LOCUS       BGC0001911             10599 bp    DNA     linear   BCT 18-FEB-2016
DEFINITION  Streptomyces anulatus DNA, related genes for raimonol biosynthesis,
            strain: GM95.
ACCESSION   BGC0001911
VERSION     BGC0001911
KEYWORDS    .
SOURCE      Streptomyces anulatus
  ORGANISM  Streptomyces anulatus
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 05:21:25
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..10599
                     /db_xref="taxon:1892"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces anulatus"
                     /strain="GM95"
     misc_feature    1..10599
                     /note="related genes for raimonol biosynthesis"
     protocluster    1..10599
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[8924:9893]"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      8925..9893
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..10599
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..10599
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001911"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..10599
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="1"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            592..1992
                     /gene="cvnA"
     CDS             592..1992
                     /codon_start=1
                     /gene="cvnA"
                     /product="histidine sensor kinase"
                     /protein_id="BAR97455.1"
                     /transl_table=11
                     /translation="MTSPSEPALALGAVTVVMAVVALLLALSRRKQVRRCREMDAALKS
                     AEARKRYAESRTQDLEAHEERFRAEVGHLVSARLPALALNLISSHHPVPGLLQEKAAGP
                     EDAELLDSVLTRVSEIVLKERRRVDAAARAALRGASQDSQALSYRLQSELDGLQREFTG
                     SRHLTHRMLAADHLNEQNLRLIQRTAIVCGAWPGHVRKDTYVAEIVTGASSRLRGFDRI
                     KINSRIATNVGIVGRAAEPIAVACAELMANALEHSRDDLAVDVSLIQTGNGNVSITVDD
                     AGKGMTAEAAARGVRLVSADSQDVMLTELGDPPSQGFVAIGRLVADYGFHVSVDNPSPY
                     GGVRAVVTIPPNLLASIDEEAEPPSAMAPQPAVAPKAERRPATVAASVTGHGSDPAAEA
                     GDEKPSTPAPDGADGLPQRRRRGPAATAGLAAPTYRAPDPERSLKAWSEFQDGLDSGRT
                     GSDSEETQ"
     gene            1989..2408
                     /gene="cvnB"
     CDS             1989..2408
                     /codon_start=1
                     /gene="cvnB"
                     /product="hypothetical protein"
                     /protein_id="BAR97456.1"
                     /transl_table=11
                     /translation="MTMPDGANETWYLAPITEIPGVRHALLMTLDGMVQARSENLSADD
                     ADGVAAMTSALHAASRAAVIPALGAAADTPIETVTVKVAEGTYMVMPAGANTLIAAAGD
                     DSMHMGVVVHMMARQAKKLGEQHMSVSARSHDGAS"
     gene            2405..2785
                     /gene="cvnC"
     CDS             2405..2785
                     /codon_start=1
                     /gene="cvnC"
