LOCUS       BGC0001910             12425 bp    DNA     linear   BCT 18-FEB-2016
DEFINITION  Streptomyces cyslabdanicus DNA, related genes for cyslabdan
            biosynthesis, strain: K04-0144.
ACCESSION   BGC0001910
VERSION     BGC0001910
KEYWORDS    .
SOURCE      Streptomyces cyslabdanicus
  ORGANISM  Streptomyces cyslabdanicus
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-08 05:21:11
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12425
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..12425
                     /db_xref="taxon:1470456"
                     /mol_type="genomic DNA"
                     /note="type strain of Streptomyces cyslabdanicus"
                     /organism="Streptomyces cyslabdanicus"
                     /strain="K04-0144"
                     /type_material="type strain of Streptomyces cyslabdanicus"
     misc_feature    1..12425
                     /note="related genes for cyslabdan biosynthesis"
     subregion       1..12425
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="Terpene"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..12425
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             238..732
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111:GCN5-related N-acetyltransferase (Score: 64.1;
                     E-value: 2.5e-19)"
                     /gene_kind="biosynthetic-additional"
                     /note="05613"
                     /product="acetyltransferase"
                     /protein_id="BAR97444.1"
                     /transl_table=11
                     /translation="MPELKRLHAGHAPAVLAFELANRAYFAASISDRGDAFFDRFTDRH
                     NALLAEQEAGSCAFYVLVAEDGSVLGRFNLYDLEDGTAKLGYRVAEQVAGRGVATATVR
                     ELCRIATARHGLRTLRAATSHDNAASQKVLTKAGFVPVGPATPADLGGKSGTWYERDLQ
                     P"
     gene            1305..2657
                     /gene="cvnA"
     CDS             1305..2657
                     /codon_start=1
                     /gene="cvnA"
                     /product="histidine sensor kinase"
                     /protein_id="BAR97445.1"
                     /transl_table=11
                     /translation="MTSNPEAAFAVLGATTVAGAAAAAALARSRVVLSRRCAALTRQIA
                     EQNEELATLRARERAQFEELSHLVNNRLPAAALHLISDHHPVPDGLLSDDSDFATQAQA
                     AHDLFVETLIGERGRIDSAARAALRGACTAIQAQSFRLQTLIDELQRDCRDPEVVKEYF
                     RIDQLNEQVLRLVQKAAIVSGSWPGLVRPDTHLPDVVAGATSRLNGFERIQVHTKLLVG
                     GVGIVGRAAEPVAVACTELMANALESSRGDLAVEVTLLQTDNGNVCIQIDDAGKGMTRE
                     SVARGTRLVSGENAGKLLLTELGDPPALGFAAIGQLVADHGFHVSVDQVSPYGGVRAVL
                     AVPKHLLTTIDEQAEPPSAMAALPAPAPRTPVPPAAAVPGEGLRDVSAPSPRDASGLPQ
                     RRRRSGSSRGRSLTRTARPVDPDEAGAAWGDFEQAVAAGRDATDSENKDKS"
     gene            2654..3088
                     /gene="cvnB"
     CDS             2654..3088
                     /codon_start=1
                     /gene="cvnB"
                     /product="hypothetical protein"
                     /protein_id="BAR97446.1"
                     /transl_table=11
                     /translation="MTQSTLSDQIPDPSWVLGPIIEIGVRHALILSADGIVVGASGSLG
                     RDESEGMAAMVSALHGAARAAAVVSLEAPEETPISTITVQLDASGTLMVMPAGGANAFI
                     AASFGTDVPMNIVAHTLARQAKNLGEALMSVPTRSHGPAS"
