BGC0001919: neoantimycin biosynthetic gene cluster from Streptomyces orinoci
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Location: 1 - 42,361 nt. (total: 42,361 nt).
This entry is originally from NCBI GenBank LC375136.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001919
Short description neoantimycin biosynthetic gene cluster from Streptomyces orinoci
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
LC375136.1
via
Compounds
  • neoantimycin
Species Streptomyces orinoci [taxonomy]
References
Chemical products information
neoantimycin Evidence:
Copy SMILES
C36H46N2O12
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BBD17757.1
 1 - 1368 (-) hypothetical protein
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    • BBD17758.1
    • natA
    		 1510 - 2037 (-) sigma factor
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      • BBD17759.1
      • natB
      		 2484 - 16343 (+) non-ribosomal peptide synthetase
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        • BBD17760.1
        • natC
        		 16336 - 20571 (+) polyketide synthase
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          • BBD17761.1
          • natD
          		 20656 - 27867 (+) non-ribosomal peptide synthetase
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            • BBD17762.1
            • natE
            		 27864 - 28061 (+) mbtH
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              • BBD17763.1
              • natF
              		 28058 - 29086 (+) NAD-dependent reductase
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                • BBD17764.1
                • natG
                		 29083 - 29850 (+) thioesterase
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                  • BBD17765.1
                  • natH
                  		 29813 - 30508 (-) 4'-phosphopantetheinyl transferase
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                    • BBD17766.1
                    • natI
                    		 30513 - 32000 (-) AMP-ligase
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                      • BBD17767.1
                      • natJ
                      		 32000 - 32221 (-) acyl carrier protein
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                        • BBD17768.1
                        • natK
                        		 32469 - 33470 (+) epoxidase component
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                          • BBD17769.1
                          • natL
                          		 33467 - 33760 (+) epoxidase component
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                            • BBD17770.1
                            • natM
                            		 33747 - 34502 (+) epoxidase component
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                              • BBD17771.1
                              • natN
                              		 34499 - 34996 (+) epoxidase component
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                                • BBD17772.1
                                • natO
                                		 35004 - 36104 (+) epoxidase component
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                                  • BBD17773.1
                                  • natP
                                  		 36215 - 37027 (+) tryptophan dioxygenase
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                                    • BBD17774.1
                                    • natQ
                                    		 37020 - 37844 (+) kynurenine formamidase
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                                      • BBD17775.1
                                      • natR
                                      		 37847 - 39097 (+) kynureninase
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                                        • BBD17776.1
                                        		 39340 - 41106 (-) phosphoesterase
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                                          Biosynthesis information

                                          Biosynthetic modules

                                          Name
                                          Unk01
                                          Type
                                          nrps-type1
                                          Genes
                                          natB
                                          Substrates
                                          threonine (evidence: Structure-based inference, Homology, Heterologous expression)
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk02
                                          Type
                                          nrps-type1
                                          Genes
                                          natI
                                          Substrates
                                          anthanillic acid (evidence: Structure-based inference, Homology, Heterologous expression)
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Annotation changelog

                                          Entry version: 3

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2022-10-07
                                          Update chemical activity to schema version 2.11
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 2

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2022-09-15
                                          Cleaned up synonym list
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          2022-09-15
                                          Fetch compound properties from PubChem
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          2022-09-15
                                          Updated bioactivity data
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          2022-09-15
                                          Added NRP substrate specificities
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 1

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2019-10-16
                                          Submitted
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          Detailed domain annotation
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