LOCUS       BGC0001954             19896 bp    DNA     linear   PLN 18-FEB-2019
DEFINITION  Talaromyces wortmannii strain CBS 387.67 TwmA, TwmB, TwmC, TwmD,
            TwmE, and TwmF genes, complete cds.
ACCESSION   BGC0001954
VERSION     BGC0001954
KEYWORDS    .
SOURCE      Talaromyces wortmannii
  ORGANISM  Talaromyces wortmannii
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Trichocomaceae;
            Talaromyces; Talaromyces sect. Islandici.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-08 05:36:57
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 19896
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     mRNA            complement(join(<1..929,1008..>1125))
                     /product="TwmA"
     CDS             complement(join(1..929,1008..1125))
                     /codon_start=1
                     /note="putative thioesterase"
                     /product="TwmA"
                     /protein_id="QBC19709.1"
                     /transl_table=1
                     /translation="MASGKAGGASALFSEATQAEQLDSHTYRVNLNQGFCIGAVPNGGY
                     TSACMLAAASKHLGPRGQPDTLTAHFEYPNRTSTGPAIVVIEDVKLGRQISTLHLTLWQ
                     GGLLSQAPWIDRSVSRRIVLAYTTHTNLRTFSGISMPTGYEVTPAAELPSVSDFEALKT
                     HGADDAWAESKLPKGWAAMMLSLTQWRFYVPRKEPLSPGVLDMWIRLASGEKITQGALA
                     YVVDSFPHNMHTFLAAPALRELLNASPERSGDSEVKDVRKKDQQRAEMWFPTVVMNIEA
                     KTALPEEGVEWLSVRVSSKQIKEGKFDLEVLVRDTDGEMVALSNHVAMILSVERNTGKK
                     SGSSKASL"
     source          1..19896
                     /culture_collection="CBS:387.67"
                     /db_xref="taxon:28567"
                     /mol_type="genomic DNA"
                     /organism="Talaromyces wortmannii"
                     /strain="CBS 387.67"
     subregion       1..19896
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="NRP, Polyketide"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..19896
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     mRNA            complement(join(<1606..1951,2018..4153,4211..7236,
                     7295..9464,9515..9934,9985..>10826))
                     /product="TwmB"
     CDS             complement(join(1606..1951,2018..4153,4211..7236,
                     7295..9464,9515..9934,9985..10826))
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (7-436). E-value:
                     2.6e-161. Score: 529.1. Matches aSDomain:
                     nrpspksdomains_QBC19710.1_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (548-859). E-value: 7.1e-88.
                     Score: 286.6. Matches aSDomain:
                     nrpspksdomains_QBC19710.1_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (935-1110). E-value: 7.1e-19.
                     Score: 60.6. Matches aSDomain:
                     nrpspksdomains_QBC19710.1_PKS_DH.1"
                     /NRPS_PKS="Domain: PKS_KR (2097-2270). E-value: 6e-55.
                     Score: 177.8. Matches aSDomain:
                     nrpspksdomains_QBC19710.1_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (2417-2462). E-value: 1.4e-09.
                     Score: 30.0. Matches aSDomain:
                     nrpspksdomains_QBC19710.1_PKS_PP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (2534-2829). E-value:
                     1.1e-38. Score: 124.8. Matches aSDomain:
                     nrpspksdomains_QBC19710.1_Condensation_LCL.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 225.2; E-value:
                     2.5e-68)"
                     /gene_kind="biosynthetic"
                     /note="wortmanamide synthase"
                     /product="TwmB"
                     /protein_id="QBC19710.1"
                     /sec_met_domain="Condensation (E-value: 2.5e-35, bitscore:
                     110.6, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3.1e-08, bitscore:
                     22.8, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 7.8e-89, bitscore: 286.6,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="itr_KS (E-value: 6.1e-163, bitscore:
                     531.1, seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 7.2e-46, bitscore:
                     145.1, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MAGEGAEIAIIGSGCRFPGNASSPSKLWALLQNPTSVASKVPALG
                     GYYHEDALYHGHANVKEAYLLAGEETHRRFDAAFFGIKPSEANVLDPQVRLLLETVYEA
                     LEDGGQPMDSLRGSDTAVYAGQMVNDYELLMYRDLENLGRYHATGTSRTMVSNRVSFFF
                     DWHGPSMTIDTACSSSLVALHNAVQQLQSGHSRVAIVAGANLIHDVGSFIAESSLQMLS
                     PNGQSRMWDADADGYARGEGVAAIVLKTREAAEADGDHIECIIRGTAVNQDGKTPGQTM
                     PSASAQAQLIRDCYARAGLDLTNSLHRPQYFEAHGTGTPAGDPIEAEAISSAFFPGASS
                     SLSIFVGSIKTVVGHTEGTAGIAGLLKASLALQNKLIPPNLLFNTLNPRIKPFYDHLHV
                     PTALTPWPSVASGYPRRASVNSFGFGGTNAHAILESYSPPSHPTQVLSTVYIPFVFSAF
                     SEASLKSYLVAFSTYLRENKTTYDLRDIAYSLDARRTRHQVVTTISASTADELCDSIEK
                     KLELSRADPDQRVGVRATHQTAEARKPRVLGVFTGQGAQWAQMGLELITASAVAKSTVE
                     SLQKRLDRLPDADRPTWSLVQELERDSSSSHIMEAKFSQPLCTAIQILQINLLRAAGIE
                     FTAVVGHSSGEIAAAYAAGRISAEDAICIAYYRGLYSSLAYGLNGKPGAMMAVGTSPED
                     AEDLLGFPEFEGRACVAAVNSATSVTISGDQDALEELKVVFEDEHKQARFLKVDKAYHS
                     HHMKECSAKYLESLAALNIQVGSGSQTSWFSSVYEQEVKGRDFLKGPYWDDNMVEPVLF
                     MQAVDNACASTRHFDLAIELGPHPALKGPALQTIQERLSHQIPYTGLFTRGVPAITAFS
                     EGLGYCWTHLGQGVVNLQNYDNFISGNLKCRLVKGLPTYAWDHENEYWHETRYARAVRM
                     RPGPVHDLLGHLTPNSTDQDMRWRQFLRLPEVKWVTGHRLQNLTVFPAAGYIVSVIEAA
                     MSLCKDVSVTLIEIIDVDIDSALVFDNDDVSIEVIISLTGITRRENKAIEADFKYHATS
                     GKDTEPLKLKASGRVRIHLGEACPTVLPPRAQKPPNLVSVSEKKFYDSISELGYQYSGQ
                     FASLERIERKLGAATGFISITEASKYLIHPGALDAAFQSTHLTYAAPEDGESRSIYIPR
                     RIKRLTFNPNLCIHARNKQTDLAFDASQPIELPHANKLCDINLYPEHLDHAIIRVQGLE
                     CVPFSRQTAKDDREAFSNIVWDVLDPDVEAITKDYHSKTSDSLELAGLLERVAAFYLRS
                     LEKEVPENHPSRYEAPCKGLLQYASNISSQSCATRSQLTQAHWDHDTSEVLTAVCEPYA
                     DSIDMKLVFDCGKNLASSVMGESTAGEVSGLMQEWYRSGSGVKNFTAHLAGILKQIVHR
                     YPQMHILEVGPEAGAATNVILTEIGPAFASYTVATSTDILFNPEKALPDIYKAKVLPKE