     gene            3085..3456
                     /gene="cvnC"
     CDS             3085..3456
                     /codon_start=1
                     /gene="cvnC"
                     /product="hypothetical protein"
                     /protein_id="BAR97447.1"
                     /transl_table=11
                     /translation="MSPGPARRLVPSYLATGGISAPEHSTLQDLTALTATGQSALPHHT
                     PAHQRLLDLVSDGGLTVMEIAGYLRLPIGVVKMLAAQLVSDGHLRAAAPLPDALAPTAH
                     AGRPSRALLEEVMHGLLAL"
     gene            3437..4033
                     /gene="cvnD"
     CDS             3437..4033
                     /codon_start=1
                     /gene="cvnD"
                     /product="ATP/GTP-binding protein"
                     /protein_id="BAR97448.1"
                     /transl_table=11
                     /translation="MGSSPSSAPVYLPDSNHERVKILVAGPFGIGKTTMIRTLSEIPSL
                     HTEEVMTDAAAQVDELAVADKKTTTVAIDFGRLTIAQGRIVLYLFGTPGQRRFKALWSD
                     YARGALGALVIVDTRRLADSFEVMDLIEETGLDYAVAVNQFPESPAYDEETLRVKLDLE
                     DHTPMVICDARDWDSSLNALRALAVHLVTRAGGNL"
     CDS             4030..5268
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 230.9; E-value: 4e-70)"
                     /gene_kind="biosynthetic-additional"
                     /note="05618"
                     /product="cytochrome P450"
                     /protein_id="BAR97449.1"
                     /transl_table=11
                     /translation="MTAAPNAVPLYGPEHAADPQRSYQLLREQGPVGRAEIDPGLVVWV
                     VTDYRAALDLLQDPGTWTKDTRGWDTTVPADSPVREPLQWRPSLAFADGEEHAHLRKVI
                     TDSFALLDPQYLRDVTLRHADTLLDEFAHTGRADLVAQYARRLPLMVLNTLFGMPDEGA
                     DQLMSAIEALMSTVPQAKEAGEQALTAYLGSLYAMKSARRGRDLTSWFIDHPHGLGPEE
                     VINQVLITQGAAYGTLAGLIANTLAQILSDQRYRGTLTTGSLPIRHAIDEVLWADPPLA
                     MYSLHRARRSVTFHRRAIEAGEPVMVSYAAVNTCPHTGQVADEQRSDHKAHLAFAAGPH
                     SCPAEDIVFVVAVAAIERLMGRLPDVELTVPAATLTYQPGPIYRVLTSLPCRFTPQTPD
                     SRRSTRGSVPVSA"
     gene            5403..6488
                     /gene="cldA"
     CDS             5403..6488
                     /codon_start=1
                     /gene="cldA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 283.7; E-value:
                     2.5e-86)"
                     /gene_kind="biosynthetic-additional"
                     /product="geranylgeranyl diphosphate synthase"
                     /protein_id="BAR97450.1"
                     /transl_table=11
                     /translation="MAGTAWDTDIPTLISVRDDVDAVLEDFVDVQERAAHGPEMAPLFT
                     TARRLLFSNGKRLRPLLCVAGWQAAGAPGDPHAVLRVAAALELFQTFALIHDDVMDDSD
                     TRRGRPSAHRALAAEYMSGGGRLSKAEAHGRGAAILLGDLLLVWSDEMLAGAGLEARAR
                     ARVLPLVDSMRAELVYGQYLDLLSTDRMSGDVEAALRVARYKTGKYTVERPLHLGVSLA
                     GGDPRLLQTCTDFALPLGEAFQLRDDLLNVFGDPVRTGKPVGDDIREGKATVLLALAIQ
                     DASEADLKLLGTLVGSPELGSEDIDRFRTVMETTGARQRVEDMIIARRDTALATLEEAD
                     LPQDVAETLRQIVWMATERQS"
     gene            6485..8083
                     /gene="cldB"
     CDS             6485..8083
                     /codon_start=1
                     /gene="cldB"
                     /product="labdadienyl diphosphate synthase"
