LOCUS       BGC0001948              3579 bp    DNA     linear   BCT 06-NOV-2018
DEFINITION  Streptomyces sp. strain CMB-MQ030 NASs biosynthetic gene cluster,
            complete sequence.
ACCESSION   BGC0001948
VERSION     BGC0001948
KEYWORDS    .
SOURCE      Streptomyces sp
  ORGANISM  Streptomyces sp.
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 05:33:45
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 3579
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..3579
                     /country="Fiji"
                     /db_xref="taxon:1931"
                     /identified_by="Robert J. Capon"
                     /isolation_source="Fijian marine sediment sample"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sp."
                     /strain="CMB-MQ030"
     misc_feature    1..3579
                     /note="NASs biosynthetic gene cluster"
     protocluster    1..3579
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[62:788]"
                     /cutoff="5000"
                     /detection_rule="(CDPS or cycdipepsynth)"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      63..788
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(CDPS or cycdipepsynth)"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
     cand_cluster    1..3579
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(CDPS or cycdipepsynth)"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..3579
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001948"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..3579
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="CDPS"
                     /region_number="1"
                     /rules="(CDPS or cycdipepsynth)"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             63..788
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     cycdipepsynth"
                     /gene_kind="biosynthetic"
                     /note="involved in synthsis of dipeptides"
                     /product="CdpS"
                     /protein_id="AWF71595.1"
                     /sec_met_domain="cycdipepsynth (E-value: 3.4e-64, bitscore:
                     204.0, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="CDPS (E-value: 5.5e-64, bitscore: 203.5,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTSLAAVAGDHIVEPYSPNCERLLEAADHLLIGVSPGNSYFGIP
                     TLTRILTWAHATFRRIDVIVPDRSLAANYRAQGYSEQVAHKKARTEISSVRRRIRRAWE
                     RSGIPEHEQRTHLLSELALLPAYEKLHRRVREALASDERVFDVCQRTTSRAVPVAEQTG
                     EGTGSVAVPAPGPHLALDYLIDEMPFFIDTPNILGVPSSLVNYHMPVPFAGLLYTGDGP
                     LRAPSHQGLILLRDRAAER"
     CDS             880..2085
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 291.8; E-value: 1.3e-88)"
                     /gene_kind="biosynthetic-additional"
                     /note="P450 family member"
                     /product="NascB"
                     /protein_id="AWF71596.1"
                     /sec_met_domain="p450 (E-value: 2.4e-23, bitscore: 70.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTATLTYPFHDWSQELSPRYAQLRASDAPVCPVVSEGTGDPLW