                     LDLSKNPRDQGFTEKSFDVVVASLVLHQSPEFEKCLRNARRLLKPGGHLIVLELRPSLP
                     YFLSVIFSAKSHQWFNAEEGRTSFPAITLLEWDSLLRQTGFSGIDTSTVEQPEIGGPFS
                     IFVSQAMDEKIAFLREPLSTAFPISSPGPTIQDLLILGGNSLKTARLVNQLSAVLKEHC
                     GSLRTARSMGFVDDISPKTIILSLTDLDTNEFKQLDESKWDSLKKIVSHTGTLVWVTHG
                     RLADNPHANMMLGLLRGSARDNSTLDYLLLDIEEAHRIEHSVIAEAILRHRAASQWRES
                     ESISYSVESELVMDKAGRFLIPRLMMNEKMNDRYNSNWREIREPARPSLDNIAISASGS
                     GWDVVLEPLPPVRRAQLRTTHSLLSPIRVTGSGCMYISLCSGLLSGDKVIALSSKNNSV
                     VCPQDELSVPVEVPPGSEARFLWLTAHYLLASSILKGLSEEDQVLIHEPSLEFSTAIEN
                     EASMLGVEVTFTTKNQDAPDSWMVIHPFSFEQSALARFEDEIFSVFINMAPSQEETESV
                     ADIFATALPGHCRKESLRSLFGNKAWTPKGSQIKEIQRRLLRAVSWASGMLTKSHCDGM
                     TSLAIDVLPGTVGQLEPFAVIEWDTVSEVSVKVQPVDTLVSFSDKKTYWLVGLTGGLGL
                     SLCEWMVRRGARYFVISSRQPNIERGWLDGMHKKGVRVEISACDLSKRDQVEGLYAEIC
                     SSMPAIGGVAQGAMVLEDVAIQNMTLEQLSRVTKPKVDGSIYLNELFQENTLDFFVFFS
                     SVSSVVGNHGQANYAAANTFMASLAEQRRRKGLAASVMDIGAVFGVGYITRSGNEKLMG
                     KVTLQSGGYVRTSERDFHQLFGEAVLAGKPGSTGPIELVSGVRKVSQREEERPVWETWP
                     RMSHFVMDHEGPEYTTDASNKAHIPVKVRLAEARNNEEAYGIVWEDFVRKLQSLFQIDI
                     TSLTKAELGAMRLDQMGIDSLTAVEIRGWLMKTFEVNLPVLKILNGISVGELVDTATEA
                     IPSHLVPNLAGYPAEQTSSQNSDSGQDMASSFDTVVNNPFDSDQVSSFHSDLSSNQEDA
                     TATDSKSTVLKSIPVSFTQARFYPSGLFLEDKVGLNHIAWARFTGEVSAERLQRALHSL
                     AEQHEILRTAFFDQAGKQMQHILNTSPVYLEHKQIQNEDEVTELVMSLQKEYVYDVARG
                     ETMRVILLSRSATENYFILGVHPLVLDATSFQIYLKWLAFHYTSPNKIHRVKQFAESSE
                     QRHADYAAGKFEAELQFWRNEFSTPIKPLPLLTVAKVNERPKLKAYENIRSSLTIEVDT
                     KTRILDICRRIRATPFHFYLAVLRVLLLQYTAYGDNSEDVTIAVAENGRGYDAEEMDVI
                     GPLYNLVLVRILAQQTTRFEDLLETTRNKTYAALSNSKLPYPMLVEELGLQRIAKDYPF
                     VQVFADYRVGQRTTAEFGEDNKLVMMGFDFNVPYDVFLDTIDEPEGECLHELFLRNDLF
                     GREEADRLARSYKSLVVAFAEHPAMTLGQAALAESECGGKIAQ"
     CDS_motif       complement(join(1903..1951,2018..2079))
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QBC19710.1_0012"
                     /evalue="1.60E-04"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="QBC19710.1"
                     /protein_end="2881"
                     /protein_start="2844"
                     /score="13.9"
                     /tool="antismash"
                     /translation="RNKTYAALSNSKLPYPMLVEELGLQRIAKDYPFVQVF"
     aSDomain        complement(2125..3009)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QBC19710.1_Condensation_LCL.1"
                     /domain_subtype="Condensation_LCL"
                     /evalue="1.10E-38"
                     /label="QBC19710.1_Condensation_LCL.1"
                     /locus_tag="QBC19710.1"
                     /protein_end="2829"
                     /protein_start="2534"
                     /score="124.8"
                     /tool="antismash"
                     /translation="SIPVSFTQARFYPSGLFLEDKVGLNHIAWARFTGEVSAERLQRAL
                     HSLAEQHEILRTAFFDQAGKQMQHILNTSPVYLEHKQIQNEDEVTELVMSLQKEYVYDV
                     ARGETMRVILLSRSATENYFILGVHPLVLDATSFQIYLKWLAFHYTSPNKIHRVKQFAE
                     SSEQRHADYAAGKFEAELQFWRNEFSTPIKPLPLLTVAKVNERPKLKAYENIRSSLTIE
                     VDTKTRILDICRRIRATPFHFYLAVLRVLLLQYTAYGDNSEDVTIAVAENGRGYDAEEM
                     DVIGPLYNLVLVRI"
     CDS_motif       complement(2833..2919)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QBC19710.1_0011"
                     /evalue="4.40E-09"
                     /label="C2_LCL_024-062"
                     /locus_tag="QBC19710.1"
                     /protein_end="2593"
                     /protein_start="2564"
                     /score="28.8"
                     /tool="antismash"
                     /translation="RFTGEVSAERLQRALHSLAEQHEILRTAF"
     aSDomain        complement(3226..3360)
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QBC19710.1_PKS_PP.1"
                     /evalue="1.40E-09"
                     /label="QBC19710.1_PKS_PP.1"
                     /locus_tag="QBC19710.1"
                     /protein_end="2462"
                     /protein_start="2417"
                     /score="30.0"
                     /tool="antismash"
                     /translation="LDQMGIDSLTAVEIRGWLMKTFEVNLPVLKILNGISVGELVDTAT
                     "
     aSModule        3226..10805
                     /complete
                     /domains="nrpspksdomains_QBC19710.1_PKS_KS.1"
                     /domains="nrpspksdomains_QBC19710.1_PKS_AT.1"
                     /domains="nrpspksdomains_QBC19710.1_PKS_DH.1"
                     /domains="nrpspksdomains_QBC19710.1_PKS_KR.1"
                     /domains="nrpspksdomains_QBC19710.1_PKS_PP.1"
                     /iterative
                     /locus_tags="QBC19710.1"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(join(3802..4153,4211..4377))
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QBC19710.1_PKS_KR.1"
                     /evalue="6.00E-55"
                     /label="QBC19710.1_PKS_KR.1"
                     /locus_tag="QBC19710.1"
                     /protein_end="2270"
                     /protein_start="2097"
                     /score="177.8"
                     /tool="antismash"
                     /translation="TYWLVGLTGGLGLSLCEWMVRRGARYFVISSRQPNIERGWLDGMH
                     KKGVRVEISACDLSKRDQVEGLYAEICSSMPAIGGVAQGAMVLEDVAIQNMTLEQLSRV
                     TKPKVDGSIYLNELFQENTLDFFVFFSSVSSVVGNHGQANYAAANTFMASLAEQRRRKG
                     LAASVMDIGA"
     CDS_motif       complement(3841..3951)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QBC19710.1_0010"
                     /evalue="1.40E-21"
                     /label="PKSI-KR_m4"
                     /locus_tag="QBC19710.1"
                     /protein_end="2257"
                     /protein_start="2220"
                     /score="69.1"
                     /tool="antismash"
                     /translation="LDFFVFFSSVSSVVGNHGQANYAAANTFMASLAEQRR"
     CDS_motif       complement(4282..4377)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QBC19710.1_0009"
