LOCUS       BGC0001959             15160 bp    DNA     linear   BCT 22-MAR-2019
DEFINITION  Streptomyces hiroshimensis strain A18 taylorflavin biosynthetic gene
            cluster, complete sequence.
ACCESSION   BGC0001959
VERSION     BGC0001959
KEYWORDS    .
SOURCE      Streptomyces hiroshimensis
  ORGANISM  Streptomyces hiroshimensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 16:37:03
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15160
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..15160
                     /collected_by="Princeton University"
                     /collection_date="08-Feb-2018"
                     /db_xref="taxon:66424"
                     /isolation_source="soil"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces hiroshimensis"
                     /strain="A18"
     subregion       1..15160
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001959"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..15160
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1220..1825
                     /gene="toxB"
     CDS             1220..1825
                     /codon_start=1
                     /gene="toxB"
                     /note="GTP cyclohydrolase II"
                     /product="ToxB"
                     /protein_id="QBK46610.1"
                     /transl_table=11
                     /translation="MGIRARVEIPVQRADGAWTPGQMVTFTGLGDGLEHVAVQFGPIAD
                     VPLVRLHSECLTGDVFGSARCDCGPQLTESMQLLAASGGVLLYLRQEGRGIGLYNKLDA
                     YRLQDQGLDTFAANRELNFSDDLRDYRSAAQMLQALGVTRVRLHTNNPDKAAQLASYGI
                     EVVEQIRTGIFRNENNDHYLRAKAEYGGHSIELVEGTA"
     misc_feature    1220..11580
                     /note="taylorflavin biosynthetic gene cluster"
     gene            1822..3534
                     /gene="toxC"
     CDS             1822..3534
                     /codon_start=1
                     /gene="toxC"
                     /gene_functions="other (smcogs) SMCOG1173:WD-40
                     repeat-containing protein (Score: 135.2; E-value: 4.7e-41)"
                     /gene_kind="other"
                     /note="WD-40 repeat-containing protein"
                     /product="ToxC"
                     /protein_id="QBK46609.1"
                     /transl_table=11
                     /translation="MIQHRGPISGIAAWRDAYVATAGYDNQVICWDQRTGTAIARSFHD
                     HLANQCSFSPDGRHLVTSSSDYTARLWTVPDLRLVAVLADQEDDVEMSVFHPSKELIAT
                     ASRDHRVRVYDFTGKLVARFTGHTADVISVEWARDSDELISSSDDGTIKRWSLETGGLI
                     ADLDMDGIETDTIAISSGGTIFAGNDEGQIIVVGPTERTVLPAHEAGIKRLVLDDARNL
                     LVSLSYDRTMQLWDVASGVPERRDTTALPDDVWPRSCAFAGGSRLVFATFGAGYRGYDY
                     EGRAWDAAEVPPTQGVNAVLPTASGTLTIGDAGIVHRGDTGVVHHEGEVVARTGSLCNF
                     LTPLGGLVLSGGQLGKVFDALTGRELHQHRSPLNCGAAFERDGASYAVVGAYTGEGLLL
                     RLTGAGEAEHVEDLPLHTNAVKGVAVSGDLIFSVAADASATWYRISDLSKVATIEDAHD
                     RIANGCAGLGEGWFASVSRDLKLRIWDPQQRAQVLDTPHTHSIKCVAASGDGRVVAAGA
                     YNGRIALYDRTAGEWTAVVRPTTAGISSLTWDAERKAFAASSYDGQVYYTPGV"
     gene            3675..4430
                     /gene="toxA"
