LOCUS       BGC0001926             28006 bp    DNA     linear   PLN 15-NOV-2018
DEFINITION  Talaromyces verruculosus TPU1311 chrodrimanin B biosynthetic gene
            cluster, complete sequence.
ACCESSION   BGC0001926
VERSION     BGC0001926
KEYWORDS    .
SOURCE      Talaromyces verruculosus
  ORGANISM  Talaromyces verruculosus
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Trichocomaceae;
            Talaromyces; Talaromyces sect. Talaromyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 16:33:45
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(1..882)
                     /gene="cdmA"
     CDS             complement(1..882)
                     /codon_start=1
                     /gene="cdmA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /product="2-oxoglutarate/Fe(II)-dependent dioxygenase CdmA"
                     /protein_id="BBG28480.1"
                     /sec_met_domain="PhyH (E-value: 9.5e-34, bitscore: 106.9,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKLPSDASAIKRVEANTSPEQVIELLKQDGVVVLKDFLDQATVQ
                     SFREEIKPAIDDFEGGPNFNPDGVKVDIGRGTKHVANLTAISKTYRHDILNNKWMHSIL
                     EPLFRPHFGDYWMNRGSVLHIEPGEPAQNLHRDDILYRVTKLRQPGDPDLMINILIAVT
                     EFRDDNGATRFVPGSHVWDDTRGVPTPDQASSAALRPGDALLFVGSLWHGAGSNQSDAF
                     RQGLLLCIHPCHFTPMESHLHVPRTIVESMTPQAQKMIGWRSGITQHDVPIWLAGDHKM
                     EETMGLRSQEVQ"
     misc_feature    1..28006
                     /note="chrodrimanin B biosynthetic gene cluster"
     protocluster    1..28006
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[10098:18422]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10099..18422
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     cand_cluster    1..28006
                     /SMILES="C([*])C(-O)(C)"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..28006
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001926"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..28006
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            order(2659..2943,3010..3816,3902..4546)
                     /gene="cdmB"
     CDS             join(2659..2943,3010..3816,3902..4546)
                     /codon_start=1
                     /gene="cdmB"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 373.1; E-value:
                     2.5e-113)"
                     /gene_kind="transport"
                     /product="putative MFS toxin efflux pump CdmB"
                     /protein_id="BBG28481.1"
                     /transl_table=11
                     /translation="MQENPKDLACLSELPADSPSHGGIQASPDLESTPHDISPDQDNYQ
                     LPPKQEERVESVSVKEDAKDLEDGGPEYPSSWKLAVIMLGLCFAVFCMALDNTIIATAI
                     PTITDEFNSLDDIGWYGSAYLFTTCSLTLVFGKLYTFYSIKWVYLIAILVFEVGSVVCG
                     ATPNSVGLILGRAIAGLGGAGIFSGSMLIIAQTMPLERRPICTGLLGGLYGVAGVAGPL
                     MGGAFTEYVTWRWCFYINIPFGAVTALFILCFFKAPKPIRKTSSIREQLAQLDLLGLLF
                     FIPAIVSILLALQWGGTQYAWGNGRIIGLFVTFGVLILIFIGIQWKKQETATVNPRLVK
                     DRNVSGAAFYCLCLTGSFIVFTYYLPLWFQSIKDVSATKSGIMNLPTILGVVICTILSS
                     GFVSGLGYYTPFMYIAPVVASVGAGLLSTLQVHSGHAEWIGYQALYGIGLGFGMSQPMV
                     VVQAVLAPADVPTGTAIITFMQSIGGAIFVSVAQNVFNNLLLQRLAQDAPTADAAMIAA
                     TGATSLQSVVPQNLLPSVLEAYNSAITQAFYVGVALAAVSILGALPLQWISVKGKKIEA
                     GA"
     gene            order(5678..6429,6490..6991)
                     /gene="cdmC"
     CDS             join(5678..6429,6490..6991)
                     /codon_start=1
                     /gene="cdmC"
                     /product="acetyltransferase CdmC"
                     /protein_id="BBG28482.1"
                     /transl_table=11
                     /translation="MLSLEPLSRPVLDSSQTLLVIFLLAFTRQNSIFRYLSIPVLTFIV
                     KEQITQPPAVVENFHQWLNESSVPFNYLHHINILALTSIDLRNDNNGVLPGLFDRIKSA
                     FIYQLNPRGVGTRYQVKNIPPVPEYYKKRKGYLSQRYRFVVRQLCLFVWQYLIVDVGCS
                     LWHNLPDQERFALFGPGTEWNIINAGPQQWKVRLMAAMIFWTTARNAVDLSHRLGSAVL
                     TGIGATSVHEWPPMCGSLRDAYTLRNLWGKWWHQQLRWTLSSHSNFVTRRLLKLPRRSL
                     LERYLNNAIVHVFSAFIHVNGWRLAGIPDGYIGPSLFYMSFVGGYLVEDFVQHIWATLF
                     RSRSRTSTGIFFERLTGIFWVATFLTVTTPWWIYPLLRREHSFALPVSLVESVGMNNAL
                     AMIGVGAFILKTRFDANI"
     gene            complement(7827..8750)
                     /gene="cdmD"
     CDS             complement(7827..8750)
                     /codon_start=1
                     /gene="cdmD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /product="2-oxoglutarate/Fe(II)-dependent dioxygenase CdmD"
                     /protein_id="BBG28483.1"
                     /sec_met_domain="PhyH (E-value: 1.3e-32, bitscore: 103.2,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVTINKSSVPHKVDFATPLSDVICHIKEDGAVIVRGFMDVETIQ
                     KLQEEVDTAVEKGSFGPRYQEYNEEAGEIPKHEIYKRGEGKKTKHMKNLALTSETFRND
                     VLNHKWMHAVCEQIYGEEFGDYWMNCAHILHLEPGEKAQFFHRDTGVYRVSDFRRRLND
                     PEFMINFLVSLTEFREDNGATQLIPGSHKWDAAHPPTFYGSDEAVPAILEPGDAVVYLG
                     SLFHGAGENRSLDYRRGMIVSMHPAHFTPMESHFHLPKEIVESMTPLAQQMVGWRTMNN
                     QNKIPIWQAGDDKIEDVLRLQHKEVY"
     gene            order(10099..10507,10564..10832,10893..11649,11710..12168,
                     12232..13370,13427..15091,15169..15230,15291..17154,
                     17208..17528,17589..18422)
                     /gene="cdmE"
     CDS             join(10099..10507,10564..10832,10893..11649,11710..12168,
                     12232..13370,13427..15091,15169..15230,15291..17154,
                     17208..17528,17589..18422)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (35-456). E-value:
                     5.7e-160. Score: 524.7. Matches aSDomain:
                     nrpspksdomains_cdmE_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (588-906). E-value: 7.9e-89.
                     Score: 289.8. Matches aSDomain:
                     nrpspksdomains_cdmE_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (977-1166). E-value: 9.2e-25.
                     Score: 79.8. Matches aSDomain:
                     nrpspksdomains_cdmE_PKS_DH.1"
                     /NRPS_PKS="Domain: cMT (1478-1651). E-value: 2e-34. Score:
                     110.1. Matches aSDomain: nrpspksdomains_cdmE_cMT.1"
                     /NRPS_PKS="Domain: PKS_ER (1888-2199). E-value: 7.5e-68.
                     Score: 220.8. Matches aSDomain:
                     nrpspksdomains_cdmE_PKS_ER.1"
                     /NRPS_PKS="Domain: PKS_KR (2222-2398). E-value: 3.5e-48.
                     Score: 155.8. Matches aSDomain:
                     nrpspksdomains_cdmE_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (2510-2586). E-value: 4.3e-12.