                     /evalue="2.60E-15"
                     /label="PKSI-KR_m1"
                     /locus_tag="QBC19710.1"
                     /protein_end="2129"
                     /protein_start="2097"
                     /score="48.9"
                     /tool="antismash"
                     /translation="TYWLVGLTGGLGLSLCEWMVRRGARYFVISSR"
     aSDomain        complement(7397..7921)
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QBC19710.1_PKS_DH.1"
                     /evalue="7.10E-19"
                     /label="QBC19710.1_PKS_DH.1"
                     /locus_tag="QBC19710.1"
                     /protein_end="1110"
                     /protein_start="935"
                     /score="60.6"
                     /tool="antismash"
                     /translation="HDLLGHLTPNSTDQDMRWRQFLRLPEVKWVTGHRLQNLTVFPAAG
                     YIVSVIEAAMSLCKDVSVTLIEIIDVDIDSALVFDNDDVSIEVIISLTGITRRENKAIE
                     ADFKYHATSGKDTEPLKLKASGRVRIHLGEACPTVLPPRAQKPPNLVSVSEKKFYDSIS
                     ELGYQYSGQFAS"
     CDS_motif       complement(7760..7837)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QBC19710.1_0008"
                     /evalue="4.90E-07"
                     /label="PKSI-DH_m2"
                     /locus_tag="QBC19710.1"
                     /protein_end="989"
                     /protein_start="963"
                     /score="22.3"
                     /tool="antismash"
                     /translation="WVTGHRLQNLTVFPAAGYIVSVIEAA"
     aSDomain        complement(8150..9082)
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QBC19710.1_PKS_AT.1"
                     /evalue="7.10E-88"
                     /label="QBC19710.1_PKS_AT.1"
                     /locus_tag="QBC19710.1"
                     /protein_end="859"
                     /protein_start="548"
                     /score="286.6"
                     /tool="antismash"
                     /translation="VFTGQGAQWAQMGLELITASAVAKSTVESLQKRLDRLPDADRPTW
                     SLVQELERDSSSSHIMEAKFSQPLCTAIQILQINLLRAAGIEFTAVVGHSSGEIAAAYA
                     AGRISAEDAICIAYYRGLYSSLAYGLNGKPGAMMAVGTSPEDAEDLLGFPEFEGRACVA
                     AVNSATSVTISGDQDALEELKVVFEDEHKQARFLKVDKAYHSHHMKECSAKYLESLAAL
                     NIQVGSGSQTSWFSSVYEQEVKGRDFLKGPYWDDNMVEPVLFMQAVDNACASTRHFDLA
                     IELGPHPALKGPALQTIQERLSHQIPYTGL"
     CDS_motif       complement(8258..8284)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QBC19710.1_0007"
                     /evalue="1.90E+01"
                     /label="PKSI-KS_m3"
                     /locus_tag="QBC19710.1"
                     /protein_end="823"
                     /protein_start="814"
                     /score="-0.9"
                     /tool="antismash"
                     /translation="AVDNACAST"
     CDS_motif       complement(8732..8830)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QBC19710.1_0006"
                     /evalue="2.50E-10"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="QBC19710.1"
                     /protein_end="665"
                     /protein_start="632"
                     /score="32.8"
                     /tool="antismash"
                     /translation="GIEFTAVVGHSSGEIAAAYAAGRISAEDAICIA"
     CDS_motif       complement(9035..9082)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QBC19710.1_0005"
                     /evalue="8.10E-05"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="QBC19710.1"
                     /protein_end="564"
                     /protein_start="548"
                     /score="15.2"
                     /tool="antismash"
                     /translation="VFTGQGAQWAQMGLEL"
     aSDomain        complement(join(9419..9464,9515..9934,9985..10805))
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QBC19710.1_PKS_KS.1"
                     /domain_subtype="Iterative-KS"
                     /evalue="2.60E-161"
                     /label="QBC19710.1_PKS_KS.1"
                     /locus_tag="QBC19710.1"
                     /protein_end="436"
                     /protein_start="7"
                     /score="529.1"
                     /tool="antismash"
                     /translation="IAIIGSGCRFPGNASSPSKLWALLQNPTSVASKVPALGGYYHEDA
                     LYHGHANVKEAYLLAGEETHRRFDAAFFGIKPSEANVLDPQVRLLLETVYEALEDGGQP
                     MDSLRGSDTAVYAGQMVNDYELLMYRDLENLGRYHATGTSRTMVSNRVSFFFDWHGPSM
                     TIDTACSSSLVALHNAVQQLQSGHSRVAIVAGANLIHDVGSFIAESSLQMLSPNGQSRM
                     WDADADGYARGEGVAAIVLKTREAAEADGDHIECIIRGTAVNQDGKTPGQTMPSASAQA
                     QLIRDCYARAGLDLTNSLHRPQYFEAHGTGTPAGDPIEAEAISSAFFPGASSSLSIFVG
                     SIKTVVGHTEGTAGIAGLLKASLALQNKLIPPNLLFNTLNPRIKPFYDHLHVPTALTPW
                     PSVASGYPRRASVNSFGFGGTNAHAILESY"
     CDS_motif       complement(9799..9846)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QBC19710.1_0004"
                     /evalue="8.40E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="QBC19710.1"
                     /protein_end="326"
                     /protein_start="310"
                     /score="11.7"
                     /tool="antismash"
                     /translation="YFEAHGTGTPAGDPIE"
     CDS_motif       complement(10101..10139)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QBC19710.1_0003"
                     /evalue="4.60E-04"
                     /label="PKSI-KS_m4"
                     /locus_tag="QBC19710.1"
                     /protein_end="242"
                     /protein_start="229"
                     /score="13.3"
                     /tool="antismash"
                     /translation="WDADADGYARGEG"
     CDS_motif       complement(10182..10238)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QBC19710.1_0002"
                     /evalue="3.20E+01"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="QBC19710.1"
                     /protein_end="215"
                     /protein_start="196"
                     /score="-2.1"
                     /tool="antismash"
                     /translation="VAIVAGANLIHDVGSFIAE"
     CDS_motif       complement(10281..10328)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QBC19710.1_0001"
