTVPPAGSPAEGTLQSWPDVLSALLAGQDLSTDTTAWAMDRIMR
                     GEATNAQIAGFAVALRAKGETVGEIAGLVRTMYEHANLIEVPGPTVDIVGTGGDRAKTV
                     NISTMSAIVVAGTGARVVKHGNRASSSASGASDVLEKLGVNLELTPRRVQEVAAEAGIT
                     FCFAVKFHPALRYVAAARKELGIPTSFNFLGPLTNPARVRAQATGVADARMAPIIAGVL
                     AERGSSALVFRGDDGLDELTTTGTSTVWTVRDGEVRRSSFDPRDVGIRLVPIEALKGAD
                     ASYNADVARRLLNGEQGPVRDAVLLNSAAALAALEPSDAPLAEQIAAGMAKAAESIDSG
                     AAKAALDRWVAASTS"
     subregion       1..10870
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="Other"
                     /subregion_number="1"
                     /tool="antismash"
     gene            1..1068
                     /gene="nzsA"
     misc_feature    1..10870
                     /note="neocarazostatin A biosynthesis gene cluster"
     region          1..10870
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1253..1810
                     /gene="nzsB"
     CDS             1253..1810
                     /codon_start=1
                     /gene="nzsB"
                     /product="IPP isomerase"
                     /protein_id="ALL53316.1"
                     /transl_table=11
                     /translation="MTLPEISPILLELVNSDGETIGTEEKLAAHQAPGKLHRAFSVFLF
                     DGEGRMLLQQRALTKYHSPGVWSNTCCGHPYPGEAPEAAAARRTREELGLTEITLVPAG
                     TVTYNHPDEISGLVEQEYNHLFAGTVAQACAPDPEEVHDTRFVTQDELKALQAEKAFSA
                     WFPTVMDAALPGIRKVAPSGGW"
     gene            complement(1887..2864)
                     /gene="nzsC"
     CDS             complement(1887..2864)
                     /NRPS_PKS="Domain: Aminotran_1_2 (5-322). E-value: 5e-46.
                     Score: 149.3. Matches aSDomain:
                     nrpspksdomains_nzsC_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="nzsC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 132.5; E-value:
                     3.2e-40)"
                     /gene_kind="biosynthetic-additional"
                     /product="aminotransferase"
                     /protein_id="ALL53317.1"
                     /transl_table=11
                     /translation="MQHLLQLNENPLPPLPSVADEITRQVGSVNRYPEFFPEHLKSAIA
                     GWLGLPEEWVVVGSGSVGVALQALQAAVRPGRQLVYGWRNFDAYPLLARMTGARPVQVP
                     LLPGGHQDIAAIAKAAAADTDAVIVCNPHNPTGRLVAPEELRELVLSVPSDTVVVLDEA
                     YIEFVRPDERPASLEWTQEFSNLLVLRTFSKAYGLAGMRVGYGVAGPELAERINAFQLP
                     FAMSSLSLAAVEASLKAEDELRERVEFLVGERERVLTGVRSTGWQALPSHTNFFWLDEP
                     ARVDAVRTRLEAAGVAARYYPGEGVRITVGDRAANDAVLGALTH"
     aSDomain        complement(1899..2849)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_nzsC_Aminotran_1_2.1"
                     /evalue="5.00E-46"
                     /label="nzsC_Aminotran_1_2.1"
                     /locus_tag="nzsC"
                     /protein_end="322"
                     /protein_start="5"
                     /score="149.3"
                     /tool="antismash"
                     /translation="QLNENPLPPLPSVADEITRQVGSVNRYPEFFPEHLKSAIAGWLGL
                     PEEWVVVGSGSVGVALQALQAAVRPGRQLVYGWRNFDAYPLLARMTGARPVQVPLLPGG
                     HQDIAAIAKAAAADTDAVIVCNPHNPTGRLVAPEELRELVLSVPSDTVVVLDEAYIEFV
                     RPDERPASLEWTQEFSNLLVLRTFSKAYGLAGMRVGYGVAGPELAERINAFQLPFAMSS
                     LSLAAVEASLKAEDELRERVEFLVGERERVLTGVRSTGWQALPSHTNFFWLDEPARVDA
                     VRTRLEAAGVAARYYPGEGVRITVGDRAANDAVLGA"
     gene            complement(2960..3202)
                     /gene="nzsD"
     CDS             complement(2960..3202)
                     /NRPS_PKS="Domain: PP-binding (25-67). E-value: 3.7e-08.
