LOCUS       BGC0001924              6000 bp    DNA     linear   PLN 08-MAY-2019
DEFINITION  Acremonium egyptiacum F-1392 DNA, ascofuranone biosynthesis gene
            cluster, complete sequence.
ACCESSION   BGC0001924
VERSION     BGC0001924
KEYWORDS    .
SOURCE      Acremonium egyptiacum
  ORGANISM  Acremonium egyptiacum
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Sordariomycetes; Hypocreomycetidae; Hypocreales; Hypocreales
            incertae sedis; Acremonium.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 16:33:15
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 6000
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..6000
                     /db_xref="taxon:749675"
                     /mol_type="genomic DNA"
                     /organism="Acremonium egyptiacum"
                     /strain="F-1392"
     misc_feature    1..6000
                     /note="ascofuranone biosynthesis gene cluster"
     subregion       1..6000
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="terpene"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..6000
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(619..1605)
                     /gene="ascJ"
     CDS             complement(join(619..1004,1054..1491,1539..1605))
                     /codon_start=1
                     /gene="ascJ"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     119.1; E-value: 3.8e-36)"
                     /gene_kind="biosynthetic-additional"
                     /product="dehydrogenase"
                     /protein_id="BBF25320.1"
                     /transl_table=11
                     /translation="MTDIHIQDGDLSSLKDKVVVITGGSSGIGLATTNLLLDLGAKVVI
                     GDLQPPTTRVDSERCSFHKVDVTVWSDQLTLFKEARELHGRIDHVFANAGVGPKADYLS
                     TALDQNGDLVEPTFLTLDVNLKAVIYTATIACYYMREEQQSPAGGSIVIVSSVAGVSRF
                     RAVDYATAKHGNLGFARGLHQRLTAENSPTRVNLIAPSWTNTGFMPPQIMAAVGVEPQE
                     PASVGRAAAYLMADDSRKGQMIHIAKGRYREVEESIMLPAAEKVVDVENGGVMEDDTLA
                     KIIETMGIFKAKATQ"
     gene            order(2085..2431,2476..3283)
                     /gene="ascI"
     CDS             join(2085..2431,2476..3283)
                     /codon_start=1
                     /gene="ascI"
                     /product="terpene cyclase"
                     /protein_id="BBF25321.1"
                     /transl_table=11
                     /translation="MPQLAGKLILAGLIPLGAWVLHGFASCNGLIQMFEDFGKQTVLSD
                     GVTDYTGAFTGLEGLDRLLRTLLNFFWPVANGHDWALSLHAFMFAGQGVPLLVLNMLEG
                     ARPGNKSLVVSYVTVFGILYMVVGLAIMAPLYLFLHLLTSRTATAPSKAKVAVDPNTAK
                     AVGFGVFVGYVLPTIFMSLPHPSLLSTDTKVLSVVFWQAVPLWASVCAYFASTALGQSA
                     TSRSSSNLPSALGAVYAASLIIATATHVATFAISANLSDTWSGIFTFLIPPNPFNTDMR
                     ISSFLEGATWFLQWDYTMMSLAYMVWAIGIRHGVEVPRSSHHFETLGKIALRSMAKLLV
                     MGPIGAALSLVWERDQLLWQLDSESGEKGEKNRSRRMSRKWMFS"
