LOCUS       BGC0001947             23423 bp    DNA     linear   BCT 27-MAY-2018
DEFINITION  Acinetobacter baumannii strain D23 FkpA (fkpA) gene, complete cds;
            KL53 capsule biosynthesis gene cluster, complete sequence; and Wzc
            (wzc), Wzb (wzb), Wza (wza), Pgm (pgm), and LldP (lldP) genes,
            complete cds.
ACCESSION   BGC0001947
VERSION     BGC0001947
KEYWORDS    .
SOURCE      Acinetobacter baumannii
  ORGANISM  Acinetobacter baumannii
            Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales;
            Moraxellaceae; Acinetobacter; Acinetobacter calcoaceticus/baumannii
            complex.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 05:33:36
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 23423
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(1..735)
                     /gene="fkpA"
     CDS             complement(1..735)
                     /codon_start=1
                     /gene="fkpA"
                     /note="putative FKBP-type peptidyl-prolyl cis-trans
                     isomerase"
                     /product="FkpA"
                     /protein_id="AWL83845.1"
                     /transl_table=11
                     /translation="MEPFMSKALPIAVAVVLGGAALVPVYYATQHPTTEVGRKADKNAS
                     PIQKISYVLGYEVAQQTPPELDTKAFVQGIHDARNKQPSAYTQEDLKAAVAAYEKELQQ
                     KMQHQDKPEQAGTATDSADAQFLAENKTKAGVKTTASGLQYIITKEGTGKQPTAQSVVK
                     VHYEGRLINGQVFDSSYKRGQPVEFPLNQVIPGWTEGLQLMKEGGKATFFIPSNLAYGP
                     QELPGIPANSTLIFDVELISVK"
     source          1..23423
                     /country="Australia"
                     /db_xref="taxon:470"
                     /host="Homo sapiens"
                     /mol_type="genomic DNA"
                     /organism="Acinetobacter baumannii"
                     /strain="D23"
     subregion       1..23423
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001947"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..23423
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     misc_feature    736..21707
                     /note="KL53 capsule biosynthesis gene cluster"
     gene            complement(915..3098)
                     /gene="wzc"
     CDS             complement(915..3098)
                     /codon_start=1
                     /gene="wzc"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1216:exopolysaccharide biosynthesis domain protein
                     (Score: 433.7; E-value: 1.8e-131)"
                     /gene_kind="biosynthetic-additional"
                     /note="protein tyrosine kinase; involved in capsule export"
                     /product="Wzc"
                     /protein_id="AWL83827.1"
                     /transl_table=11
                     /translation="MNQKTNTDDTIDLKELFFSLIAQWKLIALCIILSLVCALLYLRVT
                     PDTYSVDALVQVEDSKGASAALLGDLSQMIEQKSPAQAEIEILKSRLVLGSVIKDLHLN
                     IQISSTENTLTHRLLSDTEYKTEYNKKSVIFKDGLKSFEIVQFEIPAYYLDKKLLLNFD
                     KNSLRLSDPSTEQTILTVPLNQLNQVTGPHGTWKVGIFTKDHFDATYNIKNLSLPAAVD
                     AISSDYSVAERGKLTGIIGLNYQGEDQEHITKVLNAILVTYGDQNVERRSAESAQTLKF
                     LDEQLPDLKKQLDDAERQFNKFRQQYNTVDVTKESELYLTQSITLETKKAELEQKQAEM
                     AAKYTAEHPAMREINGQLTAINKQIGELNNTLKQLPDIQRQYLQLYREVEVKTQLYTAL
                     LNSYQQLRIAKAGEIGNVRIVDTAVEPVEPIKPKKLQVLILSLFLGGFIGTLIALLRNM
                     LRTGIKDSGQIENELDLPVYATVPRSPIQESRIKILKKKKSIPILAVKNSDDIAIESLR
                     SIRTAIHFALANAKNNIIMIAGPSPEVGKSFISTNLATIFAQGDKRVLLIDADMRRGYM
                     HKYFDVDVKPGLSELLSGQADLQKVLHKTQVTNLDVITRGKSPTNPSEILSSNQFKELL
                     EQLQSQYDHIIIDTPPVLAVTDGIIISQYTGVNLIVARYAKSQMKELELTLNRFEQAGV
                     KVNGFILNDIQRASAGYGYGYNYAYAYKAQKED"
     gene            complement(3117..3545)
                     /gene="wzb"
     CDS             complement(3117..3545)
                     /codon_start=1
                     /gene="wzb"
                     /note="low molecular weight protein tyrosine phosphatase;
                     involved in capsule export"
                     /product="Wzb"
                     /protein_id="AWL83828.1"
                     /transl_table=11
                     /translation="MQFKNILVVCIGNICRSPMAEYFLKQQYPQLNIESAGISGLTGHQ
                     ADEKARLCMQRLGIDMQPHVARKLNAEHIKKADLILVMSQNQQKHIEQTWPFAKGKTFR
                     LGHWQNKNVPDPYQHDQAVFDETCQLIQQCIADWKPYI"
     gene            complement(3550..4668)
                     /gene="wza"
     CDS             complement(3550..4668)
                     /codon_start=1
                     /gene="wza"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 240.8;
                     E-value: 3e-73)"
                     /gene_kind="transport"
                     /note="outer membrane protein; involved in capsule export"
                     /product="Wza"
                     /protein_id="AWL83829.1"
                     /transl_table=11
                     /translation="MHKGSRVKYCQFFSVLALSLSAASCAVTSGLQTYDIPSEGVYKTD
                     LGTTVNVVKISQETLPAIQPAQIDYQRDYASLFKNQQTIYRLSPGDVLSIQLWAYPEIT
                     PPVNNISNEQSIQANGYPIDQSGYIQFPLVGRYKAAGKTLAQVNRELHNQLARFLKNPD
                     IVVRVLSYEGQRFSVQGSVLKGGQFYLSDQPISIYAALGLAGGVSDKGDNTYIQLIRNG
                     RTYNLNTIDLERAGYSLHKLLVQPNDTIYVSTRENQKIYVMGESGKNQALPMRDQGMTL
                     SDALGESLGLNPLSASASRIYVLRTNPNDRTTELYHLNLMSIGDFGLANQFRMRSNDIV
                     YVDATGLTRWQRVVNQIIPFSSALYNIDRLGQ"
     gene            4994..6283
                     /gene="gna"
     CDS             4994..6283
                     /codon_start=1
                     /gene="gna"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1152:nucleotide sugar dehydrogenase (Score: 474.9;
                     E-value: 3.4e-144)"
                     /gene_kind="biosynthetic-additional"
                     /note="UDP-N-acetyl-galactosamine dehydrogenase"
                     /product="Gna"
                     /protein_id="AWL83830.1"
                     /transl_table=11
                     /translation="MRLTFMQLADLRIAIIGLGYVGLPLAVEFGKKVPVVGFDIYQKRI
                     DELKSGQDHTLEVSPEELEQAAQLSYTANLEDLKDCNFFIVTVPTPIDDYKQPDLTPLV
                     KASTSIGKILKKDDIVVYESTVYPGATEEVCIPVLEKVSGLTFNKDFYAGYSPERINPG
                     DKLHRVTNILKITSGSTPEISEFIDEVYNLIIEAGTHKAPSIKVAEAAKVIENTQRDVN