                     /product="hypothetical protein"
                     /protein_id="BAR97457.1"
                     /transl_table=11
                     /translation="MSRGQHQRRLLPAYLATGAGSAPLPSTLDTLTALRASGVPLAAYH
                     TPVHRRVVELVSGGSLTAVEIAAYLSLPASVGLMLAEQLVSDGLLKASVPIPDALAPSR
                     AGRPSLQLMEEVLNGLQSLRVA"
     misc_feature    2672..2674
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2757..3377
                     /gene="cvnD"
     CDS             2757..3377
                     /codon_start=1
                     /gene="cvnD"
                     /product="ATP/GTP-binding protein"
                     /protein_id="BAR97458.1"
                     /transl_table=11
                     /translation="MDSSPSASPDPRPVYLPEGDHQRVKILVAGPLGVGKTTAIRTLSQ
                     IPTLHTDEVMTDAAAGADDLSFVGLRDKTTTTVAIDFGRLTLPGDRVVLYLYGTPGQRR
                     FLPLWEGIAFGALGALVLVDTRRLDESFEVMDLIEERGLPYAVAVNTFPDSPDYDLEIV
                     RKKLDLAPDTPLVTCDAREMDSSLNSLIALTAHSIASAGVGAS"
     CDS             3374..4684
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 240; E-value: 7.2e-73)"
                     /gene_kind="biosynthetic-additional"
                     /note="00405"
                     /product="hypothetical protein"
                     /protein_id="BAR97459.1"
                     /transl_table=11
                     /translation="MSITPSTATAVRLYGPEHAADPQRSYELLRRQGPVGLAEIDTDLV
                     VHLVTDYEAAINLLQDTDTWSKDTRPWLGQVPEHSTIRPLVEWRPSLLFADGDEHAHLR
                     KVITDSFALLDPNDVRVLTFRHADRLLQDFADTGTVDLVGQYAHQLPLMVFNGLFGMGD
                     EHGPRLVGALTAMMDTDPERKAAGAQSFGAYLGALYQTKAAQRGHDLTSWFIDHPNGLS
                     QEEAINQIIITLGAGNEPTANLIANTCVRMLSDDRYFGTLTTGSLPVQHAIDDALWYDS
                     PLANFSFHFPKKDVTFYGTRIPVGSPVMVSYAAANTCPHSGVPADGYRSGTKAHLAFAA
                     GPHACPARSLALLIATAAIERLASYLPDIELAVAPEELTYRDGPIHRTLTSLPARFTPL
                     TPDAEGVTPWSRSSTGPETESDSPSLVTAGRGSVRSS"
     gene            4832..5914
                     /gene="rmnA"
     CDS             4832..5914
                     /codon_start=1
                     /gene="rmnA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 259.3; E-value:
                     6.4e-79)"
                     /gene_kind="biosynthetic-additional"
                     /product="geranylgeranyl diphosphate synthase"
                     /protein_id="BAR97460.1"
                     /transl_table=11
                     /translation="MAKTCPTTSLPDLPSVRHEVSTALTGFLDAKDQAAPGTELLYLTT
                     TLRAFLTSGKRLRSVLCVYGWQAAGGDGELTAAIRAAASLELFQVFALVHDDVMDDSDV
                     RRGQPSAHRALATAYTDSGGPQGRAEAHGLGAAVLLGDLALVWSDELLHSAVLDPGRLA
                     DVLPLVAEMRSELMYGQLLDLQTTGRLTGDVETALHIIRYKTAKYTVERPLHIGAAVAG
                     AGAPVLDACTAFGIPLGEAFQLRDDLLGVFGDPAETGKSILDDLREGKGTVLMALAVQR
                     ASSAERKTLRALVGRSDLDEDLAAEVRAILESTDARRTVEEMITERRDAAFAALDDAPF
