LOCUS       BGC0001937              8410 bp    DNA     linear   BCT 12-SEP-2018
DEFINITION  Streptomyces tubercidicus strain NBRC 13090 tubercidin biosynthetic
            gene cluster, complete sequence.
ACCESSION   BGC0001937
VERSION     BGC0001937
KEYWORDS    .
SOURCE      Streptomyces tubercidicus
  ORGANISM  Streptomyces tubercidicus
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 05:28:04
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..8410
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[443:821]"
                     /cutoff="20000"
                     /detection_rule="(LipM or LipV or LipU or ToyB or TunD or
                     pur6 or pur10 or nikJ or nikO or truD)"
                     /neighbourhood="10000"
                     /product="nucleoside"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      444..821
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(LipM or LipV or LipU or ToyB or TunD or
                     pur6 or pur10 or nikJ or nikO or truD)"
                     /neighbourhood="10000"
                     /product="nucleoside"
                     /protocluster_number="1"
     cand_cluster    1..8410
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(LipM or LipV or LipU or ToyB or TunD or
                     pur6 or pur10 or nikJ or nikO or truD)"
                     /kind="single"
                     /product="nucleoside"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..8410
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001937"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..8410
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="nucleoside"
                     /region_number="1"
                     /rules="(LipM or LipV or LipU or ToyB or TunD or pur6 or
                     pur10 or nikJ or nikO or truD)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1..177
                     /gene="orf-1"
     CDS             1..177
                     /codon_start=1
                     /gene="orf-1"
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="AVW83008.1"
                     /transl_table=11
                     /translation="MTSPPTDDPLVCLCAHVPESVILTAVDSGVRDIPALREATGANTG
                     CGDCLQDLEELLA"
     gene            444..821
                     /gene="tubA"
     CDS             444..821
                     /codon_start=1
                     /gene="tubA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     nucleoside: ToyB"
                     /gene_kind="biosynthetic"
                     /product="6-Pyruvoyltetrahydropterin synthase"
                     /protein_id="AVW83009.1"
                     /sec_met_domain="ToyB (E-value: 1.3e-65, bitscore: 208.8,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSITKEFHFSASHQLDGLPPDHQCGRLHGHNYIVLLELSAAQDE
                     LTEPGFVRDYGELGVVKKWLDDTVDHRHLNDLMPGVNPTAEHLAQWVYRTWSSDFPELT