     CDS             3675..4430
                     /codon_start=1
                     /gene="toxA"
                     /note="methyltransferase"
                     /product="ToxA"
                     /protein_id="QBK46611.1"
                     /transl_table=11
                     /translation="MGASHSIADRYTVERTEAAPLDEALYAAVLHSDFRDHYAGGRDVW
                     TGEEAMRRAPRLLMHALRTRTGAGAPAHVLDIGAGRGRDAGLLLAAGHRVTGIDLVASP
                     EWEALTRSHPGRARFLATAALDLPGTAQYDAVLDNGCFHHQHPGTYGTYLRRVHELLRP
                     GGLLTLSVFHAADGRGGLYANEGSRLYREFTEAELTALAACHGFALVTARQVPRAVGNL
                     TYLVSTFRRAGDRVRPTGSLLRPSTGDQS"
     gene            4427..5419
                     /gene="toxD"
     CDS             4427..5419
                     /codon_start=1
                     /gene="toxD"
                     /gene_functions="other (smcogs) SMCOG1226:hypothetical
                     protein (Score: 187.8; E-value: 5.1e-57)"
                     /gene_kind="other"
                     /note="serine/threonine kinase"
                     /product="ToxD"
                     /protein_id="QBK46612.1"
                     /transl_table=11
                     /translation="MTSSTPPVVLANPNTLTDRAAMGLPDAFVSRGPQYLLAGHRDLLA
                     AEPEALVAIAQDPAEPFARRHAAGTVLGLVGDPRIRPEDPPMADVPAARVRLGLEPGEV
                     GTVTARWRHAGVEEEWIAKESPVYEADLAAFRIALYPVTNAEYRLFLEDTGRTELPTTW
                     RFGVYPAQLANHPVWTVTPEAADAYAAWLAGRTGRAFRLPTEAEWEYAASGGDGRDFPW
                     GDDFRPGAANTVEEGPLATTPIGVFPAGRSPFGVHDLAGNVEEYVADDYAAYPGGQEIA
                     DDLAVTQGAYRIARGGSFTRFGDLARVRRRHGWYKREIYAMGFRLAETA"
     gene            5416..6546
                     /gene="toxE"
     CDS             5416..6546
                     /codon_start=1
                     /gene="toxE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1240:riboflavin biosynthesis protein RibD (Score:
                     278.2; E-value: 1.2e-84)"
                     /gene_kind="biosynthetic-additional"
                     /note="riboflavin biosynthesis protein, RibD"
                     /product="ToxE"
                     /protein_id="QBK46613.1"
                     /transl_table=11
                     /translation="MTAPGGATPAEREAMRRALALAVTALGRTSPNPVVGCVLLDADGA
                     TVAEGHHRGAGHMHAEVEALAAAGHRARGATAVVTLEPCAHQGRTGPCADALLAAGVAR
                     VVYAVPDPVPGHAGGAERLRAAGVEVVGGVLREEAERANELWLTATRLGRPCVTWKFGG
                     SLDGRSAAPDGTSRWITGHEARADAHTLRATHDAVLVGSGTLRADDPHLGLRHGVEGKP
                     PLRVVLDRTGGIRPDARVLDDAAPTLVVVGESAAPPVLPHGHAVLTLPEPGGRLDLTAL
                     VKALYERGLCSVLLEGGARLAAEFAAQGLLDRVVAYVAPVLIGGEGRAVLDGFGAGTLS
                     EALRLRLDEVARLGDDVRMVLRARPLPGGPEPEEVS"
     gene            6543..7796
                     /gene="tflA"
     CDS             6543..7796
                     /codon_start=1
                     /gene="tflA"
                     /note="quinone oxidoreductase"
                     /product="TflA"
                     /protein_id="QBK46614.1"
                     /transl_table=11
                     /translation="MTPRVAVVYHSRRGTMRALAEAAAAGARAHGARVRLLRVADDDEA