                     PAAAVAQLRQIALVATERQT"
     gene            5911..7560
                     /gene="rmnB"
     CDS             5911..7560
                     /codon_start=1
                     /gene="rmnB"
                     /product="labdadienyl diphosphate synthase"
                     /protein_id="BAR97461.1"
                     /transl_table=11
                     /translation="MTARPNPVTATVRSDIPMSDTVVSTTYSEQAAHLVARIDQDGLGS
                     VRPSLYETARVISAAPWLPGEPRRLAYLLDEQAPDGSWGEGPERYRLLPTLSGVEAALA
                     VLRRGATPTETARRLAGAVDRGLAALRALPRSGPWPDTAAAEILVPGLVAKIHEQIARI
                     AEDGTPALDGWRPGPGPALPGGYDEALPAYVAKRYASVGSLPVKFHHTFEGIAGYLPPA
                     LIPDVPDLLGSSPAATAARAATASSAPSAGTVAALESVAERYAGSFPEAAPILVFERLW
                     VAAALAHTHLPAAALPTVRRWAADIYDPRGVRGAPGLMKDADDTAMAVLVSSLVGLEHT
                     LEPLDQFHNGSHYDCYIGEDTGSITANAHALQALGGYQRRNPETQHIYGPRTDKLRDWL
                     IDQQRPEGPWPDKWHASPYYATARSVAALTRFGGGHAVTAVETAVTWALDTQRDDGSWG
                     VWGGTAEETAYAVQILLSTSTHRPQHTRALHRAETYLGDSAGSGRHPALWHDKTLYAPD
                     AMIEAEILAARQTLRTRHDLNRRVTTPIHAEK"
     gene            7570..8928
                     /gene="rmnC"
     CDS             7570..8928
                     /codon_start=1
                     /gene="rmnC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 386.8; E-value:
                     2.4e-117)"
                     /gene_kind="biosynthetic-additional"
                     /product="cytochrome P450"
                     /protein_id="BAR97462.1"
                     /sec_met_domain="p450 (E-value: 5.9e-77, bitscore: 248.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNSGHVPPMAPGKLPLVGHAIPLIKDRLAFIQRLRTHGPVVRIA
                     VGPKTLTVVNSPELMHKMLTSQADEFTKGLLFEKLKLFGKDALPVAEGKPHLRRRRLMQ
                     PAFHRQQIAGYVDTMRTAVEPYVASWDGGTPVDVKTEMQLMAQGVVMSALFSATPRRAP
                     AATILNSVDTVFKTAIQRALLPISLLERLPTRRNRKADEASSALRTAVAEIIAEHRAHP
                     DTYDDIVSLLLTAQDETGATLPDDEILSEIVALLAAGSETTAVVLSWLFHELGRNPEME
                     RLLHEEVDSVLAEGPLTAERLPLLVHTRRLVSESLRMYSPAWLVTRQAVSDVRLGEFTL
                     PAGSDVIWSAYALHREPELYPDPLRFDPDRWLPERPQPPKGAFVPFGSGKRMCIGDTFA
                     WTETIIITALIASRWRLRPTPGAVRPVGAISTHPSSLQMVPELRHHTVVGKAR"
     gene            8925..9893
                     /gene="rmnD"
     CDS             8925..9893
                     /codon_start=1
                     /gene="rmnD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Terpene_synth_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Terpene synthase/cyclase metal-binding domain
                     protein (Score: 178; E-value: 5e-54)"
                     /gene_kind="biosynthetic"
                     /product="labdatriene synthase"
                     /protein_id="BAR97463.1"
