BGC0001954 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001954 (Talaromyces wortmannii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	19,896	High	wortmanamide A/wortmanamide B	NRPS:Type I+PKS

BGC0001954 - Region 1 - T1PKS

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Location: 1 - 19,896 nt. (total: 19,896 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 19,897
Label		BGC0001954

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

QBC19712.1: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

QBC19713.1: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Ligases: synthase

QBC19710.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001954.2	1.00	NRPS, PKS	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.75	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.75	PKS	asperlactone	Aspergillus ochraceus
BGC0002192.3	0.67	PKS	FR901512	fungal sp. No.14919
BGC0001254.3	0.65	PKS	ACT-Toxin II	Alternaria alternata
BGC0001268.4	0.63	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.62	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0002240.3	0.50	PKS	BAB, BAA	Metarhizium anisopliae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001954.2	1.00	NRPS, PKS	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.75	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.75	PKS	asperlactone	Aspergillus ochraceus
BGC0002192.3	0.67	PKS	FR901512	fungal sp. No.14919
BGC0001254.3	0.65	PKS	ACT-Toxin II	Alternaria alternata
BGC0001268.4	0.63	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.62	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0002240.3	0.50	PKS	BAB, BAA	Metarhizium anisopliae

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 19896:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

QBC19710.1: pk

PKS_AT (548..859): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 62.5%; Methoxymalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 82.9
Methoxymalonyl-CoA: 74.5
Ethylmalonyl-CoA: 55.9
Isobutyryl-CoA: 44.5
Malonyl-CoA: 31.0
Benzoyl-CoA: 28.7
Propionyl-CoA: 26.0
trans-1,2-CPDA: 24.0
fatty_acid: 20.0
3-Methylbutyryl-CoA: 15.6
2-Methylbutyryl-CoA: 15.1
CHC-CoA: 11.4
Acetyl-CoA: 7.5
inactive: 0.0

Link to PARAS substrate predictor