BGC0001955: keratinimicin A biosynthetic gene cluster from Amycolatopsis keratiniphila
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Location: 1 - 71,301 nt. (total: 71,301 nt).
This entry is originally from NCBI GenBank MH428036.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001955
Short description keratinimicin A biosynthetic gene cluster from Amycolatopsis keratiniphila
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: MH428036.1
Compounds
  • keratinimicin A
  • keratinimicin B
  • keratinimicin C
  • keratinimicin D
Species Amycolatopsis keratiniphila [taxonomy]
References
Chemical products information
keratinimicin A
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C84H92Cl2N8O33
Chemical database entries
PubCHEM
keratinimicin B
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C78H83Cl2N9O26
Chemical database entries
PubCHEM
keratinimicin C [synonyms: Keratinimicin D]
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C84H89Cl2N7O34
Chemical database entries
PubCHEM
keratinimicin D [synonyms: Keratinimicin C]
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C84H90Cl2N8O32
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AYA22303.1
 328 - 864 (-) Ker4
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  • AYA22304.1
 878 - 1324 (+) HxiR
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  • AYA22305.1
 1399 - 2475 (-) DahP
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  • AYA22306.1
 2647 - 3438 (-) DpgD
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  • AYA22307.1
 3435 - 4649 (-) DpgC
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  • AYA22308.1
 4646 - 5275 (-) DpgB
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  • AYA22309.1
 5302 - 6420 (-) DpgA
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  • AYA22310.1
 6556 - 7173 (-) KraD
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  • AYA22311.1
 7197 - 8306 (-) KraC
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  • AYA22312.1
 8303 - 9280 (-) KraB
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  • AYA22313.1
 9282 - 10592 (-) KraA
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  • AYA22314.1
 10906 - 12252 (-) Ker3
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  • AYA22315.1
 12325 - 13401 (-) Hmo
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  • AYA22316.1
 13398 - 14450 (-) HmaS
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  • AYA22317.1
 14561 - 15751 (-) OxyD
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  • AYA22318.1
 15766 - 17499 (-) KerE
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  • AYA22319.1
 17496 - 18326 (-) Kph
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  • AYA22320.1
 18502 - 19788 (+) HpgT
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  • AYA22321.1
 20191 - 22062 (-) GtfD
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  • AYA22322.1
 22133 - 22945 (-) Ker2
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  • AYA22323.1
 23008 - 24183 (-) GtfC
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  • AYA22324.1
 24274 - 25203 (-) KerM
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  • AYA22325.1
 25255 - 26481 (-) GtfB
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  • AYA22326.1
 26515 - 27702 (-) GtfA
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  • AYA22327.1
 27755 - 29209 (-) KhaI
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  • AYA22328.1
 29292 - 30512 (-) OxyC
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  • AYA22329.1
 30630 - 31826 (-) OxyB
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  • AYA22330.1
 32250 - 32435 (-) Ker1
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  • AYA22331.1
 32463 - 33668 (-) OxyA
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  • AYA22332.1
 33749 - 33958 (-) MbtH
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  • AYA22333.1
 33955 - 39549 (-) KerD
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  • AYA22334.1
 39698 - 51877 (-) KerC
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  • AYA22335.1
 52184 - 55351 (-) KerB
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  • AYA22336.1
 55348 - 61596 (-) KerA
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  • AYA22337.1
 61593 - 63500 (-) Tri
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  • AYA22338.1
 63664 - 64575 (-) Pdh
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  • AYA22339.1
 64624 - 65310 (-) AjrR
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  • AYA22340.1
 66863 - 67471 (-) VanX
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  • AYA22341.1
 67461 - 68507 (-) VanA
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  • AYA22342.1
 68509 - 69372 (-) VanH
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  • AYA22343.1
 69662 - 70336 (-) Orf1
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  • AYA22344.1
 70456 - 71115 (+) Orf2
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
AYA22318.1
Module ?
Specificity: tyrosine
Evidence for specificity:
  • Homology
AYA22333.1
Module ?
Specificity: 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
AYA22334.1
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: R-beta-hydroxytyrosine
Evidence for specificity:
  • Structure-based inference
AYA22335.1
Module ?
Specificity: phenylalanine
Evidence for specificity:
  • Structure-based inference
AYA22336.1
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: R-beta-hydroxytyrosine
Evidence for specificity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Hidden contributor (ID: D5JND5QKNDZL5GA5REF5XZTD, no GDPR consent given).
  • Cleaned up synonym list
  • Fetch compound properties from PubChem
  • Corrected biosynthetic class
  • Added NRP substrate specificities
Detailed domain annotation
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