                     /sec_met_domain="Terpene_synth_C (E-value: 2.9e-16,
                     bitscore: 49.1, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDATRTSTTPPALPMPDLRDSFPGPFPASAHADDIERHATQWLR
                     TFPLIRSERALSALTHITGQGVARTFPTAGRDELFLCADLFLWLTAFDDAHGEATGAAD
                     PARLLRTTSEYVHLLAGHHEPPGGPSVFGAALRDLLDRYGERATPAQYARLTAHLRDNL
                     FGILWEAHHLHRPDRVTLPDYLAMRPHTVFVRTVVATAEVMLGYELTEPDRSSEPVREL
                     ETAVADLAGWINDLASYAKETARDGSATLGLPALLMRQHECDLEEAFRRASLMCEQQAA
                     VAAARIAELTAGGGPLADHAHALRSVASSYVWHIDDSRYRT"
     CDS             9871..10299
                     /codon_start=1
                     /note="00400"
                     /product="hypothetical protein"
                     /protein_id="BAR97464.1"
                     /transl_table=11
                     /translation="MTPATGPSPAGPVANPVELPLGAPPRVLNLGVGVHGVTSDRDVFR
                     LPGLWQLHVYGYAADLAVDTTAYAIRPGRVSVIPPGKRVEYRYRGRSEHLYAHFELTGD
                     GEPARVPLIQDMGAEAPVLTDLLHRAVAATAHSPARPG"
ORIGIN
        1 acgatccgtt gacgagccgc cagttctgag ccgcgcgggt cacgatccga cctctgtacc
       61 cgccgcgcgg cggtcgcagg aagcggtacg aaggtggtca tctccgtacg ggtgcacgct
      121 ccgcccgttc cggtggcgcg gacgcgctca tcctcacaac cgctcgcgat cggccaattt
      181 tctggcagcg gttgctcccc acctggcact atttcttccg tcaagatcat cgcggcgtgt
      241 gtactcgcgc tgtgagttgg cggccaactc ccctaaactg actccgcttt ggcgtgaacc
      301 cccaccgcgg cacagcagca ttgacggcgg aggttcctgc gtcgccctat gtcaggcatg
      361 gagagacacc cgatgtacat gagcgatcgt caccggtcga gcacctgtgc gtcggagacc
      421 ctccgcgtcc cggcagttcc gcgactccgt ctctccgccg tcccgaatcc gcggcgctgt
      481 ggctcgccag gcctccgcct ccacccggcg tacaccactt caccggcggg gaaggccgac
      541 agcgtcgtcg cccccgcacg ttcccccctc gacccctagg accctttttc cgtgacctct
      601 ccctcagaac ccgccctcgc gctgggcgcc gtgaccgttg tcatggccgt cgtcgcgctg
      661 ctgctggctc tctcccgtcg caaacaggtg cgacggtgca gagagatgga cgcggcgttg
      721 aagagcgccg aggcgcgcaa gcgctacgcc gaatcacgca cccaggacct ggaggcccac
      781 gaggagcggt tccgcgccga ggtgggtcat ctcgtctccg cccggctgcc ggccctcgcg
      841 ctcaacctga tcagctctca ccaccccgtc cccgggctgc tccaggagaa ggcggcgggt
      901 cccgaggacg cggagctgct cgactccgtc ctcacccggg tctcggagat cgtcctgaag
      961 gagcggcgcc gggtggacgc cgcggccagg gccgcgctgc gcggcgcgag ccaggactcg
     1021 caggcgctgt cgtaccggct ccagtcggaa ctcgacgggc tccagcggga gttcaccggg
     1081 tcgcggcatc tgacgcaccg gatgctcgcc gccgaccatc tgaacgagca gaatctgcgg
     1141 ctcatccagc gcaccgccat cgtgtgcggc gcatggccgg gtcacgtgcg caaggacacg
     1201 tacgtcgccg agatcgtcac cggcgcctcg tcccgtctgc gcggcttcga ccggatcaag
     1261 atcaactctc gaatagccac caacgtcggg atcgtcggtc gtgccgccga gcccatcgcg
     1321 gtggcctgcg cggagctgat ggccaacgcg ctggagcact cccgcgacga cctcgcggtg
     1381 gacgtcagcc tgatccagac cggcaacggc aacgtcagca tcaccgtcga cgacgccggc