                     LVTRYATAVKLLEDSRFSSEAAQASGAPRQEPVELRAPGTRGDAIAMLREAGLRSVLAD
                     GLGPRAVRRHQKWIHEYAETLIGELVDREGTFDLAREFAEPLSSAVVSRTLLGELTSDE
                     RARLVGWADTGLRFCGATHEEQVRAFTEMHRFFLEHARRLAAGPGEHLLKHIAEAPTPA
                     GPLSDEALAEAAELLVVAGFPTSSGFLCGALITLLRHPESVQELHTHPDRVPSAVEELL
                     RHTPLATGAAKRMATEDLELDGVRIGAGEVVMVSFEAVNRDPDAFEDPDRFRPGREGPM
                     HFGFGRGRHTCPGNRLARCLIEATVRAVACHPGLRLAVAPEEIRWHEGLFFRRPRALPA
                     TW"
     CDS             2104..3579
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 230.6; E-value:
                     4.1e-70)"
                     /gene_kind="transport"
                     /note="major facilitator superfamily member"
                     /product="trasportor protein"
                     /protein_id="AWF71597.1"
                     /transl_table=11
                     /translation="MSTKPPAGQPATAEVSAPARLSRDRALLLAVLVTATFTMILNETI
                     MSTALPRLMADLHLTASTAQWLTTGFTLVMAIVAPTTGFLLQRLGSRTVFLAGTGAFAA
                     GTLLALLAPGFEVLMAARVTQACGTAVMLPLLTTTIARIVPAARLGQYLGLATIAVSFA
                     PAVGPPLSGLIVDALGWRGIFLVLLPVGLAALVLGAAKLRDHDAPERVGLDGWSIPLCA
                     LAFGGLVHGAAALGEGHAVAPPWLLVAVGAVALAAFVARQVARERRGHSPLLNLRPFAR
                     RPFALATALLGLSVLGQAGSMMLLPLHLQESLGVSTRTAGLLLLPGGLALALLAPPVGR
                     LCDRFGPRPLLLSGSGVLTASLAGLGVLAGHEVSLPTVAAVYLAVNTGVICITGAAMSA
                     AMGSLPPSLHPYGSATLSTLQPLVAALATALYISVMSRARAAGLGDGLGPAAAGAAGAR
                     AAFLLGALISSLGIALACLFRRPAPTTASAPAH"
ORIGIN
        1 gccttgctgt cccactcctc tcctccgatg cggacaaccc tccgcgattc caagggagtt
       61 tcgtgaacac ttccctcgct gcggtggccg gcgaccacat cgtcgagccg tacagcccca
      121 actgcgagcg gctgctcgaa gcggccgatc acctgctgat cggggtcagc ccggggaaca
      181 gctacttcgg gattcccacc ctcacccgga tactgacctg ggcacacgcc acgttccggc
      241 ggatcgacgt catcgtcccc gaccgttccc tggcggccaa ctaccgcgcc cagggctact
      301 cggaacaggt ggcgcacaag aaggcacgca ccgagatctc cagcgtgcgg cggcggatcc
      361 ggcgtgcctg ggagcgcagc ggcatccccg agcacgagca gcgcacccat ctgctgtccg
      421 agctggccct gctgcccgcc tacgagaagc tgcaccggcg ggtgcgggaa gcgctcgcct
      481 ccgacgagcg ggtcttcgac gtctgccaac ggacgacctc gcgggccgtg cccgtcgcgg
      541 agcagaccgg cgagggcacg ggatccgtgg ccgtcccggc cccgggcccc cacctcgcgc
      601 tggactatct gatcgacgag atgcccttct tcatcgacac cccgaacatc ctcggcgtcc
      661 cctcctcgct ggtgaactac cacatgccgg tgccgttcgc cggactgctc tacaccggcg
      721 acggcccgct gcgcgcgccc tcccaccagg gcctcatcct gctgcgggac cgggcggccg
      781 aacgctgacg cggcacgccg acgcccctgc accacggctc cgcgcccggc ctccggcggg
      841 cgcggagccg tccccgccgc ccacgaagga gcccacgccg tgaccaccac cgccacgctg
      901 acctacccct tccacgactg gagccaggaa ctctccccgc gctacgcgca gttgcgggcg
      961 agtgacgccc cggtctgccc cgtcgtctcg gagggcaccg gcgacccgct ctggctcgtg
     1021 acccgttacg ccaccgccgt caagctcctg gaggactcgc ggttcagctc ggaggccgca
     1081 caggcgtccg gcgcgccccg ccaggaaccg gtcgagctgc gggcgcccgg cacccggggc