                     IALINELALIFNKLGIDTEDVLKAAGTKWNFLPFRPGLVGGHCIGVDPYYLTHKAQAIG
                     YHPEIILAGRRLNDSMGAYVVTQLVKEMIKKKIQVEGAKVLVLGLSFKENCPDIRNTKV
                     IDIVKELHEYHMDVDVYDPWIDSEETQHEYGITPVKQPTAGQYDAVILAVAHNEFKEMG
                     IEAIRSLGKTSHVLYDLKYVLAQSESDIRL"
     gene            6292..7332
                     /gene="gne2"
     CDS             6292..7332
                     /NRPS_PKS="Domain: NAD_binding_4 (24-202). E-value:
                     8.1e-11. Score: 33.3. Matches aSDomain:
                     nrpspksdomains_gne2_NAD_binding_4.1"
                     /codon_start=1
                     /gene="gne2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 269;
                     E-value: 1e-81)"
                     /gene_kind="biosynthetic-additional"
                     /note="UDP-N-acetyl-glucosamine-4-epimerase"
                     /product="Gne2"
                     /protein_id="AWL83831.1"
                     /transl_table=11
                     /translation="MLRINMNRYEEVLEQLKSNPKTWLITGVAGFIGSNLLETLLKLNQ
                     KVIGLDNFATGHQYNLDEVETLVSSDQWKNFTFYTGDIRNLEDCQKACANVDYVLHQAA
                     LGSVPRSIADPILTNSANITGFLNMLVAARDAQVKSFTYAASSSTYGDHPALPKVEENI
                     GNPLSPYAVTKYVNELYAEVFARTYGFKAIGLRYFNVFGKRQDPKGAYAAVIPKWTAAM
                     IQGDDVFINGDGETSRDFCYIENTVQANILAAIANDEAKNQVYNVAVGDRTTLNDLFKA
                     IKSALNENGISCDKEPVYREFRVGDVRHSQADVTKIKTLLGYDPKFRIFEGIGLAVNWY
                     LLNNGK"
     aSDomain        6364..6897
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_gne2_NAD_binding_4.1"
                     /evalue="8.10E-11"
                     /label="gne2_NAD_binding_4.1"
                     /locus_tag="gne2"
                     /protein_end="202"
                     /protein_start="24"
                     /score="33.3"
                     /tool="antismash"
                     /translation="ITGVAGFIGSNLLETLLKLNQKVIGLDNFATGHQYNLDEVETLVS
                     SDQWKNFTFYTGDIRNLEDCQKACANVDYVLHQAALGSVPRSIADPILTNSANITGFLN
                     MLVAARDAQVKSFTYAASSSTYGDHPALPKVEENIGNPLSPYAVTKYVNELYAEVFART
                     YGFKAIGLRYFNVFG"
     gene            7329..7877
                     /gene="atr18"
     CDS             7329..7877
                     /codon_start=1
                     /gene="atr18"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 55.7;
                     E-value: 8.3e-17)"
                     /gene_kind="biosynthetic-additional"
                     /note="acetyltransferase"
                     /product="Atr18"
                     /protein_id="AWL83832.1"
                     /transl_table=11
                     /translation="MNMWKIFTVLARITSLLPLFLFHFFWRCLDIFDGKFGAVARYILI
                     AGRLKKCGTNVYIGPFVSIESVRNLSLGNNVSIHHQCTLICLGGIDIGDNVAIAHASSL
                     ISTNHTWNDNNLPIKYNPVVCDNLEIHDDVWIGCGVRILAGVKIPKRCVVAAGAVVTKS
                     LSDSGALYGGVPVKKIRDI"
     gene            7874..9049
                     /gene="wzx"
     CDS             7874..9049
                     /codon_start=1
                     /gene="wzx"
                     /note="oligosaccharide-unit translocase"
                     /product="Wzx"
                     /protein_id="AWL83833.1"
                     /transl_table=11
                     /translation="MKFSRILEGLQILFLKFSSLLIMSLIFLFLWVQMGVQGIGEFATY
                     ATILAPIVMFSQFRYVEYINIVNIKEDKEKRFLQSLFASGMVVLLLLGILFIFYLVTHQ
                     PIKILVVAGLYKVFELFSDIYISFLVSIKELRNAFFVIFKRLFLILSGLIFFYFKQFSL
                     NPIEFVFYLLLGVYFTFFVIDVVIEKRRFNEGPDIKNITDYIKDNFLYGFNSLLISINS
                     LVPRYFFIFFNDKKGLGIFTIVYLLASTTTTLMQFLISVKVSLIEKFIDTRFNQYLLIN
                     LIIVGLCFGFYIFINELSDNYFLFGLSFVVMLISLLLRGVNLTASFSKKMKNVINIALI
                     LPMILVSLLLVFLCFYYREFAFKFSILYVFTSALMTSMILMFSLRKSKLIC"
     gene            9037..10179
                     /gene="wzy"
     CDS             9037..10179
                     /codon_start=1
                     /gene="wzy"
                     /note="oligosaccharide-unit polymerase"
                     /product="Wzy"
                     /protein_id="AWL83834.1"
                     /transl_table=11
                     /translation="MDMLILSCLFFALFTYLIFYFIARKQSFSFLVISFFLNLYHYIFS
                     LGFYFYSLGRPNDSLNYYIWGTEQLENFPFSSGTGFLVHLVHFINYILNSYENVFLFFS
                     MISSWVILSFFLIIYNFYSKREISSNSFLFLTILLFIPGLHFWTVAIGKDCLVLLFISL
                     FLYAYIYKKIKLLVFSLVFLALIRIHIFAIVFLTFILHEFIYGNFKLKKISMGVYRFVI
                     FVLSIPSIFVLYQFLFSFIQKYSEDGFSDIGGFVENRNEAYSEEGSGLLLASQPYILKM
                     LAFVLGGLPWLSLDPLSLFSMAEGVIVIGILLYSYYYLFTKDRFNNSKQIFILIFIALF
                     ILFMPLISANLGIMVRMRVMLYIPILTVLLMFMLSNERKI"
     gene            10179..11324
                     /gene="gtr2"
     CDS             10179..11324
                     /codon_start=1
                     /gene="gtr2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 121.8;
                     E-value: 6.9e-37)"
                     /gene_kind="biosynthetic-additional"
                     /note="glycosyltransferase"
                     /product="Gtr2"
                     /protein_id="AWL83835.1"
                     /transl_table=11
                     /translation="MMNFVIISSFLPSILNFRGKLLEAIHKKGYQIHIIAPDLELFQDE
                     VNKLQLLGYSVYSVEMQRTGTNPITDIKTLFEIYKITNKIKPDYVLSYTIKPVIYGTLA
                     TYFAKVPNRFSLITGLGYAFQNVDSTSKRSTFQKIIHWLYKQALIRSSKVFFQNPDDLA
                     LFKQLNLLSNKVPAVVVNGSGVNVNDFEVVSLPRAVNGEVKVSFLLIARLLQDKGIREY
                     VEAAKLIKKEYPQIEFNLVGWIDENPTAIKQQELDSWIDEKIIKYWGKLSDVRPAIAES
                     SIYVLPSYREGTPRTVLEAMSMGRAIITTDAPGCRETVEHDGNGYLVEVKSVTSLEMAM
                     RKFIQNPELAEIMGTRSREIALHKYDVHQVNHHMMTEMGIK"
     gene            11325..11933
                     /gene="itrA1"
     CDS             11325..11933
                     /codon_start=1
                     /gene="itrA1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1146:sugar transferase (Score: 263.1; E-value:
                     8.8e-80)"
                     /gene_kind="biosynthetic-additional"
                     /note="initiating transferase for oligosaccharide
                     synthesis"
                     /product="ItrA1"
                     /protein_id="AWL83836.1"
                     /transl_table=11