                     /evalue="3.70E-07"
                     /label="PKSI-KS_m3"
                     /locus_tag="QBC19710.1"
                     /protein_end="182"
                     /protein_start="166"
                     /score="21.9"
                     /tool="antismash"
                     /translation="GPSMTIDTACSSSLVA"
     mRNA            join(<12309..12507,12572..12648,12732..13111,13174..13229,
                     13292..>13671)
                     /product="TwmC"
     CDS             join(12309..12507,12572..12648,12732..13111,13174..13229,
                     13292..13671)
                     /codon_start=1
                     /note="GPCR-like protein"
                     /product="TwmC"
                     /protein_id="QBC19711.1"
                     /transl_table=1
                     /translation="MAFEIPEDSTQLSQFVTLLIFTPLGIVVTALRFVAVRRVTRKVGF
                     EDWLAVIATIFFILTNLAGLMAISILNGRQLTQEVIESPSDYSRMRKWDIAGLFFYFAQ
                     TLSVKLSILAFYHRIFGISSTRCRICIYLLAAAQTILFIAFCIFQGFQCIPLQRYFDLS
                     VPGECKDEGTVILGGELPNSLVDFAMVILAMIMIRPLQLSFSDKFRVTVLFGLGFVVGI
                     IGFVKIAVTYSTSELYAFSMIALWTGVQMFTALLCCSLPMYNTFLPIVADFWNRLSHHS
                     LGWVSRVRSSQSSSKNSRKHGPYDSDQSPGPGWDDLVAYNGTKGLTLPQAPYHGDNHAL
                     GNVSPITHPQAYSKQTTRQFDVV"
     mRNA            join(<14060..14131,14198..14310,14363..14412,14463..14522,
                     14579..14908,14956..15518,15579..>15929)
                     /product="TwmD"
     CDS             join(14060..14131,14198..14310,14363..14412,14463..14522,
                     14579..14908,14956..15518,15579..15929)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 251.9; E-value: 2e-76)"
                     /gene_kind="biosynthetic-additional"
                     /note="P450-like protein"
                     /product="TwmD"
                     /protein_id="QBC19712.1"
                     /sec_met_domain="p450 (E-value: 7.1e-57, bitscore: 181.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MAFLDYPPFDICTIQQLLTFIIISYTFYLTTRSIWRLYFHPLSKY
                     PGPKVAAISDIWYAYHALAGRWPWAVADALEKYGDVVRIAPNEIAFVTPKALSDIYGSH
                     NKNLENFAKTQINNHGNDEHGGLIWEWDPARHREVARQLSPAFSGRALRAKEATLHKYI
                     DLFVERMTTLGGETGGVSLPTWINWLCVDISADMAYNREMNALKDMKEPPYLSILSGFN
                     RAVVVTQMSWRFPLLSPLKGLFLAITAMRSHSHIRNHSRFQLEQRIRRKGAVEHLDFFE
                     QLIPENREPPKDRKEMRHLEQVAGQLLVAGYEPPALWFYFTIYYLLKNPATLDTLTKEI
                     RSAFKNYDEITSGSAAQLAYLSACLSESLRIMPGVLTGMPVVSPGAMVDGTYIPKGVVC
                     QSSSLALARSPRNFRHALSFRPERWLQEDHALYDAQFAQDNRKGFQPFSQGPRICAGKE
                     IAWWQSRVFLAKVLWTFDLEMVSGQQIDMARDLRGWGMYDKPEIRVRFRPKFVV"
     mRNA            <16510..>17616
                     /product="TwmE"
     CDS             16510..17616
                     /NRPS_PKS="Domain: PKS_ER (20-238). E-value: 1e-21. Score:
                     69.2. Matches aSDomain: nrpspksdomains_QBC19713.1_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase
                     (Score: 164.8; E-value: 4.7e-50)"
                     /gene_kind="biosynthetic-additional"
                     /note="enoyl-reductase"
                     /product="TwmE"
                     /protein_id="QBC19713.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 8.7e-14, bitscore:
                     40.4, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MTPTTLPTSQRAVQQDGNGKLHVANNAAIPSLLPGHVLVKTYAVA
                     LNPSDYKIQKNFPIPGAYVGIDFSGTVVQVANDVDSINPGTEVFGAAFTFSSAHRLANG
                     AFAEYVRVRADLLFRIPSEQQCQNDGDLTLFKAATLGTAMSTCLLSLWSPDALGLVGKP
                     EEPVLSEKPIPVLVYGGSTSVGTIAIQLLKLSGYDPIATCSPRSFDLVRSRGASNVFDY
                     SSADVALKIKTHTGGRLKYALDCISDVASVATCYAAIQRPGGRYVSLEYIPDELLAQRR
                     AVRPNFVLSAELYGEEIVLGEEAYDRPANREKHQLAVQNVGMLQRLIDSGGLKTHPTEE
                     IEGGLEGVVKGLVALAGGGHPRKLVAVV"
     aSDomain        16570..17223
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QBC19713.1_PKS_ER.1"
                     /evalue="1.00E-21"
                     /label="QBC19713.1_PKS_ER.1"
                     /locus_tag="QBC19713.1"
                     /protein_end="238"
                     /protein_start="20"
                     /score="69.2"
                     /tool="antismash"
                     /translation="LHVANNAAIPSLLPGHVLVKTYAVALNPSDYKIQKNFPIPGAYVG
                     IDFSGTVVQVANDVDSINPGTEVFGAAFTFSSAHRLANGAFAEYVRVRADLLFRIPSEQ
                     QCQNDGDLTLFKAATLGTAMSTCLLSLWSPDALGLVGKPEEPVLSEKPIPVLVYGGSTS
                     VGTIAIQLLKLSGYDPIATCSPRSFDLVRSRGASNVFDYSSADVALKIKTHTGGR"
     mRNA            join(<18193..18416,18471..>19896)
                     /product="TwmF"
     CDS             join(18193..18416,18471..19896)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 305.8; E-value:
                     6.7e-93)"
                     /gene_kind="transport"
                     /note="MFS protein"
                     /product="TwmF"
                     /protein_id="QBC19708.1"
                     /transl_table=1
                     /translation="MKSPSSSAEMQSSSPEPAPWKPDFQVYAIVIGLGITNLLAALENT
                     VLTIAAPVVLTDLELGENFIWVTNAFFLSSTAILPLFGQFSNIFGRRYVMLTAVAIFVL
                     GSGLCGGASTGAMLIAGRAIQGVGSGGIIMLSSIIISDLVPLRQRGNFSAILMSILGIG
                     SALGPLIGGAIVSSISWRWVFYLNLPIGGVSFVFLFIFLRVKYNKEMTFWQKIKRIDLV
                     GNAIVIASTVAILYALSYAGTRYPWRSWHTLVPLLVGFLGLFIFAGLQTTAFSAEPLMP
                     TRFFRAPTSIILAINTFVSAALLYWCLFFLPVFLQSVKLYSPRRAGVALLPISLLGIPG
                     SMVGAIALVRWGRYKPVHIFAFALQTLGLGLFTLFREDTSVAEWAVFQCIVAFGGGMIF
                     TTMLPAFQAFIHERDIAACTAAWYFIRLFGHIWGVAIPAAIFNQRIDTLLGQGAISDPS
                     VSKTIAAGGAYQAASAAFVKQFPGSLQLEIRSVYSQAIQRVFQVSIAFAGVAFLLTLLE
                     KDVGLRKTLETDFGLEKEGAGQQADVEGRSHE"
ORIGIN
        1 ttataaagaa gcctttgaag aaccgctctt cttgcccgta ttccgttcaa cactcagaat
       61 catcgcaaca tgattgctca acgcaaccat ctccccatcc gtgtcccgca cgagcacctc
      121 gagatcgaac ttgccttctt tgatctgttt tgacgacacc cgaacagaaa gccactcaac
      181 gccttcctct ggaagcgctg tcttcgcttc gatattcatc accacagtcg gaaaccacat