     gene            order(3612..4725,4784..5003,5106..5310)
                     /gene="ascH"
     CDS             join(3612..4725,4784..5003,5106..5310)
                     /codon_start=1
                     /gene="ascH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 276.8; E-value: 5.8e-84)"
                     /gene_kind="biosynthetic-additional"
                     /product="cytochrome P450 monooxygenase"
                     /protein_id="BBF25322.1"
                     /sec_met_domain="p450 (E-value: 7.4e-59, bitscore: 187.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGLSLGYSPDRGSIGSWICAAPLILALFVISYRLFQSVIDYRLSH
                     RNGCKPPPTYPHKDWYLGLHHVFGLLKAKKENRLPTAFSELFDASGPDVHTLGHYVLGK
                     KSYWTRDPENIKAVLSSKFNDWGLPSARKATFRTCLGGGIFGVDGKEWEHSRAMLKPSF
                     TRTQIGDTATLSKHADNLIARIPEGETVDLAELFPLLTMDVGTEMLFGESVGSLDPAEI
                     KQATRFTTSFDYIVQTMSKHMALPILTKLRDKTLQGCVEFVDDFAADVVNRTIANESKT
                     EKPSSLGKYIFPTELAKMGLPEKQIRIEVINIMVAGRDTTAALLSLIWWYLAKRPDAVM
                     KLHQELEPLGGRPPTGEEVKKMKYLRNFVNEILRLHPINPLNSRTAAKDTTLPRGGGPD
                     GKSPVFIRKGTQLMFSSAALQRRKDLYGEDALDLRPERWERIRPSAFEYIPFGGGPRIC
                     PGQQLALTEASYFTARLLQEFQGVTSESSGPFQEAFAILVTSGDGVKVKFHKKH"
ORIGIN
        1 tgccttcagg accaactgag aaattaaact ttcaaggcca ggcatagtgt catttgattg
       61 caaacctggt gatgttcgat gttcacgacg ggtacgttcc tgaagatctt tggtaagacg
      121 gacgattgtg tggccgtgca cctgccacaa agggaatatt gaagattgtt cagaaccaag
      181 agatccaaag gtagcgcaaa agtctgagag gcccaacatg tgcaactcac taaacagtca
      241 ggcaatgctt gcggtccaca aacaagggaa catccagact tgaaactgag ttgacgaggc
      301 caccacttac ataggggtgt ggggccgtgt ccgatcacct gtgtaagtca gtccattgcc
      361 tgttccagca ctgcctatac agcaagccgt ggacatttca cgaagtgttc attcaatcta
      421 gtgtgatagg agatatttag ccatatggta gtatctagcc taacagcgag gtttgcatgt
      481 agttgtggag ctaccaaact tcagttagct ctaacgtctc aggccagcag ctcatctact
      541 agatgacact gttgagatgg gcgatacaga tctcgacgcc ctcaagcctc aaattaggtc
      601 tcttccacac tccacagttc attgtgttgc cttcgctttg aatatgccca tggtctcaat
      661 aatcttagcc agggtgtcgt cttccatcac acccccgttc tccacgtcaa caactttctc
      721 agcagcgggc agcataatgc tctcttcaac ctcgcgatat cgccccttcg caatgtgaat
      781 catctgtcct tttctcgagt catcagccat cagataagcc gcagctcgac ccaccgaggc
      841 aggctcttga ggctcgacgc caacggccgc cataatctgg ggtggcatga agcccgtgtt
      901 ggtccacgac ggagcgatga ggttgacgcg agttggcgag ttctcagccg tcaaccgctg
      961 atgcagaccg cgggcgaaac caagatttcc gtgcttggca gtggctgatt atgtcagttt
     1021 catcggagct aaccatctac tccttgatct taccatagtc gaccgccctg aagcgcgaca
     1081 caccagcaac agacgagaca atgacgatgc ttcctccagc agggctttgc tgctcttccc
     1141 gcatgtagta gcaagcaatg gtcgcggtgt agatgactgc cttcaagttg acatcgagcg
     1201 tcaagaacgt tggctctacc aaatcgccat tctggtcaag tgccgttgat aggtagtcgg
     1261 ctttaggccc aacgcctgcg ttggcaaaaa cgtggtcaat tcttccatgg agctctcgag