                     GPAWPDEEARPEDVLWADGLVLASPTYFGNVSAPFKRFLDGTTKLWWDGLLTDRVVTGM
                     TASTCPHGGREATLLTMYQSAHHWGAWTVGAGPAGPGDPADPAGPARRGAGGNPYGLAV
                     TALRDGGVAEHDRDAAWELGRRLAGVAARARSGGPPGPDAAARSRVTVVHCAEDETVRL
                     LAQECAAGARELGAEVRLRRLTGPGVRRESGLPGRAGGAPAAAAVDPADVAWADSVVFG
                     TPVRAGAVAAPLLGFLQSLEPPAGPGPLAGKPASGFVSTARPHAGSESALLSLHHVLHH
                     CGAVVVPPGYTDPVVFEAGGNPYGTSHARSAGVLPTVQALAAARHQGRRAALAGDRLRG
                     RPVPGAGLLDTPLEKELT"
     gene            7793..8533
                     /gene="tflB"
     CDS             7793..8533
                     /codon_start=1
                     /gene="tflB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 79.7; E-value: 4e-24)"
                     /gene_kind="biosynthetic-additional"
                     /note="methyltransferase"
                     /product="TflB"
                     /protein_id="QBK46615.1"
                     /transl_table=11
                     /translation="MTVQQYDDIGEAYEGFKSLPMARYPESDSFLRMLGDLSGKSVLDL
                     ACGTGFYSRQAKLLGAAEVLGVDVSDTMVAAAWSIEKRNPLGVRYLVGDGADLPLFDRH
                     FDVATAVYLLNYADDAATMEWMCRGVHRSLRPGGEFFVLTQAPEFRFDGPPTEKYGFRY
                     EQVGEGEVGPRVRVTALLDSPVEFVTNYPRREVCEGALWAAGFRDVTWVPLQVPEDGVS
                     RYGAEFWENFLANPPLAMLRCTAG"
     gene            complement(8645..9247)
                     /gene="tflC"
     CDS             complement(8645..9247)
                     /codon_start=1
                     /gene="tflC"
                     /note="hypothetical protein"
                     /product="TflC"
                     /protein_id="QBK46616.1"
                     /transl_table=11
                     /translation="MENVLLLGLSAPADDDPYGDPLLRALSAPGASGTRLVVSTAPSVL
                     ARAGSEIIAPSHPVADALRQMASLADGIVITTPETAAAPPTSLRTLLNWLTWPTEGSPL
                     IGKPVAVITTSTAPAAEPEPYCEVERMLFSAGATIIGPRTVVARVDRTLREEPDGQVAF
                     GDPGAAVRLLFHIHRTAAAARETSGLPPADDFRPWLL"
     gene            complement(9366..10850)
                     /gene="tflD"
     CDS             complement(9366..10850)
                     /codon_start=1
                     /gene="tflD"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 111.9; E-value:
                     4.2e-34)"
                     /gene_kind="transport"
                     /note="MFS transporter"
                     /product="TflD"
                     /protein_id="QBK46617.1"
                     /transl_table=11
                     /translation="MLEVVVSQEVNQAVEGPGGPLAPPGADVSPSPTAGEGPAESVFSG
                     ARRALTLGVVLSVSMVAFESLGVATVLPGIADDLHGLGAYGWGLSALMLANIVGTVVAG
                     RAADRGGPARSMAAGTLVFAAGCAVAGAAVSWPLFLLGRALQGLGVGAVMSMAYTVIGL
                     AYPEHLRARMFALLSSAWTIPSLIGPVVAGTLSDLAGWRGVFLLMLPLIAVAAALTLPG
                     LRRLDRPAACAATPAGPWWRSPLAASILLTAGTALFLQALLLDNLALLIPLALAGPAVA
                     VPALRRVTPAGTLRLRAGVGAGIGIRFLLCGVYFGSEAFLPLGLQELRGVHASPAGLGL
                     SAGAITWVAGSAWQARRDGRAQGRTGSVTLGFAVLLAGLAVMAAAVLAEAVPPLVAVAG