                     AVRVSETPKTWATYRPAGPTA"
     gene            1221..1640
                     /gene="tubB"
     CDS             1221..1640
                     /codon_start=1
                     /gene="tubB"
                     /product="Radical SAM family protein"
                     /protein_id="AVW83010.1"
                     /transl_table=11
                     /translation="MLPVVQALAEHRIMVEFETNGTVEPSDALVAAGARFNVSPKLAHS
                     GVAEGRRIVPQALQRFGQMPGVAFKFVCGDASDLAEVEELVRRFGLKNIWIMPRGQSPE
                     EIDLGMRTLADDVIARKWNLSGRLHVNVWGSKRGV"
     gene            1641..2240
                     /gene="tubC"
     CDS             1641..2240
                     /codon_start=1
                     /gene="tubC"
                     /product="GTP cyclohydrolase I"
                     /protein_id="AVW83011.1"
                     /transl_table=11
                     /translation="MTSSIEVLSEDLPLLGEEGKDPLEAVARQLLVEIGEDPEREGLRD
                     TPARYARWWREFTQYDPGSVDTLFETTASGNLVGVSGISVWSLCEHHLLPFSCRFTIGY
                     LPQEKMLGLSKFARIAHQHAHKLQSQEQLSQQIADEVERLTGSPDVAVIGRGEHLCMAM
                     RGIRTPATMTTAVWRGALKDSALRSELIALTSDSNR"
     gene            2257..3414
                     /gene="tubD"
     CDS             2257..3414
                     /codon_start=1
                     /gene="tubD"
                     /product="Guanosine monophosphate reductase"
                     /protein_id="AVW83012.1"
                     /transl_table=11
                     /translation="MRISEPKRTGLSFDDVLFVPRRTSLTSRRHADPGTELLPGLTLRV
                     PVISANTQWCTGDRMATAMALQGGLGILHRMQTVEQQVAQLDAVKAAPVDGEQAGRATL
                     DDRGRLLAGAAVGVTGDWRERADRLVAHGADILLVDVAHGHSDQTIATVRELRAAYPDT
                     PLIAGNVATAEGVRDLAAAGAQVVKVGIGPGGVCTTRLVAGTGVPQLTAVMDCADAAAG
                     AGVAIIADGGIRQAGDIAKALAAGAQAVMLGSALAGADESEATPVERDGRHYRVSNGFV
                     SLGMELTLRSAAGGTVTQEEVDDYVPEGVEATFPASGPLARTLRQLVGGVQSAMSYSGA
                     RDLDTFRAQAEFIRVTAAGRAENVPHARERSVQIDIDHVAKAVAG"
     gene            3411..3995
                     /gene="tubE"
     CDS             3411..3995
                     /codon_start=1
                     /gene="tubE"
                     /product="Phosphoribosylpyrophospate transferase"
                     /protein_id="AVW83013.1"
                     /transl_table=11
                     /translation="MSAEQVAEPTAVAGEQPGMWTRQGPYLLDMATFGQLLEDIAGEVR
                     AAGFTPDAVLAVARGGLAAGGYLTCALDVPVMHTIRVRRTADDSRYAAKQRPVVDTSVP
                     LGLGAGDKVLVVDDIVGTGATADAVLEFLAAAGVAREDVRFAAVVRNHRSGYVPEHCPA
                     VIDDWIVFPWETSREATDDCRPFPAAARVHR"
     gene            3992..5260
                     /gene="tubF"
     CDS             3992..5260
                     /codon_start=1
                     /gene="tubF"
                     /product="UbiD family decarboxylase"