                     /protein_id="BAR97451.1"
                     /transl_table=11
                     /translation="MSSISHQAAPTRAQHTNSYVQLARQLVTSVDNDPWGDVPPSVYET
                     ARVTSWAPWLEGHERRLAWLLERQSAAGSWGEGPTPYRLLPTLSVTEALLSTLRQNTAA
                     GVSRERLAAAVDNGLAALRDLSGTGGWPDTAAIEILAPDLVVLINDHLDQPEVAALPRL
                     GPWARGQRLAQPHGFQAALPDRVAERCQVAGGVPLKLHHTFEGVARRLPRMVPGVPGGL
                     LGSSPAATAAWLATGPDEGRDQAVTALTAVAERYDGLFPEATPISVFERLWISVALARP
                     GLPAACVPTIRAWAAEIYDATGVRGAPGLLPDTDDTAMAVLASALAGSPRDPSPLSAFE
                     AGDHYDCYVGEDTGSSTANAHALQALTAWLSHRPATGDALQARRDLTRDWLLAQQESDG
                     AWRDKWHASPYYATERCVTALSGHTGPTTRDAIRSAADWVLDAQSDDGSWGVWGGTAEE
                     TAYAVNILLNSPDHTGTPEATQALKLAENVLREAVHSSGHHHPALWHDKTLYAPQAMAQ
                     AEVIAALELLQARRP"
     gene            8132..9496
                     /gene="cldC"
     CDS             8132..9496
                     /codon_start=1
                     /gene="cldC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 389.3; E-value:
                     4.1e-118)"
                     /gene_kind="biosynthetic-additional"
                     /product="cytochrome P450"
                     /protein_id="BAR97452.1"
                     /sec_met_domain="p450 (E-value: 1.7e-81, bitscore: 263.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTDLHFPPYAPGRVPFIGHAVPLARDRLAFLQRLREHGPIVRIS
                     IGPKTLTVINSPDLVQEMLTRKSGQFSKGLLFEKLKLFGNDALPVAEGGRHLRRRRLMQ
                     PAFHHQQVDQYVRTMQTTVEPMIAAWQSMGPLDLKTEMQLMTQNVVMGALFSTIPDRKT
                     GHAILESVDTLFAAALRRALLPLPLLERLPTRGNRRARRAGQVMRAAVGEVIADHLARP
                     DEHDDIVSLLLSAQEPDGTPLADEDILSEVTGLLAAGSETTAVTLTWLFHELSRNPDLE
                     RQLHSEVDAVLTDEPLTTKTLSRLTFTRRLVNESLRLYSPAWLVTRQTTEPVRLGTVDL
                     PAGEDIVWSPYTLHRDPGLYPDPLRFDPDRWLPERPQPPKGAFIPFGAGKRQCMGNEFA
                     VAEATLITALIASRWRLRPVAGPAVRPVGAITLHPSTLRMTAEARTPVRRHQEAA"
     gene            9493..10482
                     /gene="cldD"
     CDS             9493..10482
                     /codon_start=1
                     /gene="cldD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Terpene_synth_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Terpene synthase/cyclase metal-binding domain
                     protein (Score: 173.6; E-value: 1.1e-52)"
                     /gene_kind="biosynthetic"
                     /product="labdatriene synthase"
                     /protein_id="BAR97453.1"
                     /sec_met_domain="Terpene_synth_C (E-value: 1.1e-16,
                     bitscore: 50.6, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRTGDAVTILPQPDFTATFPGPFPTSPHGERTERQLLGWLEEYP
                     LLPSARARSVLVNITSHGVSRTLPTADADDLVLFAELLLWLTAFDDMHGESNAARDLVA
                     LVDRTAELTLVLAGGSPPPLTNPFPAALYDLLARFRARTGPAAYLRLAASLRDTIMALV
                     WEAHHVAEPERVALETYLEMRPHTVFVRTIFAAAEIVLDYELTDAQRALAPVRHLETAV
                     ANLAGWINDLASYEREAARGPAQPLSLPTLLRARHGGSLEEAFARAGGMCENEAAVARQ
                     GITSLAGDPPSALTAHARALEDIARSFVWHTSHARYQGPKRGAAPTSR"
     CDS             complement(10784..11923)
                     /codon_start=1
                     /note="05623"