      241 ctcggcacgc tgctggtcct ttttccggac atccttcacc tcggaatcac cagaccgttc
      301 aggcgacgca ttcagaagct cacgcaatgc gggagctgcc aggaacgtgt gcatgttgtg
      361 tggaaatgag tcaaccacgt acgccagcgc accttgcgtg attttttctc cgctggccaa
      421 ccggatccac atgtctagta ctccggggct cagcggttcc ttgcgaggga cgtagaagcg
      481 ccactgggtc aaggacagca tcatggcggc ccatcccttt ggaagtttcg attccgccca
      541 ggcatcgtcg gcgccgtggg tctttagagc ttcaaaatca gacacagatg ggagttcggc
      601 agctggggtt acttcgtagc ctgtgggcat tgatattcca gagaatgtac gcagatttgt
      661 gtgggtggtg taggcgagga caatgcggcg tgaaacggaa cggtcaatcc atggcgcttg
      721 tgagagaagc ccgccctgcc aaagtgtgag atggagggtg gatatctggc ggccaagctt
      781 gacatcctcg atcacgacaa tggcaggccc agtcgacgtc ctgtttggat actcaaagtg
      841 tgcggtcagt gtgtcaggct gaccgcgtgg gccgaggtgt ttgcttgctg ctgcgagcat
      901 gcatgcggac gtgtagccgc cattggggac taaaaggggt tcaggtcaga gcactcaaac
      961 aacatttgaa agcgacaaag aaacttgaaa cgagggagat ggcatacctg cgccaataca
     1021 gaagccttgg ttgagattaa ctcggtatgt gtgagagtcc agctgctcag cttgggtagc
     1081 ttcggagaag agagcagaag ctcctcccgc tttacctgag gccatgatgg tgctcagctg
     1141 gaatgaattt tatgaaattg agagatgaat gaagcgaacg gagagctaag agtatgtctg
     1201 gtatgaggtg gtgttggcgg cctgccacag cctcggtcat tcaggtcgtg aaagaagcgg
     1261 gccggttaca tagtcgccgg atcgacagag cttatactaa atataggcgg aagcgctaaa
     1321 cctaatttga atcaaagatt accgccttac cgtattatta cggctgtatc gttttgtcat
     1381 gaattataca tagtattatt ataattgtga acgagtggac cagaggcttc gtacagatgg
     1441 atcataggga tgtaaagaat tggtatctaa ctggtgtttg ttattttatg ctccttcgaa
     1501 gagtcaattt gattatattc ataaactgtt acactgaaag cacttcaaat attgcgaaac
     1561 tggataaata tcatggaaca acaaaagacc ttatatggta cataattact gagcaatttt
     1621 tccaccgcac tcggactcag ccaaagctgc ctggcctaga gtcatggcag gatgctcagc
     1681 aaaggcaacc accaaactct tatagctcct ggcgagtctg tctgcttctt ctctcccgaa
     1741 cagatcattc cgcaggaaca gctcgtggag gcactcgccc tctggctcgt cgattgtgtc
     1801 aaggaaaacg tcataaggta cgttgaaatc aaagcccatc atcacaagtt tattatcttc
     1861 gccaaattcc gcagtcgtgc gctggcccac ccggtagtcg gcaaagactt ggacgaaagg
     1921 atagtctttg gcgatgcgct ggagaccgag cctgtaggga aagggttagt tagggttcag
     1981 tgaaatgacg aggtacagaa gaagaagaaa cacttactct tccacgagca tcggatatgg
     2041 gagttttgag tttgacagtg cagcgtatgt tttgtttctt gttgtttcca acaaatcttc
     2101 aaaccttgta gtttgttgag ctagaatacg aacgagcaca agattataaa ggggcccgat
     2161 aacatccatc tcctcggcat cgtagcctct cccattctcg gcaaccgcaa ttgtaacatc
     2221 ttcactgtta tcgccataag ccgtatactg cagtaatagg acgcggagaa ccgctaagta
     2281 gaaatggaaa ggtgtcgctc gaatacgacg gcatatgtcg agaatccgcg ttttggtgtc
     2341 cacttcaatg gtcaaagatg atcggatatt ttcatatgcc ttcaatttcg gacgctcgtt
     2401 gactttggct accgtcaaca gcggcaacgg ctttattggc gtcgaaaatt cgttacgcca
     2461 gaactgtaac tcagcctcaa attttcctgc agcgtagtct gcgtgcctct gctcggaaga
     2521 ctctgcaaac tgcttcaccc gatgtatttt gttcggcgag gtgtaatgaa acgcaagcca
     2581 tttcaagtat atctgaaacg acgttgcatc aagaacgaga gggtgtacac ctaatatgaa
     2641 atagttctcg gtcgctgagc gagagagcaa gataacccgc attgtttctc ctctcgccac
     2701 gtcatacacg tattcctttt gaagagacat gactaattcg gtcacttcat cttcattttg
     2761 aatctgcttg tgctccaaat acacagggct ggtattcaat atgtgctgca tctgctttcc
     2821 agcttggtca aagaatgctg ttctcaagat ttcgtgttgc tctgctagag aatgtagcgc
     2881 ccgttgaagc ctttctgcgc ttacttcccc agtaaaccga gcccatgcga tatgattgag
     2941 cccgacttta tcctccaaga aaagacccga aggatagaac ctcgcttggg tgaatgaaac
     3001 ggggatcgac ttgagaactg tcgacttgga gtctgtagca gtcgcgtctt cttggtttga
     3061 tgaaaggtcc gagtggaatg agctcacttg atctgaatca aatgggttat taacaaccgt
     3121 atcaaaacta ctagccatat cctggccaga gtcagaattt tgagagctgg tttgctcagc
     3181 aggataccca gctagatttg gaacaagatg ggatgggatg gcttctgttg ctgtgtcgac
     3241 cagctcgcca acagagattc cattgaggat tttgagaacc gggaggttga cttcgaacgt
     3301 tttcatgagc caaccgcgaa tttcaaccgc tgtaagagag tcgataccca tttggtctaa
     3361 acgcatagcg cccagctcag ccttggtaag actagtaatg tctatttgaa atagcgattg
     3421 gagtttgcga acaaaatcct cccacacaat tccatacgct tcttcgttgt ttcgggcctc
     3481 tgcaagtcgt accttgactg ggatatgagc cttgttgcta gcatctgtcg tatactcagg
     3541 tccttcatgg tccatgacaa agtggctcat gcgtggccat gtttcccaaa cgggccgctc
     3601 ttcttctctt tgactaacct ttcgcacccc agatacaagc tcgatagggc cagtggaccc
     3661 aggtttcccg gcaagcacag cttctccaaa aagctgatga aagtctcgtt cagatgtgcg
     3721 aacgtaacct cctgattgca acgttacctt ccccattagt ttttcgttgc cagaccgagt
     3781 aatgtagccg actccaaaaa cagcgccaat atccatgact gaggcagcaa gaccttttcg
     3841 tctacgttgt tcggcaagac tggccatgaa tgtgttggcg gccgcgtaat ttgcttgtcc
     3901 atggtttcca accacagatg acacggacga gaaaaacacg aaaaagtcca atgtgttctc
     3961 ttggaagagc tcgtttaagt agatgctacc gtcgactttt ggcttcgtga cccgtgacag
     4021 ttgctctagg gtcatgttct gaatagctac atcctccaaa accatggcac cctgggccac
     4081 gccgccaatg gctggcatac tcgagcaaat ttcagcgtag agcccctcta cttggtctct
     4141 cttgcttagg tcactagttc aagttagcta aaaacaaccc cgtttttctt tatcagaagg
     4201 tttcactgac caggcggaga tttccactcg aactcccttt ttgtgcattc catccagcca
     4261 gcctctttca atatttggtt gacgacttga gatgacaaaa tatcgtgccc ctcgccgcac
     4321 catccactcg cacagagaca aaccaagccc gccagtaagc ccgacaagcc aataagtctt
     4381 cttgtcagaa aatgatacca atgtgtcgac aggctggacc ttaaccgaga cttcggagac
     4441 tgtgtcccat tcaataacgg caaatggttc tagttggccg acagtgcccg gaagaacgtc
     4501 gatcgccaag cttgtcatac catcgcaatg agacttggta agcataccgg aagcccacga
     4561 aactgctctt agaaggcgtc gttgtatttc ttttatctgc gagccttttg gagtccaagc
     4621 cttattccca aacagcgacc tcaagctttc cttcctacag tggcctggga gtgcagttgc
     4681 aaaaatatct gcgacggact cggtttcttc ctgggatggt gccatgttga tgaataccga
     4741 gaagatttca tcttcaaaac gtgctagtgc agactgctcg aaagaaaatg ggtgaataac
     4801 catccaacta tccggagcat cttgattttt tgtggtgaag gtaacttcga caccaagcat
     4861 tgacgcttcg ttctcaatgg ctgttgagaa ttccagacta ggctcatgga tcaatacttg
     4921 gtcttcttca gacaatcctt tcaagatgga tgatgctagt aagtagtggg ctgtcaacca
     4981 caaaaagcga gcttcagagc ctggtggtac ctcgacggga actgataact catcttgcgg
     5041 gcaaacaaca gaattattct tggatgataa agctattact ttatcacccg agagcaggcc
     5101 actgcagagg cttatataca tgcagccaga accagtaact ctaataggtg agagtaggga