                     Score: 25.7. Matches aSDomain:
                     nrpspksdomains_nzsD_PP-binding.1"
                     /codon_start=1
                     /gene="nzsD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /product="ACP"
                     /protein_id="ALL53318.1"
                     /sec_met_domain="PP-binding (E-value: 6.7e-09, bitscore:
                     25.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METLNNRLEALLEERFPQAAAALVGGATFQEAGVDSMGVVEFIVT
                     VERHFGLPMLDGNELSGTSTLDDARELLTSKGASA"
     aSDomain        complement(3002..3127)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_nzsD_PP-binding.1"
                     /evalue="3.70E-08"
                     /label="nzsD_PP-binding.1"
                     /locus_tag="nzsD"
                     /protein_end="67"
                     /protein_start="25"
                     /score="25.7"
                     /tool="antismash"
                     /translation="GATFQEAGVDSMGVVEFIVTVERHFGLPMLDGNELSGTSTLD"
     gene            complement(3210..4223)
                     /gene="nzsE"
     CDS             complement(3210..4223)
                     /codon_start=1
                     /gene="nzsE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084:3-oxoacyl-(acyl carrier protein) synthase III
                     (Score: 376.4; E-value: 1.7e-114)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative 3-oxoacyl-ACP synthase III"
                     /protein_id="ALL53319.1"
                     /sec_met_domain="fabH (E-value: 2.7e-114, bitscore: 370.9,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRAAVVGGLGAWVPPHVVTNDMLAAELDTSDDWIRTRTGIAQRH
                     IAGPGLATGRLAVEAGRRALASAGVDSVDVVVLATSTPDRPCPGTAPVVAAELGLDGAG
                     AFDVAAVCTGFVYALATAAGLIATSVARSALVIGADTFSTILDPADRTTRVIFGDGAGA
                     MVLRAGDAAEPGALLGFDLGSDGRGADLITVRAGGSEQRSREAAVPEADTYFRMDGPQV
                     FTRAVRYMTGSVRSTLERVGWTAEEVGAVVPHQANVRILDTCARELGIPVERVVKNIDR
                     VGNTVAASIPLALADAAADGRLKTGERVVLTGFGGGLTWGSAALTWPDITIGLQEQ"
     gene            complement(4220..5335)
                     /gene="nzsF"
     CDS             complement(4220..5335)
                     /codon_start=1
                     /gene="nzsF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /product="phytoene synthase"
                     /protein_id="ALL53320.1"
                     /sec_met_domain="phytoene_synt (E-value: 6.1e-37, bitscore:
                     116.7, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADPRLAPERRNDDPGLGTGPPPHHPAPSIQHTGRATMTVHELDL
                     AGITDSGLRADYLKSSRLFRDIGRGRFLGRYMFPAAKRPYFDTFFSFVCYVDDLVDDVN
                     RSLEVRKQRLDEFERAYLAACDGEEIETDGPPSGDHVADAALSRALVHMMRTWDLPYRD
                     VPQFVQAQREALTTYEYATYEEMDPFIQGVTLLPAVWINGLFEPQSEDSEELCRHTITA
                     FQLLDFAWDVQEDLELGRLYLPLEDLAKFGLDRTSLAREVGSGHVSEAVRELMKFEIDR
                     AVGHLDAGRAWGRTLHPTSRTFVDLDIETHRQMAVELVKDDYAFFGRPKKGLGFNSAKI
                     APRTAAAAARAKRINREAEQSGYRIRRPWSA"
     gene            complement(5284..7065)
                     /gene="nzsG"
     CDS             complement(5284..7065)