                     /product="amidase"
                     /protein_id="BAR97454.1"
                     /transl_table=11
                     /translation="MVMHEHEVDRRTLFRVGLGTAVAAVVGTEVAFPTAAGATPSPQFP
                     WIIDCDSWGARPPSSPTEITGNTTNKIILHHMAFPNVTDYSPEHAMQLARDCQDLHMDT
                     NGWADTGQHFTVSRGGYVLEGRHRSLETLVAGEHQVTAAHCPGENGNAIGIENEGTYIT
                     ETPPAALLDSLVELCTAVCRQFHLNAWDIFGHWDFRLGTDCPGIAFYRLFPQIRKRVLQ
                     SMGVSPAAAPTRRWPDIWRFVDSQVVQVAQYLLVNAGYSDLPIDGVFSTDMNTVVADFQ
                     TSHGIAVTPDATFDTPTWEALAPPLDKDSSGLPVEAVQYLLTIKGYADTVGITGTYDHH
                     TMKAVQDMQRLHNLRPTGRTDLSTWCALAGGTVRETFTR"
ORIGIN
        1 caattgagcc gcacggagtt ggacgaggac ggcctcctgc ccgaccgggt cacggtgtcc
       61 gtgctggcca ccgcctacaa gcctcggtga ccacgagcgg gcgcctgctg accgacgagc
      121 agtgggcacg cctggcgccc cggcttcctg gattgttatg tgccctggtc ctgggggctg
      181 actgccgccg gcggaaactc gggtggcctc agcacgcgat ctgggtagag tcgggcaatg
      241 cccgagctga agcggctgca tgccggccac gccccggcgg tcctggcctt cgagctggcg
      301 aaccgcgcct acttcgctgc ctcgatctcc gaccgcggcg acgccttctt cgaccggttc
      361 accgaccggc acaacgcctt gctggccgag caggaggccg gcagctgcgc cttctacgtg
      421 ctcgtcgccg aggacggctc ggtactcggc aggttcaacc tgtacgactt ggaggacggc
      481 accgccaaac tcggctaccg ggtcgcggag caggtggccg gccgcggcgt ggcgaccgcg
      541 accgtccggg agctgtgccg gattgcgacc gcgcggcacg gcctgcgcac actgcgggcg
      601 gccacctccc acgacaacgc cgcgtcccag aaggtcttga ccaaggccgg gttcgttccg
      661 gtcggccctg ccaccccggc cgatctcggc ggcaagtcag gcacctggta cgagcgcgac
      721 ctccagccat agaccttgat cttgctcgtg ggtcggcctc gtggcggacg aggagtgtct
      781 gggccgcctg gcgaccgagc acatctacac cggctacccg ggaaaccctg cccaccgacg
      841 cggcctggac ctcgtgccgc gcccggtgcc ggagcaaccg ggatgaccgg aacacccccg
      901 cgtcggcggg gaggccgagc gtggccgcac cgatccgcac tcgacggcca agtggccttt
      961 ggggcctgct ttgtgggagc agcgtgaaga tgtcccacgc tgatcatctt atgagtaaca
     1021 tgccggatca tctgctcgtt gtcgaccgga gcgaaatgcc ctgcttccct tggcccccag
     1081 tctgtctggc gtgtccgtgt tctgtatctc ggcgcgaacc agtcgctgga cgggctcctg
     1141 ggagcccggg gttccgggaa gcaggccgtc ccacccggtg gcctgcagac gtgcgcgcct
     1201 cttccttacc cacatcgcca ggtctgcctg tcgggcgtga gcttccgctg aatcgcccga
     1261 tgccggcggg ggcctggctc tgactctccg aggaccccct atccgtgaca tcaaatcccg
     1321 aagctgcctt cgcggtgctg ggtgcgacaa ccgtcgcggg cgctgccgcc gcagcggctc
     1381 tggccagatc ccgcgtggtc ctgtcccgtc gctgtgcggc gctgacccga caaatcgcgg
     1441 agcagaatga ggagttggca accctccggg cacgcgagag ggcgcagttc gaagaactga
     1501 gccacctggt gaacaaccgg ctgcccgccg ccgctctgca cctgatcagc gatcaccacc
     1561 ccgtacccga cggcctgttg agcgacgaca gcgacttcgc gacgcaggcc caggcggccc
     1621 acgacctgtt cgtggagaca ctgatcggtg agcgcggccg tatcgactcc gccgcccggg
     1681 cggcactgcg cggcgcctgc acggcgatcc aggcccagag cttccggctg cagacgctca
     1741 tcgacgaact gcagcgcgac tgccgcgacc cggaggtcgt caaggagtac ttccgtatcg
     1801 accagctcaa cgagcaggtc ctccggctgg tgcagaaggc ggccatcgtc agtggttcgt
     1861 ggcccggcct ggtccggccg gacacccacc tcccggacgt cgtcgcggga gccacgtcgc
     1921 gtctgaacgg attcgagcgg atccaggtcc acaccaaact gctggtcggc ggggtgggca
     1981 tcgtcggccg ggccgcggaa ccggtggcgg tggcctgcac cgagctgatg gcgaacgcgc