                     WAVGGFGMGVAFNAATTDTLEQAPAGRQGLVSGSLQLAQTLATGLVSGIGGAAVATAHR
                     HGATTRAGLLFTFALTAALALAGVLLSRRLRPAPAG"
     gene            10930..11580
                     /gene="tflE"
     CDS             10930..11580
                     /codon_start=1
                     /gene="tflE"
                     /gene_functions="regulatory (smcogs) SMCOG1224:TetR family
                     transcriptional regulator (Score: 140.3; E-value: 1.1e-42)"
                     /gene_kind="regulatory"
                     /note="TetR family transcriptional regulator"
                     /product="TflE"
                     /protein_id="QBK46618.1"
                     /transl_table=11
                     /translation="MAEARETREGGQQRTGRPRDGRIDAAVPAAVMEILNESGYGNLTL
                     EAVAARAGTSKPALRRRWQSRQHLVVDALVTTVGATPTPDTGCTHCDLIAGIGTLSQAF
                     GTTLGRRVLPALVADLADHPELESLFLERFFHTRRASTAEALRRGIRRGDLRPDADIDL
                     LLDMLASTTYYRVLFGHLPVTATLAEDVVEVVLKGVATEAWRGRHSHGVFDGF"
ORIGIN
        1 cgctgaccga cctcgggctc gactcggtga tgtcgatgcg ggtctgcgcc cagctggaga
       61 agctgctcgg cgtacggctg ccggtgacgg tgctgtggaa ctacccgacg gcgaagggac
      121 tggcgggcta cgtcacctcc gtcctcgccc cgcaggacga gccggcgggg acccccgccg
      181 cctagcggcc ggcgcaggac ggaccgcaca ggcggctcgt gcacggcccg gccgggtcgt
      241 gcacgagccg ccgtgccgtc cggcagccct tgcggcggac ggctagacca gcggggtaag
      301 gaaccgttcc ggctgacagg cctcgcaggg gtgggcgttg cgggtgagga gctcttcgcg
      361 ggcctgcggg gtggacatgg tcctctcgcc ccccttcggt acccagcatc cggcgtgatg
      421 cagctcgtgc atgttgcggc cggagccgcg gtgggtggtg accggccaca cggcgtgctc
      481 catgtcggcc cggtacggcg gccggccgtc ccccgcgcgg tggccgccgg agtcggccgg
      541 gtcctcctcc aagtactcct cgtcggtgag gagttgcaga accacggcgc ggacccagtc
      601 gcgcgggtcc atccccgact cctgcgcggc cgccgcgatg agggcgagtt cgtcgtcgct
      661 gaagagctgc tccatgccgc gcgacggtag cagcgcgggg ggcccggcgg ggggtggttg
      721 cgcaggtcgc ggtaccggtg cccggagtac ccccgcggtg ccgcgcagcg gttcccggcg
      781 gccgggagat tagcccgaag gagtgatgtc gaggggtggt ccggccggcc ggtgacccac
      841 cgtgacggac gggcggccgt ctcccctagg ctccgggagg cgcctcccac cacatcagag
      901 acagaaccgg acgagcggtt tccgggtagc aggagtccgg ctgaagatcc cgaagcgtcc
      961 ggatcgcacg gcggaactga cgcgccaaaa gcttcgggct tccaaacgaa cagaccggat
     1021 ggttcggtac cgctgtcaaa tgatctcggt acccgtaccg gtacggaccg tgctgtccac
     1081 gctgccctcc gcacccatgc tgtgactgcg ccctggggtt cggggcgtgc tcgttctacg
     1141 ggaggaagca gtgcccaaaa cactcaatgg ggaggacacc ccgttgcacg gggcgtcggt
     1201 ggaaccgccg gaggggtccg tgggcatcag agcccgcgtc gagatccccg tgcagcgggc
     1261 cgacggggcc tggacgcccg gccagatggt gacgttcacc ggcctcggcg acggcctcga
     1321 gcacgtggcg gtgcagttcg gaccgatcgc ggacgtcccg ctggtccggc tgcactccga
     1381 gtgcctgacc ggcgacgtct tcggctccgc gcggtgcgac tgcggccctc agctgaccga
     1441 gtcgatgcag ctgctcgccg cctccggcgg cgtcctgctc tacctgcgcc aggagggccg
     1501 gggcatcggg ctctacaaca agctcgacgc ctaccgcctg caggaccagg gcctggacac
     1561 gttcgccgcc aaccgcgagc tgaacttctc ggacgacctg cgggactacc gctcggccgc
     1621 ccagatgctc caggccctcg gagtgacgcg ggtcaggctg cacaccaaca accccgacaa