     5161 gtgcgtggta cgcaactgtg cccgtctaac tggtggcaac ggttctaaca cgacatccca
     5221 ccctgagcca gatgctgata tagcgatatt gtcgaggcta ggtcgagctg gttcacgaat
     5281 ctctctccaa tttgaattgt aacggtcatt catcttttcg ttcatcatga gacgagggat
     5341 caaaaatcgg cctgctttgt ccatgaccag ctcgctttca acactataac taatgctttc
     5401 agattctcgc cactgagaag ccgccctgtg ccgtaaaata gcttccgcaa tgacactgtg
     5461 ctcaattctg tgagcttcct caatgtcaag tagcaggtaa tctagggttg aattgtcgcg
     5521 ggcagagcca cggagcaaac ccagcatcat gttggcatgt gggttatccg caaggcggcc
     5581 atgtgtgacc catactaggg tccccgtatg ggaaactatt ttcttcaagg aatcccattt
     5641 cgactcatcg agctgcttga attcgtttgt gtctaaatcg gttaaactta aaatgatagt
     5701 tttcggtgaa atgtcgtcga caaaccccat cgagcgggcg gttctgagac tgccacaatg
     5761 ttctttgaga acggctgaga gttggttaac aagcctggct gtttttaaac tattcccacc
     5821 tagtatcaag aggtcttgta ttgtcggtcc cggcgatgaa atggggaaag cagttgaaag
     5881 cggttcgcga aggaaagcaa ttttctcgtc catagcctgg gatacaaaga tagaaaatgg
     5941 cccgcctatc tcaggctgtt ccacagtact ggtatcaatc cccgaaaagc cagtttgacg
     6001 tagtaaactg tcccactcca agagtgtgat agctgggaat gaggttctac cttcttcggc
     6061 attgaaccac tggtgggact ttgcactgaa gataacactg agaaagtaag ggagagaagg
     6121 ccgtagctcc agtacaatga gatgaccacc tggtttaagc aggcggcgtg cattgcgcag
     6181 acatttctca aattctggac tctggtgtag gacgagagat gccacaacca cgtcaaacga
     6241 tttttcggta aagccttggt cccgtggatt ctttgagaga tccaattctt ttggtaaaac
     6301 cttggccttg tatatatcgg gaagagcttt ttccgggtta aataaaatgt ctgtagaggt
     6361 agcgacagtg taagaagcaa atgctgggcc tatctcagtc aatatcacgt ttgtagcggc
     6421 accagcttcc ggtccaactt cgaggatatg catctgaggg tatcgatgca caatctgctt
     6481 caatattccg gccagatggg ctgtgaaatt ttttactccg gaaccactac gataccattc
     6541 ttgcatcaaa ccggagactt ctccggcagt gctttcaccc atgacggaac ttgctaggtt
     6601 ttttccgcaa tcaaagacca gcttcatgtc aatactatca gcatatggct cacacactgc
     6661 agtcaggact tcggaagtgt catgatccca gtgtgcttgc gtgagctgtg acctcgtagc
     6721 acatgattga gaagagatat ttgatgcgta ttgcagtaaa cctttgcagg gcgcctcgta
     6781 tctcgatggg tggttttccg gcacttcttt ctccagactg cgcaagtaga atgccgcaac
     6841 cctttcaagg agaccagcta gttctaatga gtcagatgtt tttgagtggt agtccttggt
     6901 tatggcctca acgtctggat caaggacatc ccatacaata ttagaaaagg cttccctgtc
     6961 gtccttggct gtctgtctgg aaaatgggac gcattctaac ccttgaacac ggataatcgc
     7021 atgatccaga tgttctgggt acaaattgat atcacataac ttgttggcgt gtggaagttc
     7081 gatgggttga gatgcgtcaa aggccagatc tgtctgctta tttctcgcat gtatacagag
     7141 atttgggttg aaagtaagac gcttaatcct tcttggaata tatatcgacc ttgattcccc
     7201 gtcttcagga gctgcataag tcaggtgggt agattgctgc cacatgaatt agcagttatt
     7261 tcacgagaat acatgacata gttttcaaac ttacaaaggc ggcatctagc gctccagggt
     7321 gaattagata tttagatgct tccgtgatgg agatgaaccc tgttgcagcg ccgagctttc
     7381 tttcaatcct ttctagcgac gcaaactgac cactatactg gtaaccgagt tccgatatag
     7441 agtcgtagaa ctttttctca ctgaccgaaa caagatttgg tggtttttgg gcacgaggag
     7501 gaaggactgt aggacaggcc tcgcccaaat gaattcgcac acggccgctg gcttttagtt
     7561 tcaggggttc tgtgtcttta cccgacgtag catgatactt gaaatcggct tcaattgcct
     7621 tattttcacg tcttgtaatg cctgtaagag aaataatcac ctcaatgctc acatcatcat
     7681 tgtcgaatac caaggccgag tcaatgtcaa catcgataat ttcaatcagc gtcacggaaa
     7741 catctttgca cagcgacatg gccgcttcta tgacactgac aatataccca gcagcaggaa
     7801 ataccgtaag attctgcagt ctgtgtcctg tcacccactt cacctcgggc agacgcaaaa
     7861 attggcgcca tcgcatatcc tgatcggtgc tatttggagt caagtggccc agtagatcgt
     7921 gtactggacc gggtcgcatg cgcactgctc gggcatatct cgtctcgtgc caatattcat
     7981 tttcgtggtc ccatgcatac gtaggaagcc cctttaccaa tctgcatttc aagttgcctg
     8041 atataaaatt atcatagttt tgtagattga caactccttg accaaggtgg gtccagcagt
     8101 agccaagccc ttcagaaaag gcagtaatgg ccgggacgcc acgagtgaaa agaccagtat
     8161 aaggaatctg atgtgaaagt ctttcttgta tagtctgaag ggcaggtccc ttcagagcag
     8221 ggtgtggacc tagttcgatg gctaggtcaa aatgtcttgt agaagcacaa gcgttatcga
     8281 cagcctgcat aaaaagcact ggttcgacca tgttgtcatc ccagtatggt cccttcagaa
     8341 aatcccgacc ttttacttcc tgctcataaa cactggaaaa ccaggacgtt tgacttccag
     8401 agcctacttg aatgttcaag gctgcaagag attccaggta tttggcagag cattccttca
     8461 tgtgatggga atgataagct ttgtccactt tgagaaatct agcctgttta tgctcgtcct
     8521 caaaaacgac cttcaattct tctagagcgt cttgatcccc ggatatggtc acactcgttg
     8581 ctgaattgac tgctgccaca catgcacgcc cctcaaactc gggaaatccc aagagatctt
     8641 cagcatcttc aggagatgtt cccacagcca tcatggcccc tggctttccg ttaaggccat
     8701 atgcaagcga cgaatataga ccacggtaat aagcaatgca gatagcgtct tctgccgata
     8761 tacggccggc tgcataggcg gccgcaatct cgccggaaga atgaccaaca acagcggtaa
     8821 attcgatgcc tgcagcgcgc agaaggttta tttggagaat ctggattgca gtgcagaggg
     8881 gctgtgaaaa tttcgcctcc attatatgcg aggaggaaga gtccctctca agctcttgta
     8941 caagtgacca tgtagggcga tctgcgtcgg ggagtcggtc aagtcgtttt tgaagacttt
     9001 ccacagtgga tttcgcaaca gccgatgcgg ttatcagctc caaccccatc tgggcccatt
     9061 gggctccctg tccagtaaac actccgagca ctcgaggctt cctggcctct gctgtttggt
     9121 gtgttgctct taccccaacg cgctgatcag ggtctgcgcg tgacagctcg agcttcttct
     9181 ctatactgtc acagagctca tcagcagttg aagcgctgat agtagtgact acttgatggc
     9241 gcgtccgtcg tgcatctagt gagtatgcaa tgtctcttag gtcatatgtg gtcttgtttt
     9301 cgcgcaggta ggtactaaat gctaccagat acgacttgag agaggcttct gagaatgcag
     9361 aaaaaacaaa gggaatatac acggttgata gaacttgggt tggatgggac ggagggctgt
     9421 agctttcgag aatggcgtgg gcgttggtcc ctccaaagcc aaagctaaca cggcatcagc
     9481 tcatagaaca gaacacaaat tcagaatatc ctacctgttg acgcttgctc gacgcgggta
     9541 gccactggca acggatggcc atggtgtcag cgctgttggc acgtgcaagt gatcgtaaaa
     9601 aggtttgatg cgaggattga gagtattgaa gagaagattg ggtgggatca gcttgttctg
     9661 cagggcgagc gatgccttga gcagccctgc gatgccagct gtgccttcgg tatggccgac
     9721 aacggtctta atgctgccga caaatatcga tagagagctt gacgcccctg gaaagaaggc
     9781 ggaactaatg gcttcagcct cgataggatc gcccgctggc gtgcctgtac cgtgcgcttc
     9841 gaaatactgt ggacggtgta aggaatttgt caagtctagt ccggcacgag catagcaatc
     9901 tcggatgagt tgagcctgtg cagacgcgct tggcctagaa gattgtcagt cagtttgcag
     9961 gcaggcaact ttttttttgc ttacattgtt tgaccaggtg tcttgccatc ctgatttacc
    10021 gctgtcccgc ggataatgca ctctatatgg tccccatcgg cctcagcagc ctctcgtgtc