     1141 gacgccatcg cgatgctccg cgaggccggg ctgcggtccg tactcgccga cgggctcggc
     1201 ccccgcgccg tccgccgcca ccagaagtgg atccacgagt acgccgagac gctgatcggt
     1261 gaactggtcg accgcgaggg gacgttcgac ctcgcgcgcg agttcgccga gccgctctcc
     1321 tcggcggtgg tctcccgcac cctgctggga gagctgacat ccgacgaacg agcccggctc
     1381 gtgggctggg ccgacaccgg actgcggttc tgcggagcca cacacgagga acaggtacgc
     1441 gccttcaccg agatgcaccg gttcttcctg gagcatgcgc gacgactggc cgccgggccg
     1501 ggcgagcacc tgctcaagca catcgccgaa gcacccaccc ccgcgggacc cctcagcgac
     1561 gaggcgctgg ccgaggccgc cgaactcctc gtcgtcgccg gcttcccgac ctcgtccgga
     1621 ttcctgtgcg gcgcgctgat caccctgctg cggcaccccg agagcgtcca ggaactgcac
     1681 acgcacccgg accgggtccc ctccgccgtg gaggaactgc tgcggcacac ccccctcgcc
     1741 accggcgcgg ccaagcggat ggccaccgag gacctggagc tcgacggagt gcggatcggg
     1801 gccggggagg tggtgatggt ctccttcgag gccgtcaacc gcgacccgga cgccttcgag
     1861 gacccggacc gcttccggcc gggacgcgag ggaccgatgc acttcgggtt cggccgcggc
     1921 cgtcacacct gccccggcaa ccggctggcc cgctgcctca tcgaggcgac ggtgcgcgcc
     1981 gtggcgtgcc accccgggct gcggctcgcc gtcgcccccg aggagatccg ctggcacgaa
     2041 gggctcttct tccgccgtcc gcgggcgctt cccgccacct ggtgaaccgc cccgaggaga
     2101 accatgtcga cgaaaccccc tgccgggcag cccgcgacgg cggaggtgtc cgcccccgct
     2161 cggctgtcca gggaccgggc gctgctcctg gccgtcctgg tgaccgccac attcaccatg
     2221 atcctcaacg agacgatcat gagcacggcg ctgccccggc tgatggccga cctccatctc
     2281 accgcgtcca ccgcccagtg gctgacgacc gggttcaccc tcgtcatggc gatcgtggcg
     2341 cccacgaccg gcttcctgct ccaacgcctc ggctcccgta cggtcttcct cgccggaacc
     2401 ggcgcgttcg ccgccggcac cctgctggcc ctgctggccc cggggttcga ggtgctgatg
     2461 gccgcacggg tgacacaggc gtgcggcacg gccgtgatgc tgccgctgct gacgacgacc
     2521 atcgcccgga tcgtgcccgc cgcccggctg ggccagtacc tgggactcgc cacgatcgcg
     2581 gtgagcttcg cccccgccgt gggcccgccg ttgtccgggc tcatcgtcga cgcgctcggc
     2641 tggcgcggca tcttcctggt gctgctgccg gtcgggctcg cggccctcgt gctcggcgcc
     2701 gcgaagctcc gcgaccacga cgccccggag cgggtcgggc tcgacggctg gtcgatcccc
     2761 ctgtgcgccc tcgccttcgg cggtctggtg cacggggcgg ccgcgctcgg cgagggccac
     2821 gccgtcgctc cgccgtggct cctggtggcg gtcggcgcgg tcgcgctggc cgcgttcgtc
     2881 gcacggcagg tcgcccgcga acgacgcggc cacagcccgc tgttgaacct gcgccccttc
     2941 gcccgccgcc cgttcgcgct cgccacggca ctgctgggcc tgagcgtgct ggggcaggcc
     3001 ggctcgatga tgctgctgcc gctccatctc caggagtcgc tcggcgtcag cacccgcacg
     3061 gccgggctcc tgctgctgcc ggggggcctc gccctggccc ttctcgcgcc gcccgtgggc
     3121 cgcctctgcg accggttcgg cccccgcccc ctgctgctga gcggcagcgg ggtgctcacc
     3181 gcctcgctcg ccggtctcgg agtgctcgcc gggcacgagg tgtcgctgcc caccgtcgct
     3241 gccgtctatc tggcggtcaa caccggcgtc atctgcatca cgggtgcggc gatgtcggcc
     3301 gccatgggat ccctgccccc gtccctccac ccgtacggca gtgcgacgtt gagcacgctg
     3361 caacccctcg tcgccgccct cgccaccgcc ctgtacatca gcgtcatgtc ccgggcccgc
     3421 gccgccgggc tcggcgacgg gctgggcccg gcggcggccg gagccgcggg cgcccgggcc
     3481 gcgttcctcc tcggcgccct catctcgtcc ctcggtatcg ccctggcctg cctcttccgg
     3541 cgccccgcgc ccaccacggc gtccgccccg gcgcactga
//