     1441 aagggcatga ccgcggaagc ggccgcgcgc ggcgtacggc tggtgtcggc cgacagccag
     1501 gacgtcatgc tcaccgagct gggcgatccg ccgtcccaag ggttcgtcgc catcggccgt
     1561 ctcgtcgccg actacggctt ccatgtctcc gtcgacaatc cctctcccta tggcggggtg
     1621 cgcgctgtgg tgaccattcc cccgaacctg ctcgcctcga tcgacgagga ggccgagccg
     1681 ccgtccgcga tggctcccca gcccgctgtg gcaccgaagg cggagcggcg gcccgccacg
     1741 gtcgcggcat ccgtcaccgg tcacggaagc gatcccgccg ccgaggcggg cgacgagaag
     1801 ccgagcaccc ccgcaccgga cggtgcggac ggtctgccgc agcgtcgtcg ccgcgggccc
     1861 gcggcgaccg ccggactcgc cgctcccaca taccgtgccc cggacccgga gcggtctctc
     1921 aaagcctgga gtgaattcca ggacggcctc gacagcggcc gaaccggttc tgattcggag
     1981 gaaacacagt gaccatgccc gacggtgcga acgagacctg gtacctggcc cccatcactg
     2041 agattccagg agtccgccac gccctgctca tgaccctcga cgggatggtc caggcgaggt
     2101 ccgagaacct ttcggccgac gacgcggacg gtgtggccgc gatgacctcc gccctgcacg
     2161 ccgcctcgcg cgccgccgtc atcccggcgc tgggagccgc ggccgacacc cccatcgaga
     2221 ccgtcaccgt gaaggtcgcc gaggggacct acatggtgat gccggccggc gccaacacgc
     2281 tgatcgccgc cgcgggcgac gattcgatgc acatgggcgt cgtcgtccac atgatggcgc
     2341 gtcaggcgaa gaagctcggg gagcagcaca tgtctgtctc cgcgcgtagc cacgacggcg
     2401 cgtcatgagc cgaggacagc accagcggcg tctgctgccc gcgtatctgg cgaccggcgc
     2461 cggcagcgct cccctgccca gcaccctcga cacgctgacg gccctgcggg ccagcggagt
     2521 tccgctcgcc gcgtaccaca cgccggtgca tcgccgggtg gtcgagctgg tgtcgggtgg
     2581 ttccctcacc gccgtggaga tagccgccta tctctcgctg ccggccagtg tcgggctgat
     2641 gctcgccgaa cagctcgtca gtgacggctt gttaaaggcc agtgtgccca tcccggatgc
     2701 cctcgccccc tcacgcgcgg gacggccgtc gcttcaactc atggaagagg tgctgaatgg
     2761 actccagtcc ctccgcgtcg cctgacccgc ggccggtgta cctccccgag ggggaccacc
     2821 agcgagtcaa gatcctggtg gcgggtcctc tcggtgtcgg caagacgacc gccatcagga
     2881 cgctttccca gatccccacg ctgcacaccg acgaagtcat gacggacgcg gcggccggag
     2941 ccgacgatct ctccttcgtc ggcctgcggg acaagacgac caccacggtc gccatcgact
     3001 tcggccgtct gactcttccc ggcgaccgcg tcgtgctgta tctgtacgga actcccggtc
     3061 agcgccgctt ccttccgctg tgggagggca tcgccttcgg ggctctcggc gcgctcgtcc
     3121 tggtcgacac ccggcgcctg gacgaatcct tcgaggtgat ggatctgatt gaagagcgcg
     3181 gtttgccgta cgccgtggcg gtcaatacct tccctgactc acctgactac gacctggaga
     3241 tcgtgcgcaa gaagctcgac ctcgccccgg acaccccact ggtcacctgt gatgcccgcg
     3301 agatggacag cagcctcaac tcactcatcg cactgacagc ccattccata gcatctgccg
     3361 gagtcggagc ctcgtgagca tcacaccctc aaccgccaca gccgtgcgcc tgtacgggcc
     3421 cgagcacgcg gccgatcctc agcgcagcta tgaactgctg cgccgtcagg ggccggtggg
     3481 cctcgccgag atcgacaccg atctcgtcgt ccacctggtc accgactacg aggcggcgat
     3541 caatctcctg caggacacgg acacctggtc caaggacacc cgcccctggc tgggccaggt
     3601 tccggagcac agcacgatca gacccctggt ggagtggcgg cccagtctcc tcttcgccga
     3661 cggtgacgag cacgcgcacc tgcgcaaggt catcaccgac agtttcgccc tcctggaccc