                     Score: 38.1. Matches aSDomain:
                     nrpspksdomains_cdmE_PKS_PP.1"
                     /codon_start=1
                     /gene="cdmE"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 225.4; E-value:
                     2.2e-68)"
                     /gene_kind="biosynthetic"
                     /product="polyketide synthase CdmE"
                     /protein_id="BBG28484.1"
                     /sec_met_domain="PKS_KS (E-value: 1e-160, bitscore: 524.7,
                     seeds: 2284, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 1.4e-89, bitscore: 289.8,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 3.3e-12, bitscore:
                     36.0, seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 7.3e-46, bitscore:
                     145.8, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 5.8e-09, bitscore:
                     25.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVLHPSDRRFPETNGVGGHSKDSSAKSGYTSLEPLAIVGFASHLA
                     GDATDNENLWKHILEGQSASGPFPQNRLQGNQYFHPDPEHGGTCATKGGYFLKKDIDTF
                     DASFFRLSEYDIAAMDPQQKILLENVYHAVENAGLPMESLAGSRTSVYVGSSTNDHAAL
                     TNEDLDFTIKNKATGTLPSLLANRVSWFYDLKGASIVIDTACSSSLVALHMACLDIRAG
                     GSEMAIVSGINLLQHPASLMLLSNLGVLSPDGRSYAFDDRANGYGRGEGVITVVVKSLQ
                     AAIRDGDRVRALVRASGVSSDGKTAGITLPSEEEQKVLIRNVYASANLDVNETTYVEAH
                     GTGTPVGDPLECKAIMSAFRTQRRKQTLYIGSIKANIGHLEGGAGLAGLVKAIMMLEKQ
                     IIPPIAGLQRLNPLISQDGHNVCFTREAIPWPKSHVRRASVNSFGFGGTNAHVVLESPD
                     MFLHGRSLDTTSTSLVRLPNGYLNGINGQKTPPEDSPKSYVFMISANDENGIQRNAMLL
                     KKYIDNYLKTQCSFSEDQFMKDLVYTLSEKRSRLKWRASIIASSLTELSQQLTGGTLPK
                     FRAANTEPGISFVFTGQGAQWPGMGKMLMEFPIFRQSVEAASLHLQKQGSQWTLHDAFD
                     PIEDSKTDINNPIQSQTACTVLQVALVDLLQSWNISPSIVIGHSSGEIAAAYCAGAISR
                     EAAWNISYYRGLVSSILVKGGGGAMIAVGLHPQEAQKYINQLSPELQCMVQIGCYNSPN
                     NTTITGERNAILILQALLDENGVFNRVLATPVAYHSQYMQPVADTYSTLLRLSDLSVGR
                     MRQPQIDEEIVMISSVTGEPIGAKRLQDPQYWTQNLISPVKFMNALHQLKNFAPQFNLQ
                     ELLELGPHSALQSAIRESMADGQSTAPQIRYSHTITRKKMTYSTILSTAAGLFCRGYPV
                     NLVATSCTDSHHGTLLTDLPGYEFNHDAGLRAESRRMKNSRLPEFPRHELLGSPDPDWD
                     RREPRWRNFLRTSELPWLRDNKVNGGIIFPGVGYSIMAMEAVKQISDRSISIAGYRLKQ
                     ISMEAALIVPDTRDGLEVMTSLREVYDEGSTTSPKYQFSVKTHDTMRNEWIEHCSGFIE
                     SKCESDSIEDMGTWRPLPWDAVHDLQFSEESCTQIGSISAFYDALERSGFDLGPTLKNL
                     VDVRTSATSPHCMTKMAAPSIAEHMPKGYNFPYIIHPSTMESMAHAILHVCTTKEAPVG
                     SALLARYIDNIWISNKIPMDPGHLFVTVADGEQVSPGKWRCAITVWNDATKEVVIQIRG
                     TELCLLSAGRGDQKTVPECFLVKWYPSLDLVTDKLPFASLSSPETGVTEARHAHKTYEQ
                     LCTLYIARALKSLHGYDRKLLPQHLQQYLDWMVRQTMDSDAHTMRAILVENEVKLKEES
                     GMLEALRTQAQGLGSRGELLVNVGDHIVPLIKGEKDPQSIIIGGNDLRPWTLDQDLSGN
                     IKNVLSDNLKALRHGQGQLKVLEIGTGFGSVTAHIIKALTSVEDMSQTVFGKYQYTNKH
                     NSSFEDVRQKCGDWLSLMDFQVLDVDQSVAEQGFEEHSYDLVISAHAFTRTVSLERSLK
                     NAHSLLKPGGKLLVIENVQPQYKSTPFVYGLFPGWWHSTEPFRSTTPLVSEDKWVELLE
                     ATGFTTSSVKDVENEKSNETCLFLSTAIRTKELIAAPPFDDIVLTHHAYDPKNLVSSLL
                     AAIKQISGLPVIVVPFSQLSHRKMERSFCIVVGELGQGYLDLSCVNEDIYREMKRLLLT
                     CQNLLWISLDDVDYPKAALSTGLVRTLRWEREMDKINFLTLKFAQSSSHVPEIVSAVTS
                     LYQHYFDGKVEASPNSEFLYKDGSFWVNRLYPAKTANNFLQSHISEAPQSQMLGDNVDR
                     SLKARFKGSGRQGLLVWSDDEALSQPLSASEIQIDVQASGLTFQDGMAIRGDIDQHVFG
                     KQVAGTVTQVGQKVEALEPGDHVMALLVGSEQHSLSRSIRVNANFAQRLSPDADFMEAA
                     TIPTTFTAVHYALHNVARVMESEKVLVHGAMQAAGQAAIQLAKLAGADVFVTVKTFEQK
                     QKIETKYGIPENHVFIANEHLDAGIKEATGGASGVDIVLNFLHGSATRSAWQCVGMMGR
                     FVDMALKAPGRHRGLDMSPFSRNAMYIGVDIAALGTAHHPSIMKAFSKVGELFRQRLIF
                     GPGHKPFSYNNFGAAMIHIQNDSNMDTAVIVPKADDVIQVVPCKYTAYEFPTDATYVIA
                     GGLGGLGRSAARWMCSKGARHLILISRSGARTASAKELLQDLASQGCKIKICQCDITDK
                     DNLQIAMRECASGMPPIKGCLQSTMLLQDSIFENMSFQQFMAGIHPKVQGSLNVLDAIP
                     DQLDFFLVLSSAASIVGNRGQANYNSANAFQDSLAEHLTSKGIPGMSVNLGNMLSVGWV
                     AENEGALPLDLVYSSIDEPEFHALLEYHLDPRWGASQSVETCHTIAGVRSATRFNEDRT
                     PIPSFMNDPLFTIIRESTNGTTDNGEQEREISISTLLKESSSVQVAASHVTEAIICKLS
                     SVMSFPAAEIDPSQGLASYGVDSLVTVDFRTWIAKDMGANLSTADILDDGNIIGLSEKI
                     ARQSKFVKVA"
     aSDomain        join(10204..10507,10564..10832,10893..11582)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cdmE_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="5.70E-160"
                     /label="cdmE_PKS_KS.1"
                     /locus_tag="cdmE"
                     /protein_end="456"
                     /protein_start="35"
                     /score="524.7"
                     /tool="antismash"
                     /translation="AIVGFASHLAGDATDNENLWKHILEGQSASGPFPQNRLQGNQYFH
                     PDPEHGGTCATKGGYFLKKDIDTFDASFFRLSEYDIAAMDPQQKILLENVYHAVENAGL
                     PMESLAGSRTSVYVGSSTNDHAALTNEDLDFTIKNKATGTLPSLLANRVSWFYDLKGAS
                     IVIDTACSSSLVALHMACLDIRAGGSEMAIVSGINLLQHPASLMLLSNLGVLSPDGRSY
                     AFDDRANGYGRGEGVITVVVKSLQAAIRDGDRVRALVRASGVSSDGKTAGITLPSEEEQ
                     KVLIRNVYASANLDVNETTYVEAHGTGTPVGDPLECKAIMSAFRTQRRKQTLYIGSIKA
                     NIGHLEGGAGLAGLVKAIMMLEKQIIPPIAGLQRLNPLISQDGHNVCFTREAIPWPKSH
                     VRRASVNSFGFGGTNAHVVLES"
     aSModule        10204..18401
                     /complete
                     /domains="nrpspksdomains_cdmE_PKS_KS.1"
                     /domains="nrpspksdomains_cdmE_PKS_AT.1"
                     /domains="nrpspksdomains_cdmE_PKS_DH.1"
                     /domains="nrpspksdomains_cdmE_cMT.1"
                     /domains="nrpspksdomains_cdmE_PKS_ER.1"
                     /domains="nrpspksdomains_cdmE_PKS_KR.1"
                     /domains="nrpspksdomains_cdmE_PKS_PP.1"
                     /iterative
                     /locus_tags="cdmE"
                     /monomer_pairings="pk -> Me-pk"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       10740..10787
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cdmE_0001"
                     /evalue="2.70E-05"
                     /label="PKSI-KS_m3"
                     /locus_tag="cdmE"
                     /protein_end="211"
                     /protein_start="195"
                     /score="16.4"
                     /tool="antismash"
                     /translation="GASIVIDTACSSSLVA"
     CDS_motif       10989..11027
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cdmE_0002"
                     /evalue="7.60E-04"
                     /label="PKSI-KS_m4"
                     /locus_tag="cdmE"
                     /protein_end="271"
                     /protein_start="258"
                     /score="12.6"
                     /tool="antismash"
                     /translation="FDDRANGYGRGEG"
     CDS_motif       11220..11267
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cdmE_0003"
                     /evalue="3.50E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="cdmE"
                     /protein_end="351"
                     /protein_start="335"
                     /score="12.8"
                     /tool="antismash"
                     /translation="YVEAHGTGTPVGDPLE"
     CDS_motif       12036..12089
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cdmE_0004"
                     /evalue="3.20E-06"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="cdmE"
                     /protein_end="605"
                     /protein_start="587"
                     /score="19.4"
                     /tool="antismash"
                     /translation="FVFTGQGAQWPGMGKMLM"
     aSDomain        join(12039..12168,12232..13055)
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cdmE_PKS_AT.1"
                     /evalue="7.90E-89"
