BGC0001941 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001941 (Myxococcus fulvus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS,T1PKS	1	55,204	High	Fulvuthiacene A/Fulvuthiacene B	PKS:Type I

BGC0001941 - Region 1 - NRPS,T1PKS

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Location: 1 - 55,204 nt. (total: 55,204 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 55,205
Label		BGC0001941

Tailoring functions

Oxidoreductases: dehydrogenase

ftaA: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

ftaM: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

Transferases: acetyltransferase acylase methyltransferase

ftaC: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

ftaL: acetyl-CoA acetyltransferase

smcogs: SMCOG1124: acetyl-CoA acetyltransferase

ftaN: methyltransferase

smcogs: SMCOG1089: methyltransferase

Lyases: hydratase

ftaH: Nitrilase/cyanide hydratase and apolipoprotein

smcogs: SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

Ligases: ligase synthase

ftaB: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

ftaD: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ftaE: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001941.3	2.00	PKS	Fulvuthiacene A, Fulvuthiacene B	Myxococcus fulvus
BGC0001276.3	0.94	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001257.3	0.68	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.67	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001273.3	0.67	PKS	asperlactone	Aspergillus ochraceus
BGC0002192.3	0.67	PKS	FR901512	fungal sp. No.14919
BGC0001258.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001284.4	0.67	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001244.3	0.67	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001941.3	1.00	PKS	Fulvuthiacene A, Fulvuthiacene B	Myxococcus fulvus
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.67	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001273.3	0.67	PKS	asperlactone	Aspergillus ochraceus
BGC0002192.3	0.67	PKS	FR901512	fungal sp. No.14919
BGC0001258.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001284.4	0.67	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001244.3	0.67	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 55204:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk) + (Cys - ccmal) + (OMe-Me-ohmal) + (OMe-mal) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ftaA: pk - pk - pk

PKS_AT (533..830): pk

ATSignature: 3-Methylbutyryl-CoA

Top 3 matches:: 3-Methylbutyryl-CoA: 91.7%; Methoxymalonyl-CoA: 54.2%; Methylmalonyl-CoA: 54.2%

minowa: 3-Methylbutyryl-CoA

Prediction, score:

3-Methylbutyryl-CoA: 212.0
Methylmalonyl-CoA: 94.5
Methoxymalonyl-CoA: 89.4
Isobutyryl-CoA: 81.1
Ethylmalonyl-CoA: 67.7
Benzoyl-CoA: 58.4
2-Methylbutyryl-CoA: 56.6
Propionyl-CoA: 54.5
Acetyl-CoA: 39.9
trans-1,2-CPDA: 38.3
Malonyl-CoA: 25.8
fatty_acid: 17.4
CHC-CoA: 16.6
inactive: 15.0

PKS_AT (962..1259): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; Methylmalonyl-CoA: 75.0%; Methoxymalonyl-CoA: 70.8%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 113.8
Malonyl-CoA: 109.7
Methoxymalonyl-CoA: 105.2
Ethylmalonyl-CoA: 70.5
Propionyl-CoA: 65.9
trans-1,2-CPDA: 51.5
Isobutyryl-CoA: 48.6
CHC-CoA: 44.2
3-Methylbutyryl-CoA: 39.5
fatty_acid: 39.1
Acetyl-CoA: 33.1
Benzoyl-CoA: 32.3
inactive: 31.8
2-Methylbutyryl-CoA: 29.5

PKS_AT (2728..2943): pk

ATSignature: (unknown)

No matches above 50%

minowa: Isobutyryl-CoA

Prediction, score:

Isobutyryl-CoA: 41.4
Methylmalonyl-CoA: 25.8
Benzoyl-CoA: 20.7
Methoxymalonyl-CoA: 19.8
Malonyl-CoA: 17.7
fatty_acid: 15.4
Propionyl-CoA: 8.9
trans-1,2-CPDA: 7.6
2-Methylbutyryl-CoA: 6.2
Ethylmalonyl-CoA: 2.5
inactive: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

ftaB: Cys - mal

Search NORINE for peptide: strict or relaxed

AMP-binding (527..924): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNWSLIWK
Nearest Stachelhaus code(s):: Cys DLYNWSLIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

PKS_AT (1931..2218): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 160.8
inactive: 109.0
Methoxymalonyl-CoA: 74.0
Methylmalonyl-CoA: 59.6
Propionyl-CoA: 37.0
Isobutyryl-CoA: 36.6
Ethylmalonyl-CoA: 33.2
Acetyl-CoA: 27.3
Benzoyl-CoA: 23.2
CHC-CoA: 20.7
2-Methylbutyryl-CoA: 15.8
fatty_acid: 11.2
3-Methylbutyryl-CoA: 3.0
trans-1,2-CPDA: 0.0

ftaC: mmal

PKS_AT (572..869): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 70.8%; Malonyl-CoA: 70.8%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 167.9
Ethylmalonyl-CoA: 141.3
Methoxymalonyl-CoA: 128.8
Isobutyryl-CoA: 120.2
Benzoyl-CoA: 104.9
Malonyl-CoA: 102.0
2-Methylbutyryl-CoA: 93.1
CHC-CoA: 78.0
Propionyl-CoA: 77.2
Acetyl-CoA: 76.8
trans-1,2-CPDA: 69.7
fatty_acid: 46.4
inactive: 37.0
3-Methylbutyryl-CoA: 31.7

ftaD: mal

PKS_AT (566..853): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 159.8
inactive: 108.9
Methoxymalonyl-CoA: 73.9
Methylmalonyl-CoA: 59.6
Propionyl-CoA: 37.0
Isobutyryl-CoA: 36.6
Ethylmalonyl-CoA: 33.2
Acetyl-CoA: 27.3
Benzoyl-CoA: 23.2
CHC-CoA: 20.7
2-Methylbutyryl-CoA: 15.8
fatty_acid: 11.2
3-Methylbutyryl-CoA: 3.0
trans-1,2-CPDA: 0.0

ftaE: X

A-OX (554..1312): X

Link to PARAS substrate predictor