     3721 caacgacgtc cgcgtcctga cgttccgtca tgccgatcgt ctgctccagg acttcgcgga
     3781 caccggcacg gtcgacctcg tcggccagta cgcgcatcag ctcccgttga tggtgttcaa
     3841 cggcctgttc ggcatgggcg acgaacacgg cccccggctg gtgggcgcgc tcaccgcgat
     3901 gatggacacc gatcccgaac gcaaggcggc gggcgcccag tcgttcggcg cctacctggg
     3961 ggcgctgtac cagaccaagg ccgcccagcg cggccacgat ctgacgtcct ggttcatcga
     4021 ccaccccaac gggctgagcc aggaggaggc gatcaaccag atcatcatca ccctcggcgc
     4081 ggggaacgag ccgacggcca acctcatcgc caacacctgc gtgcggatgc tgagcgacga
     4141 ccggtacttc ggcacgctca ccaccggaag tctccctgtg cagcacgcca ttgacgacgc
     4201 gctgtggtac gactcgccgc tggcgaactt cagcttccac ttcccgaaga aggacgtcac
     4261 cttctacggc acgcgcattc ccgtcggctc cccggtgatg gtctcgtacg ccgccgccaa
     4321 cacctgcccc cactcggggg taccggccga cgggtaccgc tcgggcacca aggcgcatct
     4381 ggcgttcgcc gccgggccgc acgcctgtcc cgcccgttct ctcgccctgc tgatcgcgac
     4441 cgccgcgatc gaacggcttg ccagctatct gccggacatc gaactcgccg tcgctcccga
     4501 agagctgacg tatcgcgacg ggcccatcca ccggacgctc acgtcgctgc ccgcccggtt
     4561 cactccgctg acccccgacg ccgaaggcgt caccccgtgg agccgcagct ccaccggtcc
     4621 ggagacggaa tcggactcgc cgtccctggt gacggcgggc cgcgggtcgg tgagatcttc
     4681 gtaacctgct cccacaccgt gtcgcggtgg tgccgtcggc cgtagtccag caccaccgcg
     4741 acatctgtgc ggaaagcagt gtcctggccg cgtcctctgc ccgaccggaa tcgccacaca
     4801 cggttctcga ccgaaagggg atcaatcacc gatggcaaaa acctgtccca ccacgagtct
     4861 gccggacctc ccgtccgtac ggcacgaggt gagtaccgct ctcaccggat tcctcgacgc
     4921 caaagaccag gccgcgcccg gaaccgagct gctctatctg accaccaccc tgcgcgcctt
     4981 cctcaccagc gggaaacggc tgcgatccgt gctgtgcgtc tacggatggc aagccgcggg
     5041 aggggacgga gagttgacgg ccgccatccg cgccgccgcc agccttgaac tcttccaagt
     5101 cttcgccctg gtgcatgacg acgtcatgga tgacagcgat gtcagacgcg gccagccgtc
     5161 cgcacaccgg gcactggcca ccgcgtacac cgacagcggc ggtcctcagg gccgcgcgga
     5221 ggcgcacgga ctgggcgcgg ccgtcctcct cggagacctg gcgctcgtgt ggtccgacga
     5281 actcctccac tcggcggtcc tcgacccggg caggctcgcc gacgtcctgc cgctggtggc
     5341 cgagatgcgc agcgagctga tgtacggcca gctcctggac ctccagacca ccggccggct
     5401 gaccggcgac gtcgagacgg cgctgcacat catccgctac aagaccgcca agtacaccgt
     5461 cgaacggccc ctccacatcg gggcggcggt ggccggagcc ggcgcgcccg tgctcgacgc
     5521 ctgcaccgcc ttcggcatcc cgctgggaga agcgtttcag ctgcgcgacg acctgctcgg
     5581 cgtgttcggc gatcccgccg agaccggcaa atcgatactg gacgatctgc gcgagggcaa
     5641 gggcaccgta ctgatggccc tcgccgtcca acgggcctca tccgccgagc gcaagaccct
     5701 gcgtgccctc gtcggccgga gcgacctcga cgaggacctg gccgccgagg tccgcgccat
     5761 cctcgaatcc accgacgccc ggcggacggt ggaagagatg atcaccgaac gccgggacgc
     5821 ggccttcgcc gcgctggacg acgcgccctt cccggcggcg gccgtcgccc aactgcgcca
     5881 gatcgcactg gtcgccacgg agcggcagac atgaccgccc gcccgaaccc cgtcaccgca
     5941 accgtgaggt cggacatacc catgagcgac acggtcgtca gcacgaccta ctccgaacag
     6001 gccgcacacc tggtggccag gatcgaccag gacgggctgg gcagcgtccg cccctccctg