                     /codon_start=1
                     /gene="nzsG"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 378.2;
                     E-value: 1.2e-114)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative
                     2-hydroxy-4-methyl-2-(2-phenylacetyl)pentanoic acid
                     synthase"
                     /protein_id="ALL53321.1"
                     /transl_table=11
                     /translation="MRIADALVTTLRDLDTRYVFGVSGANIEHFHDAVERLGRGRLSAV
                     LTKREDGAAFMADARARVHRTLGVCCSTSGGGMMNLVAGLAESHAESVPVLALVGQPPA
                     ALDGRGSFQDSSGIGRTVDALPLLAAVTKKTLRLTDPALFWAQLRDAIETALSGRMGPV
                     ALLVPRDSYELEVGPVPADWPQDLAGFVRQQPVDTDDVAALFRRLREASAPVLLIGHGV
                     RRSTDPGAVVRFAQQAGIPVMTTMGARGEFPNDDPLHFGVVGAGGNPSAAAYLTDTADC
                     VVLAGTGLAAMTRSALRGWDPQKAVAVNIDPGEIRRSSLADTVVEGDAGVVFGQLLELL
                     DTDPFTAPPAVGYELTRFVPRLAEPIPGRDADPDVLLQSEAVAILEEHLPADGHLLYDA
                     GNCAVASMHYSSVPRGSSSTIALGSGGMGYSIAAAVGAQLGADRGTRTVVFCGDGAFLM
                     SGLEIHTAVELGLPILYIVFNNGMHGMCASRQQTFFDSRITAVDYTPVDVPAVARGLGS
                     PGRLWTGSAGTAPELTGQLEEYRRSACPTGVLELRLTTEEVPPFANFLPADEPTMPAKT
                     SWRIPASLRSAGTMTPA"
     gene            complement(7089..7772)
                     /gene="nzsH"
     CDS             complement(7089..7772)
                     /codon_start=1
                     /gene="nzsH"
                     /product="putative cyclase/dehydrolase"
                     /protein_id="ALL53322.1"
                     /transl_table=11
                     /translation="MYERVPDESGLMQNYRLDSSDLEGLGLTWSETISGDDMMKLMEGM
                     TKESYTHDEIYGQYCPLSTHINVPYDIVFEYAANSRALAEWTYSIRNMKHLGGGLYRAD
                     EMIQPNTEIYIRTEAQKGPDMGTVVYPCAWDQGHELWMRYYLTIIDSAKVFNKPGTVVL
                     WTNCKHPYYDRETTDVPDYIAEGRARTDRVWVGDIWPLFHAGHTLEINNMKKILEHRFG
                     TTAQG"
     gene            complement(7842..8837)
                     /gene="nzsI"
     CDS             complement(7842..8837)
                     /codon_start=1
                     /gene="nzsI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084:3-oxoacyl-(acyl carrier protein) synthase III
                     (Score: 215.4; E-value: 1.7e-65)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative 3-oxoacyl-ACP synthase III"
                     /protein_id="ALL53323.1"
                     /sec_met_domain="fabH (E-value: 1.5e-43, bitscore: 138.5,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSTSIVDVVNFMPERVVRNSELTHDGHDLSEHKFFAGVNERRFG
                     SPDYTSAELGTAALKKLLDRNGVRAEDLDLIICAAQFNDAFSPGIGTAVQHAVGATSAA
                     VLHIENGCCSWISALNTARAFIDSGHYRRIAIVTVTNFISRLTEFQKSPESWVLGDGAS
                     ATLVAPGSPTILSLHEQAFGQNWGALRVEPDAVGEQELPHWERGSGPLTVKFSPNMLAR
                     LWAVTMECLPEAAAAALDKAGLTADDISCLITHQPNESYIAEWRKRIGVDASRAHDTLS
                     VYGNMFQSSLPVTFADALEKKKISTGDVIAFATFTHGGEQVSSMVWRWTG"
     gene            9542..10870
                     /gene="nzsJ"
     CDS             9542..10870
                     /NRPS_PKS="Domain: Aminotran_5 (44-428). E-value: 1.3e-77.