                     /label="cdmE_PKS_AT.1"
                     /locus_tag="cdmE"
                     /protein_end="906"
                     /protein_start="588"
                     /score="289.8"
                     /specificity="substrate consensus: pk"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mxmal"
                     /tool="antismash"
                     /translation="VFTGQGAQWPGMGKMLMEFPIFRQSVEAASLHLQKQGSQWTLHDA
                     FDPIEDSKTDINNPIQSQTACTVLQVALVDLLQSWNISPSIVIGHSSGEIAAAYCAGAI
                     SREAAWNISYYRGLVSSILVKGGGGAMIAVGLHPQEAQKYINQLSPELQCMVQIGCYNS
                     PNNTTITGERNAILILQALLDENGVFNRVLATPVAYHSQYMQPVADTYSTLLRLSDLSV
                     GRMRQPQIDEEIVMISSVTGEPIGAKRLQDPQYWTQNLISPVKFMNALHQLKNFAPQFN
                     LQELLELGPHSALQSAIRESMADGQSTAPQIRYSHTI"
     CDS_motif       12345..12437
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cdmE_0005"
                     /evalue="2.00E-09"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="cdmE"
                     /protein_end="700"
                     /protein_start="669"
                     /score="29.9"
                     /tool="antismash"
                     /translation="ISPSIVIGHSSGEIAAAYCAGAISREAAWNI"
     CDS_motif       12855..12899
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cdmE_0006"
                     /evalue="2.60E-03"
                     /label="PKSI-AT-mM_m8"
                     /locus_tag="cdmE"
                     /protein_end="854"
                     /protein_start="839"
                     /score="10.5"
                     /tool="antismash"
                     /translation="DPQYWTQNLISPVKF"
     aSDomain        join(13269..13370,13427..13891)
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cdmE_PKS_DH.1"
                     /evalue="9.20E-25"
                     /label="cdmE_PKS_DH.1"
                     /locus_tag="cdmE"
                     /protein_end="1166"
                     /protein_start="977"
                     /score="79.8"
                     /tool="antismash"
                     /translation="HELLGSPDPDWDRREPRWRNFLRTSELPWLRDNKVNGGIIFPGVG
                     YSIMAMEAVKQISDRSISIAGYRLKQISMEAALIVPDTRDGLEVMTSLREVYDEGSTTS
                     PKYQFSVKTHDTMRNEWIEHCSGFIESKCESDSIEDMGTWRPLPWDAVHDLQFSEESCT
                     QIGSISAFYDALERSGFDLGPTLKNL"
     CDS_motif       join(13353..13370,13427..13486)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cdmE_0007"
                     /evalue="1.40E-05"
                     /label="PKSI-DH_m2"
                     /locus_tag="cdmE"
                     /protein_end="1031"
                     /protein_start="1005"
                     /score="17.7"
                     /tool="antismash"
                     /translation="WLRDNKVNGGIIFPGVGYSIMAMEAV"
     aSDomain        join(14828..15091,15169..15230,15291..15483)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cdmE_cMT.1"
                     /domain_subtypes="cMT"
                     /evalue="2.00E-34"
                     /label="cdmE_cMT.1"
                     /locus_tag="cdmE"
                     /protein_end="1651"
                     /protein_start="1478"
                     /score="110.1"
                     /tool="antismash"
                     /translation="QLKVLEIGTGFGSVTAHIIKALTSVEDMSQTVFGKYQYTNKHNSS
                     FEDVRQKCGDWLSLMDFQVLDVDQSVAEQGFEEHSYDLVISAHAFTRTVSLERSLKNAH
                     SLLKPGGKLLVIENVQPQYKSTPFVYGLFPGWWHSTEPFRSTTPLVSEDKWVELLEATG
                     FTTSSVKDVE"
     aSDomain        16195..17127
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cdmE_PKS_ER.1"
                     /evalue="7.50E-68"
                     /label="cdmE_PKS_ER.1"
                     /locus_tag="cdmE"
                     /protein_end="2199"
                     /protein_start="1888"
                     /score="220.8"
                     /tool="antismash"
                     /translation="LVWSDDEALSQPLSASEIQIDVQASGLTFQDGMAIRGDIDQHVFG
                     KQVAGTVTQVGQKVEALEPGDHVMALLVGSEQHSLSRSIRVNANFAQRLSPDADFMEAA
                     TIPTTFTAVHYALHNVARVMESEKVLVHGAMQAAGQAAIQLAKLAGADVFVTVKTFEQK
                     QKIETKYGIPENHVFIANEHLDAGIKEATGGASGVDIVLNFLHGSATRSAWQCVGMMGR
                     FVDMALKAPGRHRGLDMSPFSRNAMYIGVDIAALGTAHHPSIMKAFSKVGELFRQRLIF
                     GPGHKPFSYNNFGAAMIHIQNDSNMDTAVI"
     CDS_motif       16501..16545
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cdmE_0008"
                     /evalue="5.10E-02"
                     /label="PKSI-ER_m4"
                     /locus_tag="cdmE"
                     /protein_end="2005"
                     /protein_start="1990"
                     /score="7.4"
                     /tool="antismash"
                     /translation="AATIPTTFTAVHYAL"
     CDS_motif       16573..16632
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cdmE_0009"
                     /evalue="1.60E-05"
                     /label="PKSI-ER_m5"
                     /locus_tag="cdmE"
                     /protein_end="2034"
                     /protein_start="2014"
                     /score="17.5"
                     /tool="antismash"
                     /translation="EKVLVHGAMQAAGQAAIQLA"
     aSDomain        join(17250..17528,17589..17837)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cdmE_PKS_KR.1"
                     /evalue="3.50E-48"
                     /label="cdmE_PKS_KR.1"
                     /locus_tag="cdmE"
                     /protein_end="2398"
                     /protein_start="2222"
                     /score="155.8"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: (unknown)"
                     /tool="antismash"
                     /translation="ATYVIAGGLGGLGRSAARWMCSKGARHLILISRSGARTASAKELL
                     QDLASQGCKIKICQCDITDKDNLQIAMRECASGMPPIKGCLQSTMLLQDSIFENMSFQQ
                     FMAGIHPKVQGSLNVLDAIPDQLDFFLVLSSAASIVGNRGQANYNSANAFQDSLAEHLT
                     SKGIPGMSVNLGN"
     CDS_motif       17253..17351
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cdmE_0010"
                     /evalue="7.90E-17"
                     /label="PKSI-KR_m1"
                     /locus_tag="cdmE"
                     /protein_end="2256"
                     /protein_start="2223"
                     /score="53.8"
                     /tool="antismash"
                     /translation="TYVIAGGLGGLGRSAARWMCSKGARHLILISRS"
     CDS_motif       17688..17792
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cdmE_0011"
                     /evalue="9.50E-19"
                     /label="PKSI-KR_m4"
                     /locus_tag="cdmE"
                     /protein_end="2383"
                     /protein_start="2348"
                     /score="60.0"
                     /tool="antismash"
                     /translation="LDFFLVLSSAASIVGNRGQANYNSANAFQDSLAEH"
     aSDomain        18174..18401
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cdmE_PKS_PP.1"
                     /evalue="4.30E-12"
                     /label="cdmE_PKS_PP.1"
                     /locus_tag="cdmE"
                     /protein_end="2586"
                     /protein_start="2510"
                     /score="38.1"
                     /tool="antismash"
                     /translation="ASHVTEAIICKLSSVMSFPAAEIDPSQGLASYGVDSLVTVDFRTW
                     IAKDMGANLSTADILDDGNIIGLSEKIARQS"
     gene            order(19257..19277,19332..19770,19830..19916,19978..20201)
                     /gene="cdmF"
     CDS             join(19257..19277,19332..19770,19830..19916,19978..20201)
                     /codon_start=1
                     /gene="cdmF"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     171.4; E-value: 4.1e-52)"
                     /gene_kind="biosynthetic-additional"
                     /product="short-chain dehydrogenase/reductase CdmF"
                     /protein_id="BBG28485.1"
                     /transl_table=11
                     /translation="MGLLQDYVIIVTGSASGIGYATSSTALREGAHVFGVDVSPLPADL