                     /protein_id="AVW83014.1"
                     /transl_table=11
                     /translation="MSGGFPGSGLTPAADAAAAGLPGCYDAVDLYTYDRPISSRVEVAR
                     TLAGIEQEHGARPTVVFTDIAERPGARVLCHPYPREVLLAALGTTEEKHLPEMSRRLAG
                     PVPSPGASSQLPVRRRELPGMLDDLPILQHRPGDAGPYITAGVGVTTRPDGSGVNMGFY
                     RTQVVGPNEARIFLDPRTDGHRNLLAWLETGRPMPISLFSGADPALTVVAASRLPAEGD
                     DYEIAARLLGRPVDVGGSVGGFPPVPDHATHVITGYVQEQDAVEGPFGEFKGYYAEARR
                     SNVLTVTGVFATPGAPWPTIVAGARSGLTLMSFQNEYLMYAQLHGLGHQIKSVHYSIRA
                     RGEFVAYIETDEPSQELVRAAMAFDVRSKVVICGPDLANPGQALATYGFTTRTEPYYRK
                     GRVEGERIGLALVIPPDGWPTEY"
     gene            5301..5807
                     /gene="tubG"
     CDS             5301..5807
                     /codon_start=1
                     /gene="tubG"
                     /product="Nudix hydrolase"
                     /protein_id="AVW83015.1"
                     /transl_table=11
                     /translation="MDRFARALPAALMVIPGPGDTVTFIRQLKGPYANNWLLPGGGIEP
                     GEPAEAAALREAREETGIAVTSCSLFSVYEFTGTWEQGGYHLLMFAFLADGEYALRPGF
                     DGDNVGAIRQARISEIDMHSTDLQILTDAGLASYDEETIARALAADGITMHAHRVASTA
                     RCGAP"
     gene            complement(5755..6699)
                     /gene="tubH"
     CDS             complement(5755..6699)
                     /codon_start=1
                     /gene="tubH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276:PfkB domain protein (Score: 85.4; E-value:
                     7.2e-26)"
                     /gene_kind="biosynthetic-additional"
                     /product="Carbohydrate kinase family protein"
                     /protein_id="AVW83016.1"
                     /transl_table=11
                     /translation="MGYDVLVLGSLVMDRKYFAVGSLGGAAPVWGVQRHHGGVGRNIAV
                     NTARLGARTAFAGLSGYGRDAADLEAELTGLGVRPLHLLRTEDGTGHWDVLLDEGGRQI
                     TSRIALPDPAAGRDLAGPALAGTVAAAKAVAAEGGLDEELLTWLSREAGKHGTPVVGLP
                     TRQRDFGPRAHLLPLYDVLLLNAREAQALTGQPGTPAEQARRLLGRGPRVVVVTAGADG
                     AAVASAEQPEPLTLPAEAGPCADDTGAGDALASAFLVHLVRGASPKAALALGLRAARLT
                     IACRQNTCRTLATDPALTARRTGRWTPPGERAS"
     gene            6889..8013
                     /gene="tubI"
     CDS             6889..8013
                     /codon_start=1
                     /gene="tubI"
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 79.7; E-value: 2.8e-24)"
                     /gene_kind="transport"
                     /product="MFS transporter"
                     /protein_id="AVW83017.1"
                     /transl_table=11
                     /translation="MTPISVALRADLSLSLAQVALLTSLVTSVAAVLGLFVSYLVRPLP
                     PHRMLVAGLAVMGAAGLFCARTDSFGAMLGGRLVEGVGYVVVVIVAPVLLFSLGDGKQL