                     Score: 253.1. Matches aSDomain:
                     nrpspksdomains_nzsJ_Aminotran_5.1"
                     /codon_start=1
                     /gene="nzsJ"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 291.2; E-value:
                     1.9e-88)"
                     /gene_kind="biosynthetic-additional"
                     /product="cysteine desulfurase"
                     /protein_id="ALL53324.1"
                     /transl_table=11
                     /translation="MSACPAATAAATVEPVSAADGPLPVLGCDVRVPLVTGGEVPYAAL
                     DYAASAPALQRVWDDVAAYAPYYGSVHRGAGHLSQLSTDLFETSRADVARFLGCRPGDQ
                     VVFTRSTTDSLNLLAAVLPADCRVFVFETEHHAALLPWRGAQVTCLDAPRSPEHAVEIL
                     ERALADRAPYGPALVCVTGASNVTGELWPVRELAAAAHAHGARIVLDAAQLAPHHPVDI
                     AELDVDWAAFSGHKLYAPFGAGVLAGRADWLRDAEPYLAGGGASRSVTRRPDGALDVEW
                     HTTAARHEAGSPNVIGAYALASACRALTEAGFEALVAREQRLLAAVRAGLAEVPEVGVL
                     SLFGPDAPRVGVLSFVVEGWDSAEFAAALSAEYGIGVRDGLFCAHPLVRALLGGGTGEC
                     GDASGEGAGVRAVRVSFGAGTPDEHVERFLRAVRELAVRVRRG"
     aSDomain        9674..10825
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_nzsJ_Aminotran_5.1"
                     /evalue="1.30E-77"
                     /label="nzsJ_Aminotran_5.1"
                     /locus_tag="nzsJ"
                     /protein_end="428"
                     /protein_start="44"
                     /score="253.1"
                     /tool="antismash"
                     /translation="LDYAASAPALQRVWDDVAAYAPYYGSVHRGAGHLSQLSTDLFETS
                     RADVARFLGCRPGDQVVFTRSTTDSLNLLAAVLPADCRVFVFETEHHAALLPWRGAQVT
                     CLDAPRSPEHAVEILERALADRAPYGPALVCVTGASNVTGELWPVRELAAAAHAHGARI
                     VLDAAQLAPHHPVDIAELDVDWAAFSGHKLYAPFGAGVLAGRADWLRDAEPYLAGGGAS
                     RSVTRRPDGALDVEWHTTAARHEAGSPNVIGAYALASACRALTEAGFEALVAREQRLLA
                     AVRAGLAEVPEVGVLSLFGPDAPRVGVLSFVVEGWDSAEFAAALSAEYGIGVRDGLFCA
                     HPLVRALLGGGTGECGDASGEGAGVRAVRVSFGAGTPDEHVERF"
ORIGIN
        1 atgaacaccg ttccccccgc cggctctccc gccgaaggca ccctgcagag ctggccggac
       61 gttctgagcg cactgctggc cgggcaggac ctgagcacgg acaccaccgc gtgggccatg
      121 gaccgcatca tgcggggcga ggcgacgaac gcgcagatcg cgggcttcgc ggtggcgctg
      181 cgggccaagg gcgagacggt cggcgagatc gccggcctgg tgcgcacgat gtacgagcac
      241 gccaatctga tcgaggtgcc cggacccacc gtcgacatcg tcggcaccgg cggcgaccgg
      301 gcgaagacgg tcaacatctc cacgatgtcg gccatcgtcg tggccggcac cggcgcccgc
      361 gtcgtcaagc acggcaaccg cgcctcctcc agcgcctccg gcgcctcgga cgtgctggag
      421 aagctgggcg tcaacctcga actcaccccg cggcgggtgc aggaggtggc cgccgaggcg
      481 ggcatcacct tctgcttcgc cgtgaagttc cacccggcgc tgcgctacgt ggcggccgcc
      541 cgcaaggagc tcggcatccc cacctccttc aacttcctcg gcccgctgac caatccggcc
      601 cgcgtccggg cccaggccac cggggtcgcc gacgcccgga tggcgcccat catcgccggg
      661 gtgctcgccg aacgcggttc gtccgccctg gtcttccggg gggacgacgg cctggacgag
      721 ctgaccacca cgggcacgtc cacggtgtgg accgtgcgcg acggcgaggt gcggcgctcc
      781 tccttcgacc cgcgggacgt gggcatccga ctggtgccga tcgaggcgct gaagggcgcg