                     CDHPNFQSFQGDLTEDSTAQAVVTACTQAFGNRIDGLLNVAGVLDNFASVDAVTDQIWN
                     KCLAVNLTAPVKLMRAVIPIMRTQKRGSIVNVSSKAGISGGAAGVAYTASKHGLIGVTK
                     NVAWRFKEENIRCNAVCPGGVLTNIGSDIDRESFDMEAFETMKPVQLAHMPDQSKGPRI
                     TPEEVAQVMIFLVSGLSSKVNGAVIPVDDAWSTI"
     gene            complement(20539..21318)
                     /gene="cdmG"
     CDS             complement(join(20539..20743,20801..21318))
                     /codon_start=1
                     /gene="cdmG"
                     /product="terpene cyclase CdmG"
                     /protein_id="BBG28486.1"
                     /transl_table=11
                     /translation="MDYFYGTSPPPEYERYASIVDAATLVQGFLWALNYGEASYRSIKD
                     RTYGMAIFPLCCNYAWELVYTVIYSSQNKYERIIMTTWLILNSIMMGFTIKFAPNEWRH
                     APLVQRNIPFIFLAGVAAFVIAQLALAATVGPGLAMNWVAALCYLLLTIGSLCQLMTRG
                     SSRGVSYTMWLSRFVGTYVGVICVYFRYNYWPQNFSWVDEPIMKCFSGISLAVEIVYGV
                     TLWHIRKQERHHIVEKSK"
     gene            complement(22293..23407)
                     /gene="cdmH"
     CDS             complement(join(22293..22860,22928..23204,23275..23407))
                     /codon_start=1
                     /gene="cdmH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ubiA"
                     /gene_kind="biosynthetic-additional"
                     /product="prenyltransferase CdmH"
                     /protein_id="BBG28487.1"
                     /sec_met_domain="ubiA (E-value: 2e-19, bitscore: 59.3,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVLKQPQHHHGKHGGRSFYQLIAYLMLTSRLDNYGMLFTSFGGA
                     GIYKSQDYTSTTSQASILRLAGLCTAHCVLLGAAGNTWNDWMDRDIDSKVARTKDRPLA
                     SGKISSGEAFTWMAFLYSTSVGMLKAMLGDRNVWPFMVPLTAIILVYPLGKRPIARKLR
                     IYPQYLLGIAVGYPTMYGWAAVYGPCMPISEILHRCVPLWIFLFFWSFYANTSYSYQDV
                     EDDRKMKVNSAYNLAGKRIRALLAILASIALSTIPFVLRPFSSAWLWLSWVGAWVPGII
                     QQLLSFDPSKPESGGVLHLSTVKLGLWTVFACTLELYLSNRAVI"
     gene            order(24089..24405,24464..24732,24784..25154,25209..25691)
                     /gene="cdmI"
     CDS             join(24089..24405,24464..24732,24784..25154,25209..25691)
                     /codon_start=1
                     /gene="cdmI"
                     /gene_functions="other (smcogs) SMCOG1087:hypothetical
                     protein (Score: 248.8; E-value: 1.8e-75)"
                     /gene_kind="other"
                     /product="flavin-dependent monooxygenase CdmI"
                     /protein_id="BBG28488.1"
                     /transl_table=11
                     /translation="MQNLGASMDNNKKFKVVIVGGSIAGLTLAHCLSKFGIDYVVLEKR
                     REIAPQEGASVGIMPNGGRVLEQLGLFDDVERAIEPLSVAQLVYPDGFCSESEYPKKLC
                     ERFGFPLAFLDRQMLLESLYANLPDITRVKTNSAVIAVEHEDDRVRVLTTDNCSYEGHL
                     VVGADGIHSTIRKEMWRAASSLHQGQVEDTNSMMNITYACVYGISSAHPLLKPGQQITC
                     FNDGWSILSVVGKNGRTFWFLFLKLEREYKYNEAPKYTKEDAIANCDRLSAHTFWDTVT
                     FGDVWSRREVFTMTPLEEGVFEQWSCGRIVCIGDSMHKFAPNIGQGANCAIEDAGELAN
                     ALARIFNDREKGDGFKPSTPDLSNMLEQFQGKRISRIKALYKVARLAIRLQARDGLAMT
                     LMGRYVMPYLGDKVADWASRDIADGAILEFLPPPERSGSGWQKYSQKSKKSNTPFILAV
                     LAGLGFLLTMFKQQWEYHQDS"
     gene            order(26160..26381,26440..26557,26611..26709,26763..26831,
                     26896..27495,27561..28006)
                     /gene="cdmJ"
     CDS             join(26160..26381,26440..26557,26611..26709,26763..26831,
                     26896..27495,27561..28006)
                     /codon_start=1
                     /gene="cdmJ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 129.4; E-value: 3.1e-39)"
                     /gene_kind="biosynthetic-additional"
                     /product="cytochrome P450 monooxygenase CdmJ"
                     /protein_id="BBG28489.1"
                     /sec_met_domain="p450 (E-value: 1.7e-39, bitscore: 125.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSEDLATSFLPPSYMWSLTLFALCLSAILMFPFLTGRRLSITHR
                     KQGWRISLVNTRGDFQNEAEQLIRMGFSKSPSAFRMSTDGGPRLILSQKHLDAMSDDDH
                     FNVAEAVKRDYLLDLFGFETAFHGTLHSEIVAPAVTAMTKKLVPLVPLMSKEAALGLEK
                     EWTDNSEYHDVPLQPTLGGVVARLASLAFVGPDLCRNPTWLEITVSYTINRVIAVYVLR
                     IFPSFLQPFVHWVLPPCRKLRAQIQQARELILPALKHERQLQSAGNAKRDPNRPFSSLA
                     WNDEYAAGRLYDPTVAQLRMIFVSIHTTIDMAVKVLVRLCEHPELIQPLREEIVTVCGE
                     NGLTHSSLERLLLMDSLMKETQRLEPASLATIARYTHRKTTLSDGTIVPKGTQVVLPNM
                     FMWNNESIYPDSNTFDAYRFLRMRDDPETAKLASFTRSSHIHTAFGHGKHTCPGRFFAS
                     DTIKIILCHILLKYDLQLCDGEAPAKKRYGFAMYRDPDARIRVRRRGVEGVSEGILAGF
                     "
ORIGIN
        1 ctattgtacc tcttgagacc gcaatcccat cgtctcctcc atcttatgat ctcccgccaa
       61 ccaaattgga acatcatgct gagtgatccc tgaacgccat ccaatcatct tctgtgcctg
      121 aggagtcata ctctcaacaa tcgttcgtgg tacatgcaag tgtgactcca taggagtaaa
      181 gtggcaagga tgtatacata acaacagtcc ctgtcgaaac gcgtcggact gattcgatcc
      241 tgctccgtgc cacaaacttc ccacgaatag cagggcatcc ccaggtcgga gagctgcgga
      301 ggaggcttga tcaggagtcg gtacaccgcg tgtgtcatcc cagacatgac tcccaggcac
      361 aaaacgagtc gcaccattat catcacggaa ctcagtgacc gctataagga tattgatcat
      421 caaatccgga tcacctggct gacggagctt cgtcactcga tacaagatgt catcgcggtg
      481 cagattctga gctggttcac cgggttcaat atgaaggact gagcctcggt tcatccagta
      541 atcgccaaag tgtggacgga aaaggggttc gaggatacta tgcatccact tgttgttgag
      601 aatgtcgtgt cggtatgtct tcgaaatggc tgtgaggttg gccacatgtt tggtcccacg
      661 gccaatgtcg actttgactc catcggggtt gaagtttggt cctccttcga agtcgtcgat
      721 ggcaggtttg atttcttctc ggaaagattg gactgtggct tgatcgagaa aatctttcaa
      781 aaccaccaca ccgtcctgtt taagaagttc aatgacctgt tctggggagg tattcgcctc
      841 cactcttttg atggcggaag cgtctgatgg taatttagtc atttttaaca aagcgcgtag
      901 gaaagatctc cagagcctta gagcaataga caagctggac tcgagttgac gggtgatcga
      961 atacatggat tctactgtac aagtgacgca tgaacggaac aagaacaagg tcggaggacc
     1021 aggctttaaa gcagttgtca ttactataac atcatcctaa catagtacat tatgacagtg
     1081 tagttattcg actgtcgata acctcttgtt gcgctattgt agtgcctatc gaaatgaatc
     1141 cttgcagccg ggtcgggtcg catatgatgt gatatgtctg catgtccacc acaatcatat
     1201 agtctccatc ttcctgtcag cctctgccac attgaaacta ctcaaaaaac ttactattta
     1261 aatcattgct tatagttaac gcaggccagt cggtaatggc tctttcaggg ttaatcgctg
     1321 atgacgcgag tcattatatt tacagccgtc tatttttcta cacactaatt ataccgctgg
     1381 actgatctat gctatttata agcctaatgg agtgctaata agaacaacca tcagatattt
     1441 acgtgtatat acaatgtgtc gaagtttgcg tttataaatg actgcacatg tgcatttgag
     1501 tggcgaccct ttacggtaag cgtagcccta agttaccttc gtattgctgc tgtacagatc
     1561 gaagaccgcg cagtaataca tcattaccaa tggactagtg gtataattac atttagctct
     1621 cgaatctaca tgagtgcaag caagccacct tttcaaaaat gcagtgacgt ccacgaggat
     1681 gaatcagaca aaaagatcat cgctcaaggt ttctacattt gtacacagga atgcagtttc
     1741 ttttctcgat atcccatgta agatacgtgc taggaaaaaa gaaaggttgg cacgtcaaaa
     1801 acgggtcagc tgatgagcaa tccgcattat attgctccca gcctttgtac ccagtggctt
     1861 cgcggaccga tttcccaaaa atgggaagta ataagagcgc ttataggttt atgactatga
     1921 atagtcttcc aagcatttgc aaactatcgc tataagacat ccataaataa aagagctgtg
     1981 cattttccga atttggaatc tgttgcagtg cagtgtcaag gtgcagatgg aaacagagcg
     2041 ccccctgctt ccaacccgat ctgctcgctc aagacatgtc tagctcctcg aggcatcatg
     2101 atctacccga gaccagatct gcatcctgca tatatcatga tcgccttgag tccttgccat
     2161 cgtgggccca aatatgacac cggcttctcc gtaactcctt gcttcgacga cttctcgatt
     2221 tggcacaggt ctctgcccca ttttgttggg cttctttgtt atggtgtggc aactgtgtac
     2281 tatgttatat ggtgtttgct tacgacaatt tcagttatag ccgaacaagc aaggtggcca
     2341 aagtgggagg gtggctggta ggcataggga catggcaacg acagatcagg aagtaaacgc
     2401 actatgcata tcatgtacat ggatatatct gtgttagtta cacaaacagt agctgggttt
     2461 aaagttgaag aaaacataca ctcggcgaaa cacggcagta ttctttctca ttgacatagt
     2521 atacttgcgc agtaactaat ttgttccttc tttggcagct gcttctaact accaacttgc