                     TGALAIWGTFMPVGLALGSFAGGMLSMWLDWRGWLTVAAVGTLVVAVGATRLPAVAPKR
                     EEKTPPGADRAATVRRLARPMALGAGFATVSGSIVACVTLYPACLHEEFGLSMETAGTL
                     TGVVSLAGVAGGFLASWLLVRGIPVKFLFVATLLMPAGAFAAFAGTGGLGVSVGSALVV
                     ALANELVVATVFAAVPLAVRAAADLGAANGLVAQFGSIGALATPPLVGLAVTAAGGWWA
                     VGPCLLAVCAAGLVLLLIAVRQPSYGTRAAGEAA"
     gene            complement(8204..8410)
                     /gene="orf1"
     CDS             complement(8204..8410)
                     /codon_start=1
                     /gene="orf1"
                     /product="hypothetical protein"
                     /protein_id="AVW83018.1"
                     /transl_table=11
                     /translation="MHEKCEVEMSHCVTKTFRAMSLSLLSPPFTLPVLSAAQVPDGGVA
                     SASRGGLPQVATAMMATNNWAWD"
     misc_feature    complement(8255..8257)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 atgacctcac ccccgacgga cgatccgctg gtctgtctgt gtgcgcacgt cccggagagc
       61 gtcatcctga cggcggtgga ctcgggggtt cgcgatatcc ccgccctgcg cgaggccacc
      121 ggtgccaaca ccggctgcgg cgactgtctg caagacctcg aagaactcct ggcgtgaccg
      181 gccggggcct ctcgccccgg cccgccggcg ccccggtcgc acctggccgt tgaaggtcat
      241 ggcctgcaaa tgccaggggc aagcactgac accgagccgt ttcacccttc aagatctatg
      301 gagtgggccg gagagacctt ccgccccggc cacttcagag gacttcccgc gcgtcgcagg
      361 aaagcggata ccgcttcggg tgcacaccgg agccggtgcg cagccgacgc catgggaacg
      421 acacgggaga gaggatccgg accgtgtatt ccatcaccaa ggagttccac ttctccgcca
      481 gtcaccagct ggacggactt ccgccggacc accagtgcgg ccgactgcac ggccacaact
      541 acatcgtact gctcgaattg agcgccgctc aggacgagtt gaccgaaccc ggcttcgtgc
      601 gggactacgg cgaactgggc gtcgtcaaga agtggctcga cgacacggtc gaccaccgcc
      661 atctgaacga cctgatgccc ggcgtgaacc cgacggccga gcacctcgcc cagtgggtct
      721 accggacgtg gtcctccgac tttccggagc tgaccgccgt acgggtctcg gagacgccga
      781 agacctgggc gacgtaccgg cccgccgggc ccaccgcctg accgagcgcg acaacccgat
      841 tcgcagacca actccgggaa ttctccgatg aattcccgga cggacaagcc cgttcgggct
      901 tgagggggtg gtgaaaatgg cggttccgaa gctcgtggtc aacgagatgt tcggacccac
      961 ctagcgccgt acagggcgaa ggaccttcga ctggaagatc gtgtgcgttt ctccggctcg
     1021 gcggctgcaa tctcacctgc cgctggtgcg atacgccgta cacgtgggac tggaagggtg
     1081 agtcggacac cggcatcgcc taccgtgctg cggatgagct gcacaccctg accgtcaccg
     1141 aggtcaccga gcggctgctc ggcttcggtg tcgagctgat cgtcatctcg ggcggtgaac
     1201 cgctcagcca gcaggaccgg gtgctgcccg tggtccaggc gctggcggaa caccggatca
     1261 tggtcgaatt cgagaccaat ggcaccgtcg agccgtccga tgcgctggtg gccgcgggcg
     1321 cccggttcaa tgtgtcgccg aaactggcgc actccggggt cgccgaggga cggcggatcg
     1381 tcccgcaggc gctgcaacgc ttcggccaaa tgccgggcgt ggccttcaag ttcgtctgcg
     1441 gcgacgcgtc ggatctggcc gaggtcgagg agctggtacg ccggttcggc ctgaagaaca
     1501 tctggatcat gccccggggg cagtcccccg aggagatcga cctgggaatg cgcacgttgg