     1321 cttccttgaa aagggtcagt tggtcagacc acacggtcac atctactttg tgaaagctgc
     1381 atcgctcgct gtccacacgg gtcgtgggcg gttggagatc gccaatgacc acctttgcac
     1441 cgaggtcgag cagaaggttc gtagtagcaa gaccgatacc tgaggagcca cctgattcaa
     1501 attagattca tgctggcccg tgaaaatttc tcacttgcct gtgatcacca ccaccttgtc
     1561 cttgagactc gagagatctc cgtcctgaat atgaatgtct gtcatggttt tagctaggat
     1621 attaaatgtg atacgaatag cggtcttcaa tataaaaatg ttttatgcaa taactaatct
     1681 atcctatacc ctgatatcaa gaagttccaa cgttgtgtct atctgcacgc tgtcggcgca
     1741 tttaaagtgg ctagggtgcg ccacgaagtc tggagaggac tctcggtgca ttattccaca
     1801 actatgtgag accccgcgtt ccatgtgtct cgcgggatcg tctctcatcc tacagactca
     1861 tgcatggaac agttccaaga atgtggcatt tcgatcctca gtcacaggca aatccgccga
     1921 atgatacttc ttccatcagg caacgaatcc ttcatcttta gagtacaaat tttggaactg
     1981 ttgacatgga actgactgca ttctgatcat tcaaactcga agcacctcca gtatctgttt
     2041 atcatttgtt gcaaatcgat cagtgtctgc ccgttgtatt caggatgccc cagctcgcag
     2101 gtaagttaat actggcaggg ctcattcccc tgggtgcatg ggtcctccat ggtttcgcct
     2161 cctgcaacgg actcatccag atgttcgaag acttcgggaa gcagacagtc ctgtcagacg
     2221 gagtgaccga ttacactggg gctttcaccg gccttgaggg cctggatcgc ctcctcagga
     2281 ctctgctcaa ttttttctgg ccagttgcca acggacatga ttgggcactg tcgctgcatg
     2341 ctttcatgtt tgctggccaa ggagtcccgc tcctggtgct taacatgctg gaaggggctc
     2401 gacctgggaa caagtctctg gtcgtcagct agtaagtgct tccgccttct ctgagctgct
     2461 gagactgacc agcagcgtta ccgtcttcgg aattctgtac atggtggttg gattagccat
     2521 catggccccc ttgtatctct tccttcacct cttgacatct cgaaccgcca ctgcaccgtc
     2581 caaggctaaa gtggccgtgg accctaacac ggcaaaagcc gtcggcttcg gcgtgttcgt
     2641 aggctacgta ctgcccacaa ttttcatgtc attgcctcat ccttcgcttc tgtccacgga
     2701 cacaaaggtc ttgtcagttg tcttctggca agcagtgccg ctgtgggcct cagtgtgtgc
     2761 atactttgca tctacagctc ttggccagtc ggcaacttca cggtcgtcca gcaacctgcc
     2821 ttcggcattg ggagcggtat atgccgcctc tctcatcatc gcaactgcca ctcacgttgc
     2881 cacattcgcc atatccgcaa atctatcgga tacctggagc ggcattttca cctttttgat
     2941 tccaccgaat cccttcaaca cggatatgag gatctcatcc ttccttgagg gcgcaacttg
     3001 gttcttgcag tgggactaca caatgatgtc cttggcatac atggtctggg ccatcggtat
     3061 ccggcacggg gttgaagtac ctcggagctc gcaccacttc gagacactcg gaaagatcgc
     3121 cctgcgctcg atggcgaagt tgttggtcat gggacccatt ggcgcagcgc tcagtcttgt
     3181 atgggagaga gatcaactac tgtggcaact tgacagcgag agcggtgaga agggtgagaa
     3241 aaataggtct aggaggatgt caaggaagtg gatgttctca tagaacgata cctagtcttt
     3301 ggcagtcact aatgtaacct ccaatcaagg cgatatcgcc aaccgcggta cgaaatagtc
     3361 tccttcttcc tttgataatg atcgcacatt gtatgaaagg atccttgttc ggtctattta
     3421 cgatacccta ccctcaaatt cggggctttc ccacaaactg aacctgcaga gactgccgat
     3481 tcacgccctt ttcacttctt ccactaatct cgcttgagtt ttgcttggac atttcacatc
     3541 gctaagcgag gttcaactta ccgggtttgc ggagacacta atcgactttt caatcgattg
     3601 gttctatcaa tatggggcta tcactcggtt acagccccga tcgaggcagc attgggtctt
