BGC0001955 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001955 (Amycolatopsis keratiniphila)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS-like,T3PKS,NRPS	1	71,301	keratinimicin A/keratinimicin B/keratinimicin C/keratinimicin D	saccharide+NRPS:Type I	100%

BGC0001955 - Region 1 - NRPS,NRPS-like,T3PKS

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Location: 1 - 71,301 nt. (total: 71,301 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 71,302
Label		BGC0001955

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001955	1.66	NRP	keratinimicin A, keratinimicin B, keratinimicin C, keratinimicin D	Amycolatopsis keratiniphila
BGC0001461	1.42	NRP	nogabecin	Amycolatopsis keratiniphila subsp. nogabecina
BGC0000375	1.02	NRP	indigoidine	Streptomyces chromofuscus
BGC0002631	0.96	RiPP	myxarylin	Pyxidicoccus fallax
BGC0001561	0.92	NRP	curacomycin	Streptomyces curacoi
BGC0000900	0.89	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.88	NRP	dimethylcoprogen	Alternaria alternata
BGC0000844	0.87	Other	clavulanic acid	Streptomyces clavuligerus
BGC0001460	0.87	NRP	decaplanin	Amycolatopsis decaplanina DSM 44594
BGC0001459	0.84	NRP	decaplanin	Amycolatopsis regifaucium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001955	1.00	NRP	keratinimicin A, keratinimicin B, keratinimicin C, keratinimicin D	Amycolatopsis keratiniphila
BGC0001461	0.97	NRP	nogabecin	Amycolatopsis keratiniphila subsp. nogabecina
BGC0001460	0.81	NRP	decaplanin	Amycolatopsis decaplanina DSM 44594
BGC0000322	0.79	NRP	chloroeremomycin	Amycolatopsis orientalis
BGC0000455	0.78	NRP	vancomycin	Amycolatopsis orientalis HCCB10007
BGC0001459	0.78	NRP	decaplanin	Amycolatopsis regifaucium
BGC0001462	0.77	NRP	avoparcin	Amycolatopsis coloradensis
BGC0000419	0.76	NRP, Saccharide	ristomycin A	Amycolatopsis japonica
BGC0000418	0.76	NRP	ristocetin	Amycolatopsis lurida
BGC0000311	0.75	NRP	balhimycin	Amycolatopsis balhimycina DSM 5908

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 71301:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Hpg - D-bOH-Tyr) + (Phe) + (D-Hpg - D-Hpg - bOH-Tyr) + (Dhpg) + (Tyr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 37499:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Tyr) + (Dhpg)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 0 - 26420:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Tyr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 13954 - 71301:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Hpg - D-bOH-Tyr) + (Phe) + (D-Hpg - D-Hpg - bOH-Tyr) + (Dhpg) + (Tyr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AYA22318.1

Search NORINE for peptide: strict or relaxed

AMP-binding (12..402): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DAATLAAVAK
Nearest Stachelhaus code(s):: Tyr DAATLAAVAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AYA22333.1

Search NORINE for peptide: strict or relaxed

AMP-binding (471..865): Dhpg

nrpys: Dhpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: dhpg (Dhpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DPYHGGTLCK
Nearest Stachelhaus code(s):: Dhpg DPYHGGTLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AYA22334.1

Search NORINE for peptide: strict or relaxed

AMP-binding (457..852): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DIFHLGLLCK
Nearest Stachelhaus code(s):: Hpg DIFHLGLLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1945..2337): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DAAHLGLLCK
Nearest Stachelhaus code(s):: Hpg DAAHLGLLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3460..3847): bOH-Tyr

nrpys: bOH-Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: bht (bOH-Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DASTLGAICK
Nearest Stachelhaus code(s):: bOH-Tyr DASTLGAICK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AYA22335.1

Search NORINE for peptide: strict or relaxed

AMP-binding (467..855): Phe

nrpys: Phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: phe (Phe)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFVLSAVCK
Nearest Stachelhaus code(s):: Phe DAFVLSAVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AYA22336.1

Search NORINE for peptide: strict or relaxed

AMP-binding (14..405): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DAYHLGLLCK
Nearest Stachelhaus code(s):: Hpg DAYHLGLLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1040..1426): bOH-Tyr

nrpys: bOH-Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: bht (bOH-Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DTSKTAAICK
Nearest Stachelhaus code(s):: bOH-Tyr DTSKTAAICK (100% 8Å match)
Stachelhaus code match:: 100% (strong)