     2581 ctgcatcagc agaacacgcg gttaggaaga cgcatcggag ctttttcatt gtgtgaccgc
     2641 tgggcgataa atcggaagat gcaagaaaat cccaaagacc tcgcttgctt gagtgagttg
     2701 ccagcagact cacctagtca tggcggtatc caagcatctc cagacttgga gagtacgccg
     2761 cacgatatat cccccgacca agacaactac caactgcctc ctaaacagga agagagagtc
     2821 gaatcagtgt cggtaaaaga agatgcaaaa gatctcgaag atggtggacc tgagtatcca
     2881 tcgtcgtgga agcttgccgt catcatgctg ggactctgct tcgctgtgtt ctgtatggca
     2941 ttggtccgta aagcatcata aatctctgga tcgcaacagt catcatcatt ttactaacct
     3001 ttgcttcagg acaacactat catagcaacc gcaatcccaa caatcacgga cgaattcaat
     3061 tcccttgacg atataggatg gtacggaagc gcctatcttt tcacaacatg cagtctgaca
     3121 ctggtgtttg gaaagttgta tacgttctac tcaatcaaat gggtatatct cattgccatc
     3181 ctggtttttg aggttggatc tgttgtttgc ggcgcaaccc caaattccgt gggtttgatc
     3241 ctaggacgtg ctattgctgg ccttggtgga gctggaatat tttcaggctc catgctgatc
     3301 attgcacaaa ccatgccgtt ggagaggcgg ccaatctgta ctggacttct tggtggcctg
     3361 tatggagttg ccggtgtggc tgggccgctt atgggtggtg ctttcactga gtacgtcaca
     3421 tggagatggt gcttctacat caatatccca ttcggagcag ttacggctct gttcatcttg
     3481 tgcttcttca aagcaccgaa gcctatcaga aagacatcta gcattagaga gcaactggcg
     3541 caactggacc tacttgggtt gctatttttt attcctgcta ttgtgagcat tctactggca
     3601 ttacagtggg gaggcaccca atacgcgtgg ggaaatggcc ggattatcgg cttgttcgtg
     3661 acctttggtg ttttgatttt gatcttcatt gggattcagt ggaagaagca ggaaactgcc
     3721 accgtcaacc ctcgattggt caaagatcgt aatgtttccg gcgctgcctt ttactgtcta
     3781 tgtttgactg ggtcattcat tgtcttcacg tattatgtga gtgaaagtcc ccccctaacc
     3841 ttccatttct cttcactccg aagcaagtag acgagtactg ggctaattca actcacttca
     3901 gctcccttta tggttccaaa gcatcaagga tgtatcagcc acaaagtccg gtataatgaa
     3961 cctcccaacg atcctgggtg ttgtcatttg caccatcctc agcagtggtt ttgtcagtgg
     4021 gctcggatac tacacgccat tcatgtacat cgcacctgtt gtagcctcag ttggagccgg
     4081 actactttcg acattacaag ttcattcggg tcatgcggaa tggataggct accaagcttt
     4141 gtacggaatc ggattagggt ttggcatgtc acagcccatg gttgtcgttc aggctgtttt
     4201 ggctcctgct gatgtcccta ctggtactgc aattattacc tttatgcagt cgataggagg
     4261 tgccatattt gtctctgttg ctcagaacgt cttcaacaat cttttgttgc aaagactagc
     4321 ccaggatgcc cctaccgctg acgctgcgat gattgccgcg actggtgcga cttctttgca
     4381 atcggtggtt ccacagaatc tactaccctc agtactcgag gcgtataact cggctattac
     4441 gcaggctttc tatgtcggtg ttgctcttgc agcagtgtcg attctggggg cattgcctct
     4501 tcagtggatc tctgtgaagg gaaagaaaat cgaggcaggt gcctaacttt acgcaaaatc
     4561 ggtttagacg gaggatgact tggagtagag catatagttt aaaggctggg tgagctttta
     4621 tgttctctta catatatttt attatcagtt accagctatc gtcaatagat gtaatattat
     4681 actaatgttg catgctctat tgttaaatag aaggaccagg cctctgtaga atttcgcaat
     4741 aatcttttag gagttgaatc cgtaatttac aatgtacctg cgacacgcag atgttatctt
     4801 tgatcatatt tggaatctat ttccagcaat gcaggttatg aagacccggg cgttgccttg
     4861 ttagccctta acatgcccca aaggccctat aacttagtcc gcacaggaat ggaatcgaag
     4921 cctggaatcg gattacgcta gggacggtta ggggttatca tccctaaaag ggttcgcact
     4981 cctagcgggc actagccctg agagctaggg cgcttatgta gcgccacata gaaaaatatg
     5041 acgcgttgaa acgtaccaga aaagtctcca agtaaaatcc ctcacgagat aggtgctgat
     5101 caccatctat gcgttgttga tctggaaacc atacgctaac taatccgata ctttctaggc
     5161 cccattgttc taatgactat gatgcaaggg caaggctgga catatcttct ttctttatgc
     5221 actccgaagc cactagttgc acaatctttt cttccaatat ctgaagcaag atgaagttat
     5281 ccatttcaat agtttatggg actggagata gtttactgcg catgtaggtg tgctgctagt
     5341 tcctgtgctg cagtccttca gagacattta catagtcaag atgatgaatc attattttat
     5401 tatcaaaagg aaaaaaatcc aagtgcaaat cttgcggtga agaactggct gattctatcc
     5461 ggattgtcaa aaaaatgagc gtcatgcaaa cctggtaggt gagagagagt ttgtagctga
     5521 ttctagaatt catgctcttt tagaaaaaac tgagaaaata acggtctagt tacatctgaa
     5581 attttccctt ttttggatac aaaaattgaa atcattcttt caaaacatca cgatatctga
     5641 attatcaacg ggcacctgcc tttgagctac actcaaaatg ctctccttag agcctctcag
     5701 caggccggtc ctcgactcat cacagacctt gctggtgatt tttctgctag catttacacg
     5761 gcaaaattcg atctttcggt acctgagtat tccagttttg acgttcattg taaaggaaca
     5821 aatcactcaa ccgccagcag tggttgaaaa cttccatcaa tggttgaatg agagctctgt
     5881 accattcaac tatcttcacc atatcaatat tttggctctc acgagtatcg atcttcggaa
     5941 cgacaacaac ggtgtactac cgggtctgtt tgacagaatc aagagtgcct tcatctatca
     6001 gctcaatcct cgaggagttg gtacaaggta tcaagtcaaa aacatcccac ccgttccaga
     6061 gtactacaag aagaggaaag gatacctgtc tcagagatat cgcttcgtcg ttaggcagtt
     6121 atgtctcttt gtttggcagt atctcatcgt ggacgtggga tgctcactct ggcataattt
     6181 acctgaccag gaaagatttg cacttttcgg acctggaaca gaatggaaca taatcaatgc
     6241 tgggccacag caatggaagg ttcgcttgat ggccgcaatg atattttgga ctacagccag
     6301 aaacgccgtg gacctttccc atagacttgg ttctgcagtc ttgacgggaa tcggggcaac
     6361 atcggtgcat gagtggcccc ctatgtgtgg atcactgcga gatgcataca cattgcgcaa
     6421 tctctggggg taagttcaat ccattcacac ttctttctac tgttgctctt agtgactaat
     6481 atctttcagg aagtggtggc atcaacaact gagatggacg ctgagcagcc attcaaattt
     6541 cgtcactcgc cgacttttga agctcccacg ccggtctctc ctcgagcgtt acctcaacaa
     6601 cgcaatcgtt cacgtctttt cagcatttat acatgtcaat ggttggcgat tagccggaat
     6661 tcctgatggc tacataggtc cttcgctgtt ttacatgtct tttgtcggag ggtatttggt
     6721 tgaggacttc gtccaacata tctgggctac attgtttcga tcgagaagcc gcactagcac
     6781 tgggatattt tttgagagac tcacgggcat tttttgggtt gcaacttttc taacagtgac
     6841 cacaccttgg tggatctatc ctcttctgcg ccgcgagcat tctttcgcat tgcctgttag
     6901 tcttgtggaa tctgtaggca tgaataatgc tctcgcaatg attggtgtcg gagcattcat
     6961 tctcaaaact cgcttcgatg ctaacattta ggacacgagg atttaccttc gttgcaaaga
     7021 gatcgacggt taggtattgt cgtacgccta ggagataagg tgttgaagcc ctaaagacct
     7081 caaacgagac ttgcgaaggc cctatatagt atgttcaaat agtgtatcat ctggagttta
     7141 tttagtaatt taatccaaga gaccctattc atgtgtaaag aaatctaatt tgcttagaaa
     7201 cagaacttat tatcatgata taaacgagag ccatctgcaa tagctacctt tgtaatatat
     7261 atagttaccg aacatccatg gatatgcgtg acgagggttc ttttgcatca aacagtacta
     7321 acagtacgaa catttacact ttccttgaac ataaatgtat ttctaataca gcaaaaagct
     7381 atcgcaacaa tttaatgtca tatgcgtcta ggaagcgcac cgaagacagt ttgatggggt
     7441 ccttccatca tgtttttgga acgctttcta tcaacatata taatatatac ctaatatatg
     7501 catggtgtgt agttaacgac aaaagaacta gcaagaaata aaagagtttc tgatttgttt
     7561 ccctgtatca tgctacctaa gtaggcagcg aagctacttt tgcttgatca tgttgatgat
     7621 tgatgctgtt ctcttacttg caatagatat ctggacggtg catatacttg tagctactgc
     7681 tgacatcaaa aggcaggcta tacgtgattg tattcgtcta tcacaagatt atctagtaga
     7741 tatgcgtggt ttagaaaata agatagtaat gtgttgaaac tgtgtatgag tatgtgctcc
     7801 tactcgttcc ctgacaagaa acaggtctaa taaacctcct tgtgctgtag ccgcaagaca
     7861 tcctcgatct tgtcatctcc tgcctgccag attggtatct tgttctggtt gttcattgtt
     7921 cgccatccga ccatttgctg cgccaagggc gtcatacttt cgacgatttc ctttggtaga
     7981 tggaaatggg actccatggg cgtgaaatgg gcggggtgca ttgaaacaat cattcctcgc
     8041 cgataatcca aagaacggtt ttctcctgct ccatgaaaca agcttcccaa gtagacaact
     8101 gcatcgccag gttcaagaat tgccggtact gcttcatcgg agccgtaaaa cgtaggtgga
     8161 tgtgcagcat cccatttatg acttccaggt atcagctgag tagcgccatt gtcctctcga
     8221 aattccgtaa gagacacgag aaagttgatc ataaactctg ggtcattcag tcggcgccga
     8281 aaatcactga cacgatagac cccggtatct cgatggaaga actgggcctt ttcgccaggt
     8341 tcaaggtgaa ggatatgagc acagttcatc cagtaatcac cgaattcttc tccgtaaatc
     8401 tgctcgcaga cagcgtgcat ccatttgtga ttcagaacgt cattgcgaaa agtctcagat
     8461 gtcaaggcaa ggttcttcat gtgcttggtc tttttgccct ctccacgttt gtaaatttcg
     8521 tgtttgggaa tttcaccagc ctcctcgttg tattcttgat atctaggacc aaatgatccc
     8581 ttttccacag cggtgtcaac ttcttcttgg agtttttgga tagtctcaac gtccatgaaa
     8641 cctcgtacaa ttaccgcccc gtcctctttg atgtgacaga tcacatcgct caggggtgtc
     8701 gcgaaatcca ccttgtgagg tacagacgat ttattgatcg tgaccgtcat tttttcggct
     8761 gcgctttcct caaattatga ctcgaaaaaa attctagaga aaattcaaaa gctcgaagga
     8821 tgttgattga aagcaatgtt cggaatagag atgtgctcag cagaggctgg taaagtccga
     8881 agcaaactcg actgaggaaa ctacccactt ttatgtcaaa gaattacttc tcaagagagg