     3661 ggatctgtgc tgcgccgcta attctggctc ttttcgtcat ctcgtaccgt ctttttcaat
     3721 ctgtgatcga ctatcgactg tcgcaccgca acggctgcaa accaccccct acgtaccctc
     3781 acaaggattg gtatcttggc ctccaccacg ttttcggcct cctgaaagcg aagaaagaaa
     3841 accgtctgcc gactgcattt agcgagcttt tcgacgccag tggccctgat gttcacactc
     3901 tgggccacta tgtccttggc aaaaagtctt actggacaag agaccccgag aacatcaaag
     3961 ctgtcctgtc gtccaagttc aacgactggg gtcttccgtc tgcgaggaag gcaactttca
     4021 ggacatgtct tgggggcggc atctttggtg tcgatggcaa agagtgggag cactcaagag
     4081 caatgctcaa gccttcattc acccggactc agattgggga cactgcgact ctgtccaagc
     4141 acgccgacaa cctcatcgca aggattccag agggggagac ggtggaccta gctgagctat
     4201 ttcccctcct taccatggat gttggaacgg aaatgctctt cggcgaaagc gtcgggagcc
     4261 tggatccagc ggagatcaag caggccacta ggttcactac atcatttgac tacattgttc
     4321 agacaatgtc caagcacatg gccttgccta tccttacaaa gcttcgcgat aagacactac
     4381 aaggatgcgt tgaatttgtc gacgacttcg cagctgatgt ggtaaatcgg accatcgcca
     4441 atgaaagcaa aacggagaag ccgagctccc ttgggaagta catctttcct actgagctgg
     4501 ccaagatggg cttgccggag aaacaaatca ggatcgaggt tatcaacatc atggttgctg
     4561 gaagagatac gactgctgca ctcctgagtc tcatctggtg gtacttagcg aaacgacctg
     4621 atgccgtcat gaagcttcat caggagcttg agccgctcgg aggacggccg ccaacaggtg
     4681 aagaggtcaa gaagatgaag tacctcagaa acttcgtcaa tgaaagtgag ccatgcccag
     4741 ttcgctttac ctatcattaa gaactcaggc taatcagaga cagtcctgag gctccaccca
     4801 atcaacccct tgaactcccg taccgccgcc aaagacacta ccctgccacg cggtggggga
     4861 ccggacggga agtcccctgt attcatacga aagggaacac agctcatgtt ctcttctgct
     4921 gccctgcaac gtagaaagga tctgtacgga gaagatgctt tggatctgag gcccgagaga
     4981 tgggagcgca tccgaccatc cgcgtaagtc catacagtta aacagtcgcc tcgccttttg
     5041 aatgattgga ttatcataca tactctacca caaatgataa ccgattgctg acccaagcgt
     5101 cccaggtttg aatacattcc cttcggtggc ggtccaagga tttgtccagg tcaacagctt
     5161 gccttgacag aagcatcata cttcactgca agactcttgc aagagtttca gggagtgact
     5221 tccgagtcga gcggaccgtt ccaggaagca ttcgctattc tcgtgaccag cggagacggg
     5281 gtcaaggtta agttccacaa gaagcactga gattgagaag acggccttgc ggtagccttg
     5341 ccgatttggt ggacaaagat cgtcgggttc tgcgaaagtc acgtcgggga attatggatt
     5401 ggaataagag gaatacacgc cggaagaacg gatagaagtc taaccgaaaa gaaattgctg
     5461 ttgcgaatgt ccaccgtacg ctatgctatg ctatgcagac cgaaagctcc atcccatcct
     5521 ttgattaatc tgtgggatgc agatcgcttg tactgaatgt ttccccgatg aacgccatgc
     5581 caaactcctc taactataaa ttgataaccg tgagcaccga gcctctatca tgcaatttcc
     5641 attcccaatc ccaaaatcaa tcccgtaaac aatacacgta cccaatatca tccgtccata
     5701 cactgcttgt cacacactga gacaggtctg cggctacttc ctgctcgttt ttgagtagtc
     5761 cgagggaggg gtttgtctgc tttctgcttt atccatcaac aacaaagaaa agagcccaaa
     5821 acaacagtca tttcatggcc caaagtaccg catagattcc cgctcctcgg gtatcgctgt
     5881 caaggtagtt gcgacctgtc tttgatctag tttgacagat gcaagacggt gaggcggcac
     5941 cggagtgacc aggtcgtcct ccgtcgctcc cctgttccaa ggccctggtg tttctgggct
//