                     /translation="MLKRLLDIIIASIALILLSPLYFYVAYKVKKNLGSPVLFRQVRPG
                     LHGKPFEMIKFRTMKDATDAQGNPLPDSERLTPFGKMLRSTSLDEMPELWNVIKGDMSI
                     VGPRPLLMEYLPLYNKEQAKRHDVRPGMTGHAQVNGRNAISWEEKFKLDTWYVENRSLW
                     LDFKIMLQTVKKVIAKDDINEAGEATMTKFTGSKSEADK"
     gene            11930..12589
                     /gene="qhbC"
     CDS             11930..12589
                     /codon_start=1
                     /gene="qhbC"
                     /note="acetyltransferase"
                     /product="QhbC"
                     /protein_id="AWL83837.1"
                     /transl_table=11
                     /translation="MNNSIYAIYGASGCGRSLMPIARQQLQRQGISAEIYFIDDSLKEK
                     KIVNGHTALSYQTFKSINCTNKYVLIAIANSHIREKIANQLIVDGIKLWSIQADNTIIM
                     DNVEIGEGAALSPFVSITSNIKIGKCFHANLYSYVEHDCVIGDYVTFAPGVKCNGNIHI
                     EDHAYIGAGAVIKQGTPDKPLIIGKGAIVGMGSVVTKSVPAGVTVVGNPARILERK"
     gene            12614..13789
                     /gene="qhbB"
     CDS             12614..13789
                     /codon_start=1
                     /gene="qhbB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     325.5; E-value: 7.7e-99)"
                     /gene_kind="biosynthetic-additional"
                     /note="UDP-4-keto-6-deoxy-N-acetyl-glucosamine
                     4-aminotransferase"
                     /product="QhbB"
                     /protein_id="AWL83838.1"
                     /transl_table=11
                     /translation="MLNTAFEPWPSFTTEEADAVKNVLLSNKVNYWTGQECRIFEKEFA
                     EFSDTKYAVALANGTVALDVALKALDIGAGDDVIVTSRTFLASASSIVTAGANPVFADV
                     ELDSQNISRRTIEAVLTPNTKAIICVHLAGWMCDMDPIMQLAAERGIYVIEDCAQAHGA
                     KYKGKAAGSIGHIAAWSFCQDKIMTTGGEGGMVTTNDETLWKKMWSYKDHGKSYDSIYN
                     KQHPPGFRWLHDSFGTNWRMMEMQAVIGRIQLTRMAEWTKKRTENAEKILKAFEGSPFF
                     SVHIPSVDYIHAYYKCYVQVNLEALPDGWSRDRIMQEINSQEVPCFSGSCSEVYLEHAF
                     DDTPWRPEKRLENAQKLGGTSLMFLVHPTLSQDSIEKTILAINAVNRALQS"
     gene            13928..15805
                     /gene="gdr"
     CDS             13928..15805
                     /codon_start=1
                     /gene="gdr"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     100.6; E-value: 1.8e-30)"
                     /gene_kind="biosynthetic-additional"
                     /note="UDP-N-acetyl-glucosamine 4,6-dehydratase"
                     /product="Gdr"
                     /protein_id="AWL83839.1"
                     /transl_table=11
                     /translation="MVKKIIYQFASAPRLTKQCFLVLIDLFAFPIILWLCYAIRLFDLG
                     AEVIPGINYGVAFVTILAILSLMVTGVYRFIVRTFNEAFIAKLAIAVTLMVIVLYGMNA
                     FSPAFVPTSIPLMFGFLMFGWVWCSRAFIRFIVKAVLQTGEERKRIAIYGAGDAGQQIA
                     AVLYRSGNHLPVFFIDDNTSLQDHIVGGLKVLSLEKALQRFEKYKTDEILLALPSVGRV
                     RKSEIIQQLEPAHLKITELPGLTQLVDGELKVADIREVDIIDLLGRDPVPPVDHLLAKN
                     IQNKVVMVTGAGGSIGSELCRQIVKNQPKKLIIYEITEFALYSIDKELRLTAQCEIVPI
                     LGTVQDQQKLERIIEQYGIQTVYHAAAYKHVPLVECNPIAGLKNNAIGTANSLNAAIKK
                     GVETFVLISTDKAVRPTNVMGASKRMAELYCQAMAEAQKQTQISIVRFGNVLGSSGSVV
                     PLFKQQIAKGGPITVTHPEVTRYFMTIPEASQLVIQAGALGRGGDVFLLDMGEPVRIQD
                     LARQMISLSGLTVREQGSMQGDIEIQYSGLRPGEKLYEELLIDQENTEYTEHSRILRSF
                     EKFYPLTEIQEVFERINNMTAVQQDIDWALCQLEHYVDGYKRSKDIMVN"
     gene            15817..16692
                     /gene="galU"
     CDS             15817..16692
                     /codon_start=1
                     /gene="galU"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 199.9; E-value:
                     8.8e-61)"
                     /gene_kind="biosynthetic-additional"
                     /note="UTP-glucose-1-phosphate uridylyltransferase"
                     /product="GalU"
                     /protein_id="AWL83840.1"
                     /transl_table=11
                     /translation="MIKKAVLPVAGLGTRFLPASKSIPKEMVTVVDRPAIEYVVREAVE
                     AGIEQIILVTHSSKASIENYFDRSFELETTLEQKKKFDLLAEITQIVPEHVSVISVRQP
                     QPLGLGHAVLCAKSVVGEDDFAVLLPDVLVKDGSGQNDLSRMISRYNSSQAAQIMVEAV
                     PDHLVDQYGIVDVAQSPNEGESIAMQGIVEKPPVGAAPSNLSVVGRYVLPAKIMQLLEN
                     TPKGAGNEIQLTDAIAMLQDTDTVEAYRMQGQTFDCGSKLGYLKAVLHYGLEHPKLGME
                     FKQLIQELKL"
     gene            16798..18072
                     /gene="ugd"
     CDS             16798..18072
                     /codon_start=1
                     /gene="ugd"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1152:nucleotide sugar dehydrogenase (Score: 222.7;
                     E-value: 1.1e-67)"
                     /gene_kind="biosynthetic-additional"
                     /note="UDP-glucose 6-dehydrogenase"
                     /product="Ugd"
                     /protein_id="AWL83841.1"
                     /transl_table=11
                     /translation="MRCAMKIAVFGTTLHAGVMAALLAEYGNQIYWCTCVSCEENISVL
                     SYQDQEVNHYLNKQRKAGFLKESPFSEIPLDIEVYLFCFSPTQIELALKTVEKLSERPI
                     IHPKLMINGSTFGLHGTEKLKQHLPKDEWVYFPDVIQEGNAINSVLDVKHVIVGVESRD
                     ASEIMQELLRPFFQFSYQYLFMPILDAEFTKLSISGMLATRISYMNDLAMVAEKLGIDI
                     ANVKHGIAADTRIGAAYLSPGVGFGGENFSHDILTLSSTVLETGTKSRLLEQVWAINEQ
                     QKEILFRKLWNYYHCDLSGKTVAIWGASFKENTSNIHNSPIHILLAALWAQGVKVRLHD
                     PQALDEIAITYGDREDLVLCADQYEAAQNAHALCVVTAWKQYWSPDFKRLQQLMKHPLI
                     LDGRNIYDPAYVKARGFAYEGVGRL"
     gene            18069..19736
                     /gene="gpi"
     CDS             18069..19736
                     /codon_start=1
                     /gene="gpi"
                     /note="glucose-6-phosphate isomerase"
                     /product="Gpi"
                     /protein_id="AWL83842.1"
                     /transl_table=11
                     /translation="MSKSIEQFPKDLSSPLIQLKSSVEKNSKVHIKELFALEPERFQNY
                     SVKFNQLFFDYSKQRITKNILEQLVALANNKQLTQWINRLFSQDKINCTEQREAMHWAL
                     RLPSEYSKFPALTKQVHTQLQRMYALVEKIHAGQYRGATGEVIQDIVNIGVGGSDLGPQ
                     MVTHALCDFKVKTTKPLNVHFVSTMDGSQLSDLLHQLRPETTLFIISSKSFGTIDTLSN
                     AQTVRQWLEKALGKHDRVVKSHFIGVSTKADKMTEWGIAPDNQLLLWDWVGGRYSLWSC
                     IGFPIALTIGIDGFQQLLAGAHAVDEHFQNTSFEQNIPVLMALLGIWNNNFLNIQTHAV
                     LPYDGRLKYFAAYLQQLEMESNGKSVQRDGQKVELDTCPIVWGEVGPNAQHAFYQLLHQ