     1681 ggccgcgcag ctcgcctcgt acgggatcga ggtcgtcgaa cagatccgta ccggaatctt
     1741 ccgtaacgag aacaacgacc actacctgcg cgccaaggcc gagtacggcg gccactcgat
     1801 cgaactcgtg gaaggaacag cgtgatccag caccggggac ccatcagcgg catcgcggcc
     1861 tggcgggacg cctacgtcgc caccgccggc tacgacaacc aggtcatctg ctgggaccag
     1921 cggaccggga cggccatcgc ccgctccttc cacgaccacc tggccaacca gtgctcgttc
     1981 tcgccggacg gacgccacct ggtgacctcc tccagcgact acaccgcccg cctgtggacg
     2041 gtgccggacc tgcgcctggt cgcggtcctc gccgaccagg aggacgacgt ggagatgtcc
     2101 gtcttccacc cgtccaagga gctcatagcc accgcctccc gcgaccaccg ggtacgggtc
     2161 tacgacttca cgggcaagct cgtcgcccgc ttcaccggcc acaccgccga cgtcatctcg
     2221 gtggagtggg cccgcgacag cgacgagctg atctcctcca gcgacgacgg caccatcaag
     2281 cgctggtccc tggagaccgg cgggctgatc gccgacctcg acatggacgg catcgagacc
     2341 gacaccatcg ccatctcctc cggcggcacc atcttcgcgg gcaacgacga ggggcagatc
     2401 atcgtcgtcg gccccaccga gcgcacggtc ctgccggccc acgaggcggg catcaagcgc
     2461 ctggtcctgg acgacgcccg caacctgctg gtcagcctca gctacgaccg caccatgcag
     2521 ctgtgggacg tcgcctcggg cgtccccgag cggcgcgaca ccaccgccct gcccgacgac
     2581 gtctggcccc gctcctgcgc cttcgccggc ggctcccggc tggtcttcgc gaccttcggc
     2641 gccggctacc gcggctacga ctacgagggc cgggcctggg acgccgccga ggtgccgccc
     2701 acccagggcg tcaacgccgt gctgcccacc gcctccggca cgctgaccat cggcgacgcg
     2761 ggcatcgtgc accgcggcga caccggcgtc gtgcaccacg agggcgaggt cgtggcccgc
     2821 accggcagcc tgtgcaactt cctcaccccg ctcggcggcc tggtgctctc cggcggccag
     2881 ctcggcaagg tcttcgacgc cctgaccggc cgtgagctcc accagcaccg ctccccgctc
     2941 aactgcggcg cggccttcga gcgcgacggc gcctcctacg cggtcgtcgg cgcctacacc
     3001 ggcgagggcc tgctgctgcg cctgaccggc gccggcgagg ccgagcacgt cgaggacctg
     3061 ccgctgcaca ccaacgccgt caagggcgtc gcggtctccg gcgacctcat cttctccgtg
     3121 gccgccgacg cctccgcgac ctggtaccgc atctccgacc tcagcaaggt cgccacgatc
     3181 gaggacgcgc acgaccggat cgccaacggc tgcgcgggcc tgggcgaggg ctggttcgcc
     3241 agcgtcagcc gcgacctgaa gctgcgcatc tgggacccgc agcagcgcgc ccaggtgctc
     3301 gacaccccgc acacccactc catcaagtgc gtcgccgcct ccggcgacgg ccgcgtggtc
     3361 gccgccggcg cctacaacgg ccgcatcgcg ctctacgacc gcaccgccgg cgagtggacc
     3421 gccgtcgtcc gcccgaccac cgcgggcatc tcgtccctga cctgggacgc cgagcgcaag
     3481 gccttcgccg cgtcctccta cgacggccag gtgtactaca cgcccggcgt ctagcacggg
     3541 cacccgcacc ggttgcgggg gaggcgagga ctgctcgccc gcctcccccg cgaccgcccc
     3601 atgtccggac ccgccgcagc acgagcagca gcacaagcac caccagcacc agaacacgac
     3661 aggaccgtgc accgatgggc gcaagccact ccatagccga ccggtatacg gtcgaacgca
     3721 ccgaagccgc accgctcgac gaggccctct acgccgccgt cctgcacagc gacttccgcg
     3781 accactacgc cggcggccgc gacgtctgga ccggtgagga ggccatgcgc cgggcgccgc
     3841 gcctgctcat gcacgccctc cgcacccgga ccggcgccgg cgcccccgcc cacgtgctcg
     3901 acatcggcgc cggccgcggc cgcgacgccg ggctcctgct cgccgccgga caccgggtca
     3961 ccggcatcga cctcgtcgcc tcccccgagt gggaggccct cacccgcagc caccccggcc
     4021 gcgcccgctt cctcgccacc gccgccctcg acctgcccgg caccgcgcag tacgacgcgg
     4081 tgctggacaa cgggtgcttc caccaccagc accccggcac ctacggcacg tacctgcgcc
     4141 gcgtccacga actgctgcgc cccggcggcc tcctcacgct ctccgtcttc cacgcggcgg
