BGC0001904 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001904 (Micromonospora rosaria)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	40,128	High	fluostatin L/fluostatin D/difluostatin A/fluostatin C/fluostatin F/fluostatin G/H/fluostatin J/fluostatin K/rabelomycin	PKS:Type II aromatic

BGC0001904 - Region 1 - T2PKS

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Location: 1 - 40,128 nt. (total: 40,128 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 40,129
Label		BGC0001904

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

ALJ99849.1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

ALJ99850.1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

ALJ99852.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

ALJ99859.1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

ALJ99864.1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

ALJ99868.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

ALJ99869.1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Transferases: methyltransferase transferase

ALJ99848.1: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

ALJ99866.1: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Hydrolases: amidase dehalogenase

ALJ99867.1: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

ALJ99875.1: amidase

smcogs: SMCOG1105: amidase

Lyases: cyclase hydratase lyase

ALJ99851.1: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

ALJ99856.1: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

ALJ99872.1: Nitrilase/cyanide hydratase and apolipoprotein

smcogs: SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

ALJ99874.1: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Ligases: synthase

ALJ99854.1: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

ALJ99855.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001904.2	1.00	PKS	fluostatin L, fluostatin D, difluostatin A, fluostatin C, fluostatin F, fluostatin G/H, fluostatin J, fluostatin K, rabelomycin	Micromonospora rosaria
BGC0000231.5	0.83	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.77	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.74	PKS	oviedomycin	Streptomyces antibioticus
BGC0000223.5	0.70	PKS	rabelomycin, dehydrorabelomycin, fluostatin F, fluostatin G, fluostatin H	uncultured bacterium BAC AB649/1850
BGC0002047.2	0.61	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0002000.4	0.61	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0000272.3	0.60	PKS	spore pigment	Streptomyces collinus
BGC0001895.4	0.59	PKS	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0002276.2	0.58	NRPS	choline	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001904.2	1.00	PKS	fluostatin L, fluostatin D, difluostatin A, fluostatin C, fluostatin F, fluostatin G/H, fluostatin J, fluostatin K, rabelomycin	Micromonospora rosaria
BGC0000231.5	0.83	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.77	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.74	PKS	oviedomycin	Streptomyces antibioticus
BGC0000223.5	0.70	PKS	rabelomycin, dehydrorabelomycin, fluostatin F, fluostatin G, fluostatin H	uncultured bacterium BAC AB649/1850
BGC0002047.2	0.61	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0002000.4	0.61	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0000272.3	0.60	PKS	spore pigment	Streptomyces collinus
BGC0001895.4	0.59	PKS	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0002276.2	0.58	NRPS	choline	Aspergillus nidulans FGSC A4

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 40128
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 696.7; E-value: 1.9e-212)
Product class(es):: angucycline
Product molecular weight(s):: acetyl-CoA_8: 446 Da
acetyl-CoA_9: 488 Da

ALJ99849.1: OXY (Score: 586.3; E-value: 1.1e-178)
ALJ99850.1: OXY (Score: 562.1; E-value: 2.4e-171)
ALJ99851.1: CYC C7-C12 (Score: 485.2; E-value: 1.5e-148)
ALJ99852.1: KR C9 (Score: 471.4; E-value: 1.6e-144)
ALJ99853.1: ACP (Score: 114.5; E-value: 4.1e-36)
ALJ99854.1: CLF 8|9 (Score: 696.7; E-value: 1.9e-212)
ALJ99855.1: KS (Score: 793.6; E-value: 8.8e-242)
ALJ99856.1: CYC C4-C17/C2-C19 (Score: 197.2; E-value: 5.9e-61)
ALJ99859.1: OXY (Score: 511.4; E-value: 6.1e-156)
ALJ99863.1: DIMER (Score: 227.7; E-value: 4.2e-70)
ALJ99864.1: OXY (Score: 478.3; E-value: 6.4e-146)
ALJ99865.1: OXY (Score: 76.3; E-value: 5.9e-24)
ALJ99866.1: MET (Score: 283.4; E-value: 5.7e-87)
ALJ99868.1: KR (Score: 159.8; E-value: 2.3e-49)
ALJ99869.1: OXY (Score: 533.8; E-value: 9.6e-163)