                     GTQAVSCDFIAPIQRYNADHFTYVENAEALIEQHHLALSNCLAQSRLLAFGNEALDVKE
                     LEKLPIYKQYEGNQPSSTLLLDELNPYNLGMLIALYEHKVFVQSVIWNINPFDQWGVEK
                     GKQIADQLLPILNGAQNDLSTLDASTRGLIKILLGKAE"
     gene            complement(20011..21384)
                     /gene="pgm"
     CDS             complement(20011..21384)
                     /codon_start=1
                     /gene="pgm"
                     /note="phosphoglucomutase/phosphomannomutase"
                     /product="Pgm"
                     /protein_id="AWL83843.1"
                     /transl_table=11
                     /translation="MMTTLTCFKAYDIRGKLGTELNEEIAYKIGRAYGQIYKPKTVVVG
                     CDIRLSSEALKQAAIRGLNDAGVSVLDLGMTGTEEVYFAAFHLDVQGGIEVTASHNPMD
                     YNGMKLVRENARPISADTGLKEIQALAETNNFEEVGQKGTTQSYNILPEFVDHLLTYIE
                     PAKIRPLKLVVNAGNGAAGHVIDAIEEKFKALNVPVEFIKIHHEADGTFPNGIPNPILI
                     ENRDSTRNAVLEHKADMGIAWDGDFDRCFLFDEKGQFIEGYYIVGLLAQAFLIKQSGEK
                     IVHDPRLVWNTFDIVDQYKGIAVQSKSGHAFIKDVMREHNAVYGGEMSAHHYFRDFAYC
                     DSGMIPWLLTIALLSETGQSLSTLVENMITKFPCSGEINFKVADTQITIQKIFDFYADQ
                     NPQIDRTDGVSLDFGAWRFNVRASNTEPLLRLNIESRADRQAQPMQYYVDELTSLIQS"
     gene            21708..23423
                     /gene="lldP"
     CDS             21708..23423
                     /codon_start=1
                     /gene="lldP"
                     /note="predicted L-lactate permease"
                     /product="LldP"
                     /protein_id="AWL83844.1"
                     /transl_table=11
                     /translation="MFKNLRYKNSPQHFKEMTMLNMWQQLYDPLNNIWLSSAVALIPII
                     FFFLALAVFRLKGSIAGTGTVIIALLIALFFYQMPGQMAFASIIYGFFYGLWPISWIII
                     GAVFLYKISVKTGQFEVIRSSILSITEDQRLQMLLVGFAFGTFLEGAAGFGAPVAITAA
                     LLVGLGFKPLYAAGLCLIVNTAPVAFGAMGIPIIVAGQVSGVDTMEISQMVGRQLPFLT
                     IIVLFWIMAIMDGWRGVKETWPAVLVGGGAFAIAQYLTSNFIGPELPDITAAIASLVSL
                     TLLFRVWKPKHIFRFEPEAGQTLAQQPTTVQRYSIGKIAKAWSPFAILTVMVTIWSVKP
                     FKALFAKDGALEHWIFKLEVPYLHKLVEKMPPIVSEMKPYEAIYKFDWFSATGTAIFIA
                     AIITVIFLKMKASEAVTTFGETLNELKTPIYSIGMVLAFAFIANYSGLSATLALALSHT
                     GHAFTFFSPFLGWLGVFLTGSDTSSNALFSALQATTAQQIGIPEVLLVAANTSGGVTGK
                     MISPQSIAIACAAVGLVGKESDLFRFTVKHSIIFTVFVGIIITVQAYLVPWMIP"
ORIGIN
        1 ttatttcact gaaatgagtt ctacatcaaa aatcagtgta ctgtttgctg gaattccagg
       61 aagctcttgt gggccatatg caagattaga tggaataaag aacgtcgctt ttccaccttc
      121 tttcatgagt tgaagacctt cagtccaacc cggaatgacc tgattaagcg ggaattctac
      181 tggttgacca cgtttataag aactgtcaaa aacctgtcca ttaattaatc ggccttcata
      241 atgtacttta acaacagact gagcagttgg ctgtttacca gtaccttctt tagtaatgat
      301 atattgcaaa cctgatgcag tggtttttac gccagctttc gttttatttt ctgcaaggaa
      361 ctgtgcatct gcagagtcag tagctgtacc cgcttgctca ggtttgtctt gatgctgcat
      421 tttttgttgt aactcttttt cataagcagc aacggcagct tttaaatctt cttgagtata
      481 agcactaggc tgcttattac gcgcatcatg gatcccttga acaaatgctt tagtatctag
      541 ttcaggaggg gtttgctgag caacttcata cccaagaaca taactgattt tttgaattgg
      601 agaagcattt ttgtctgctt tacgtccgac ttctgtggtc ggatgttgag ttgcataata
      661 tacaggtaca agtgcagcac cgcctaaaac tacagcgaca gcaatgggta aggctttact
      721 cataaaaggt tccaaaaata atcatttgag tctaaaaggc tgcttcgatc ttagcatgct
      781 tcgacttaag catagaatgt ttaacaaaaa aaacgagtgg ttttttatat attttagtta
      841 gtttaaatgt ggcaaaactt aaaaagcaaa taaaaaaccg gatcatttga tccggttttt
      901 atgaagagtt ttaattagtc ttctttttgt gccttatagg cataagcata gttatagcca
      961 taaccatagc cagcgctagc acgctgaata tcattgagaa taaagccgtt gactttaaca
     1021 cccgcctgtt caaagcgatt aagggttaat tcaagctctt tcatttgtga cttagcataa
     1081 cgcgcaacaa ttaagttcac accagtatat tgcgaaataa taataccatc ggttaccgca
     1141 agtactggtg gtgtatcaat aatgatatgg tcatattggc tttgaagctg ctcaagtaat
     1201 tccttgaact ggtttgagct taagatctct gaaggatttg ttggactctt accacgagta
     1261 atcacatcta gattagttac ctgagttttg tgtaatactt tttgtaaatc agcttgtcca
     1321 cttaaaagtt ctgatagacc tggcttcaca tcaacatcga aatatttatg catataacca
     1381 cggcgcatat cggcatcgat caatagtact cgtttatctc cttgtgcaaa aatagttgcc
     1441 aagttagttg aaataaagga tttacctacc tcaggagagg ggcctgcaat cataatgata
     1501 ttattttttg catttgctaa tgcaaagtga atagcggtac ggatactacg taagctctca
     1561 atggctatat cgtcactgtt tttaaccgca agaataggaa tactcttctt cttctttaaa
     1621 atcttgatgc ggctttcttg aattggagaa cgaggaacag ttgcataaac tggtaaatcc
     1681 aattcatttt caatttggcc cgaatctttg atacctgtgc gtaacatatt acgtaatagg
     1741 gcaatcaacg ttcctataaa accgcctaag aataaagata aaataaggac ttgtaacttt
     1801 ttaggtttaa tgggttcaac aggctcgaca gcagtgtcta cgatacgtac attaccaatt
     1861 tcaccagctt ttgcgattcg aagttgttga tatgaattta ataaagcagt gtaaagttgt
     1921 gttttgactt ctacttcacg ataaagctgt aagtattgac gttgaatatc tggtaattgt
     1981 tttagtgtgt tatttaactc gccgatttgt ttattaatag ctgtaagctg accattaatt
     2041 tcacgcattg caggatgttc agcagtatac tttgcagcca tttctgcctg cttctgttca
     2101 agctctgctt tcttggtttc taaagtaatg ctttgagtta aatatagctc tgactctttt
     2161 gtcacatcaa cagtattgta ctgttgacgg aacttattaa attgacgctc agcatcatct
     2221 aattgttttt tcaaatcagg tagttgttca tctaaaaatt ttaaggtttg ggcagattca
     2281 gctgaacgac gttcaacatt ttgatcacca taagttacta aaattgcgtt taaaacttta
     2341 gtaatgtgtt cttgatcttc accttggtaa ttcaagccaa taatgcctgt taatttgcca
     2401 cgctcagcaa ccgaatagtc tgagctgatt gcatcaacag cagctggtaa agataaattt
     2461 tttatattgt atgtagcatc aaaatgatct ttagtgaaga tgccaacttt ccaagttcca
     2521 tgtggtcctg ttacttggtt taattgattg agtggtacag ttagaatagt ttgttcagta
     2581 ctaggatcac ttaaacgtaa ggagtttttg tcaaaattga gtaataattt tttgtcaaga
     2641 taataagcgg gaatttcgaa ttggacgatt tcaaagcttt taagtccatc cttaaaaatg
     2701 actgattttt tattatattc tgttttatat tcagtatcac ttaacaagcg atgagtaagc
     2761 gtattttctg tactggaaat ctgaatattt aagtgtaaat ctttaataac agaacctagc
     2821 actaaacgag attttaaaat ttcaatttct gcttgagcag gtgacttttg ctctatcatc
     2881 tgtgataaat cacctaaaag agctgctgaa gcccctttgc tgtcttcaac ttgaaccaaa
     2941 gcatcaactg agtaggtatc tggggttact cgtaaataga gtaaggcaca gactaggctc
     3001 aaaatgatac aaagtgcaat taatttccac tgagcaatta gtgaaaaaaa cagttctttt
     3061 aaatcaattg tatcgtcggt attcgttttt tggttcataa gtttaaaatc ttggcgttaa