     1561 ccgacgacgt gatcgcacgc aagtggaatc tgtccggacg actgcacgtg aacgtgtggg
     1621 gaagcaagcg gggtgtctga gtgaccagca gcatcgaagt gttgtccgag gacttgcccc
     1681 tgctgggcga ggagggcaag gacccgttgg aggcggtcgc ccggcagctt ctcgtggaga
     1741 tcggggagga ccccgaacgg gaggggctgc gggacacccc ggcacgctat gcgcgctggt
     1801 ggcgcgagtt cacccagtac gaccccgggt ccgtcgacac cctcttcgag accacggcga
     1861 gcggcaacct cgtcggcgtc tccggcatca gcgtgtggtc gctgtgcgag caccatctgc
     1921 tgccgttctc ctgccggttc accatcggct atctgccgca ggagaagatg ctgggcctga
     1981 gcaagttcgc ccggatcgcg catcagcacg cccataagct ccagtcgcag gagcagctgt
     2041 cgcagcagat cgccgacgag gtcgagcggc tgaccggctc ccccgatgtc gcggtcatcg
     2101 gccgcggtga gcacctgtgc atggccatgc gcggtatccg tacgcctgcc acgatgacca
     2161 ccgccgtgtg gcggggcgcg ctcaaggact ccgcgctgcg gagcgagctg atcgcgctca
     2221 ccagcgacag caaccgctga ggggaggaca ccgcagatgc gaatctccga accgaagcgg
     2281 accgggctga gcttcgacga cgtgctgttc gtgccccggc gcacctcgct gaccagcaga
     2341 cgccatgccg accccggcac cgagctgctg cccggactga cgctgcgggt gccggtcatc
     2401 tcggccaaca cccagtggtg caccggcgac cggatggcga ccgcgatggc cttgcaaggc
     2461 ggtctcggca tcctgcaccg gatgcagacc gtcgagcagc aggtcgccca gctggacgcg
     2521 gtcaaggccg caccggtcga cggtgagcag gccgggcggg ccacgctcga cgaccggggc
     2581 cggctgctgg ccggcgcggc cgtcggcgtc accggcgact ggcgggaacg ggcggaccgg
     2641 ctggtcgcgc acggtgcgga catcctgctg gtggatgtcg cgcacgggca cagcgaccag
     2701 accatcgcca ccgtgcggga gctgcgcgcc gcctatcccg atacgccgct catcgcgggc
     2761 aacgtggcca cggcggaggg cgtgcgggat ctggcggcgg ccggggccca ggtggtgaag
     2821 gtcgggatcg ggccgggcgg tgtgtgcacc acacggctgg tggcgggcac cggagtgcca
     2881 cagctgaccg cggtcatgga ctgcgccgac gcggccgccg gggccggggt ggcgatcatc
     2941 gcggacggcg gcatccggca ggccggcgat atcgccaagg cgctcgcggc cggggcacag
     3001 gcggtgatgc tcggatcggc gctcgcgggc gccgacgaga gcgaggccac ccccgtggaa
     3061 cgggacggcc gccactaccg ggtcagcaac ggcttcgtct cgctcggcat ggagctcacc
     3121 ctgcggagcg cggcgggcgg cacggtcacc caggaggagg tcgacgacta tgtcccggag
     3181 ggcgtcgagg cgaccttccc ggcctccggg ccactggccc ggacgctgcg tcagctcgtc
     3241 ggcggggtgc agtccgcgat gagctactcg ggcgcccgtg acctggacac cttccgggca
     3301 caggccgagt tcatccgggt cacggccgcg ggccgcgcgg agaatgtgcc gcacgcccgg
     3361 gagcgctcgg tgcagatcga tatcgaccat gtcgcgaagg cggtggcggg atgagcgcgg
     3421 aacaggtcgc cgagccgacg gccgtggcgg gcgagcagcc cggcatgtgg acccggcagg
     3481 ggccctacct cctcgacatg gcgaccttcg ggcagctgct ggaggacatc gccggggagg
     3541 tacgggcggc gggcttcaca ccggacgccg tgctcgccgt ggcccgcggc ggactcgcgg
     3601 cgggcggata tctgacctgc gcgctggatg tgccggtcat gcacaccatc cgggtgcgca
     3661 ggacggccga cgacagccgg tacgccgcca agcagcggcc cgtggtcgac acctcggtcc
     3721 cgctcgggct gggcgcgggc gacaaggtcc tggtcgtcga cgacatcgtg ggcacggggg
     3781 cgaccgccga cgcggtcctg gagttcctcg ccgccgccgg ggtcgcacgc gaggacgtgc