      841 gacgcctcgt acaacgcgga cgtggcccgc cggctgctga acggcgagca ggggccggtg
      901 cgggatgccg tgctgctcaa ctcggccgcg gcgctggccg cgctggagcc ctcggacgcc
      961 ccgctggccg agcagatcgc cgccgggatg gccaaggccg cggagtcgat cgactcgggc
     1021 gcggccaagg ccgccctgga ccgctgggtg gccgccagca cctcctgaac cacgccgttt
     1081 ctttctccgg gcccggcaag gaaaagggcc cggagaaagc cggtcacggc cgtcgaattg
     1141 ctgttacgat cactttgctg ttttgagttg tcgcgcacca ttcggcgtcg tcggtgccca
     1201 cccctaacga cgcccaaaca acgccgtatt cggccgacgc aaaggttcga ctgtgacact
     1261 tccggaaatc agccccattc tgctggaact ggtcaattcc gatggggaga ccatcggcac
     1321 cgaagaaaag cttgcggcgc atcaggcccc gggaaaactt caccgggcct tctcggtctt
     1381 tctcttcgac ggtgaggggc gcatgctgct ccagcagcgg gcgctcacga agtaccactc
     1441 gccgggcgtc tggtccaaca cctgctgcgg ccacccctac ccgggcgagg cccccgaggc
     1501 cgcggccgcc cggcgcaccc gggaggagct ggggctgacg gagatcaccc tcgtcccggc
     1561 cggcacggtg acctacaacc acccggacga gatctccggc ctggtggagc aggagtacaa
     1621 ccacctcttc gccggcacgg tcgcccaggc gtgcgcgccc gaccccgagg aggtgcacga
     1681 cacccgcttc gtcacccagg acgaactcaa ggccctgcag gcggagaagg ccttctcggc
     1741 ctggttcccc acggtgatgg acgcggcgct gccgggcatc cggaaggtcg ccccctccgg
     1801 cggctggtga accccgcgca tccacgcgca cggacggcct cctccggccc ggccccggtc
     1861 acacggggcc ggccggacgg gggccgtcag tgcgtgaggg ccccgagcac ggcgtcgttc
     1921 gcggcccggt ccccgacggt gatccgcacg ccctcgccgg ggtagtagcg cgcggccacg
     1981 cccgcggcct ccagccgggt gcgcaccgcg tcgacgcgcg ccggctcgtc gagccagaag
     2041 aagttggtgt ggctcggcag cgcctgccag cccgtggagc gcactccggt cagcacccgc
     2101 tcccgctccc cgaccaggaa ctccacccgc tcccgcagct cgtcctccgc cttcagggac
     2161 gcctccacgg cggccaggga cagcgagctc atggcgaacg ggagctggaa cgcgttgatg
     2221 cgctcggcga gttcggggcc ggccacgccg tagccgaccc gcatgcccgc gagtccgtag
     2281 gccttggaga aggtgcgcag caccagcagg ttggagaact cctgggtcca ctccagggac
     2341 gcggggcgct cgtcgggccg gacgaactcg atgtaggcct cgtccaggac gacgaccgtg
     2401 tcggacggga ccgacaggac gagctcccgg agctcctcgg gggcgacgag ccggcccgtg
     2461 gggttgtgcg ggttgcagac gatgacggcg tcggtgtcgg cggcggccgc cttggcgatg
     2521 gccgcgatgt cctggtggcc gccgggcagc agcggcacct ggacgggccg ggcgccggtc
     2581 atccgggcga gcagcgggta ggcgtcgaag ttccgccagc cgtagaccag ttggcggccg
     2641 ggccggacgg cggcctgcag tgcctggagg gccactccca ccgatccgga cccgacgacg
     2701 acccactcct cgggcaggcc gagccagccg gctattgccg atttcaggtg ttcggggaag
     2761 aactcggggt aacggttcac gctgccgacc tgccgggtga tctcgtcggc gacggagggc
     2821 agcgggggca gggggttctc gttgagctgc aagaggtgct gcatgtgtcc tcctggacgt
     2881 gaggaatccg cgcgaagagg agccgccggc aagcggggtg cgttgccggc ggcggagggg
     2941 ctgggtgaac gtttccgcgt caggccgagg cacccttgga cgtgaggagt tcccgcgcgt
     3001 cgtcgagcgt cgaggtgccg ctcagctcgt tgccgtcgag catcggcagg ccgaagtggc
     3061 gctccacggt gacgatgaac tcgaccacgc ccatggagtc cacgcccgcc tcctggaagg
     3121 tggcgccgcc gacgagggcg gcggcggcct gcgggaagcg ctcctcgagc agggcctcga
     3181 gccggttgtt cagagtctcc atcgtttcct cactgttcct gcagtccgat agtgatgtcc
     3241 ggccaggtca gggccgcgga tccccaggtg aggccgccgc cgaagcccgt cagcacgacg
     3301 cgttcgccgg tcttcagccg cccgtcggcc gccgcgtcgg cgagggccag cgggatggac