     3121 atataaggtt tccagtcagc aatgcattgt tgaatgagtt ggcaggtttc atcaaaaaca
     3181 gcctgatcgt gctgatatgg atctggcacg tttttatttt gccaatgacc caaacgaaaa
     3241 gttttacctt ttgcgaacgg ccaagtttgc tcaatatgtt tttgctgatt ctgactcatg
     3301 accaaaatta ggtcagcttt tttaatatgt tccgcattta actttctcgc aacatgtggt
     3361 tgcatatcaa tacctagtcg ttgcatacaa agtcgggctt tttcatcagc ctgatgacca
     3421 gtaagtccgg aaatacccgc tgattcaata tttaactggg gatattgctg ttttaaaaaa
     3481 tactctgcca taggactacg acagatattt ccgatacaga ccactaaaat atttttaaac
     3541 tgcatgaaat tactgtccca aacggtctat gttatataaa gcacttgaga acggaataat
     3601 ttggttgaca acacgttgcc agcgagttaa gccagtagca tctacataaa ctatatcatt
     3661 actgcgcatc ctaaactgat tcgctaaacc aaaatcacca atactcatta aatttaaatg
     3721 gtaaagttca gtcgttcggt catttgggtt agtacgtaat acatagattc tgctagcgct
     3781 ggccgataaa ggatttaatc ccaaactttc acctaaagca tcgctcaaag tcatcccttg
     3841 gtcacgcatc ggcaacgctt ggttcttacc tgattcgccc atcacataaa ttttctggtt
     3901 ttcacgagta ctcacataaa tagtatcatt tggttgaact aacaatttat gtaaggaata
     3961 acctgctctc tctagatcga tagtatttag attataggtt cggccgttac gaatgagttg
     4021 aatataggta ttgtctcctt tatcactgac accaccagca agtcctaaag ctgcataaat
     4081 gcttataggt tgatcgctta aataaaattg tccacctttt agtacactcc cttgtactga
     4141 aaagcgttgg ccttcataag ataaaactct cactacaata tcaggatttt ttaagaagcg
     4201 ggcaagttga ttatgtaact ccctgtttac ttgagcaagt gtcttaccgg ctgctttata
     4261 gcggccaact aatggaaact gaatataacc actttggtca attgggtaac cattcgcttg
     4321 aatagattgt tcattactaa tattgtttac aggaggggta atttccggat aagcccatag
     4381 ctggatagag agaacatcac ctggacttaa acgataaata gtttgttgat ttttaaataa
     4441 tgatgcgtag tcccgttgat aatcgatttg agctggttgt attgccggta atgtctcttg
     4501 agaaatttta actacattaa ccgttgttcc gaggtccgtt ttataaactc cctcactcgg
     4561 aatatcataa gtttgtaaac cggaagtaac cgcacagctg gcagcactta aacttaaggc
     4621 aagaacagag aaaaactggc aatacttcac acgcgaccct ttgtgtattt atctttaatt
     4681 gatattgtcc actgcatagc gacaagtgtc tattaaacgc aggctgaact gattctagct
     4741 gaaaagaaat gaaaaaacac agaaaaatcg tagagctttg tatgtttaat ttatatcaat
     4801 gctttttaac ccacatgaat agtaattttt tgctcaactc gataaataaa aaaacaggtt
     4861 atataaggag aacttaagaa ctgtaaacac ttttatacaa ttgaattacg gttaataaaa
     4921 aaaaactgat atagttacgc acgacaatat cgagtcaaga tatatttttt attatatata
     4981 caatttgtaa ggaataaggc taacttttat gcaacttgcc gatttaagaa tagcgattat
     5041 aggtttaggt tatgtaggct tgccattggc agttgagttt gggaaaaaag tacctgtagt
     5101 tggttttgat atttatcaaa aacgtattga tgagttaaaa agtggtcaag atcatacgct
     5161 agaggtttca ccagaagaat tagaacaagc agctcaatta agctatactg caaatttaga
     5221 agatctaaaa gattgtaatt tttttattgt tactgttcca acaccaattg atgactataa
     5281 gcagccagat ttaacacctt tggttaaagc ttctactagt attggtaaaa ttctaaaaaa
     5341 agatgatatt gtcgtatacg agtcgaccgt ttatcctggt gccacagaag aagtctgtat
     5401 tcctgttttg gaaaaagttt caggtttaac gtttaataaa gatttctatg ctggctatag
     5461 tccagaacgt attaatcctg gtgataaact tcaccgtgtt actaatattt tgaaaattac
     5521 ctcaggttcg acaccagaaa tttctgagtt tattgatgaa gtttataatt taattattga
     5581 ggctggaact cataaggcac ctagtattaa ggttgctgaa gcggccaagg ttattgaaaa
     5641 tacacaacgt gatgtcaata ttgcgcttat taatgaatta gcacttattt ttaataaatt
     5701 aggtatagat acagaagatg tattgaaagc agctggaaca aaatggaatt tcttaccatt
     5761 tcgtccaggt ttagttggtg ggcactgtat tggtgtagat ccgtattatt taactcataa
     5821 agctcaagcg attggatatc atccagaaat tattttagca gggcgtcgat tgaatgattc
     5881 aatgggagca tatgttgtta ctcaacttgt aaaagaaatg ataaaaaaga aaattcaagt
     5941 tgaaggagct aaggttttag tattaggttt gagctttaaa gaaaattgcc ctgatattcg
     6001 taatacaaaa gttattgata ttgtaaaaga actacatgaa tatcatatgg atgttgatgt
     6061 atatgatcct tggattgata gtgaagaaac tcaacacgaa tatggtatta caccagttaa
     6121 gcaacctaca gcaggtcaat atgatgctgt aatattagca gttgctcata acgaatttaa
     6181 agaaatgggt atagaggcaa ttcgctcttt aggtaaaaca tcgcatgtac tttatgatct
     6241 gaaatatgtt ttagctcaat ctgagtcaga tatccgtcta taaaataata tttgttgaga
     6301 ataaatatga atcgctatga agaagtattg gagcagctta agagcaatcc taaaacatgg
     6361 ttaataacgg gtgttgcggg ttttatcgga tcaaatctgt tagaaactct attaaaatta
     6421 aatcaaaaag taattggctt agacaacttt gctacaggtc atcaatataa tctggatgaa
     6481 gtagagactt tagtgagcag tgaccaatgg aagaatttta ctttctatac tggtgacatt
     6541 cgtaacttag aggattgtca gaaggcatgc gctaacgttg actatgtttt acatcaagcc
     6601 gctctcggtt ctgttccgcg ttcaattgct gatccaatat tgacaaatag tgccaatatt
     6661 acgggctttt taaatatgct cgttgcagca agagatgctc aagtcaaaag ttttacttat
     6721 gctgcgagta gctccacata tggtgaccac ccggcattac caaaagtaga agaaaatatt
     6781 ggtaatccat tatctcctta tgcggtaact aagtatgtaa atgagcttta tgctgaagtt
     6841 tttgctcgta catatggttt taaagcaata ggtttgcgtt attttaatgt gtttggtaaa
     6901 cgtcaagatc ctaaaggggc ttatgcggca gttattccaa aatggacagc agctatgatt
     6961 caaggagatg atgtatttat taatggcgat ggtgagacta gtcgcgattt ttgttatata
     7021 gaaaatacag tacaagctaa tattttagca gccatcgcaa atgatgaagc taaaaatcaa
     7081 gtctataatg tggcggtagg agatagaact actctaaatg atttatttaa ggctattaaa
     7141 tctgctttaa acgaaaatgg aatttcttgt gacaaagaac ctgtttatcg tgaatttaga
     7201 gttggcgatg taaggcattc tcaagcagat gtaactaaaa tcaaaacatt actaggatat
     7261 gatccaaaat ttagaatttt tgaaggaata ggtttggctg tgaattggta tttattgaat
     7321 aatggtaaat aaatatgtgg aaaatattta ccgttttagc tcgtattact tcattactcc
     7381 cacttttcct ttttcatttt ttttggcgtt gtctagatat ttttgacgga aaatttggag
     7441 ctgtagcacg atatattcta attgctggta gattaaaaaa atgtggaaca aatgtttata
     7501 ttggcccctt tgtttctatt gaaagtgtta gaaatttatc cttaggtaat aatgtaagta
     7561 ttcatcacca gtgtacatta atttgtttag ggggaattga tattggtgat aatgtagcaa
     7621 ttgctcatgc ttctagcttg atttctacta accatacatg gaatgataat aatttaccta
     7681 ttaaatataa tcctgttgtt tgtgacaact tagaaattca tgatgatgtt tggataggtt
     7741 gtggagtgcg tatcttagcg ggagtaaaaa ttccgaagcg atgtgttgtt gcagctggtg
     7801 ctgttgttac gaaaagctta tcagactcag gagctctata tggaggggtt ccagtgaaaa
     7861 agatacgtga tatatgaaat tttctagaat tttagagggg cttcagattt tatttctgaa
     7921 gttctcttca cttttgataa tgagtttaat ttttctattc ctttgggtgc aaatgggagt
     7981 tcaaggaatt ggagagtttg caacttacgc aacgatactc gcaccaatcg ttatgtttag
     8041 tcaatttaga tatgttgaat atattaacat tgttaatata aaagaagata aagaaaaaag
     8101 atttttacaa agtctgtttg caagtggtat ggttgtttta ttacttttag gtattttatt
     8161 tattttttat ttagtgactc atcaaccaat aaaaatttta gttgttgctg gactctataa