     3841 ggttcgccgc ggtcgtccgc aatcaccgca gcggctatgt gcccgaacac tgcccggcgg
     3901 tcatcgacga ctggatcgtc ttcccctggg agacgtcccg ggaggccacc gacgactgcc
     3961 gtccgttccc cgccgcggcg cgggtgcacc ggtgagcggc ggcttccccg gcagtgggct
     4021 gaccccggcc gcggacgccg ccgcggccgg gctgcccggc tgttacgacg ccgtggacct
     4081 ctacacctac gaccgcccga tcagcagccg ggtcgaggtg gcgcggaccc tcgccgggat
     4141 cgagcaggaa cacggggccc ggccgacggt ggtgttcacg gacatcgccg agcggccggg
     4201 ggcccgggtg ctgtgccacc cctatccgcg ggaggtgctg ctggccgcgc tgggcacgac
     4261 ggaggagaag cacctcccgg agatgtcccg gcggctcgcg ggacctgtcc cgtcgccggg
     4321 ggcctcttct caactcccgg tccgccgccg tgagttgccc ggcatgctgg acgacctgcc
     4381 gatcctccag caccgccccg gcgacgcggg accgtacatc accgccgggg tcggagtgac
     4441 cacacggccc gacggcagcg gcgtcaacat gggcttctac cgcacccagg tggtcggccc
     4501 caacgaggcg cggatcttcc tcgatccgcg caccgacggg caccgcaatc tgctcgcctg
     4561 gctggagacc ggccgcccga tgccgatctc gctgttctcc ggcgccgatc cggcactgac
     4621 cgtggtggcc gcctcccggc tgccggccga gggcgacgac tacgagatcg cggcgcggct
     4681 cctcggccgg ccggtggacg tgggcggctc cgtgggcggc ttccccccgg tgccggacca
     4741 cgccacccat gtcatcaccg ggtacgtcca ggagcaggac gcggtcgagg gcccgttcgg
     4801 ggagttcaag ggctactacg ccgaggcacg gcgcagcaac gtcctcaccg tcaccggggt
     4861 cttcgccacc cccggcgcgc cctggccgac aatcgtcgcg ggcgcccgct cggggctgac
     4921 cctgatgagc ttccagaacg agtacctgat gtacgcccaa ctgcacggcc tcggtcatca
     4981 gatcaagtcg gtgcactact cgatcagggc gcgcggcgag ttcgtggcgt acatcgaaac
     5041 ggatgagccg agccaggaat tggtgcgtgc ggcgatggcc ttcgacgtac gctccaaggt
     5101 ggtcatctgc ggccccgacc tcgccaaccc gggccaggcg ctggccactt atggcttcac
     5161 cacccggacc gagccctatt accgcaaggg ccgggtggag ggggaacgga tcggcctcgc
     5221 cctggtgatc ccgccggacg gctggccgac cgagtactga accgacgacc gacaccgcac
     5281 cgagcgagga ctgcacaacg atggaccgat tcgcgcgagc gctgcccgcg gcgctgatgg
     5341 tgatccccgg acccggcgac accgtcacct tcatccgcca gctcaagggg ccgtacgcga
     5401 acaactggct gctgcccggc ggcggcatcg agccgggcga gccggccgag gccgccgcgc
     5461 tgcgggaggc gcgcgaggag accggcatcg ccgtcacgtc ctgctcgctt ttctccgtct
     5521 acgagttcac cggcacctgg gagcagggcg gctaccacct gctgatgttc gccttcctgg
     5581 ccgacggcga gtacgcgctg cgccccgggt tcgacgggga caacgtcgga gcgatccggc
     5641 aggcccggat ctcggagatc gatatgcact ccacggacct gcagatcctc accgacgccg
     5701 gactggcctc ctacgacgag gagaccatcg cgcgggcact ggcggccgac ggcatcacga
     5761 tgcacgctca ccgggtggcg tccaccgccc ggtgcggcgc gccgtgagtg ccggatccgt
     5821 cgccagggtg cggcaggtgt tctgccggca ggcgatcgtc agccgcgccg cgcgcagccc
     5881 cagggccagg gccgccttgg ggctcgcacc gcgtacgagg tggacgagga acgcggacgc
     5941 cagcgcgtcc ccggccccgg tgtcgtcggc gcagggcccg gcctcggcgg gcagcgtcag
     6001 cggctcgggc tgctcggcgg aggccacggc ggcaccgtcc gcgcccgcgg tcaccacgac
     6061 cacccggggc ccgcgcccga gcagccgccg cgcctgctcg gcgggcgtgc ccggctgccc