     8941 aaccagtgtc tcagcgagca cattgcaact gatcgaattg atgcctatag ggcactagtc
     9001 atctcctcgg atcgacgcag ccctaaaaag tacttactaa aggacccact tctgcttgct
     9061 gctcatctat gcccccatat ccaatagtaa ttctctttta catgctagta tatgagagat
     9121 ctcattcaaa tcgcaaaatc atacctcgtt ccgtatctgg cattttgaaa tcataaaatt
     9181 gggcaaaatt gactaaggat gtcgacatag ctactagcta cccgggtata aactagctac
     9241 ggtgattgga atgtaagggc aaatagatat catgtaagtt gcccagagcg aattgatttt
     9301 tttgacattg ttgttctgta tagacccata ttggatgtgc gtaaataccg cccgtggtga
     9361 gttatacacg actatcatca cagcagctac gaactagggc atatgattac cgatatttgt
     9421 ttacttattt aacttgatcg tgcatgcacg acgctgatga agatcaatct agatagagat
     9481 gcatctagat caacaaccat tgagtatgtg catgcattag aggtgtcata ctctaaaatg
     9541 actataccat gctcacagaa aatattcctc cttgcgtgtc tttatgcagg tggtggagaa
     9601 tgctgccgag tgatctgata gtagtcattg caaacaagga aggtatcaat ggtggatatg
     9661 atttgggtaa gatatgacgt tcataataag gaaagactcc gatagcttta cgcttctgga
     9721 cattcgcatt ttctcggctg caccagtttt acttgttggg gccatgatct cttatctcgc
     9781 taatggatat acgagtcttt attgctttag tactggaaaa cagctatgga tgtcttactc
     9841 ggcatcaagt ggcatatgca aggataggct taattttcat agcacgatgt gacacgctac
     9901 gcattgaagc cgcatgctct caagatcggt gatatagctt cttgtgtgtt gaagttatca
     9961 aaatagcaga ggtagactag tctataaaac taccagataa tatctccgaa tttggttttg
    10021 tcgtgccacc attgatcttg tacaatattt tgctacttgc ttcgttattc cagctttctc
    10081 taactccatc gcgtcaaaat ggttctgcat ccatcagata gaagattccc tgagacaaac
    10141 ggagtagggg gacactccaa agactcttca gcgaagagcg gatacacatc cctagaacct
    10201 ctagcaattg tcggtttcgc ttcccacctc gccggagatg ctacggataa tgagaacttg
    10261 tggaagcata ttctcgaagg acaatctgca tccggtccgt tccctcaaaa tagattgcag
    10321 ggcaatcagt acttccatcc cgatcctgag catggaggaa catgtgccac gaagggtgga
    10381 tatttcctga aaaaggacat tgacaccttt gatgcgtctt tcttccgcct ctccgagtat
    10441 gacattgctg ctatggaccc ccagcaaaag attttattgg agaatgtgta tcatgctgtt
    10501 gaaaatggtc agttcctatc acatctggcc ttgttgatgg tccttcatta actggaattc
    10561 tagctggtct gccaatggag tcgcttgcag gatcaagaac atctgtctac gtcggtagtt
    10621 caacgaatga tcacgcagct ctgactaatg aggatctgga tttcacgatt aagaataaag
    10681 caacgggaac gttgccatca cttcttgcca accgagttag ttggttctac gatctgaagg
    10741 gcgccagtat cgtaatagat actgcatgct cgagtagtct cgtggccttg cacatggcat
    10801 gtcttgacat tcgggctggt ggatccgaga tggtacaaat ccatgtttgc atgaatcata
    10861 catgaccttt cactaattat tgagcaatct aggcaattgt tagtgggatt aatctgttgc
    10921 agcatccagc gtctctgatg ttgctcagca atcttggcgt tctttcacct gatggccgat
    10981 cgtatgcctt tgatgatcgc gccaatggtt atggacgcgg cgaaggtgtg attaccgtcg
    11041 tcgttaagtc attgcaagcg gcgatccggg acggagaccg agtgcgggcc ttggttcgag
    11101 caagcggtgt cagttcggat ggaaagacag ccggaatcac tctgcctagc gaagaggaac
    11161 aaaaggtact cataagaaac gtctacgcca gtgcgaatct tgatgtgaac gaaacgacat
    11221 atgtggaagc ccacggtact ggtacgccgg ttggcgatcc tcttgaatgc aaggctatca
    11281 tgtctgcgtt tcgaactcaa agacgcaagc aaacccttta cattggatcc attaaagcca
    11341 atatcggaca tctggaaggc ggagcaggcc tggcaggact cgtcaaagcc atcatgatgt
    11401 tagagaaaca gatcattcct ccgatagcgg gtctacagag attgaacccg ttgatttctc
    11461 aggatggtca taatgtttgt ttcactagag aggcaattcc ctggccaaag tcccatgtcc
    11521 gccgagcttc tgtcaattcc ttcggatttg gtggaactaa tgctcatgtg gttctcgaat
    11581 cgccagacat gtttttacat ggacgttctc ttgatactac gagtacctct ctcgtgcgtc
    11641 tgcctaatgg taaggactga ggactttcaa tattcgaatg taattggaga atcaaactaa
    11701 cagtcttagg ctatttgaat ggtatcaatg gccagaaaac gcctccggaa gactctccaa
    11761 agtcatatgt attcatgata tctgcgaacg atgagaatgg catccaacga aatgcgatgc
    11821 tcttaaagaa atacatcgac aattatctca agacacaatg ctctttctca gaagatcaat
    11881 tcatgaaaga cctcgtgtat acgttgagcg agaaacgttc aaggctcaaa tggcgtgctt
    11941 ctataattgc ttcatctcta accgagcttt ctcaacagtt aacaggcggc acgttaccca
    12001 agtttagagc tgcgaatact gaacccggaa tatcgttcgt gtttacaggt caaggagcac
    12061 agtggccagg aatgggaaaa atgctcatgg aattcccaat tttccgtcag agtgtagagg
    12121 ccgcatcact tcatttgcag aagcaaggca gtcagtggac tcttcacggt atgcattcaa
    12181 gctcccgccc actcatgaaa ttgatatggc tagctgactt gtcatgataa gacgcgtttg
    12241 acccaataga ggattcgaaa acggatatca ataatcctat tcaatctcag acagcatgta
    12301 ccgtattgca agtggccctg gtcgatcttc tacaaagctg gaacatttcc ccaagcattg
    12361 ttatcggaca ctcctccggt gagattgcag cagcatactg tgccggagct atttcgaggg
    12421 aagctgcgtg gaacatcagc tactatcgcg ggcttgtatc atcgatactt gtcaagggtg
    12481 gaggtggtgc gatgattgct gtgggcttac atccccagga agctcagaag tacatcaacc
    12541 aactgagccc cgagctccag tgcatggtac aaatagggtg ctacaacagc cctaataata
    12601 ccacaattac tggtgaacga aacgcgatct taattttgca ggcacttctg gatgagaatg
    12661 gggtattcaa ccgtgtatta gcaacgccgg tggcgtacca ttctcaatat atgcagcctg
    12721 tcgctgacac ttactccacc cttctcagac tgagtgatct ttcagttgga agaatgcgac
    12781 agccacagat tgatgaagaa atagttatga tatcttcagt gactggggaa ccaatcggcg
    12841 caaaacggct tcaagatcct caatactgga cgcagaacct gatatctcct gtgaagttca
    12901 tgaatgcact tcatcagctc aagaatttcg ctcctcagtt taacttgcaa gagttgttgg
    12961 aattaggacc tcattctgcc ttacagagcg ccataagaga atcaatggca gatggtcagt
    13021 cgacagcccc ccagatcaga tatagtcata caataacgag aaagaaaatg acttattcga
    13081 ctattttgag caccgccgcg ggtctattct gtcgaggtta tcccgtgaat cttgttgcca
    13141 cctcctgcac tgattcccac catggcacac tcctgacgga tcttcccggc tatgagttca
    13201 accacgatgc agggcttcgg gctgaaagcc gacgtatgaa aaacagtcga ctacctgaat
    13261 ttccaagaca cgaattactt gggagccccg atccggactg ggatcgaaga gaaccgcggt
    13321 ggcgcaactt tctacgcacg tctgaacttc cgtggctaag ggataacaaa gtgagtacag
    13381 atgtcctctg actttgatga taatacttgc taactgtaaa acacaggtca atggtggtat
    13441 catatttcca ggagtgggct attccatcat ggccatggaa gctgtcaagc aaatttcaga
    13501 ccgctctata tccatagccg gctatcgtct gaaacaaatc tccatggagg ctgctctgat
    13561 tgtacctgac actcgggacg gcttagaggt aatgactagt cttcgtgagg tctacgacga
    13621 ggggtcgact acatcgccta agtatcagtt ctctgttaag acccatgata caatgcgcaa
    13681 tgagtggatc gaacactgct ctggatttat cgagtccaaa tgcgaatcag attctatcga
    13741 agatatgggt acatggagac ctttgccatg ggacgccgta catgaccttc agttttcgga
    13801 agagagttgc acacaaatcg gtagcattag cgcattttat gatgctctgg agcgctccgg
    13861 attcgatctg gggcctacat tgaagaactt agtggatgtg cgaacctctg caacctcacc
    13921 acactgtatg accaagatgg ctgctccgtc aatcgccgag cacatgccga agggatacaa
    13981 ctttccgtac atcattcatc cttccactat ggaaagtatg gctcacgcca ttctacatgt
    14041 gtgcacaaca aaggaagctc ctgttggctc agcgttactc gccagataca ttgacaatat
    14101 ctggatttcc aacaagattc caatggatcc aggccatttg ttcgtgacag ttgctgatgg
    14161 agagcaagtt tcgccaggaa aatggcgctg tgcaattaca gtttggaacg atgcaacgaa
    14221 ggaggtcgtc atccaaatcc gtggtaccga actatgtttg ctttctgcag gacgtggtga
    14281 ccagaagacc gttccggagt gcttcctcgt caaatggtat ccttcccttg accttgtgac
    14341 cgacaaattg ccattcgctt cgctttcatc tccggaaaca ggtgtgacag aagcaagaca
    14401 tgcgcataag acttacgaac agctctgcac tttgtatatt gcacgagcac tgaaaagtct
    14461 gcatggctat gaccggaaat tactaccaca acacctccaa cagtatttag attggatggt
    14521 caggcaaact atggattccg atgcgcatac gatgagagca attcttgttg aaaacgaagt
    14581 caagctgaaa gaggaatcag gaatgctaga agcgctccgc acacaggccc aagggcttgg
    14641 ctcgcgagga gagctattgg taaatgtggg tgaccacata gtgcctttga tcaagggcga
    14701 aaaagaccct cagtcaatca taattggggg aaacgatctg agaccgtgga ctctagatca
    14761 agatctatca ggtaatatca aaaacgtact ttctgataac ctgaaagccc tcagacacgg
    14821 tcaggggcaa ttgaaggttc tggaaattgg cacaggattc ggcagcgtga cagctcacat
    14881 catcaaagcc ttgacttcgg tggaagatat gagtcaaacc gtgtttggaa aatatcaata
    14941 cacgaacaag cataactctt ctttcgaaga tgtccgtcaa aaatgtggag attggttgtc
    15001 cttgatggat ttccaagtgc tcgacgtcga ccaaagtgtt gctgagcaag gattcgagga
    15061 gcactcatat gaccttgtca tttctgccca tgtaagatat attcgtcgca cggttggcct
    15121 ggagagctat ttggccatct tattgcttgc atgctaatca gatcataggc tttcacacga
    15181 acggtatctc tagaaagaag cctcaagaac gcacactccc tgctcaagcc gtaagtttgt
    15241 tgaataccct gttagtttct tcgcctctgg tcattgctaa ttgaatacag cggcggcaag