    10081 ttaagcacaa tagcagcaac gccttctcct cgggcgtagc cgtcggcgtc ggcatcccac
    10141 atgcgtgatt gaccgttagg tgagagcatt tgcagactgg actcagcaat gaaggagcct
    10201 acatcgtgta taaggttggc tccagccacg attgcgacac gcgagtgccc ggattgcagt
    10261 tgctggaccg cattatgcag ggcaaccaga ctggaactgc atgctgtgtc aattgtcatt
    10321 gatgggccgt gccaatcaaa gaaaaaggag acccggtttg agaccatggt ccgcgatgtt
    10381 ccagtggcgt ggtatctgcc caggttctca aggtctcgat acatgagtag ttcgtaatcg
    10441 ttcaccatct gtcctgcata tacggctgtg tccgagcctc tcagggaatc catgggctgt
    10501 ccgccatcct cgagggcctc gtacacggtc tcaagaagca accggacttg gggatccagt
    10561 acatttgcct ctgaaggctt gatgccaaag aaggcggcat cgaaacgtcg gtgggtttcc
    10621 tctccagcta agagatatgc ttccttcacg ttggcatggc cgtgatacag cgcgtcctca
    10681 tgatagtatc ccccaagtgc tgggactttg cttgccacag aagttggatt ttgcagcagc
    10741 gcccagagct ttgacggtga gctagcattt ccgggaaacc gacacccaga acctataatg
    10801 gcgatctctg ccccctcacc agccatagtg aggaacgtgc tcgtaaagat gaaaatacag
    10861 ttgacacgtt acatgtgtac gtaaactaac catgccagaa agtcagttta actgttagaa
    10921 tttttataca gccaggtctg aagtcctttt ctacagacga ggctgaacta atctggacgt
    10981 cactatagct acgctgagta cgctcaagga gtgccttgga taacttatgt aataagccca
    11041 tgtcccgtta aaccatgatg gcctaaacat agtaatagct tggatgcgcg tgattggcag
    11101 gtttccagca tatcttctgt gattagacag taaaaagagc gcgtcttagt tgaaccggca
    11161 gtaatgatgc atgcaagcct ttcttattac aatgggggcc acaaatttgc cagtgccaca
    11221 gtggtcaaag actcaagtgt tcccccttgt gacagaacag ttcaaatgcg gaaaagttcc
    11281 aggcgtcgaa ggacgtgcat agaaatgtat cattagtatt aggctagtaa atgcactagt
    11341 aaactcaaca ttatcggcga atatcccaga ccaatggatt gaccgaatgg aagacgtcgc
    11401 tccagcttcg gctttctatt catgtctgcc gcctggctat gtcgatcaaa ggtacctaca
    11461 tatatgtgtg tgctacctat gcggtactat ttatatgact actccgtgtc gaggtcgaca
    11521 atatccgttg tcacgatact agtactagta cgtcgtattc cagaatttcg attatgcatg
    11581 gctgcggatc cgagtatgta ctagcagtac agccaagcat gttggctgag caggaagacc
    11641 cacttagggc tagggagcta ttctagacgg tagcaaatta ttagcactaa tcacatatat
    11701 acgtaaaacc aactcataat agatggactc ggggcaaaaa ataaggtgcg tagttatccc
    11761 acgtttgcta atggcctacg atcgtgcttt tctgttcagt gttttctata aatagaaatg
    11821 ttattagcag ctgtacggag taactacacc cgaatttgat tgtggcttgc tgtccatgca
    11881 tcaagctagg aatggtgcat gtattatcat gcgagggcca aaatgtaatg cgtgaggaaa
    11941 ccagccaccc tgcttggggc gatactccat ttacctttct taggccatcc ttttcccctc
    12001 attctttcaa gcggctgggc ctatcgcgcc gagctggttt gtacctacac ctagagtaaa
    12061 atatttccca acaccgctga cgtagactta gttcttcatt tcacggtcaa tctacctcct
    12121 catccctgtc atcctatcag gcaagaatga caagggcctg taagctcaac cctctcatgc
    12181 attcgtttcg gcgtgcgggg aaagaagcca agatcttgca agacattgtg actaaaaata
    12241 ttccggttta gttctttagg tgtttcgatg ttatctacga cctcatagca gggcgcacca
    12301 cggcaataat ggctttcgaa atacctgagg attccacaca actctcccaa tttgtcacac
    12361 ttctcatatt cactccgctg gggattgtgg taacggcgtt gcgcttcgtc gccgtccggc
    12421 gtgtgacgcg caaggtcggt tttgaggatt ggctggccgt gatagccacc attttcttca
    12481 tcttaactaa tcttgcgggt ttgatgggta agctggagag ctctatccga cagttccagc
    12541 cagtgtttct gacatgcgat atgtgcctta gcaattagca ttctcaatgg acgtcagctc
    12601 acccaggagg ttattgagag cccatcggat tattctcgta tgcgaaaggt gtgtaattat
    12661 atccacaagt ttgtcactgc cacagtcttg gggtttctac ttcaaccaga cactcaccat
    12721 gcgcaacaca gtgggatata gccggccttt tcttctactt tgcacaaacc ctctctgtca
    12781 aattgagcat tttggctttc taccaccgca tcttcggcat cagcagtact cgatgtagga
    12841 tctgcatata cctcctggca gctgcccaaa cgattctatt tatcgccttt tgcatcttcc
    12901 agggcttcca gtgtattccg cttcagagat atttcgacct ttcagtaccg ggagaatgca
    12961 aagatgaagg aacagtcata ttaggcggag aattgcccaa ctcactcgtc gatttcgcca
    13021 tggtgatttt ggcgatgatc atgatccgac ctctccagtt gtcgttcagc gacaaattta
    13081 gggtaacggt tcttttcggt ctcggtttcg tgtgagtttc ttctccgtta tgtatcgcgg
    13141 catttctgtt ccccatctaa ctctttttct tagtgttgga ataattgggt ttgtcaagat
    13201 tgcagtcact tattctacga gcgagctatg tcagtgaccc ttgattttca ccactccaat
    13261 agaagtcccc actaacttgg tctcttatca gatgcgttca gcatgatcgc cctgtggaca
    13321 ggcgtccaaa tgttcactgc tcttctttgc tgctctctgc cgatgtacaa cacgtttctt
    13381 ccgatcgtcg ccgatttctg gaaccgactc tcgcaccatt cactcggctg ggtctcccgc
    13441 gttcggtcat cacaaagctc gagcaaaaac tcgagaaagc atggtccata cgattcagat
    13501 cagagtccag gtccggggtg ggatgatctg gttgcgtata acggcaccaa ggggcttact
    13561 ttgccccaag caccctacca tggagacaat catgccctag gcaatgtttc tccaatcacg
    13621 catccacaag cgtacagtaa acagacgacg aggcagtttg atgtggtctg attcaaattg
    13681 tgtttattat tgtacatagc gtttgacgat ctatatattt aataggacat gacaagtctg
    13741 acatgaaagg actgtaacat acgtaaaatg accaatatga ctgtaaaaaa cattaaattt
    13801 tataatcata atcagaagat gttcaaagaa agtgccaaaa atattacaaa gtccttgtaa
    13861 gatcatcggc atgtcaacaa agaaaggcga ctgtcacatg ccaagacgga cccctccagt
    13921 ctctcttctt tccaccgcat cctccctctc cctcctctct tctactctgc atcacaattt
    13981 caaatgttac ggttcctcat gattctagcg ttgttttcgt ttcgtgaagt ttcttattga
    14041 ctcctggtcg ctctcagaca tggcgtttct cgattacccg ccgtttgata tatgcacaat
    14101 ccaacagctg cttacattca ttattatcag tgtatgcctg tctactcaca ggcttttttc
    14161 gtcggcagtc ttcattaatt tgtcatttct ataacagtat actttttatc ttacgacccg
    14221 gtccatctgg cgtctctact tccacccgtt gtccaaatat cccggcccga aagttgccgc
    14281 catttccgac atttggtatg cgtaccatgc gtaagtgttt ctagaaattg acagttgata
    14341 ttataactga cctgaggtct agattagcag gacgatggcc ctgggccgtt gcagatgctc
    14401 tcgaaaaata tggtacgtga aaagccatcc ctcttttttt cgtaactaac tcctctatcc
    14461 aggtgatgtt gttcggattg caccgaacga aatagcgttt gtaaccccaa aggctctgtc
    14521 tggtaagaac ctgaatgcat ggggatttgc tatctaggct cacgcaggaa gttttcagat
    14581 atctatggtt cccataacaa gaatctggaa aatttcgcca aaacccagat caacaatcat
    14641 ggaaatgacg agcatggagg tttgatctgg gaatgggatc cagctcggca ccgcgaggtg
    14701 gccaggcagt tgtctccggc tttcagcggt cgggctctca gagccaaaga agcgactttg
    14761 cacaaatata ttgacctctt tgtcgagcgt atgaccacgt tgggcggcga aactggcggt
    14821 gttagtttgc ctacatggat caactggctc tgtgttgata tttctgccga tatggcctat
    14881 aatcgggaaa tgaacgccct caaagacagt aagaagcact ctttattcta gagaaaaatg
    14941 ctgactattg aacagtgaaa gaaccgccct atttatcaat cctttccggg ttcaatagag