     8221 agtttttgaa ttattttcag atatttatat ttcattctta gtctcaatta aagaacttag
     8281 aaatgctttt tttgttatat ttaaaagatt attcttaatt ttatctgggt taatattttt
     8341 ttattttaag cagttttcgt tgaatcctat agaatttgta ttttatttac ttttgggagt
     8401 ttattttact ttctttgtaa tagatgtagt gatagaaaaa agaagattta atgaaggtcc
     8461 agatataaaa aatattactg actatattaa ggataatttt ttatatggtt ttaactcatt
     8521 gttaattagt ataaatagcc ttgtaccaag atattttttc atttttttta atgataaaaa
     8581 agggttaggt atttttacaa ttgtctattt gttagcctct actactacta ctttgatgca
     8641 atttctaata agcgtaaaag ttagtttaat agagaaattt attgatacaa gatttaatca
     8701 atacttatta attaatttaa ttatcgttgg attatgtttt ggtttctata tttttataaa
     8761 tgaattgagt gataactatt ttttatttgg actatctttt gttgtaatgt tgatttcatt
     8821 acttttacga ggggttaatt taacagcaag tttttcaaag aaaatgaaaa atgttattaa
     8881 tattgctctt atcttaccaa tgattttagt ttctctttta ctggtttttc tatgttttta
     8941 ttatagagaa tttgctttta aattctctat tttatatgtt tttacctctg cattgatgac
     9001 aagtatgatt ttaatgtttt ctttaaggaa gagtaaattg atatgttaat attgagctgc
     9061 ctattttttg ccttatttac gtatctaata ttttatttta ttgctagaaa gcagtcattc
     9121 tcgtttttgg taatatcttt tttcttaaat ttatatcact atatattttc tctaggcttt
     9181 tatttttact cattaggaag accaaatgat agtcttaatt actatatttg gggaactgaa
     9241 caattagaaa actttccatt ttctagtggt acaggattct tagtacattt agtacatttt
     9301 ataaattata tattaaatag ctatgaaaac gtttttttat tttttagcat gatatcttcg
     9361 tgggttattc tatccttttt tttaataatc tataattttt attccaagag agaaatttct
     9421 tctaatagtt ttttatttct tacaatatta ctttttattc ctggtcttca tttttggacg
     9481 gtagctattg ggaaagattg cttggtttta ttgtttatat ctttattttt atatgcttat
     9541 atttataaaa aaataaagtt gttggttttt tcattagttt tcttagcatt aattaggatt
     9601 catatttttg caattgtttt tttaactttt atactgcatg aatttatata tggtaatttt
     9661 aaacttaaaa aaatatctat gggtgtttat agatttgtaa tttttgtttt gtcaattcca
     9721 tcaatttttg ttttgtatca atttctgttt agctttattc aaaaatactc tgaggatggt
     9781 ttctcggata tcggtggatt tgtagaaaat agaaatgaag cttactctga ggagggctcc
     9841 ggattattgc tcgcttcaca accttatata ttaaaaatgc tcgctttcgt attaggtggt
     9901 ttaccgtggt tatcactaga tcctctttca ttattttcaa tggcggaagg cgttatcgtt
     9961 attggtattt tactatattc atattattat ctatttacta aggatagatt taataattct
    10021 aaacaaattt ttattttaat atttatagca ttatttattt tatttatgcc tttaatttct
    10081 gcaaatttag gtattatggt cagaatgagg gtaatgttgt atataccaat tttaacggtt
    10141 ttacttatgt ttatgctttc taatgaaagg aaaatttaat tatgaatttt gttattattt
    10201 ctagttttct tccttcaata ttaaattttc gtggaaaatt acttgaggct attcataaaa
    10261 aaggctatca aattcatatt attgctccag atctagaact atttcaagat gaagtaaata
    10321 aattacaatt gcttggttac tcagtttact ctgttgaaat gcaaagaact ggaactaatc
    10381 caatcacaga tataaaaaca ctatttgaaa tatataaaat tacaaacaag attaagccag
    10441 actatgtttt gtcatatacg attaaacctg ttatctacgg cacgcttgct acttattttg
    10501 caaaagtgcc aaatcgtttt tcacttataa cagggttggg atatgctttt cagaatgtag
    10561 atagtacaag taaaagaagt acttttcaaa aaatcataca ttggctttat aaacaagcat
    10621 taataagatc atccaaagtt ttttttcaaa atcctgatga ccttgcttta ttcaaacaat
    10681 taaatttatt aagtaataag gtgccagcag tagttgtcaa cgggtctggt gttaatgtga
    10741 atgattttga agttgtaagt ttgcctcgtg ctgtgaatgg tgaagttaag gtttcatttt
    10801 tattaattgc tcgattatta caagataaag gaataagaga gtatgtagaa gctgctaaat
    10861 taattaaaaa agaatatcct caaattgaat ttaatttagt gggttggata gatgaaaatc
    10921 caactgcaat aaaacaacaa gaattagatt catggattga tgaaaaaatt attaaatatt
    10981 ggggaaagct ttccgatgtt cgtcccgcta ttgccgaaag ttcaatttat gtattacctt
    11041 catatagaga aggcacacct cgtactgtct tagaagcaat gtctatgggg cgagctatta
    11101 ttacaacaga tgctcctgga tgtagagaaa ctgtagagca cgatggaaat ggttatttag
    11161 ttgaagtaaa gtctgtcact agcttagaga tggcaatgag aaagttcatt cagaatcctg
    11221 aattggctga aattatggga acacgttcta gagaaattgc attacataaa tatgatgtac
    11281 atcaagtgaa tcatcatatg atgacagaaa tgggaattaa ataagtgtta aaacgtttac
    11341 ttgatatcat tattgcatct atagcattaa ttctgctttc acctttatat ttctatgttg
    11401 catataaggt gaaaaaaaac ttaggttcgc cagtattgtt ccgtcaagtt cgtcctggtt
    11461 tgcatggtaa gccgtttgaa atgattaagt ttcgaacaat gaaagacgca acagacgcgc
    11521 aaggtaatcc tttaccagac agtgagcgcc taacgccatt tggtaaaatg cttcgttcta
    11581 ctagtctgga tgaaatgcct gagctttgga atgttattaa aggtgatatg agtatagtag
    11641 ggccaaggcc tttattgatg gagtacttac cgctttataa taaagaacaa gcaaagcgtc
    11701 atgatgtacg tccaggtatg actggtcacg ctcaagtcaa tggtcgtaat gcaattagct
    11761 gggaagaaaa atttaaacta gatacgtggt acgttgaaaa tagatcactt tggttagact
    11821 ttaaaataat gctgcaaacc gttaaaaaag taatcgctaa agatgatatt aatgaagctg
    11881 gcgaggcgac gatgacgaag tttacaggtt caaagtcgga agcagataaa tgaataactc
    11941 aatctatgct atttatggtg cttctggctg tggccgtagt ttgatgccta ttgcacgaca
    12001 acagctccaa cgtcagggta tttcagctga aatttatttt atcgacgata gtttaaaaga
    12061 aaaaaaaata gtaaatgggc atacagcttt aagctatcaa acctttaaat caataaattg
    12121 cacgaataaa tacgtattaa ttgccatagc gaatagtcat attcgtgaaa aaatcgcaaa
    12181 tcaattgatt gttgatggta ttaaactttg gtccatacaa gctgataata caataattat
    12241 ggataatgtt gaaattggtg aaggggctgc tttaagtcca ttcgtttcga ttacatcaaa
    12301 cataaaaatt ggtaaatgtt ttcatgctaa tttatacagc tatgttgagc atgattgtgt
    12361 gattggtgac tatgtgacat ttgcaccggg tgttaagtgc aatggtaata ttcacattga
    12421 agatcatgct tatattggtg ctggagcagt tattaaacag ggcacacctg ataagccttt
    12481 aataattggt aaaggtgcta ttgttggaat gggctccgta gtaacgaaaa gtgttcctgc
    12541 tggcgtaact gttgtgggta atcctgcaag aattttagaa agaaagtaag aaatatttta
    12601 ttaggaagtt aaaatgttaa acactgcatt tgaaccatgg ccaagtttta caacagaaga
    12661 agctgacgca gtcaaaaatg tattactatc aaataaagta aattattgga ccggtcaaga
    12721 gtgtagaatt tttgaaaaag aattcgctga gttttctgat acaaaatatg cggttgcttt
    12781 agcaaatggt accgtggctc tagatgtcgc attgaaagct ttagatattg gtgcaggtga
    12841 tgatgttatt gtgacgtctc gtactttttt agcttcagca agttcgattg taacagcggg
    12901 tgctaatcct gtttttgcag atgtagagtt agattctcaa aatatttcgc gtcgtactat
    12961 tgaggctgta cttaccccaa atactaaagc cattatttgt gtgcatttag ctggttggat
    13021 gtgtgatatg gatccgatta tgcaacttgc tgccgagcgt ggcatatatg ttattgaaga
    13081 ctgcgcccaa gctcatggag caaaatataa aggtaaagca gcgggttcta tcggtcatat
    13141 tgcggcatgg tcattttgcc aagacaaaat tatgacaact ggtggtgagg gcggtatggt
    13201 caccacgaat gatgaaacgc tttggaaaaa aatgtggtct tataaagatc atggtaaaag
