BGC0001940 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001940 (Pyxidicoccus fallax)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS	1	19,375	pyxidicycline A/pyxidicycline B	PKS	100%

BGC0001940 - Region 1 - T2PKS

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Location: 1 - 19,375 nt. (total: 19,375 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 19,376
Label		BGC0001940

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001940	1.00	Polyketide	pyxidicycline A, pyxidicycline B	Pyxidicoccus fallax
BGC0000272	0.38	Polyketide	spore pigment	Streptomyces collinus
BGC0000275	0.33	Polyketide	tetracenomycin C	Streptomyces glaucescens
BGC0000271	0.31	Polyketide	spore pigment	Streptomyces avermitilis
BGC0001137	0.30	Alkaloid	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0000231	0.29	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000867	0.25	Other	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0000234	0.25	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000866	0.24	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0001723	0.23	Polyketide	oviedomycin	Streptomyces antibioticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001940	1.00	Polyketide	pyxidicycline A, pyxidicycline B	Pyxidicoccus fallax
BGC0000272	0.71	Polyketide	spore pigment	Streptomyces collinus
BGC0000275	0.66	Polyketide	tetracenomycin C	Streptomyces glaucescens
BGC0000271	0.64	Polyketide	spore pigment	Streptomyces avermitilis
BGC0001137	0.63	Alkaloid	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0000231	0.63	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000867	0.58	Other	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0000234	0.58	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000866	0.58	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0001723	0.57	Polyketide	oviedomycin	Streptomyces antibioticus

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

pcyJ

AMP-binding (183..584): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: -LMYSGGPLK
Nearest Stachelhaus code(s):: Ala DLFFCGGPLK (21% 8Å match)
Stachelhaus code match:: 60% (weak)

Type II PKS gene cluster prediction details

Cluster section:: 0 to 19375
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)

pcyB: CYC C5-C14/C3-C16 (Score: 312.5; E-value: 5.1e-96)
pcyC: CYC C7-C12 (Score: 212.7; E-value: 1.3e-65)
pcyD: KR C9 (Score: 346.3; E-value: 2.4e-106)
pcyE: KS (Score: 552.2; E-value: 1.7e-168)
pcyF: CLF (Score: 407.7; E-value: 1.2e-124)
pcyJ: CYC (Score: 80.0; E-value: 4.8e-25)
pcyL: CYC (Score: 68.2; E-value: 1.9e-21)