BGC0001955: keratinimicin A biosynthetic gene cluster from Amycolatopsis keratiniphila NRRL B24117
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Location: 1 - 71,301 nt. (total: 71,301 nt).
This entry is originally from NCBI GenBank MH428036.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001955
Short description keratinimicin A biosynthetic gene cluster from Amycolatopsis keratiniphila NRRL B24117
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • saccharide (None)
  • NRPS (Type I)
Loci
MH428036.1
1 - 71301
via Correlation of genomic and metabolomic data, Homology-based prediction
Compounds
  • keratinimicin A
  • keratinimicin B
  • keratinimicin C
  • keratinimicin D
Species Amycolatopsis keratiniphila NRRL B24117 [taxonomy]
References
Chemical products information
keratinimicin A Evidence:
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C84H92Cl2N8O33
Chemical database entries
PubCHEM
keratinimicin B Evidence:
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C78H83Cl2N9O26
Chemical database entries
PubCHEM
keratinimicin C Evidence:
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C84H89Cl2N7O34
Chemical database entries
PubCHEM
keratinimicin D Evidence:
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C84H90Cl2N8O32
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AYA22303.1
 328 - 864 (-) Ker4
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    • AYA22304.1
    		 878 - 1324 (+) HxiR
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      • AYA22305.1
      		 1399 - 2475 (-) DahP
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        • AYA22306.1
        		 2647 - 3438 (-) DpgD
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          • AYA22307.1
          		 3435 - 4649 (-) DpgC
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            • AYA22308.1
            		 4646 - 5275 (-) DpgB
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              • AYA22309.1
              		 5302 - 6420 (-) DpgA
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                • AYA22310.1
                		 6556 - 7173 (-) KraD
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                  • AYA22311.1
                  		 7197 - 8306 (-) KraC
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                    • AYA22312.1
                    		 8303 - 9280 (-) KraB
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                      • AYA22313.1
                      		 9282 - 10592 (-) KraA
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                        • AYA22314.1
                        		 10906 - 12252 (-) Ker3
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                          • AYA22315.1
                          		 12325 - 13401 (-) Hmo
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                            • AYA22316.1
                            		 13398 - 14450 (-) HmaS
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                              • AYA22317.1
                              		 14561 - 15751 (-) OxyD
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                                • AYA22318.1
                                		 15766 - 17499 (-) KerE
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                                  • AYA22319.1
                                  		 17496 - 18326 (-) Kph
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                                    • AYA22320.1
                                    		 18502 - 19788 (+) HpgT
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                                      • AYA22321.1
                                      		 20191 - 22062 (-) GtfD
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                                        • AYA22322.1
                                        		 22133 - 22945 (-) Ker2
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                                          • AYA22323.1
                                          		 23008 - 24183 (-) GtfC
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                                            • AYA22324.1
                                            		 24274 - 25203 (-) KerM
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                                              • AYA22325.1
                                              		 25255 - 26481 (-) GtfB
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                                                • AYA22326.1
                                                		 26515 - 27702 (-) GtfA
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                                                  • AYA22327.1
                                                  		 27755 - 29209 (-) KhaI
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                                                    • AYA22328.1
                                                    		 29292 - 30512 (-) OxyC
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                                                      • AYA22329.1
                                                      		 30630 - 31826 (-) OxyB
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                                                        • AYA22330.1
                                                        		 32250 - 32435 (-) Ker1
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                                                          • AYA22331.1
                                                          		 32463 - 33668 (-) OxyA
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                                                            • AYA22332.1
                                                            		 33749 - 33958 (-) MbtH
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                                                              • AYA22333.1
                                                              		 33955 - 39549 (-) KerD
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                                                                • AYA22334.1
                                                                		 39698 - 51877 (-) KerC
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                                                                  • AYA22335.1
                                                                  		 52184 - 55351 (-) KerB
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                                                                    • AYA22336.1
                                                                    		 55348 - 61596 (-) KerA
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                                                                      • AYA22337.1
                                                                      		 61593 - 63500 (-) Tri
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                                                                        • AYA22338.1
                                                                        		 63664 - 64575 (-) Pdh
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                                                                          • AYA22339.1
                                                                          		 64624 - 65310 (-) AjrR
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                                                                            • AYA22340.1
                                                                            		 66863 - 67471 (-) VanX
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                                                                              • AYA22341.1
                                                                              		 67461 - 68507 (-) VanA
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                                                                                • AYA22342.1
                                                                                		 68509 - 69372 (-) VanH
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                                                                                  • AYA22343.1
                                                                                  		 69662 - 70336 (-) Orf1
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                                                                                    • AYA22344.1
                                                                                    		 70456 - 71115 (+) Orf2
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                                                                                      Biosynthesis information