    15301 cttctcgtga ttgaaaatgt gcagccccag tacaagtcta ctcctttcgt ttatggtttg
    15361 tttcctggct ggtggcatag caccgaaccc ttccgctcaa cgactccatt agtctccgaa
    15421 gataaatggg ttgagttact tgaagccact gggttcacca cttcatctgt caaggacgtg
    15481 gagaatgaaa aatcaaacga gacttgttta tttctatcaa cagcgatacg gacaaaagag
    15541 ctcatcgcgg cacctccatt cgatgacatt gttcttactc accacgccta tgatcccaag
    15601 aacttagtgt cctctcttct ggccgccata aaacagattt cagggctacc agtgatcgta
    15661 gttcccttca gtcagctcag ccatcgcaaa atggaacgat ccttctgtat agttgtgggt
    15721 gagcttgggc aaggatatct tgatctgtct tgtgtcaatg aggacattta ccgggaaatg
    15781 aagcggctat tactgacatg tcagaatcta ctatggatat ctctagacga cgtcgactat
    15841 cctaaggcgg cactcagtac cggtctggtg agaaccttgc gatgggaaag agaaatggac
    15901 aaaatcaact tcctgacatt gaaattcgca caatcgtctt ctcatgttcc agagatagtg
    15961 tcagccgtta caagcttata tcaacattac tttgacggta aggttgaagc ttcaccgaac
    16021 agcgagtttc tatacaagga cggttccttc tgggtaaacc gattgtatcc cgccaaaacc
    16081 gccaacaact ttttgcaatc tcatatctcg gaagctcccc agtcacaaat gctgggcgac
    16141 aatgtagacc gatcactcaa agcacgtttc aaaggctctg gtcgacaagg cttattggtc
    16201 tggtctgatg atgaagccct atctcaaccc ttgagtgcct cggagattca gattgatgtt
    16261 caagcttccg gtctaacatt tcaagacggt atggctatta gaggggatat cgaccagcac
    16321 gtttttggca aacaggttgc aggaactgta actcaagttg ggcagaaggt ggaagcactg
    16381 gagccaggcg atcacgtaat ggctttgttg gttggatctg agcagcacag cctgtctcgc
    16441 tccattcgtg ttaatgccaa tttcgcgcag cggctttctc cagatgcaga ctttatggag
    16501 gcggctacaa taccaaccac gttcaccgct gttcattatg ctttacacaa tgttgctcgt
    16561 gttatggaga gtgaaaaagt cctggttcat ggggccatgc aagccgctgg tcaggcagct
    16621 atccaactgg ccaaactggc tggagcagat gtttttgtga ctgtcaaaac cttcgaacag
    16681 aaacagaaaa ttgagacaaa gtatgggatt ccggaaaatc acgtcttcat tgcgaacgaa
    16741 cacctagatg ccggcatcaa ggaggcgacc gggggggcat caggagtcga tattgtactc
    16801 aattttttgc atggtagtgc gactcgcagt gcctggcaat gcgttggtat gatgggtcgt
    16861 tttgtcgata tggctctcaa ggctcctggt cgtcatcgag gtttggacat gtcgcctttc
    16921 tcacggaatg caatgtatat tggtgttgat attgcagcac tcggtacagc ccatcatcct
    16981 tcaattatga aggcattttc caaggttggc gagctatttc gtcaacgctt gatatttggt
    17041 cccggccata agccattcag ctacaacaat tttggggctg caatgattca tatacaaaat
    17101 gactcgaaca tggatactgc ggtgattgtt ccgaaggcag acgacgtgat acaagtaagt
    17161 tatcaaggat ggacttcgag atcttcctct gactaaattt gttctaggtg gttccatgta
    17221 aatatactgc atatgagttt ccaacggacg ctacatatgt tatcgcaggt ggccttggtg
    17281 gtttaggtcg aagtgcagct cgttggatgt gttcaaaagg cgcccgccat ctgatcctga
    17341 tatctcgatc aggagctcgc accgcatccg ccaaagagct actacaagat cttgcttcac
    17401 aaggatgcaa gattaagatc tgtcaatgtg acataactga taaggacaac cttcaaatcg
    17461 ctatgcggga atgcgcgtcc ggcatgcctc caatcaaagg ttgtttgcag tcaacaatgt
    17521 tactgcaggt gagcttctga tgtttgatat aatgcctcga agtttgacta acattttcca
    17581 ctccgcagga ttcgatattc gaaaacatgt ctttccaaca gtttatggca ggaatacacc
    17641 cgaaagtaca aggatctctc aatgttcttg atgctatacc tgaccagcta gacttcttcc
    17701 ttgttctctc ctcagcagcc tccattgttg gaaaccgagg acaagctaac tacaactccg
    17761 ccaacgcatt ccaggattca cttgccgaac atcttactag caagggcatt ccaggcatgt
    17821 ctgtcaacct tggcaatatg ttgtccgttg gctgggtcgc ggaaaacgag ggcgcactcc
    17881 ctctcgatct tgtgtactct tcaattgacg agccagaatt ccacgctctc ttagagtatc
    17941 atttggatcc ccgctgggga gcctctcagt ctgtcgagac atgccacaca attgctggcg
    18001 tgcgttccgc gactcgattc aatgaagacc ggactcccat accaagtttc atgaacgatc
    18061 ctttgttcac cattatcaga gagtctacca atggaaccac tgataacggt gagcaagagc
    18121 gtgagatctc aatcagcacg ctgctcaaag agtcctcatc tgttcaagtc gccgccagcc
    18181 atgtgaccga agccattatt tgcaaactct ctagcgttat gtccttcccg gctgctgaaa
    18241 tcgacccttc gcagggtctg gcatcctacg gtgtggactc tctggttacc gtggatttcc
    18301 gaacttggat tgcaaaggat atgggggcga acctctccac ggcagatatc cttgatgatg
    18361 gtaacattat tggtttaagt gagaagatag cccgccaaag caagttcgtg aaggtggctt
    18421 gatttgatac aaaccacggt actctattca caccgatggt ctagataaga tagcaaagcc
    18481 caaatagtgc agtcctcaat tcactgtctc cttctagtgt ggcgtcctat ttacttagac
    18541 ttgcatttgg aattatctta gctgcatacg atgttattca atacaagaat tttagatata
    18601 tttattgttc tcaaccatgg gaattgagat tcgagcttgg aagtacttta attcgttacc
    18661 taggtatatt gaaatgtcca ctgttcaggc gtatgcaatc tccctaagtg ctccctagga
    18721 gctacttctc tcaacatttt caaggttcat tcaaggggat acataataac acctattctt
    18781 tatctgtagt ggcaagtcct gcatggaaca ctcggtacga atatttggct taaagtagca
    18841 accgtcatgg catctgctcg atatatggac aagatatcat gcgcgttacc gaagactatc
    18901 ttatctaggt agaaagaaca ttaaacacca gggggcgaga ctaggtattt tgaacgcgtg
    18961 tcactcccag tcctctataa tgtcgagccc agctttgaaa aagagcagtc acacagtgtg
    19021 atactaggca atgcagaagc ccgatagctg ctgatcttgc ccccgctttc aatgtcactc
    19081 acagcctacg ccagtggaac ttgtaagggg gaatgtaaaa atgaaaagga catcctttgg
    19141 aaagatctga tcatagtcct tcctttcaat ctttcaaaaa atataacttt catttgggta
    19201 gcactattca ccagcaagtt ttcaaggtta ttacgtccaa accgtctata acaaacatgg
    19261 gtcttctaca agattatgta cgtgctaata gactctgaca attaccattg tgttacttac
    19321 tcgaattata ggtcataatc gtgaccggca gcgcttctgg gatcggatat gcaacttctt
    19381 caactgccct ccgtgaagga gctcatgtat ttggcgtgga cgtgtctccg ttgccagcag
    19441 atctttgtga tcacccaaat ttccagagct ttcaaggaga cctgaccgag gattccactg
    19501 ctcaagcggt agttactgct tgcactcagg ctttcggaaa taggattgat ggtctgctca
    19561 atgtcgccgg tgttctcgac aactttgcaa gcgtcgacgc cgtgacggac caaatctgga
    19621 ataagtgctt agcggtgaac ctgacggcgc cggtcaagct gatgcgagca gtcattccta
    19681 ttatgaggac acagaaacga gggagtatcg tgaatgtatc aagcaaagct gggatcagtg
    19741 gaggggcagc tggagtggca tatactgcta gtaagtcaga ctcctgcagt caggtaaatt
    19801 gcatgacata gcttaccaac aattactagg caagcatggc ttgattggag tgacgaaaaa
    19861 tgtagcttgg agattcaagg aagagaacat tcggtgcaac gcagtctgtc caggtggtta
    19921 gtttcatggt tttcttctcc ccccatagaa atttaacttg actgacaggt ggtccaggag
    19981 tgttgacgaa tatcggcagt gacattgacc gggaatcttt tgatatggaa gcttttgaaa
    20041 cgatgaagcc ggttcagttg gcgcacatgc cagatcagtc aaaggggcca aggattacac
    20101 cagaagaggt cgcccaagtc atgattttcc tggtttcggg cctaagtagc aaagtaaacg
    20161 gtgcagttat tcccgttgat gacgcttggt ctacaatata agaattagtt tttagttggg
    20221 ttgaagttcg aaacaaagat gatttacatt gtaacattcc tattttgttg agaacaataa
    20281 acaatctttc actaaatccg atgatatgct cgacaatctc cataaataac taacattgaa
    20341 gtatttgata tatggcacaa tgtacaattg tgtcctcatt actaatgctt tcaaaatcac
    20401 caatacacaa tcttgatccc actacttcca gccttcacct gggcaaactc acccctccgc
    20461 ccagaacctc atatccctca ggtgccaaat tgaagtcatc actcactggc ttccctgacg
    20521 ggaagctatc agatacgctc acttggactt ttccacaatg tggtggcgtt cttgtttccg
    20581 gatatgccag agagtgacac cataaacaat ctcaactgcg agcgagatac cagagaaaca
    20641 tttcattatt ggctcgtcta cccaagaaaa gttctgcggc caataattgt agcggaagta
    20701 aacacatatg actccgacat aggttccaac gaaccgcgat agcctttcaa aatcagcatg
    20761 gatcagggga gagttcaaga aacccgaaga gatgacctac cacatcgtat atgaaacacc
    20821 cctagagctc cctcgcgtca tcaattgaca taacgatccg atagtgagca atagatagca
    20881 taaagctgct acccagttca tagcaagccc tggtcccaca gtagctgcca gggcgagctg
    20941 agctataaca aaagctgcca cccctgctag gaaaataaat gggatgttgc gctgaaccaa
    21001 tggggcatgc ctccactcat ttggtgcaaa cttgattgtg aatcccatca tgattgagtt
    21061 gaggattagc cacgtcgtca taataatccg ctcatacttg ttttgtgagc tgtagatgac
    21121 cgtgtagacc aattcccaag cataattgca acacaaaggg aatatggcca ttccgtaggt
    21181 tcggtctttg atggaccgat atgacgcctc tccatagttc aaggcccaga ggaaaccttg
    21241 cacaagtgtg gcagcatcca caatactagc atagcgctcg tattccggtg gtggtgatgt
    21301 gccataaaaa taatccatgg ctggtagatt tgtggctggt ggagttctgg caaattcagg
    21361 cttgactctg aacgtttgac gaggtcctga atgtattttt caaaattgat acaatccatt
    21421 gtcgaatcag aagtctttat atctacatag ttactaaatg tcctatttgg gtcactggag
    21481 aacttccact tatcatctgc aaggggtcat cataataagc aagcatgtct catgcatgtg
    21541 gaaatcagaa aagtcatggt ttttcttgac ttcgtttgtg acgtaggcga ttagtcgtga
    21601 tgttgatcgg gtacatccag ccacctagac aatcagtgca tatggtgaag ctactagtga