     2041 tggagtcctc acggggcgac ctggcggtgg aggtcacgct gctgcagacg gacaacggca
     2101 acgtgtgcat ccagatcgac gacgcgggca aggggatgac ccgcgagtcc gtcgcgcgcg
     2161 gcacccggct ggtgagcggc gagaatgccg gcaagctgct gctcaccgag ctgggcgacc
     2221 ctccggcgct gggctttgcg gccatcgggc agctggtcgc cgaccacggc ttccacgtgt
     2281 ccgtcgatca ggtctccccc tatggcgggg ttcgcgccgt gctggcggtt ccgaagcatc
     2341 tgctgaccac catcgacgag caggcggagc cgccgtcggc gatggcggcc ctgccggccc
     2401 cggcgccgcg cacacccgta cctcctgccg ccgcggtgcc cggggaggga ctgcgcgacg
     2461 tcagcgcgcc gtctccgcgt gacgccagcg ggctgcccca gcgccgccgc cggagcggat
     2521 cctcccgtgg ccgctctctg actcgtacgg ctcgaccggt ggacccggat gaggccggcg
     2581 ctgcatgggg tgacttcgag caggccgttg ccgccggacg tgacgcaacc gattctgaga
     2641 acaaggacaa gtcttgaccc agtcaactct cagcgaccag atccccgacc cgtcctgggt
     2701 cctgggcccg atcatcgaga tcggcgtccg gcatgctctg atcctctccg ccgacggcat
     2761 cgtcgtcgga gcctcgggca gcctcggccg cgatgaatcc gaaggtatgg cggccatggt
     2821 gtccgccctg cacggcgccg cgcgcgcggc ggccgtcgtc tcgctcgagg cacccgagga
     2881 gactccgatc tccaccatca cggtccaact cgacgcctct ggaacgctga tggtcatgcc
     2941 ggccggcgga gccaacgcgt tcatcgccgc ttccttcggc accgacgtgc cgatgaacat
     3001 cgtcgcgcac accctcgcgc ggcaggcgaa gaacctcggc gaggcgctga tgtccgtacc
     3061 cacgcgctcc catggcccgg cgtcatgagc ccgggcccgg cacgacgact ggtccccagt
     3121 tacctggcca cgggagggat cagcgctccc gagcacagca ccctccaaga cctgacggcg
     3181 ttgaccgcca ccggccaatc cgcgctgccc catcacacgc ccgcccatca gcgacttctc
     3241 gacctggtca gtgacggcgg gctgaccgtg atggagatcg cgggctatct gcgtcttccg
     3301 atcggcgtgg tgaagatgct cgccgcgcag ctggtgtccg acggtcacct gcgtgccgcc
     3361 gcgccgctcc cggacgccct tgctcccacc gctcacgccg gacggcccag cagggccctc
     3421 ctggaggagg ttatgcatgg gctcctcgcc ctctagtgcg ccggtctacc tgccggactc
     3481 gaaccacgaa cgggtgaaga tcctggtggc cgggccgttc ggcatcggta agaccacgat
     3541 gatccgcacc ctgtcggaga ttccgagcct ccacaccgag gaggtcatga ccgacgcggc
     3601 ggcccaggtc gacgaactgg cggtcgcgga caagaagacc accacggtgg ccatcgactt
     3661 cggccgtctc accatcgcgc aggggcgaat cgtcctgtac ctgttcggca ctcccgggca
     3721 gcggcggttc aaagccctgt ggagcgacta cgcccgtggc gccctgggcg cactcgtcat
     3781 cgtggacacc cgaagactgg ccgactcctt cgaggtcatg gacctcatag aggagaccgg
     3841 cctggactac gccgtagccg tgaaccaatt ccccgaatcc cccgcatatg acgaggagac
     3901 cctccgcgtc aagctcgatc tcgaggatca cacgcccatg gtcatctgcg atgcgcgcga
     3961 ctgggactcc agcctcaacg cgctgcgagc gctggccgtt cacctcgtga cccgtgccgg
     4021 aggcaatctg tgacggccgc ccccaacgct gttccgctgt acggacccga gcacgccgcc
     4081 gaccctcagc gcagctacca actgctgcgc gagcagggtc cggtgggccg cgccgagatc
     4141 gaccccggcc tcgtcgtgtg ggtggtcacc gactaccggg ccgctctcga cctgttgcag
     4201 gaccccggaa cctggaccaa ggacacgcgg ggctgggaca cgacggtgcc ggcggacagc
     4261 ccggtcaggg agcccttgca gtggcgcccc agcctggcct tcgccgacgg cgaggaacac
     4321 gcgcatctgc ggaaggtcat caccgacagt ttcgcgctcc tcgaccccca gtacctgcga
     4381 gacgtgacgc tgcgccacgc ggacaccctc ctcgacgagt tcgcccatac gggacgtgcc
     4441 gacctggtcg cccagtacgc ccgcaggctg ccgctcatgg tcctgaacac tctgttcggc
     4501 atgccggacg agggcgcgga ccagctcatg tcggcgatcg aggcgctgat gagtacggtc
     4561 ccccaggcca aggaggcggg tgagcaggcc ctcaccgcct atctgggcag cctctacgcc