    13261 ttacgacagt atttataata aacagcatcc accaggtttc cgttggttac atgactcatt
    13321 tggtaccaac tggcgtatga tggaaatgca agcagtgatt ggccgaattc agttaacgcg
    13381 tatggctgaa tggactaaaa aacgtactga aaatgcagaa aagattttaa aagcctttga
    13441 aggctctcct ttctttagtg ttcatattcc ctctgtagat tatattcatg cgtattataa
    13501 atgttatgtc caagtgaatt tagaagcctt gccggatggc tggtcacgtg atcgtattat
    13561 gcaagaaatt aactctcagg aagtaccttg ttttagtggg tcttgttctg aagtttattt
    13621 agagcacgca tttgatgata caccatggcg cccagaaaag cgtttagaaa atgctcaaaa
    13681 attaggtgga accagtttaa tgttcttggt tcatccgact ttgagtcaag acagtataga
    13741 aaaaacgatt cttgcaatta atgctgttaa tagagcttta caatcataaa aatgtgaagc
    13801 tattcacata gctttctttt gaattatgat ctgatttaaa gttatgtaac cgatgcgtaa
    13861 aattcatttc tagttatact agaaatgagt ataaatatcg cacggttact agaacgatta
    13921 gaagagtatt gtgaaaaaga ttatttatca gtttgcgtca gctcctcggc ttacaaaaca
    13981 atgttttttg gttcttatcg acctgtttgc tttccccatt attttatggt tgtgttatgc
    14041 catccgatta tttgatttag gtgcagaggt tattccaggc attaactatg gtgtggcatt
    14101 tgttacgatt ttagctattt taagtttaat ggtaactgga gtttaccgat ttattgttcg
    14161 cacgtttaat gaagctttta ttgctaaatt agcaattgct gttacgttaa tggtcattgt
    14221 tttatatggt atgaatgctt tttcgcctgc atttgttccg acttcaattc cattgatgtt
    14281 tggtttctta atgtttggtt gggtttggtg tagccgtgca tttattcgct ttatcgtaaa
    14341 agctgtatta cagactggcg aagagcgtaa acgaattgca atttatggtg ctggtgatgc
    14401 aggtcaacaa attgctgcag tcctttatcg ttctggtaac catttacccg ttttctttat
    14461 tgatgataat acctctttac aagatcatat agttggtggt ttaaaagtat tatcgttaga
    14521 gaaagcctta caacgttttg aaaaatataa aactgatgaa attttattag cgttaccttc
    14581 agtaggtcgt gtacgtaaaa gtgaaattat tcaacagcta gaacctgcac atctcaaaat
    14641 tactgagctt cctggcctta cacaacttgt tgatggtgaa ctaaaagttg cagatattcg
    14701 tgaagtagac attattgatt tgttgggacg tgaccctgta cctcctgtag atcatttact
    14761 ggcaaaaaat attcaaaaca aagttgtaat ggtaacagga gctggtggtt ctattggttc
    14821 ggaattatgc cgtcaaattg ttaaaaacca gcctaagaag ttgattattt atgaaattac
    14881 agaatttgca ctttatagta tagataaaga attacggtta acggctcaat gtgaaatagt
    14941 acctatttta ggtacagtgc aagatcaaca gaaattagaa cgtattatcg agcaatatgg
    15001 tatacagact gtttaccatg ctgctgccta taaacatgta cctttagtag aatgcaatcc
    15061 aattgcagga ttaaagaaca atgcgattgg tactgcgaat agtttaaatg cagctattaa
    15121 aaagggtgta gagacttttg tgctaatttc gactgataaa gcagtacgcc ctactaatgt
    15181 tatgggtgca tcaaaacgta tggctgagct ctattgtcaa gcaatggctg aagcccagaa
    15241 acaaacccaa attagtatcg tccgttttgg taatgtatta gggtcttccg gctcagtagt
    15301 accgttattt aaacagcaaa ttgccaaagg cggcccaatt actgtgactc atccagaagt
    15361 aacacgctac ttcatgacta ttcctgaagc atctcagttg gttattcaag cgggtgcgct
    15421 aggtagaggt ggtgatgtgt ttttacttga tatgggtgaa cctgttcgta ttcaggactt
    15481 agctcgccaa atgatttctt taagtggttt aactgtgcgt gaacaaggtt caatgcaagg
    15541 ggatatcgaa attcaatata gtggattgcg tccgggtgaa aaactttacg aagaattatt
    15601 aattgatcaa gaaaatactg aatatactga gcacagtaga attcttcgat catttgaaaa
    15661 attctatcca cttacagaaa ttcaagaagt ctttgaacga ataaataata tgactgctgt
    15721 ccagcaagat attgattggg ctctttgtca acttgaacac tatgttgatg gttataaacg
    15781 tagtaaagat attatggtta attagagggt aaatgtgtga tcaaaaaagc agttttacct
    15841 gttgccggtt taggcacacg ttttttacca gcaagtaagt caattcctaa agaaatggta
    15901 acagtagttg accgtcctgc aattgagtat gtagtacgtg aagctgtaga ggctggaatt
    15961 gagcaaatta ttttagtcac tcattcatcg aaagcctcaa ttgaaaatta ttttgatagg
    16021 agctttgagt tagaaacgac tttagaacaa aagaaaaaat tcgacttact tgcagagatt
    16081 acacaaattg tgcctgagca tgtaagtgta ataagtgtta gacagcctca acctttaggt
    16141 ttaggacatg ctgttttatg tgcaaagagt gttgtcggcg aagatgattt tgcagtgcta
    16201 ttaccggatg tactagtaaa agatggttct ggacaaaatg atttatctcg tatgatttct
    16261 cgctataatt caagccaagc tgctcaaatc atggttgagg cagtgcctga tcacttggta
    16321 gatcaatatg gtattgttga tgttgcacaa agtccaaatg aaggcgaaag cattgctatg
    16381 cagggtattg ttgaaaaacc ccctgtaggt gctgcaccat caaacttatc tgtggttggc
    16441 cgctatgtgt tacctgccaa gattatgcaa ttacttgaga acacgccgaa aggtgcaggt
    16501 aatgaaattc agttaactga tgcaattgca atgcttcaag acacagatac tgttgaagct
    16561 tatcgtatgc aaggccaaac gtttgactgt ggtagtaagc ttggttattt aaaagctgta
    16621 ttacattatg gtttagaaca tccaaaatta gggatggaat ttaaacagct gattcaagaa
    16681 cttaaattat aaagttttgt agctctgctt aagtatttgt aaaaacgaat gaatataaca
    16741 acagagcagt atattctctt cctgtaaaag gaagagaaat ctataaaata ctaaagaatc
    16801 aggtgtgcaa tgaaaatcgc agtatttgga acgacgttac atgccggtgt aatggccgca
    16861 ttattggctg aatatggtaa tcaaatttat tggtgtacct gtgtaagttg tgaagaaaat
    16921 atttctgtac tttcgtatca agaccaagaa gtaaatcatt atttaaacaa acagcgaaaa
    16981 gctggtttct tgaaagaaag ccctttttct gaaattcctt tagatatcga agtttattta
    17041 ttttgtttta gtcctacaca aattgaactt gccttaaaaa ctgttgaaaa actaagtgag
    17101 cggccaatta ttcatcctaa attaatgatt aatggctcta cttttggttt acatggtaca
    17161 gagaaattaa aacagcactt gccgaaagat gaatgggtgt atttccctga tgtgattcaa
    17221 gaaggtaatg caattaatag tgtactagat gtaaaacatg tcattgttgg tgtagagtct
    17281 agggacgcaa gtgaaattat gcaggaattg ttgcgtcctt ttttccaatt tagttatcaa
    17341 tacttattta tgccgatttt agatgctgag tttaccaaac ttagtatttc gggcatgtta
    17401 gctactcgta ttagctatat gaatgatctt gcgatggtcg ctgaaaaact cggtattgat
    17461 attgcaaatg taaagcatgg tatcgctgct gatacacgta ttggtgccgc atatttatca
    17521 ccaggtgtgg gatttggcgg tgagaatttt tcgcatgata ttttgacact ttcaagcaca
    17581 gtgttagaaa cgggaacaaa aagccgactt ttggagcaag tctgggctat taatgagcaa
    17641 cagaaagaaa ttttgttccg gaagttatgg aattattatc actgtgactt gagtggtaaa
    17701 actgttgcga tttggggagc ctcttttaaa gaaaatactt caaatataca taactcaccc
    17761 attcatattt tattggctgc gttatgggcg caaggagtaa aagtacgttt acatgaccct
    17821 caggctctag atgagattgc aataacttat ggagaccgtg aagatctggt tttatgtgct
    17881 gatcaatatg aggctgcaca aaatgctcat gccttatgtg tagtaacggc atggaaacaa
    17941 tactggagtc ctgactttaa gcgattacaa cagttaatga agcatccttt aattttagat
    18001 gggcgtaata tttatgaccc agcatatgta aaggctagag gttttgctta cgaaggagtt
    18061 ggacgtttat gagtaaatca attgaacaat tcccaaagga tttaagctca cctttaatac
    18121 agcttaagtc ttcagttgag aaaaactcaa aagtacatat aaaagagctt tttgctttag
    18181 agccagaacg gtttcaaaat tattctgtaa aatttaatca gttatttttt gattatagta
    18241 aacaacgtat taccaaaaat attttggaac aacttgttgc tcttgcaaac aataaacaat
    18301 taacacagtg gattaatcgt cttttttcgc aagataaaat taattgtact gagcagcgtg