     6061 tacgagaccg cccgggtcat ctcggccgcc ccctggctgc ccggggagcc acgccggctc
     6121 gcgtacctgc tggacgagca ggcccccgac gggagttggg gagagggacc ggagcgctac
     6181 cgcctcctgc cgacgctcag cggcgtcgaa gccgcgctgg cggtcctgcg gcggggcgcc
     6241 acgcccacgg agacggcccg ccggctcgcc ggcgcggtgg acaggggtct tgccgcgctg
     6301 cgcgcgctgc cccggtcggg accgtggccc gacaccgcgg cggccgagat cctcgtcccc
     6361 ggactggtcg cgaagatcca cgagcagatc gcccggatcg cggaggacgg gacaccggcc
     6421 ctcgacggat ggcgcccggg gcccggcccc gcgctccccg gcggctacga cgaggccctg
     6481 cccgcgtacg tggccaagcg gtacgcctcg gtgggcagcc tccccgtcaa gttccaccac
     6541 acgttcgaag ggatcgccgg gtacctgccg ccggccctca tacccgacgt ccccgacctg
     6601 ctgggcagtt cgccggccgc caccgccgcc cgggccgcca cagcctcgtc ggcgccctcc
     6661 gccggaaccg tcgcggccct cgaatccgtc gcggagcgct acgcgggtag cttccccgag
     6721 gcggccccga ttctcgtctt cgagcgcctg tgggtcgccg ccgcgctggc ccacacccac
     6781 ctgccggccg ccgccctgcc caccgtccgg cgctgggccg ccgacatcta cgacccgcgg
     6841 ggagtacgtg gcgcgccggg gctcatgaag gacgccgacg acaccgccat ggcggtgctg
     6901 gtctcctcac tggtcggcct ggagcacacc ctcgaaccgc tcgaccagtt ccacaacggc
     6961 agtcactacg actgctacat aggcgaggac accgggtcca tcaccgccaa cgcccacgcc
     7021 ctccaggcgc tcggcggcta ccagcgccgc aaccccgaga cacagcacat ctacggtccc
     7081 cgtacggaca aactgcgcga ctggctcatc gaccagcagc ggcccgaagg cccctggccc
     7141 gacaagtggc acgcctcccc ctactacgcc accgcgcgaa gcgtggccgc gctcacgcga
     7201 ttcggcggag gccacgcggt caccgccgtc gagaccgccg tgacctgggc cctcgacacc
     7261 cagcgggacg acggctcctg gggagtgtgg ggcgggaccg cggaagagac cgcgtacgcc
     7321 gtacagatcc tgctgtccac ctccacgcac cggccgcagc acacccgggc gctgcaccgc
     7381 gccgagacgt acctgggcga ctcggccggc tccggccgcc acccggctct gtggcacgac
     7441 aaaaccctgt acgccccgga cgccatgatc gaggcggaga tactggcggc gcggcagacg
     7501 ctgcgcaccc ggcacgacct gaaccggcga gtcaccaccc ccatacacgc ggaaaagtag
     7561 ggcagaccca tgtcgaacag tggacacgtg ccacccatgg cgcccgggaa gctcccgctc
     7621 gtcggacacg ccatacccct gatcaaggac cgcctcgcct tcatccagcg cctgcgcacc
     7681 cacggccccg tcgtccgcat cgccgtcggc cccaagacgc tgaccgtcgt caactcgcct
     7741 gagctgatgc acaagatgct caccagccag gccgacgagt tcaccaaagg gctgctcttc
     7801 gagaagctga agctcttcgg gaaggacgcc ctgcccgtcg cggagggcaa gccgcacctg
     7861 cgccggcgcc gcctcatgca gcctgccttc caccggcagc agatcgccgg ctacgtcgac
     7921 accatgcgta cggccgtgga gccgtacgtc gcgagctggg acggcggaac cccggtcgac
     7981 gtgaagaccg agatgcagct catggcacag ggcgtggtca tgtcggccct gttctccgcg
     8041 acgccccggc gggctcccgc cgccacgatc ctcaacagcg tcgacaccgt cttcaagacc
     8101 gccatccagc gtgccctgct gcccatctcc ctcctggaac ggctgcccac ccggcgcaac
     8161 cgcaaggccg acgaggcaag cagcgcgctg cgtaccgcgg tcgccgagat catcgcggaa
     8221 caccgggcgc accccgacac gtacgacgac atcgtgtcgc tgctgctgac cgcacaggac
     8281 gagaccggcg cgacgctgcc cgacgacgag atcctctccg agatcgtcgc gctgctcgcc
