BGC0001923 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001923 (Acremonium egyptiacum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS-like	1	33,001	ascochlorin	terpene+PKS	100%

BGC0001923 - Region 1 - NRPS-like,T1PKS

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Location: 1 - 33,001 nt. (total: 33,001 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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core biosynthetic genes

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transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 33,002
Label		BGC0001923

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001923	1.81	Terpene, Polyketide	ascochlorin	Acremonium egyptiacum
BGC0001390	1.06	NRP, Polyketide	LL-Z1272beta	Stachybotrys bisbyi
BGC0002608	0.81	NRP, Polyketide	ochratoxin A	Aspergillus steynii
BGC0002341	0.65	Other	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0000037	0.60	Polyketide	cichorine	Aspergillus nidulans FGSC A4
BGC0001626	0.51	Polyketide	isoindolinone	Stachybotrys chlorohalonata IBT 40285
BGC0001219	0.48	Polyketide	shanorellin	Chaetomium globosum CBS 148.51
BGC0001720	0.46	Polyketide	oosporein	Beauveria bassiana ARSEF 2860
BGC0000099	0.43	Polyketide	monascorubrin	Talaromyces marneffei
BGC0000156	0.42	Polyketide	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001923	1.00	Terpene, Polyketide	ascochlorin	Acremonium egyptiacum
BGC0001390	0.80	NRP, Polyketide	LL-Z1272beta	Stachybotrys bisbyi
BGC0002608	0.72	NRP, Polyketide	ochratoxin A	Aspergillus steynii
BGC0002341	0.66	Other	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0000037	0.63	Polyketide	cichorine	Aspergillus nidulans FGSC A4
BGC0001219	0.61	Polyketide	shanorellin	Chaetomium globosum CBS 148.51
BGC0001475	0.59	Terpene	aspterric acid	Aspergillus terreus NIH2624
BGC0001626	0.58	Polyketide	isoindolinone	Stachybotrys chlorohalonata IBT 40285
BGC0002290	0.58	Other	biscognienyne B, eutypinic acid, compound 3, 4-hydroxy-3-prenylbenzoic acid, prenylhydroquinone, compound 15, compound 8, compound 7, compound 6, compound 11, compound 12, pestalodiol E	Biscogniauxia sp.
BGC0000688	0.56	Terpene	copalyl diphosphate	Diaporthe amygdali

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 33001:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 27429:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ascB

AMP-binding (77..389): X

nrpys: Gly, Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GLPMGGFPLK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

ascC

PKS_AT (909..1209): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 58.3%; Methylmalonyl-CoA: 54.2%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 44.8
Malonyl-CoA: 38.2
inactive: 35.5
Methylmalonyl-CoA: 34.8
Ethylmalonyl-CoA: 25.0
Propionyl-CoA: 20.0
2-Methylbutyryl-CoA: 19.7
CHC-CoA: 19.3
fatty_acid: 17.1
Acetyl-CoA: 13.4
trans-1,2-CPDA: 10.8
Benzoyl-CoA: 9.2
Isobutyryl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0