    21661 cctgcatgag atgcagattg cgcacttaag tcttagacta tcgaaaccta ccatcttgga
    21721 atttggtaaa ggtaattgct attttcggtc tcaagcagca aagcgccttc ttccaccctc
    21781 ttcatgacct gtaacatttt tcatctgctt tctatagact tgggtcccta attcgaataa
    21841 tgtatgtaaa ggtcggcaat ttcttacagg aatagactcc atagtcgatc taggtataat
    21901 ctcatgaggc ccaatcatgt agtatgaagt ggttgttctt ttctggtatc ttttccagat
    21961 cacataccac atgttatcca ttgaattgta ctgatatgat acccagtctc acagtctcag
    22021 catgtagtag attgtattta ctattcacga aattgatcgt atgaagtctt tataatgcca
    22081 tattctgagc gtcataggct gcgaaggctc aattcaattc actatactat ctcatagacg
    22141 tgtccacata taaaaaaaca tatctaatag attcccgagg tcccttttgc atctagctaa
    22201 gctcaccgcc actcagctag attcatggat tgctcgtaca gatctatatg gggcttcgat
    22261 cccacatggc aatcccaatg tctgcaactt cactagatga cagctctgtt ggacagatag
    22321 agctccagtg tacaggcaaa aactgtccac agacccaatt tcacggtcga aagatgcaag
    22381 acacctccag attccggttt gctaggatcg aaagaaagta actgctgtat gattcccggc
    22441 acccaggctc cgacccatga taaccacaac caggccgagg aaaacggacg tagcacaaaa
    22501 ggaatggttg agagagcaat tgatgccaag atcgcaagaa gagcccgaat ccgcttgcca
    22561 gctagattgt acgctgaatt cactttcatc ttgcggtcgt cttccacatc ctgataacta
    22621 tatgaggtgt ttgcgtagaa gctccagaag aaaagaaaaa tccagagagg tacacagcga
    22681 tgcaggattt ctgagattgg catgcagggt ccgtagacgg cagcccaacc gtacattgtc
    22741 ggatatccca cggcaatgcc taagaggtat tgaggatata tgcggagctt gcgtgcgata
    22801 gggcgtttgc cgagaggata gaccaggatt atagccgtca aaggcaccat gaagggccac
    22861 ctatattgat atggtcagtc cagcctcccg agaagtcaat cgatagtagc ccggtttgat
    22921 aactcacacg ttgcgatcac ccaacatcgc tttcagcatt cctacagacg tcgaataaag
    22981 aaatgccatc caagtgaacg cttcacctga cgagatcttg ccagacgcta acggacgatc
    23041 cttggtcctt gctaccttgg aatcaatatc gcgatccatc cagtcgttcc aggtgttacc
    23101 agctgctccg agtaagacgc agtgggcagt gcaaagaccg gccagtcgta aaatcgaagc
    23161 ttgggaggtg gtagaagtat aatcttgcga tttgtatata ccggctagta atgtggaaat
    23221 cacttgtgat ggacttagcg cttgccatga tacagggcct gagaagtaac ttaccacctc
    23281 cgaacgacgt gaacaacatc ccatagttgt ctagcctcga agtgagcatc aggtacgcaa
    23341 tgagttgata aaatgaacgt cctccatgtt taccatggtg atgttgaggt tgtttgagga
    23401 cagccatatc gatttgatag aaatcaagat gtgattccta tacactgaaa ggatgtacag
    23461 aaataaccag gagcggtata aaaaactgaa caaccagcac ttcttaaagt atcatcaact
    23521 tgccctgcgg actcttttgc aaattacatc aaatgcttgt tctcgtaaac aagcttggcg
    23581 atctgcacga tgtacaatat tgaagctaca gctcatacta cttgatcact agtgattatt
    23641 ttactagatc atccattacc cgagcaattt ttgcccttct cgttacaaaa tacgtacgta
    23701 tgcccaagcc agacgggtcg accgtatttt gatgcatacg agtaagccca aggtagatta
    23761 gcgaagagcc aatttgagtc aattcagagc ctgtcatgac tggggctgaa aaccgactat
    23821 tgaaaagacc tgcacttcga ttatgcataa gcaacgcata tcaatctaac agactagata
    23881 gacaccttgc gcaagacata tgcattcggc ccgccggcga tcccacgttc gatagatata
    23941 tcatttagat agtgtcgggc gaatcgagca aggggctaag tggcgttcga gggcaccaca
    24001 gtacaaaaat tgagcacttt gacgaatatc ttctatggta cagtgtacta atcaattcct
    24061 agttgcgtca gtccgtacaa ttcccattat gcaaaatctc ggtgcttcaa tggacaacaa
    24121 caaaaagttc aaagttgtga ttgtcggcgg ctccatcgca ggtcttacat tagcccattg
    24181 cctgagtaaa ttcgggattg actatgtcgt cctcgaaaaa aggcgtgaga tagcacctca
    24241 ggagggagcg tcggtgggta ttatgcccaa tggtggacgt gtcttagaac aacttgggct
    24301 gttcgatgat gtcgaaaggg ccattgaacc actcagtgtc gcacaacttg tatacccaga
    24361 tggattttgc tccgagagcg agtatccaaa gaagctttgc gaacggtagg acacatttaa
    24421 tcgtaccaca aaaaaatgtt ttaggctaat atgatgctct cagattcggt tttcctcttg
    24481 cttttctaga tagacagatg ttactagaaa gcctctatgc caatcttcct gatatcacac
    24541 gcgtcaagac taacagcgca gtcattgctg tcgaacatga agatgacaga gtccgagttc
    24601 tcaccactga taactgttcc tacgaaggtc atctagttgt gggagccgat ggcatacata
    24661 gcactatacg aaaggagatg tggcgagccg ccagttcctt gcaccaagga caagtcgagg
    24721 acaccaattc aagtaagtgt cagaattctt tactgtagac atgtagctaa gaagattctt
    24781 tagtgatgaa tatcacatat gcctgtgtct acggcatctc ttctgctcac ccgctcttga
    24841 agcccggtca acaaataacc tgtttcaatg atggttggag catactgagc gtcgtcggaa
    24901 agaacgggcg tacgttttgg tttcttttcc taaaattgga aagggaatac aaatacaacg
    24961 aagctccgaa gtacacaaaa gaggatgcta tcgccaattg tgaccgattg agcgcccata
    25021 cattctggga tacggtcacc tttggggacg tatggagcag acgagaggtt ttcactatga
    25081 ctccgcttga agaaggtgtt tttgagcaat ggtcatgtgg gagaatagtc tgcattgggg
    25141 acagcatgca caaggtatga aaggtcgaaa cagctctatc ttgcgaaaac tgacttgggt
    25201 gcccatagtt cgctccaaat ataggccagg gagcaaactg cgcaatagaa gacgccggcg
    25261 agcttgccaa tgccttggca cggattttca atgatcgaga gaaaggggat gggttcaaac
    25321 cttccactcc ggatctgagc aacatgttgg aacagtttca ggggaaacgc atcagccgta
    25381 tcaaagcgct ttacaaagta gccagacttg cgatccgtct gcaagcccgt gacggactcg
    25441 ccatgaccct tatgggacgg tacgtgatgc cttatcttgg tgacaaggtt gcggactggg
    25501 catctagaga cattgcagat ggtgcaatcc ttgaatttct tcctccacca gagcgctccg
    25561 gctccggctg gcagaaatac agccagaaat caaagaaatc aaatacccca tttattctgg
    25621 ctgtactggc tggactaggt ttcctcctga ccatgttcaa acagcagtgg gagtatcatc
    25681 aagactcata gctagcatga actctttcat caatacatga cctcttttgc catctctaga
    25741 ttttcagact tcactttggt ccctttttct agattttatg cttgactgca tcgcctgcgt
    25801 cttgtcaaat atgagtagac attccggtga ccgtttgatt tagacaccgc actatttcgc
    25861 gctattactc cttcgtatgt gtgcagacat aagtagaata taaacaggta aaaatacatt
    25921 cttgagtaga cgtgcatcca gatggcaaga tgcaaataca agctaaagct attagcctgc
    25981 actccgaaaa tatgtcatca tatgaggacc cgcaaaaatg gcactggaaa gctagggggt
    26041 gtaaagcttg ccatttaggt aagtcggagc ttgaaagtct caagtggtat ccgtataaga
    26101 ggggttcctc gtcccttaat ctattttcac cctattcttg atgtgactaa caccacaaga
    26161 tgttgtccga agacttagcg acctcttttc ttcctccctc ctacatgtgg tctctgacgc
    26221 tattcgcact ctgcttgtcc gccatactca tgtttccttt tctgacaggc cgtcgacttt
    26281 ctataactca tcgaaagcaa ggatggagga tttctttggt caatacacgt ggagactttc
    26341 agaacgaagc tgagcaactg attcggatgg gattctcgaa ggtcggcatt ttcacctctc
    26401 tcgtaatata gctacggatt ttaacgttga agctcgtagt cgccgtccgc tttccgtatg
    26461 tcgaccgatg gaggtccgag attgattcta tcgcagaaac atctagatgc aatgtcggat
    26521 gatgatcact ttaatgtcgc tgaggctgtc aaaagggtac gttttgcctc ttgtcaatcg
    26581 aactcttcct actcacattc aaattctagg actatcttct tgaccttttc ggctttgaga
    26641 ctgctttcca tgggacactg cacagtgaga ttgttgctcc tgctgtaaca gcgatgacca
    26701 agaaattagg tacgtccttc gttcctcact gctgctcttg ctatactcac ttcattgtat
    26761 agtaccacta gtgccactca tgtcaaagga ggccgcgctt ggtttggaaa aggagtggac
    26821 tgataactca ggtacctccc ccccccccct tctctttacc tcacagtagg aacaaacata
    26881 ataacaggat accagaatat catgacgtcc ctctgcaacc cactctaggc ggcgtagtag
    26941 ctcgcctagc atctctagcc ttcgtcggcc ctgacctctg tcgtaacccg acctggctcg
    27001 agataacagt gagctacacc atcaaccgcg tcatagccgt ctacgtcctt cgcatctttc
    27061 cttctttcct ccagccattt gtgcactggg tcctgccacc ttgccgcaag ttaagggctc
    27121 agatccagca agcgagagaa ctaatccttc cggccctcaa acacgaacgt cagctgcaaa
    27181 gtgctggtaa tgctaaacgt gacccgaatc gacctttctc gtcactagct tggaatgatg
    27241 aatatgccgc tggccgtctt tatgatccca ccgtcgcgca gctccggatg atctttgtct
    27301 ctatccatac gactattgac atggcagtca aggtcctcgt tcgcctatgc gagcatcccg
    27361 aactcattca gccacttcga gaagaaatcg tgacagtctg cggcgagaat ggattgaccc
    27421 attcctcgct ggagagactg ttgctgatgg acagtttgat gaaggagacg cagcggcttg
    27481 aacccgcttc tttaggtctg ctcccctctg cgatgacatc tttctcattg tatagcctta
    27541 gctaacgctc tgcatcatag ccacaatcgc gcgttacacc caccgcaaaa caaccctctc
    27601 agatggcacc atcgtcccca aagggacgca agtcgtccta cccaacatgt tcatgtggaa
    27661 caacgagtcc atctaccctg actccaacac ctttgacgct taccgcttcc tccgcatgcg
    27721 cgacgatccc gagacagcga aactcgcctc cttcacgcgc tccagccaca tccacacagc
    27781 ctttggacat ggcaaacata cctgtcccgg tcgattcttt gcgtctgaca cgatcaagat
    27841 catactctgc catatattgc tgaaatatga cttgcagttg tgcgatggcg aggcgccggc
    27901 taagaaacgg tatggattcg caatgtatag ggatccggat gcacggatta gggttcgacg
    27961 acgaggggtg gagggtgtgt ctgaggggat actggctggc ttctag
//
