BGC0001954 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001954 (Talaromyces wortmannii)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	19,896	wortmanamide A/wortmanamide B	NRPS:Type I+PKS	100%

BGC0001954 - Region 1 - T1PKS

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Location: 1 - 19,896 nt. (total: 19,896 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 19,897
Label		BGC0001954

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001954	1.00	NRP, Polyketide	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0002162	0.31	Terpene	sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8	Aspergillus fischeri NRRL 181
BGC0002229	0.30	Polyketide	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872
BGC0001068	0.30	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001244	0.30	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001275	0.29	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273	0.29	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000996	0.26	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0002670	0.24	Other	fosfonochlorin	Fusarium oxysporum f. sp. lycopersici 4287
BGC0000120	0.24	Polyketide	patulin	Penicillium expansum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001954	1.00	NRP, Polyketide	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0002162	0.64	Terpene	sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8	Aspergillus fischeri NRRL 181
BGC0002229	0.64	Polyketide	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872
BGC0001068	0.64	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001244	0.63	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001275	0.63	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273	0.63	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000996	0.59	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0002670	0.57	Other	fosfonochlorin	Fusarium oxysporum f. sp. lycopersici 4287
BGC0000120	0.57	Polyketide	patulin	Penicillium expansum

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 19896:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

QBC19710.1

PKS_AT (548..859): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 62.5%; Methoxymalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 82.9
Methoxymalonyl-CoA: 74.5
Ethylmalonyl-CoA: 55.9
Isobutyryl-CoA: 44.5
Malonyl-CoA: 31.0
Benzoyl-CoA: 28.7
Propionyl-CoA: 26.0
trans-1,2-CPDA: 24.0
fatty_acid: 20.0
3-Methylbutyryl-CoA: 15.6
2-Methylbutyryl-CoA: 15.1
CHC-CoA: 11.4
Acetyl-CoA: 7.5
inactive: 0.0