     3361 gcggccacgg tgttgccgac ccggtcgatg ttcttgacca cgcgctcgac ggggatgccc
     3421 agttcgcgcg cgcaggtgtc gaggatgcgg acattggcct ggtgcgggac gacggcgccg
     3481 acctcctcgg ccgtccagcc cacccgctcc agcgtgctgc gcaccgagcc ggtcatgtac
     3541 cggacggcgc gcgtgaacac ctgcggcccg tccatccgga agtacgtgtc cgcctccggc
     3601 accgccgcct cccggctgcg ctgctccgac ccgcccgcgc ggacggtgat caggtccgcg
     3661 ccccggccgt cgctgcccag gtcgaagccc agcagcgccc ccggctccgc cgcgtccccg
     3721 gcccgcagca ccatggcgcc ggccccgtcg ccgaagatga cgcgggtggt gcggtccgcg
     3781 gggtcgagga tcgtcgagaa ggtgtcggcc ccgatgacca gcgcgctgcg ggccaccgag
     3841 gtggcgatca ggcccgccgc ggtggccagc gcgtacacga agcccgtgca cacggcggcc
     3901 acgtcgaagg cgccggcccc gtccaggccc agctcggcgg cgaccacggg ggccgtcccc
     3961 gggcaggggc ggtcgggggt gctggtggcc agcaccacca cgtccaccga gtcgacgccc
     4021 gcggacgcga gcgcccgccg gcccgcctcg acggcgagcc ggccggtggc cagcccggga
     4081 ccggcgatgt gccgctgggc gatgccggtc cgggtcctga tccagtcgtc ggaggtgtcg
     4141 agttccgccg cgagcatgtc gttggtgacg acgtgcggcg gaacccacgc cccgagaccg
     4201 ccgacgacgg cggctcgcgt catgccgacc acgggcggcg gatccggtaa ccggactgct
     4261 ccgcctcgcg gttgatgcgc ttggcgcggg cggcggccgc ggccgtgcgc ggcgcgatct
     4321 tcgccgagtt gaagccgagg cccttcttcg gccggccgaa gaacgcgtag tcgtccttga
     4381 ccagttcgac cgccatctgc cggtgcgtct cgatgtccag gtcgacgaac gtccgcgagg
     4441 tcgggtgcag cgtccgtccc caggcgcgcc cggcgtccag gtgcccgacg gcccggtcga
     4501 tctcgaactt catcagctcg cgcacggcct cgctcacgtg cccgctgccg acctcacggg
     4561 ccagggacgt gcggtccagg ccgaacttgg cgaggtcctc caacggcagg tagagccggc
     4621 cgagttcgag gtcctcctgc acgtcccagg cgaagtccag gagctggaag gccgtgatgg
     4681 tgtgccggca cagctcctcg gagtcctcgc tctgcggctc gaagagcccg ttgatccaga
     4741 cggccgggag cagggtgacg ccctggatga acgggtccat ctcctcgtac gtcgcgtact
     4801 cgtacgtggt gagggcctcg cgctgcgcct ggacgaactg cgggacgtcc cggtacggca
     4861 ggtcccaggt gcgcatcatg tggaccaggg cccgggagag ggcggcgtcg gccacgtggt
     4921 cgccggacgg cgggccgtcg gtctcgatct cctcgccgtc gcaggccgcc aggtaggcgc
     4981 gctcgaactc gtcgaggcgc tgcttgcgca cctccagact gcggttgacg tcgtcgacca
     5041 ggtcgtcgac atagcagacg aacgagaaga aggtgtcgaa gtagggccgc ttggccgcgg
     5101 ggaacatgta gcggccgagg aagcgtccgc ggccgatgtc acggaacagc cgggagctct
     5161 tgaggtagtc ggcgcgcagc ccggagtccg ttatccccgc gagatcgagc tcatgcacag
     5221 tcatagtggc tcttcctgtg tgctgaatgc tgggtgctgg atggtgtggt ggggggccgg
     5281 tccctaggcc ggggtcatcg ttccggcgct ccggagcgag gcggggatcc gccacgacgt
     5341 cttggccggc atcgtgggct cgtccgccgg gaggaagttg gcgaacggcg gcacttcctc
     5401 ggtcgtcagg cggagttcga ggacgccggt cgggcacgcg ctccgccggt actcctccag
     5461 ctgcccggtc agttcgggtg ccgttcccgc gctgccggtc cacagccggc cgggggagcc
     5521 caggccccgg gccacggcgg gcacgtcgac cggggtgtag tccacggccg tgatgcggga
     5581 gtcgaagaag gtctgctgcc gggaggcgca catgccgtgc atgccgttgt tgaagacgat
     5641 gtacaggatg ggcaggccga gttcgacggc ggtgtggatc tccagaccgc tcatcaggaa
     5701 cgcgccgtcg ccgcagaaga ccaccgtgcg cgtcccgcgg tcggcgccca gctgggcccc
     5761 gaccgccgcc gcgatgctgt accccatgcc gccgctgccg agcgcgatgg tggaggacga
     5821 gccgcgcggc acggaggagt agtgcatgga cgcgacggcg cagttgccgg cgtcgtagag