     8341 gcgggctccg agaccaccgc ggtcgtcctc tcctggctct tccacgaact gggccgcaac
     8401 ccggagatgg agcgcctgct ccacgaggaa gtcgactccg tgctcgccga gggtccgctc
     8461 accgccgagc gccttcccct tctcgtccac acccgcaggc tcgtcagcga gtcgctgcgc
     8521 atgtacagcc cggcgtggct ggtgacccgg caggccgtat cggacgtacg gctcggcgag
     8581 ttcaccctgc ccgccggatc ggacgtgatc tggagcgcct acgcgctgca ccgggagccc
     8641 gagctgtatc ccgacccgct gcgcttcgac cccgaccgct ggctcccgga gcgcccccag
     8701 ccgccgaagg gcgccttcgt cccgttcggc tccggcaaac gcatgtgtat cggggacacg
     8761 ttcgcctgga ccgagaccat catcatcacc gcgctgatcg cctcccgctg gcggctgcga
     8821 ccgacacccg gcgccgtacg accggtcgga gcgatctcca cgcacccctc atcccttcag
     8881 atggtgcccg aactcaggca ccacacggtc gtggggaagg cccgatgaac gacgcgaccc
     8941 gcacgagcac gaccccgccc gccctgccga tgcccgacct gcgtgactcc tttcccgggc
     9001 ccttcccggc cagcgcccac gccgacgaca tcgaacggca cgccacccag tggctccgga
     9061 cgttcccgct catccgctcg gagcgcgcgc tgagcgcgct cacccacatc acgggccagg
     9121 gggtggcccg taccttcccg acggccggcc gcgacgaact cttcctctgc gccgacctct
     9181 tcctgtggct caccgcgttc gacgacgccc acggcgaggc caccggcgcc gccgacccgg
     9241 cccgtctgct ccgcacgacc agcgagtacg tccatctcct cgccgggcac cacgagccac
     9301 cgggcggccc gagcgtgttc ggcgccgcgc tgcgcgacct cctggaccgg tacggcgaac
     9361 gagccacccc cgcccagtac gcacggctca ccgcacacct gcgggacaac ctgttcggca
     9421 tcctctggga ggcgcaccac ctccaccggc ccgaccgcgt caccctgccc gactacctcg
     9481 cgatgcgccc gcacaccgtc ttcgtacgca ccgtcgtcgc cacggcggag gtcatgctgg
     9541 gctacgaact gaccgagccg gacaggtcgt cggagccggt ccgcgaactg gagacggcgg
     9601 tcgccgacct cgccggctgg atcaacgacc tcgcctcgta cgccaaggag acggcccgcg
     9661 acggttcggc gacactcggc ctgcccgcac tgctgatgcg gcagcacgag tgcgacctcg
     9721 aagaagcctt ccggcgcgcc tccctcatgt gcgaacagca ggccgccgtc gccgccgccc
     9781 gcatcgccga actgaccgcg ggcggaggcc cgttggccga tcacgcgcac gccctgcggt
     9841 ccgtcgcgtc ctcgtacgtc tggcacatcg atgactcccg ctaccggacc tagcccggcc
     9901 ggcccggtgg cgaacccggt cgagctgccg ctgggcgcac cgccgcgcgt gctgaacctc
     9961 ggggtcggtg tgcacggggt cacctcggac cgcgacgtgt tccggctgcc cggcctctgg
    10021 cagctgcacg tctacggtta cgcggcggac ctggccgtcg acaccacggc gtacgcgata
    10081 cgtcccgggc gggtcagcgt catcccgccc gggaagcggg tcgagtaccg ctaccggggc
    10141 cgctcggagc atctgtacgc ccacttcgag ctgaccggcg acggcgagcc ggcccgtgtc
    10201 ccgctcatcc aggacatggg cgccgaggcc cccgtactca ccgacctgct ccaccgggcc
    10261 gtcgccgcca ccgcgcacag cccggcccgg cccgggtgac cgcagaggtg tgggccgcgc
    10321 tctggcgcgt cgttgacctc ggccggcgcg gcgcggccgg ccggccgcac gcctgcgtcg
    10381 aggcggccgt ggcccacatc gagtcccggc ttcacgaacc cctcaccgtc cccgaggtcg
    10441 cccgggccgc gggcgtctcg cacaaccacc tcatccggct gttccacgcc cacctggaca
    10501 gcaccgtggt ggcgtacatc agggcgcgcc gtatggcgcg ggcccggcat ctgctgcgcg
    10561 agtcgacgct gtccctgtcg gcgatcgccg cggccgtgg
//