     4621 atgaagagcg cgcggcgcgg ccgcgacctc acctcctggt tcatcgacca cccgcacggg
     4681 ctcggcccgg aggaggtgat caaccaggta ctgatcactc agggcgcggc ctacggcacg
     4741 ctggcgggcc tgatcgccaa caccctcgcg cagatcctct ccgaccagcg gtaccggggc
     4801 accctcacca ccgggagcct gcccatcagg cacgccatcg acgaggtgct ctgggcggat
     4861 ccgcccctgg ccatgtacag cctccaccgc gcacggcgct ccgtcacctt ccaccggcgc
     4921 gccatcgagg ccggagagcc cgtcatggtc tcctacgcgg cggtcaacac ctgcccccac
     4981 accggtcagg tggccgacga gcagcgctcc gaccacaagg cacacctcgc cttcgcggcc
     5041 ggtccgcact cctgccccgc cgaggacatc gtgttcgtgg tggcggtcgc ggccatcgag
     5101 cggctgatgg gcaggctgcc ggacgtcgaa ctcaccgtcc cggctgccac cctgacgtac
     5161 cagccgggcc ccatctatcg cgtcctcacc tcactgccct gccgtttcac tccgcagact
     5221 ccggattcac ggagatcaac gcggggtagc gtccccgtgt ctgcttgatc tagatcaccg
     5281 acaccaacac cgacagctga ccgaccgccc ccgggtgcac acccgggggc cgtgttctgc
     5341 ctgtccacgg gaaaggggcg attttgcgtg ggattctcgc ttcaaggaag gtacgtgcgt
     5401 cgatggccgg taccgcatgg gacaccgata tcccgaccct tatatccgtt cgtgacgatg
     5461 tagacgcggt gctcgaggac ttcgtcgacg tgcaggagcg ggcagcgcac ggcccggaaa
     5521 tggcaccgct gttcaccacg gcccgccggc tcctcttctc caacggcaag cgactgcgcc
     5581 ccttgctgtg cgtggcggga tggcaggccg caggcgcacc gggagacccc cacgcggtcc
     5641 ttcgcgtcgc cgccgccctg gagctgttcc agaccttcgc cctgatccac gacgacgtca
     5701 tggacgacag tgacacccgc cgcggacggc cctcggccca ccgcgcgctg gccgccgagt
     5761 acatgagcgg cggtgggcgg ctcagcaagg cggaggcgca cggccgaggt gccgccatcc
     5821 tcctcggtga cctcctgctc gtgtggtcgg acgaaatgct ggcgggcgcg gggctcgaag
     5881 cccgggcgcg ggccagggtc ctgccactgg tggacagcat gcgcgccgag ctggtctacg
     5941 ggcagtacct ggatctgctg tcgaccgacc ggatgtccgg ggacgtcgag gccgcgctgc
     6001 gggtcgcccg gtacaagacg gggaagtaca ccgtggaacg gcccctgcac ctcggcgttt
     6061 ccctggccgg cggcgatccg cggctgctgc agacctgcac cgatttcgcc ctcccgctgg
     6121 gagaagcgtt tcagctgcgc gatgacctgc tcaacgtctt cggtgacccg gtgcggaccg
     6181 gcaagcctgt cggagacgac atccgtgagg gcaaagccac cgtgctcctg gctctcgcga
     6241 tccaggacgc ctccgaggcc gacctgaagc tgctcggcac cctggtcggc agcccggaac
     6301 tggggagcga ggacatcgac cggttccgca ccgtcatgga gaccaccggt gcccggcagc
     6361 gggtcgaaga catgatcatc gccaggcgcg acaccgccct cgccacgctg gaagaagcag
     6421 acctgcccca ggacgtcgcc gagacgttga ggcagatcgt atggatggcc acggaaaggc
     6481 agtcatgagc tccatatccc accaggcggc cccgacacgg gcacagcaca cgaacagcta
     6541 cgtgcagctg gcccggcagt tggtgacgtc ggtcgacaac gacccctggg gcgacgtgcc
     6601 tccctccgtg tacgagacgg cccgggtgac ctcctgggcg ccatggctgg agggacacga
     6661 acgccgtctg gcgtggctgc tggagcgaca gtccgccgcg ggcagttggg gagagggccc
     6721 cacgccgtac cggctgctgc cgacgctcag cgtcacggaa gccctcctgt ccacgttgcg
     6781 ccagaacacg gccgcgggcg tctcgcgcga gcggctcgcc gcggctgtgg acaacgggct
     6841 cgccgcgctg cgggacctgt ccggcaccgg cgggtggccg gacacggcgg ccatcgagat
     6901 cctcgccccc gacctggtcg tcctgatcaa cgaccacctg gaccagccgg aggtcgcggc
     6961 cctgccccga ctcggcccct gggcccgcgg gcagcgcctg gctcagccgc acggatttca
     7021 ggcggcgctg cccgaccgcg tggccgagcg gtgccaggtg gccggcggtg tgccactcaa
     7081 gctgcaccac accttcgaag gggtcgcgcg ccgcctgccg cggatggtgc ctggcgtccc
     7141 gggcgggctg ctgggcagtt cccccgccgc caccgccgcc tggctggcca ccggacccga
     7201 cgagggccgg gaccaggcgg tcaccgcgct gaccgccgtg gcggagcgct acgacggtct