     5881 caggtgcccg tccgcgggca ggtgctcctc caggatggcg acggcctcgc tctgcagcag
     5941 cacgtcgggg tcggcgtccc ggcccgggat gggttcggcc aggcgcggga cgaagcgggt
     6001 gagctcgtag ccgacggccg ggggagcggt gaacgggtcg gtgtccagca gctccagcag
     6061 ctgtccgaag accacgcccg catcgccctc gacgacggtg tccgcgagcg aggaccgccg
     6121 gatctcgccc gggtcgatgt tgaccgccac ggccttctgc gggtcccagc cgcgcagcgc
     6181 gctgcgggtc atcgcggcca gtccggtgcc cgccaggacg acgcagtcgg cggtgtccgt
     6241 gaggtaggcg gcggcggagg ggttgccccc ggcgccgacc acgccgaagt gcagcgggtc
     6301 gtcgttgggg aattcgccgc gggcgcccat ggtggtcatc accgggatcc cggcctgctg
     6361 cgcgaagcgc accacggcgc cggggtcggt ggaccggcgc acgccgtggc cgatcagcag
     6421 cacgggggcg gaggcctccc gcagccggcg gaagagcgcg gccacatcat ccgtgtccac
     6481 cggctgctgc cggacgaagc ccgcgaggtc ctgcggccag tcggcgggca cggggcccac
     6541 ctccagctcg taggagtccc gcgggaccag cagggccacc gggcccatcc gcccgctgag
     6601 ggcggtctcg atcgcgtccc tcaactgcgc ccagaacagg gcgggatcgg tcagccgcag
     6661 ggtcttcttg gtgaccgcgg ccagcagcgg gagggcgtcg acggtccggc cgatgccgga
     6721 ggagtcctgg aacgagccgc ggccgtccag ggcggccggc ggctggccca cgagggccag
     6781 cacgggcacg gactcggcgt gcgactcggc gaggccggcg acgagattca tcatgccgcc
     6841 gccggaggtc gagcagcaga cgcccagggt ccggtggacc cgggcgcgcg cgtcggccat
     6901 gaaggccgcg ccgtcctcgc gcttggtgag gaccgcggac agccgcccgc ggcccagccg
     6961 ttcgacggcg tcgtggaagt gctcgatgtt cgccccgctg acgccgaaga cgtagcgggt
     7021 gtcgaggtcg cgcagggtcg tgactaaagc gtcggctatc cgcatggtgt acccccgttg
     7081 acggttgact agccctgggc cgtggtgccg aagcggtgct cgaggatctt cttcatgttg
     7141 ttgatctcga gggtgtggcc ggcgtggaac agcggccaga tgtcaccgac ccagacccgg
     7201 tcggtgcggg cgcggccctc ggcgatgtag tccggcacgt cggtggtctc gcggtcgtag
     7261 taggggtgct tgcagttggt ccacagcacc acggtgcccg gcttgttgaa gaccttggcc
     7321 gagtcgatga tggtcaggta gtagcgcatc cacagctcgt ggccctggtc ccaggcgcac
     7381 gggtagacga ccgtgcccat gtccgggccc ttctgggcct cggtgcggat gtagatctcg
     7441 gtgttcggct ggatcatctc gtcggcgcgg tagagaccgc cgccgaggtg cttcatgttc
     7501 cggatgctgt acgtccactc cgccagcgca cgggagttgg cggcgtattc gaagacgatg
     7561 tcgtacggaa cgttgatgtg cgtggagagc gggcagtact gaccgtagat ctcgtcgtgc
     7621 gtgtacgact ccttggtcat gccctccatg agcttcatca tgtcgtcgcc gctgatggtc
     7681 tcgctccagg tgagaccgag gccctccagg tcggaactgt cgagccggta gttctgcatg
     7741 agaccggatt cgtcggggac gcgctcgtac atgcttgctc ctgaagaatg cgtgcaaaaa
     7801 aggggcgtgc aaaaaaggga aagaaattct ggaggcggga ctcagccggt ccagcgccag
     7861 accatggacg acacctgctc gccgccgtgg gtgaaagtgg caaaggcgat cacatcgcca
     7921 gtggaaatct tcttcttttc cagtgcgtcg gcaaaggtga cgggcaggga gctctggaac
     7981 atgttgccgt agacggagag cgtgtcatgg gcgcgcgagg cgtcgacgcc gatgcgcttg
     8041 cgccattcgg cgatgtagct ctcgttgggc tggtgggtga tcaggcagga gatgtcgtcg
     8101 gccgtcagtc cggccttgtc cagtgcggcc gcggccgcct ccggcaggca ctccatcgtc
     8161 acggcccaca gccgggccag catgttcggg ctgaacttca ccgtgagcgg accgctgccg
     8221 cgctcccagt gcggcagctc ctgctcgccg acggcgtccg gctcgacgcg cagggcgccc
     8281 cagttctggc cgaatgcctg ctcgtggagg gagaggatgg tcggcgagcc gggggcgacc
     8341 agggtcgcgg acgcgccgtc gccgagcacc caggactccg gcgacttctg gaactccgtc