    15001 ccgtcgtcgt tacccaaatg tcatggcggt ttcccttgct cagccctctg aaaggtctat
    15061 ttctggccat taccgctatg cgatcgcatt ctcatattcg aaaccacagc cgttttcagc
    15121 tcgaacagcg catccgccgc aagggagcag ttgagcacct tgatttcttt gaacagctta
    15181 ttcccgaaaa tcgtgaacct cccaaggacc gaaaagagat gcggcatctc gagcaagtcg
    15241 ccggccagct gttggtagcc ggttacgagc ctccggcgct atggttctat tttacaatct
    15301 actacctgct aaaaaacccg gctacgctgg acacattgac caaggagatt aggagcgctt
    15361 ttaaaaatta cgatgagatc acatcaggct cggcggcgca attggcgtat ctctcggcgt
    15421 gcttgagcga gtctctgcgc attatgcctg gcgttcttac tggaatgcct gtggttagcc
    15481 caggcgccat ggtcgacgga acatatatac ccaaaggagt aagcggccta cgttttttca
    15541 actatctatc tgttctaatt gttattatta ctctccaggt ggtttgccaa tcgagctctc
    15601 tagctttggc acggagtcca cggaactttc ggcacgcatt gagtttccgt cctgagcggt
    15661 ggctgcagga ggaccacgca ctatacgatg cacaatttgc ccaagacaac cgcaagggct
    15721 tccaaccgtt cagccaaggc cctcgtatct gcgcggggaa ggaaattgcc tggtggcaga
    15781 gcagggtgtt cctagccaag gtgctgtgga catttgacct cgaaatggta tcaggccaac
    15841 agatcgacat ggccagggac ctgaggggtt ggggcatgta cgacaaacca gagatccgcg
    15901 tgagattcag gcctaaattt gtggtgtagt tgcggcgtta acgctgcaag ctgcatggtt
    15961 tattagcagt tggcactgtt acagcttacg acgtcccact acttggctag tgtgttacca
    16021 gcacgtacta attttagtag ccggcgtcta caatagcaca ataatacgga cgagttataa
    16081 ttatggatca tgatctacgg attaccgtcg gaatacatcc ggacccactg caaatcgcat
    16141 accaaccgca taccagctgt gaattctgcg ggctaggcgt atttttcagc tgcgaaacac
    16201 cttccaattt caggttttac cgccgatttt ccgtatctgc tcacttcaat gttgcaggtg
    16261 gcgctaatag ttatttttag gttggccccg gtacttcaga ttacgtgggt tggtgccgac
    16321 ataattaacc ctaattactc catatcccgg gcgtgcttca atgctgtata ttcaatggca
    16381 atcggcggga ttagagatcc atacccaccg gaatgagcac gaacatatca attgattcac
    16441 atgttaacaa gcttcggcac gaaatcgttg tagtcgaatg ttgacacaaa gctgtcacca
    16501 atattattaa tgacaccaac aactctccca acttctcaac gagccgtcca gcaagatggc
    16561 aatggcaagc tgcacgttgc caataatgcg gccatcccct cactcttgcc aggccacgtg
    16621 cttgtaaaaa catacgcggt cgctctcaat ccgtcagatt ataagattca gaaaaacttt
    16681 cctattccag gtgcctacgt gggaatcgat ttctcgggga ccgtagtgca ggtagcgaac
    16741 gatgttgact ctatcaaccc aggaacagaa gtctttggcg ccgcttttac cttttcgtcg
    16801 gcacatcgac tagccaacgg agcttttgca gagtatgtcc gcgtacgtgc tgatctgctg
    16861 ttccgtatac catcggaaca gcagtgtcag aatgatggtg atctgactct gttcaaggct
    16921 gcgacactgg gtaccgccat gtcaacctgc ttgctgtcat tatggtctcc agatgccctc
    16981 ggccttgtgg gcaagcctga agaaccagtg ctttctgaaa agcccatccc cgtacttgtc
    17041 tacggcggga gtacatctgt gggcacaatc gcgatacagc tactgaaatt atccggctac
    17101 gatcccatcg caacctgctc gccacgcagt tttgacttgg ttcgcagcag aggagcctct
    17161 aatgtctttg actactcgag tgcagatgtt gcgctcaaaa tcaagacgca cacaggcgga
    17221 cggcttaaat atgcacttga ctgcatcagc gatgtagcca gcgtggccac ctgttacgcg
    17281 gcaatccaac gaccaggcgg tcgatacgtg tcgctggaat acatacccga cgaattatta
    17341 gcgcagcgac gcgcagtgcg tccgaatttc gttttgtcgg cggagttgta tggagaggag
    17401 attgtattgg gggaggaagc gtacgaccga ccggccaaca gggaaaaaca tcagctggcg
    17461 gtacagaatg taggcatgtt acagcgcttg atagattctg ggggtttaaa gacgcatccg
    17521 acagaggaaa ttgaaggggg gttggaaggt gttgttaaag ggctggtggc cttggctggt
    17581 ggaggacatc caaggaagct ggttgctgtt gtttaactca gacattcaat aaacgttctg
    17641 tttgatttca aaatcaatta tatcacaatt aaattgagat gatagttacg tactgttaaa
    17701 acttaagaca tctctttatt ggccgtgggg ctctcctcaa gctgtaaatc caagtctgca
    17761 cagccaactt gggatcactg cgtactacca atatgcacct ttttgatcca accgggccct
    17821 agctgtaagt aatgtcccat tttcgagcgg ccccctgcat tattgaatat tgcatggttg
    17881 aaatcagctg accatgcagt agtgctgagt cgccattggc gccgatcaag ggcccgcaat
    17941 tacaagcatg ttttgttact gtatgctgcc aggggctaat ggagacctgt ttttcagcaa
    18001 cgcaagcaac ggggaagact cactgtgcat atgtcaattt ccgaagacat ggaatagctg
    18061 gaagcattga cctcggcaac cttaataccc aagattatct aaccaaaatc aatcaattgc
    18121 tgctgccggt tgtcttctac ctttgttttt acacattttc tggcctccaa gtcggacagg
    18181 ctgggcccaa ccatgaagag cccgagctcg tcagccgaaa tgcaaagctc gtcgccagag
    18241 cctgcgcctt ggaagcctga tttccaagtc tatgccattg tcattggcct gggaatcaca
    18301 aatctgctgg cagcgcttga gaatacagtg cttaccattg cagcccccgt ggtcctaaca
    18361 gacctagagc ttggggaaaa cttcatttgg gtcaccaacg cctttttcct atccaggtac
    18421 gtgggttcta gcatgggcaa agtggctacc tccttctgac tttaccacag cactgcaatc
    18481 ctccctctgt tcggccagtt ctccaacatc ttcggccgca gatatgtcat gctcacagcc
    18541 gttgccatct tcgttcttgg cagcggatta tgcggcggtg ccagcacggg ggccatgctg
    18601 atcgctggac gagccattca gggcgttggc tctgggggta tcatcatgtt gtcaagcatt
    18661 atcatcagcg acctggtgcc gctccgccag cgaggcaact tttctgcgat tctcatgtcc
    18721 atcttgggca tcggctctgc tctcggcccc ttgattggcg gcgcgatcgt atcctcgatc
    18781 agctggcgtt gggtctttta tctaaacctg cctatcggag gagtttcatt cgtctttctt
    18841 tttattttct tgcgcgtcaa atacaacaag gaaatgacgt tctggcagaa aattaaacgt
    18901 atcgacctcg tcggcaacgc catcgttatc gccagtacag tggctatcct ctacgccctc
    18961 agctatgccg gcacgcgata cccatggcga tcatggcaca ctctcgtgcc ccttctcgtt
    19021 ggctttctcg gtctgttcat ctttgctggg ctccaaacca ccgcgttttc cgccgagccc
    19081 ctgatgccaa cccgcttctt ccgcgctccc acatccataa tcctcgccat taacaccttt
    19141 gtctccgccg ccctactcta ctggtgcctc ttcttcctcc cggtcttttt gcagagcgtc
    19201 aaactttact ctccgcgccg tgctggcgtc gctctcctcc caatttctct cctcggcatc
    19261 ccaggctcca tggtcggcgc catcgcgcta gtccgctggg gtcggtacaa accagtccac
    19321 atcttcgcct ttgcgcttca aacccttggc ctgggtctat tcacactgtt ccgtgaagac
    19381 accagcgtcg ccgaatgggc cgtctttcaa tgcatcgtcg cctttggcgg cggcatgatc
    19441 ttcaccacca tgctgccggc ctttcaggcc tttatccacg agcgtgatat tgcagcctgc
    19501 acggccgcat ggtactttat ccgtctgttc ggacatatct ggggcgtggc catccccgca
    19561 gccatattca accaacgcat cgacacgctg ctcggccagg gcgcgatatc agacccaagc
    19621 gtctccaaga ccattgcggc cggcggcgcg taccaggcgg catctgcggc ctttgtgaag
    19681 cagtttccgg ggtcgttgca gctggagatt cgcagtgttt atagccaggc gatacagcgc
    19741 gtgttccagg tttccattgc ttttgctggg gtggcgtttc tgttgacgct gcttgagaag
    19801 gatgttgggc tgaggaagac gctggagacg gattttgggc tggagaagga gggcgctggt
    19861 cagcaggctg atgttgaagg gcgaagtcat gaatga
//