     7261 cttcccggag gccacgccga tctccgtctt cgagcggctc tggatctccg tcgccctggc
     7321 ccgtcccggc ctgcccgccg cctgtgtgcc gaccatccgc gcctgggccg cggagatcta
     7381 cgacgccacc ggcgtacgcg gcgcccccgg cctgctgccc gacaccgacg acaccgccat
     7441 ggccgtgctg gcgtccgccc tcgccggctc gccccgcgac ccctccccgc tgtccgcctt
     7501 cgaggccggc gaccactatg actgctatgt cggcgaggac accggctcca gcacagccaa
     7561 cgcccacgcc cttcaggcgc tcaccgcctg gctgagccac cggcccgcga caggtgacgc
     7621 tctccaggcc cgtagggacc tgacccgcga ctggctcctc gcccagcaag aatccgacgg
     7681 tgcctggcgc gacaagtggc acgcgtcccc ctattacgcc accgaacggt gcgtcaccgc
     7741 tctctccggg cacacgggcc cgaccacccg cgacgccatc cgctcggccg ccgactgggt
     7801 actggacgcc cagagcgacg acggatcctg gggcgtgtgg ggtggcaccg ccgaggagac
     7861 cgcctatgcc gtgaacatcc tcctcaactc cccggatcac acgggcacgc cagaggccac
     7921 ccaggccctg aaactcgccg agaacgtcct gcgcgaggcc gtccactcct ccggccatca
     7981 ccaccctgcc ctctggcacg acaagaccct ctacgccccc caggccatgg cgcaggccga
     8041 ggtgatcgcg gcgctcgagc tgctgcaggc ccgtcggccc tgaaccgttc cgccgcccct
     8101 tcagcccgga ccgcattcgg aggaaccacc tgtgaacacc gacctgcact ttccgccata
     8161 cgccccaggg cgtgtgccgt tcatcggaca cgcggtgccg ttggcaaggg accgtctggc
     8221 ctttcttcag cgcctgcgtg agcacgggcc gatcgtgcgc atctcgatcg gtccgaagac
     8281 cttgaccgtc atcaactctc ccgacctcgt gcaggagatg ctgaccagga aatcggggca
     8341 gttcagcaaa ggactcctgt tcgagaagct gaagctcttc ggcaacgatg ccctgccggt
     8401 cgcggagggc ggccggcacc tgaggcgccg ccgcctgatg cagcccgcgt tccaccacca
     8461 acaggtcgac cagtacgtgc ggaccatgca gaccaccgtc gagccgatga tcgcggcatg
     8521 gcagagcatg ggcccactgg atctgaagac cgagatgcag ttgatgacgc agaacgtcgt
     8581 catgggggcc ctgttctcca ccatccccga ccgcaagacc gggcacgcga tcctcgagag
     8641 cgtcgacacc ctgttcgccg cggcgctccg ccgtgccctg ctgccacttc ccctcctcga
     8701 acggctgccg acccggggga accggcgggc gcggcgtgcc ggccaggtga tgcgcgctgc
     8761 cgtgggtgag gtcatcgccg accacctggc gcggccggac gagcacgacg acatcgtgtc
     8821 cctcctgctg tccgcccagg agccggacgg tacgccgctg gccgacgagg acatcctgtc
     8881 cgaggtcacg ggcctgctcg cggcgggttc ggaaaccacc gcggtcaccc tgacctggtt
     8941 gttccacgag ctgagccgta acccggacct ggagcggcag ttgcacagcg aggtcgacgc
     9001 ggtcctcacg gacgagccct tgacgacgaa gactctgagc cggctcacgt tcacgcgcag
     9061 actggtcaac gagagtctgc gcctgtacag cccggcatgg ctggtgaccc gtcagaccac
     9121 cgagcccgtg cggctcggaa ccgtggacct gccggccggg gaggacatcg tgtggagccc
     9181 ctacacgctg caccgtgatc ccggtctgta ccccgacccg ctccgctttg atcccgaccg
     9241 ttggctgccc gagcgtccgc agcccccgaa gggggcgttc atcccgttcg gggccgggaa
     9301 gcggcaatgt atgggcaacg agttcgccgt ggccgaagcg accctgatca cggccctgat
     9361 cgcgtcccgc tggcgactgc ggcccgtcgc gggacctgcc gttcggccgg tcggagcgat
     9421 caccctgcat ccgtccacgt tgcgcatgac cgccgaggcg cggaccccgg tgcgccgcca
     9481 ccaggaggcc gcatgacccg caccggcgat gcggtgacga ttctgcctca gccggacttc
     9541 accgccacct tccccggtcc gttccccacg agtccgcacg gggaacggac ggagcgccaa
     9601 ctcctcggct ggctggagga gtacccactg ctcccctccg ccagggccag gagcgttctg
     9661 gtgaacatca cgagtcacgg agtgtcgcgc accttgccga ccgccgacgc ggacgatctg
     9721 gtgctgttcg cggaactcct gctgtggctc accgcgttcg acgacatgca cggcgagagc
     9781 aacgccgccc gcgacctggt cgcccttgtc gaccgcaccg cggagctgac gcttgtcctg