                                                                                      Biosynthetic modules

                                                                                      Name
                                                                                      Unk01
                                                                                      Type
                                                                                      nrps-type1
                                                                                      Genes
                                                                                      AYA22318.1
                                                                                      Substrates
                                                                                      tyrosine (evidence: Homology [1])
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      adenylation
                                                                                      Name
                                                                                      Unk02
                                                                                      Type
                                                                                      nrps-type1
                                                                                      Genes
                                                                                      AYA22333.1
                                                                                      Substrates
                                                                                      3,5-dihydroxyphenylglycine (evidence: Structure-based inference [1])
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      adenylation
                                                                                      Name
                                                                                      Unk03
                                                                                      Type
                                                                                      nrps-type1
                                                                                      Genes
                                                                                      AYA22334.1
                                                                                      Substrates
                                                                                      4-hydroxyphenylglycine (evidence: Structure-based inference [1])
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      adenylation
                                                                                      Name
                                                                                      Unk04
                                                                                      Type
                                                                                      nrps-type1
                                                                                      Genes
                                                                                      AYA22334.1
                                                                                      Substrates
                                                                                      4-hydroxyphenylglycine (evidence: Structure-based inference [1])
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      adenylation
                                                                                      Name
                                                                                      Unk05
                                                                                      Type
                                                                                      nrps-type1
                                                                                      Genes
                                                                                      AYA22334.1
                                                                                      Substrates
                                                                                      R-beta-hydroxytyrosine (evidence: Structure-based inference [1])
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      adenylation
                                                                                      Name
                                                                                      Unk06
                                                                                      Type
                                                                                      nrps-type1
                                                                                      Genes
                                                                                      AYA22335.1
                                                                                      Substrates
                                                                                      phenylalanine (evidence: Structure-based inference [1])
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      adenylation
                                                                                      Name
                                                                                      Unk07
                                                                                      Type
                                                                                      nrps-type1
                                                                                      Genes
                                                                                      AYA22336.1
                                                                                      Substrates
                                                                                      4-hydroxyphenylglycine (evidence: Structure-based inference [1])
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      adenylation
                                                                                      Name
                                                                                      Unk08
                                                                                      Type
                                                                                      nrps-type1
                                                                                      Genes
                                                                                      AYA22336.1
                                                                                      Substrates
                                                                                      R-beta-hydroxytyrosine (evidence: Structure-based inference [1])
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      adenylation
                                                                                      Annotation changelog

                                                                                      Entry version: next

                                                                                      Date
                                                                                      Changes
                                                                                      Submitters
                                                                                      Reviewers
                                                                                      2023-10-24
                                                                                      Added 'Saccharide' as additional biosynthetic class. Specified BGC evidence according to 'pubmed:30617293'. Added strain information.
                                                                                      • (ID: C62OJVVH7XOTOTFZSJT727YU)
                                                                                      • (ID: 25OPJFS6AQU3ROUADEVDYF5E)

                                                                                      Entry version: 2

                                                                                      Date
                                                                                      Changes
                                                                                      Submitters
                                                                                      Reviewers
                                                                                      2022-09-15
                                                                                      Cleaned up synonym list
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      2022-09-15
                                                                                      Fetch compound properties from PubChem
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      2022-09-15
                                                                                      Corrected biosynthetic class
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                      Entry version: 1

                                                                                      Date
                                                                                      Changes
                                                                                      Submitters
                                                                                      Reviewers
                                                                                      2019-10-16
                                                                                      Submitted
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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