     8401 agtcgggaga tgaagttggt gacggtgacg atggcgatcc tgcggtagtg gcccgagtcg
     8461 atgaaggcgc gggcggtgtt cagcgcggag atccaggagc agcagccgtt ctcgatgtgc
     8521 aggacggcgg ccgacgtcgc gccgaccgcg tgctggacgg cggtgccgat gccgggggag
     8581 aaggcgtcgt tgaactgggc cgcgcagatg atcaggtcca ggtcctcggc gcggacgccg
     8641 ttgcggtcga gcagtttctt cagcgcggcg gtgccgagtt cggccgaggt gtaatccggc
     8701 gagccgaatc gccgctcgtt cacgccggcg aagaatttgt gctcgctcag gtcgtgaccg
     8761 tcgtgcgtga gctcactgtt gcggaccact cgttccggca tgaagttgac gacgtcaacg
     8821 atgcttgtgg agctcactgg caatattccc cgtctttatc tcggtggaga cagaaagggg
     8881 ggctcggcag gcccgggcaa aggcgtgcgc aaggagctgg acgaacacga ccgccccccg
     8941 ggtcacttgc ttgttcgttc ggcgttccag atgcgaacga ctctatgatc gcggtggtaa
     9001 cggttgcatc tcgctcggat aacgtattga tttcggctgt agcggaattt ttgattccgc
     9061 aatccgggac gatgtgttct cgattggatg gaacgtcgac tgtgcgggcg aacgatcgat
     9121 taatcacgat cgcgcgcggc cctttatgtc tggagctcac tccgttcaac aaaacggcgt
     9181 ccacgacccg gacacccgct gtccccggca cggtgcctgt gccatactcc tggccaggtc
     9241 acgagtgaca gcgacacagg ccccggcccg ctgtccggca accctccgtc cgtggcgggg
     9301 tgccccgggt gatgaccggg ccgcagacca ccgggtctgc ggcaagcgcg gatccctcgc
     9361 cagggatcct ggtcgtcgag ggagttcctt ccgtgatcca gcgaatgcgt tagggcctac
     9421 ggcccgttcc cgtcgtcctg cgcgtgcctt tgccgcgcgg gcctcttcgc acaccgtgct
     9481 gcgcactgcg ccgcgggtgc gtcgtccacg ccatccgcct gccctgccgg gagagttcgc
     9541 catgtccgca tgccctgccg ccaccgctgc cgccaccgtc gagcccgttt ccgccgccga
     9601 cggccccctg cccgtcctcg ggtgtgacgt gcgcgtgccg ctcgtcaccg ggggcgaagt
     9661 gccgtacgcc gccctcgact acgccgccag cgcacctgcc ctgcagcgcg tgtgggacga
     9721 cgtcgccgcc tacgcgccct actacggcag cgtgcaccgc ggtgccggac acctttcgca
     9781 gctgtcgacc gacctgttcg agaccagccg ggccgacgtg gcccgcttcc tcggctgccg
     9841 ccccggtgac caggtcgtct tcacccgctc caccaccgac tcgctcaacc tcctcgcggc
     9901 cgtactgccc gcggactgcc gggtgttcgt cttcgagacc gagcaccacg ccgcgctgct
     9961 gccgtggcgc ggcgcgcagg tcacctgcct cgacgcgccg cgcagcccgg agcacgcggt
    10021 cgagatcctg gagcgggcac tggccgaccg ggcgccctac gggccggccc tggtctgtgt
    10081 gacgggcgcg tccaatgtga ccggcgagct gtggcccgtg cgcgaactcg ccgccgccgc
    10141 ccacgcgcac ggcgcccgga tcgtcctcga cgccgcccag ctggccccgc accaccccgt
    10201 ggacatcgcc gaactggacg tggactgggc cgccttctcc gggcacaagc tctacgcccc
    10261 cttcggcgcc ggcgtcctgg ccggccgcgc cgactggctc cgggacgccg agccctacct
    10321 ggccggcggc ggggcgagcc gctccgtcac ccggcggccc gacggcgcgc tggacgtcga
    10381 gtggcacacc accgccgccc gccacgaggc cggttcgccc aatgtgatcg gcgcctacgc
    10441 cctcgcctcc gcctgcaggg cgctcaccga ggcgggcttc gaggcgctcg tcgcccggga
    10501 acagcggctg ctcgccgcgg tgcgcgcggg cctggccgag gtgccggagg tcggggtgct
    10561 ctcgctgttc gggccggacg cgccgcgggt gggggtgctg tccttcgtcg tcgagggctg
    10621 ggacagcgcg gagttcgccg ctgccctctc ggccgagtac gggatcgggg tgcgggacgg
    10681 gctgttctgc gcgcacccgt tggtgcgggc tctcctgggc ggagggaccg gtgagtgcgg
    10741 ggacgcctcc ggcgaggggg cgggagtccg cgccgttcgg gtcagcttcg gggctggtac
    10801 gcccgacgag cacgtcgagc ggttcttgcg ggccgtgcgg gagttggccg tgcgggttcg
    10861 tcgtggctga
//