     9841 gccggcggca gcccgcctcc cctcacgaac ccgttccccg ccgccctgta cgacctgctt
     9901 gcccgttttc gggcccggac cggtccggcc gcgtacctcc ggcttgccgc gagcctgcgc
     9961 gacaccatca tggccctggt ctgggaggca caccatgtgg cggagccgga gagggtcgcg
    10021 cttgagacct atctggagat gcgtccgcac accgtgttcg tcaggacgat cttcgccgcg
    10081 gcggagatcg tcctggacta cgaactgacg gacgcgcagc gggcgctggc gccggtacgg
    10141 catctggaga ccgctgtggc caacctcgcg ggctggatca acgacttggc ctcctacgag
    10201 cgtgaggcgg cgcgagggcc ggcgcagccg ttgagtctgc ccacgctgtt gcgggcgcgg
    10261 cacggcggaa gcctggagga ggcgtttgcg cgcgcgggcg gtatgtgcga aaacgaggca
    10321 gccgtcgccc ggcaagggat caccagcctc gccggcgacc ccccgagcgc gctcacagcc
    10381 cacgcccgcg ccctggagga catcgcccgc tccttcgtct ggcacaccag ccatgcccga
    10441 taccagggcc ccaaacgcgg cgcggcccca accagtcgtt gaaccaacgc gggagccaca
    10501 gccccaaaag accgcggaac tgggtacgtc gggggaggcg taccgcgtcc acagatctcg
    10561 tggccgcact caacggcagg ctgacccggg cccactcggc cgtcgggcac ctcgcgtaca
    10621 aggaggtgcc cgacggccag gagtcggcag cggcgggctg agccggccca gcaactcggc
    10681 tggaccgccg actgaacgac ccacaccgcc tgccgcacga tcggccgtcg caggagcagc
    10741 gccaccctgg ctggactcgg cccggtggtc agtcggagaa ggctcagcgg gtgaaagtct
    10801 cgcggacggt gccaccggcc agcgcgcacc acgtgctgag gtcggtcctg ccggtggggc
    10861 ggaggttgtg caggcgctgc atgtcctgca ccgccttcat ggtgtggtgg tcgtaggtgc
    10921 cggtgatgcc gacggtgtcg gcgtagccct tgatggtgag caggtactgc accgcctcga
    10981 cgggcaaccc ggaggagtcc ttgtccagcg ggggagcgag cgcttcccag gtgggggtgt
    11041 cgaaggtggc gtcgggggtg acggcaatgc catggctggt ctggaagtcg gcgacgacgg
    11101 tgttcatgtc ggtgctgaac acgccgtcga tgggcaggtc gctgtagccg gcgttcacca
    11161 gcaggtactg ggcgacctgc accacctgac tgtcgacgaa ccgccagatg tccggccatc
    11221 tccgtgtcgg cgcggcggca ggcgacacgc ccatggactg cagtactcgc ttgcggatct
    11281 gggggaagag tcggtagaag gcgatgccgg ggcagtcggt tcccaggcgg aagtcccagt
    11341 ggccgaagat gtcccacgca ttcaggtgga actgccgaca cactgcggtg cacagttcca
    11401 ccagcgagtc cagcagtgcc gccggcgggg tttcggtgat gtaggtgccc tcgttctcga
    11461 tcccgatggc gttgccgttc tcccctggac agtgggcggc ggtcacctgg tgctcgccgg
    11521 cgacgagggt ctccaggctg cggtgccggc cttcaaggac gtagccgccg cggctgacgg
    11581 tgaagtgctg ccccgtgtcc gcccagccgt tggtgtccat gtgaaggtcc tggcagtcac
    11641 gtgccagctg catggcgtgc tcgggggagt agtccgtgac gttggggaac gccatgtgat
    11701 gcaagatgat cttgttggtg gtgttgccgg tgatctcggt cggactggac ggcgggcgcg
    11761 cgccccagct gtcgcagtcg atgatccagg ggaactgcgg cgagggcgtg gcgccggcgg
    11821 cggtcgggaa cgccacctcc gtgccgacga cagcggcgac agccgtaccc aggccgaccc
    11881 ggaacagggt gcggcgatcg acttcgtgct cgtgcatcac catgaggact ccgaagtgag
    11941 tggatagccc aggagtgtgg gcggcctgtc ggagactatg cagtgaacgt ccgtttatcc
    12001 aggtgcagtt catcagtttc cccgccaccg tgatctgctt ccgatcacgg ccccgatggc
    12061 gcgcatggtc gcacccggcc ggccgaactc cgcgaccgca tcgccgagac ggtacggagc
    12121 ctggccaccc gctgcgagaa gaaggtcact tccggtcttc ccttgctcac cacgacccga
    12181 actccccatg attcaggacc cttacgagcg gggacggggg tccccgaggc gccgactcgg
    12241 aggtccgatg gatccagcca gtgtgggtac gaccgctcgc atcgcctcgt cggtcgcgcg
    12301 gccgatcatc gccaggccct tcgtcaagga gaggccgggc gcgggacgcg tcgaccagcc
    12361 ggtacgcctg tcgcggctgg tgagctggca gggcgaaaag cgcagcctga cccatctcga
    12421 catgt
//
