BGC0001940 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001940 (Pyxidicoccus fallax)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	33,728	High	pyxidicycline A/pyxidicycline B	PKS

BGC0001940 - Region 1 - T2PKS

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Location: 1 - 33,728 nt. (total: 33,728 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 33,729
Label		BGC0001940

Tailoring functions

Oxidoreductases: dehydrogenase

pcyD: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Lyases: cyclase

pcyC: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

pcyL: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: ligase synthase

pcyE: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

pcyF: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

pcyJ: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001940.3	0.98	PKS	pyxidicycline A, pyxidicycline B	Pyxidicoccus fallax
BGC0000231.5	0.63	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0002193.2	0.59	other (other)	phenguignardic acid	Aspergillus terreus NIH2624
BGC0001160.5	0.59	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.59	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001249.5	0.59	NRPS	dimethylcoprogen	Alternaria alternata
BGC0000234.5	0.58	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001641.4	0.58	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001723.5	0.57	PKS	oviedomycin	Streptomyces antibioticus
BGC0001197.5	0.55	PKS	frankiamicin	Frankia sp. EAN1pec

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001940.3	0.98	PKS	pyxidicycline A, pyxidicycline B	Pyxidicoccus fallax
BGC0000231.5	0.63	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0002193.2	0.59	other (other)	phenguignardic acid	Aspergillus terreus NIH2624
BGC0001160.5	0.59	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.59	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001249.5	0.59	NRPS	dimethylcoprogen	Alternaria alternata
BGC0000234.5	0.58	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001641.4	0.58	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001723.5	0.57	PKS	oviedomycin	Streptomyces antibioticus
BGC0001197.5	0.55	PKS	frankiamicin	Frankia sp. EAN1pec

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

pcyJ: X

AMP-binding (183..584): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: -LMYSGGPLK
Nearest Stachelhaus code(s):: Ala DLFFCGGPLK (21% 8Å match)
Stachelhaus code match:: 60% (weak)

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 0 to 33728
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)

pcyB: CYC C5-C14/C3-C16 (Score: 312.5; E-value: 5.1e-96)
pcyC: CYC C7-C12 (Score: 212.7; E-value: 1.3e-65)
pcyD: KR C9 (Score: 346.3; E-value: 2.4e-106)
pcyE: KS (Score: 552.2; E-value: 1.7e-168)
pcyF: CLF (Score: 407.7; E-value: 1.2e-124)
pcyJ: CYC (Score: 80.0; E-value: 4.8e-25)
pcyL: CYC (Score: 68.2; E-value: 1.9e-21)