     6121 ggtgagggcc tgggcctcgc gggcgttgag cagcagcacg tcgtacagcg gcagcagatg
     6181 ggcacgcggg ccgaagtccc gttgccgggt gggcagaccg accaccggtg tcccgtgctt
     6241 cccggcctcc cgcgacagcc aggtgagcag ctcctcgtcg agtccgccct cggcggccac
     6301 ggccttcgcc gccgcgacgg tcccggcgag ggcgggcccg gccaggtccc gtccggcggc
     6361 cgggtcaggc agcgcgatac gggaggtgat ctgccggccc ccttcgtcga gcaggacgtc
     6421 ccagtggccc gtcccgtcct cggtgcgcag cagatgcagc ggccgtacgc cgaggcccgt
     6481 cagctccgcc tccaggtcgg cggcatcccg cccgtacccg gacagcccgg cgaaggccgt
     6541 acgggccccg agccgggcgg tgttgacggc gatattgcgg ccgacgccgc cgtggtgccg
     6601 ctgtacgccc cagaccgggg cggcgccgcc cagactcccg acggcgaagt atttgcggtc
     6661 catcacgagc gagcccagca cgagcacgtc gtaccccaca ggattatccc ccgaaaatcg
     6721 aagagcgagg aaggcttgat gacagaggag accgaagtca ccaggcagga aaaggaaatt
     6781 cggccgaccg ccgaagaatt aacgaaagag cgatcggcgc gcgcgttccg atggaagttc
     6841 tgcctaattt atctggccgg ggtcttcgcc gccacaagta tggggaaaat gaccccgatc
     6901 tccgtggcgc tgcgcgcgga cctttccctt tccctggccc aagtcgctct cctcacctcg
     6961 ctggtgacct ccgtcgccgc cgtgctcggt ctgttcgtca gctatctggt ccgcccgctg
     7021 ccgccgcacc gcatgctggt cgccgggctc gcggtcatgg gcgcggccgg gctgttctgc
     7081 gcccggaccg acagcttcgg cgcgatgctg ggcggccggc tggtggaggg cgtgggctat
     7141 gtcgtcgtgg tgatcgtcgc acccgtgctg ctgttctcgc tgggcgacgg caagcagctg
     7201 accggggcgc tcgcgatctg gggcacgttc atgccggtgg gcctggcgct cggctccttc
     7261 gcgggcggga tgctctcgat gtggctcgac tggcggggat ggctgacggt cgccgcggtg
     7321 ggaaccctgg tggtcgccgt gggggccacc cggctgcccg cggtggcgcc gaagagggaa
     7381 gagaagacgc cgccgggcgc ggaccgggcg gcgaccgtac gccggctcgc ccggcccatg
     7441 gcgctgggcg ccggtttcgc cacggtcagc gggtcgatcg tcgcctgcgt caccctctac
     7501 cccgcctgtc tgcacgagga gttcggcctg tccatggaga cggccggcac cctcaccggt
     7561 gtggtgtcgc tggccggggt ggccggcggc ttcctggcga gctggctgct ggtacggggc
     7621 atccccgtga agttcctgtt cgtggccacg ctgttgatgc ccgccggagc gttcgccgcc
     7681 ttcgccggta cgggcgggct cggggtctcg gtgggcagcg cgctggtcgt cgccctcgcc
     7741 aacgagctgg tggtggccac cgtgttcgcg gccgtgccgc tggcggtacg tgcggccgcc
     7801 gacctgggcg ccgccaacgg tctggtcgcg cagttcggca gcatcggagc gctggccacg
     7861 ccgcccctgg tggggctcgc ggtgaccgcg gcgggcggct ggtgggccgt ggggccgtgt
     7921 ctgctggcgg tgtgcgcggc gggtctggtg ctgctgctga tcgccgtacg gcagccgtcg
     7981 tacgggacga gggctgcggg ggaggcggcg tgaccgtcgg tggcggacga gggaaaacgt
     8041 ccggggcgtt gattcctggg cgctgattcc ggggcgtcga attcggggac gctgaattca
     8101 gggtcggtga tgtccggcac ggtggacggc aggccagtcg atcgtgccgg ccgacagaca
     8161 ggccatgggc cagttgatct gatgcgacat catgcctcgc tcttcagtcc cacgcccagt
     8221 tgttggtggc catcatggcg gtcgcgacct gcggtaaccc accccgagag gccgatgcga
     8281 caccgccatc gggcacctgc gccgcggaca acacaggaag cgtgaaaggc ggggaaagca
     8341 gggaaaggga catcgcccgg aaggtcttcg tgacgcaatg gctcatctca acctcacact
     8401 tttcgtgcac
//