    18361 aagcaatgca ttgggctttg cgtttacctt cggaatattc aaaatttccg gcgctgacaa
    18421 aacaggtcca tactcaatta cagcgtatgt acgctttggt tgaaaaaatc catgctgggc
    18481 aataccgtgg cgctacgggt gaagtgattc aggatatcgt taatattggt gtaggtggtt
    18541 ccgatttagg acctcaaatg gtgacccacg cactatgcga ttttaaagta aaaactacca
    18601 aaccacttaa tgtacacttt gtttcgacta tggatggtag ccagttatca gacttactcc
    18661 atcaactgcg tccggaaacg actttattta ttatttcttc gaagtccttt ggtaccattg
    18721 ataccttatc aaatgcgcaa actgttcgac aatggcttga aaaagcttta ggaaagcatg
    18781 accgggttgt aaaaagtcac ttcattggtg tatctacaaa agctgacaaa atgactgagt
    18841 ggggaattgc tcctgacaat cagttgctac tttgggactg ggtagggggg cgttattctc
    18901 tttggtcttg tattggtttt cctatagccc taacgattgg tatagatggc tttcaacagc
    18961 ttttagctgg tgcccatgct gtcgatgaac acttccaaaa tacaagcttt gagcaaaata
    19021 taccagttct catggcatta ctcggtatct ggaataataa ttttttaaat attcagaccc
    19081 atgcagtatt accttatgac ggaagattaa agtattttgc tgcctatttg cagcagcttg
    19141 aaatggagtc taatggtaag tcggtacaac gtgatggtca aaaagttgaa ttagatactt
    19201 gtccgattgt atggggtgag gttggtccaa atgcacaaca cgccttttac cagctcttgc
    19261 atcaagggac tcaggcagta agctgtgact ttattgcacc aattcaacgt tataatgcag
    19321 atcactttac ctatgtagag aatgctgagg cattgattga acaacatcac cttgcattat
    19381 caaattgttt ggcacaatca cgtttattgg ctttcggtaa tgaagcacta gatgtaaaag
    19441 aattagagaa attgcctatt tataaacaat atgaaggtaa ccaaccaagt tctacattat
    19501 tgttagatga gttaaacccc tataatttag gaatgttgat tgctttatat gaacataaag
    19561 tgtttgttca gtctgtgatt tggaacatta acccgtttga tcagtggggg gtggaaaaag
    19621 gtaaacagat tgctgatcag ttacttccaa ttttaaatgg tgctcaaaat gatctttcaa
    19681 cactcgatgc atcaacgcgt ggattgatta agatattgtt aggaaaggcc gagtaagtat
    19741 atatgtgtta ttccatgaag taggtatatt gtgatttaag tttttacagc cgttattttc
    19801 gaatgattct aataaattca tcataagttt ttgtatgttg gaattagtcg gatgattaga
    19861 tagagcggta accttgtttt ctaacagaaa attctgttct ttgatttcgg aaaataatat
    19921 tgctgattat tataaaaaag ataaactgtt atctttggga agtaataaaa agaaggacat
    19981 catgcctcct tttcatttat gctcttagca ctaagactga attaaactcg tcaactcatc
    20041 tacataatat tgcattggct gagcttgacg atctgcacgg ctttcaatgt taagacgtag
    20101 taaaggctca gtgtttgaag cacgtacatt aaaacgccat gcgccaaagt cgaggcttac
    20161 gccatcggta cggtcaattt gtggattttg atcggcataa aaatcgaaaa tcttttgaat
    20221 agtaatttgt gtatcagcca ctttaaagtt gatttcacca ctacatggaa atttggtaat
    20281 catattttca acgagtgttg aaagtgattg tcccgtttca gagagtagag caatggtgag
    20341 taaccacgga atcataccac tgtcacagta agcaaagtca cggaaataat gatgggcact
    20401 catttcaccg ccgtatacgg cattgtgttc acgcatgaca tctttaatga atgcatgacc
    20461 agattttgac tgtacagcaa tgcctttgta ttgatcgacg atatcaaatg tgttccagac
    20521 taaacgtggg tcatgcacaa ttttttcgcc tgactgtttg attaagaaag cttgagccaa
    20581 taaaccaaca atataatagc cttcaataaa ctgacctttt tcatcgaaca agaaacagcg
    20641 gtcaaagtcg ccgtcccatg caatacccat atctgcttta tgctcaagaa cagcatttcg
    20701 ggtactgtca cggttttcaa ttaaaattgg gttagggatg ccatttggga aagtgccatc
    20761 tgcttcatga tgaattttaa taaattcaac cggtacatta agcgctttaa atttttcttc
    20821 aatggcatca atcacatgac cagctgcacc attacccgcg tttaccacta actttaatgg
    20881 acggattttt gcaggttcaa tataagtcag tagatggtca acgaactcag gcaaaatgtt
    20941 atagctttgc gttgtacctt tttgaccaac ttcttcaaag ttattagtct ctgctaaagc
    21001 ctgaatttct tttaaaccag tatcggcact aattggacga gcattttctc gaaccaattt
    21061 cataccgtta tagtccattg ggttatgact cgcagttact tctataccac cttgtacgtc
    21121 taaatgaaaa gctgcaaagt acacttcttc agtacccgtc atgcctaaat caagcacact
    21181 cacacctgca tcatttaaac cgcggatggc cgcttgtttt aaagcctcac tgcttagacg
    21241 aatatcacaa cctacaacca cagtctttgg tttatagatt tgtccgtaag cgcggccaat
    21301 tttataggcg atttcttcat tcaattcggt gccgagtttg cctcggatat cataagcttt
    21361 aaaacacgtt aaagtagtca ttattcaatt caatacatgt ggtttgagtt gtgtgcacat
    21421 tatacataga tcatcaaatt ggtacgttta tagtttttat attcaaattt tgcacttcat
    21481 ttctgtaagt caaatttaag tttataagaa agtattttta agactttagt ctaataagaa
    21541 aatttctaaa ttagaaagag cttgatttta cttagtacta ttggtcttac caattatggt
    21601 gattatttaa tgattgatct taccaatatc tgtgtttatg atgcggtctg tggtttaagg
    21661 aataacattt gcacttaatt tttaattggt cataccaatt gtgttaaatg tttaagaatt
    21721 taaggtacaa aaattcgccc cagcatttca aggagatgac aatgctcaat atgtggcaac
    21781 aactttatga ccctttaaat aatatttggc tgtctagtgc ggttgcatta atcccgatta
    21841 ttttcttctt tttggccttg gctgtttttc gtttaaaagg cagtatcgcg ggtacgggca
    21901 cagttattat tgcattactg attgcgctat ttttctatca aatgccgggg caaatggcct
    21961 ttgcatcaat catttacggt ttcttctacg gtctatggcc aatttcatgg atcattattg
    22021 gggcagtttt tctatacaag atttcggtaa aaacaggcca gtttgaagtt atccgctcaa
    22081 gcattctatc tattaccgaa gaccaacgtc tgcaaatgtt actcgttggt tttgcatttg
    22141 gtactttcct tgaaggagct gcgggctttg gtgctcctgt cgcaattacc gctgcactac
    22201 ttgtcggttt agggtttaag ccactttacg ctgctggttt atgtttaatt gtaaatacag
    22261 caccagttgc attcggtgca atgggtattc caattattgt ggcagggcag gtttccggtg
    22321 tagacactat ggaaattagc cagatggtgg gtcgtcagtt gcctttttta accattattg
    22381 tgctgttctg gattatggcg attatggatg gctggcgtgg tgttaaggaa acttggcctg
    22441 cggtattggt cggtggtggt gcttttgcga ttgctcagta tctcacctct aactttattg
    22501 gccctgagtt accagacatt accgcagcaa ttgcttcatt ggtcagcctg acattgttat
    22561 tccgtgtgtg gaaaccaaaa catattttcc gttttgaacc tgaagcgggt cagactttgg
    22621 ctcagcaacc tacaacagtt caacgttata gcattgggaa aattgcaaag gcatggtctc
    22681 catttgctat tttaacggta atggtcacga tctggagcgt taagccattt aaagcattat
    22741 ttgcaaaaga tggtgctctt gaacactgga tttttaaact tgaagtgccg tatttacaca
    22801 aattggtcga gaaaatgcca ccgattgtgt ccgagatgaa accatacgaa gcgatttata
    22861 agtttgactg gttctctgca acaggtactg caatttttat tgctgcaatc atcacagtta
    22921 ttttcttgaa aatgaaagca agtgaggcag taacaacctt cggtgaaacg ctcaatgagt
    22981 taaaaacacc gatttactcg attggtatgg tgttggcatt tgcttttatt gcgaactatt
    23041 caggtttatc tgcaactttg gctttggctc tatcgcatac gggtcatgcg tttactttct
    23101 tctcgccatt tttgggttgg cttggtgtgt tccttactgg ttcagacact tcttcaaatg
    23161 ctttattctc ggcattacaa gcaaccaccg ctcagcaaat tggtattccg gaagtgttat
    23221 tggtcgctgc gaataccagt ggtggtgtga caggtaaaat gatttcgcca cagtcgattg
    23281 cgattgcttg tgccgcagta ggcttagttg gaaaagagtc tgacttgttc cgtttcacgg
    23341 taaaacatag catcatattc actgtctttg ttggcatcat tatcacggtt caggcatatc
    23401 tggttccgtg gatgattcca taa
//