     4201 acggcagggg cggcctctac gccaacgagg gcagccgcct ctaccgcgag ttcaccgagg
     4261 ccgagctgac cgcgctggcc gcctgccacg ggttcgccct cgtgacggcc cgccaggtgc
     4321 cccgcgccgt cgggaacctc acctacctgg tgagcacgtt ccgccgcgcc ggagaccgcg
     4381 tgcggccgac cggaagcctc ctccgaccgt ccacgggaga ccagtcatga ccagcagcac
     4441 gccgccggtc gtcctcgcca accccaacac cctgaccgac cgggccgcga tgggcctgcc
     4501 cgacgccttc gtgtcgcgcg gcccgcagta cctcctggcc ggccaccgcg acctgctcgc
     4561 cgcggagccg gaagccctcg tcgcgatcgc gcaggacccc gccgagccgt tcgcccgccg
     4621 ccacgccgcc ggcaccgtcc tcggtctcgt cggcgacccc cggatccgcc ccgaggaccc
     4681 gccgatggcc gacgtgccgg ccgcccgggt ccgcctcggc ctggagcccg gcgaggtcgg
     4741 cacggtcacc gcccgctggc gccacgccgg cgtcgaggag gagtggatcg ccaaggagtc
     4801 ccccgtctac gaggcggacc tcgcggcctt ccgcatcgcc ctgtaccccg tcaccaacgc
     4861 cgagtaccgc ctgttcctgg aggacaccgg ccgcaccgag ctgccgacca cctggcgctt
     4921 cggcgtctac cccgcgcagc tcgccaacca cccagtgtgg accgtgaccc ccgaggccgc
     4981 cgacgcctac gcagcctggc tcgcgggccg caccggccgc gccttccggc tgccgaccga
     5041 ggccgagtgg gagtacgcgg cctccggcgg ggacggccgc gacttcccct ggggcgacga
     5101 cttccggccc ggggccgcca acaccgtcga ggagggcccc ctggcgacca cgccgatcgg
     5161 cgtcttcccc gccggccgct ccccgttcgg cgtgcacgac ctcgcgggca acgtcgagga
     5221 gtacgtggcc gacgactacg ccgcctaccc cggcgggcag gagatcgccg acgacctcgc
     5281 cgtgacccag ggcgcctacc ggatcgcccg cggcggcagc ttcacccgct tcggcgacct
     5341 cgcccgcgtc cggcgccggc acggctggta caagcgcgag atctacgcca tgggcttccg
     5401 cctcgcggag acggcgtgac ggccccgggc ggcgccacgc ccgccgaacg ggaggcgatg
     5461 cggcgggcgc tcgcgctcgc ggtgaccgcg ctgggccgca ccagccccaa cccggtcgtc
     5521 ggctgcgtcc tgctggacgc cgacggcgcc accgtggcgg agggccacca ccgcggcgcc
     5581 ggccacatgc acgccgaggt cgaggcgctg gccgcggccg ggcaccgggc gcggggcgcg
     5641 acggccgtgg tcaccctgga gccctgcgcg caccagggcc gtacgggacc ctgcgcggac
     5701 gcgctgctcg cggccggggt cgcccgcgtg gtgtacgcgg tgccggatcc cgtccccggc
     5761 cacgcgggcg gcgccgagcg gctgcgcgcc gccggggtcg aggtcgtcgg aggcgtcctg
     5821 cgggaggagg cggagcgggc caacgagctg tggctgaccg cgacccgcct cggccggccg
     5881 tgcgtgacct ggaagttcgg cgggagcctc gacggtcgct cggcggcgcc cgacggcacc
     5941 tcgcgctgga tcaccggcca cgaggcccgc gccgacgcgc acacgctgcg ggccacgcac
     6001 gacgcggtgc tcgtcggctc ggggacgctg cgggcggacg acccgcacct cggcctgcgg
     6061 cacggtgtgg agggcaagcc gccgctgcgc gtggtgctgg accgcaccgg cggcatccgc
     6121 ccggacgcgc gcgtcctgga cgacgcggcg cccaccctcg tggtcgtcgg cgagtcggcg
     6181 gccccgcccg tactccccca cggccacgcg gtgctgaccc ttcccgagcc cggcgggcgg
     6241 ctggacctca cggcgctggt gaaggcgctg tacgagcgcg ggctgtgctc cgtgctgctg
     6301 gagggcggcg cccggctggc cgcggagttc gcggcgcagg gcctgctcga ccgcgtcgtg
     6361 gcgtacgtcg ccccggtgct gatcggcggt gaggggcgcg cggtgctcga cgggttcggc
     6421 gcaggcaccc tgagcgaggc gctgcgcctg cggctggacg aggtggcccg gctcggcgac
     6481 gacgtccgga tggtgctgcg cgcccgcccc ctccccggcg gcccggagcc ggaggaggtg
     6541 tcgtgacccc gcgggtcgcg gtcgtctacc acagcaggcg cggcaccatg cgggcgctgg
     6601 ccgaggccgc ggccgccggg gcgcgggcgc acggcgcccg ggtgcggctg ctgcgcgtcg
     6661 ccgacgacga cgaggccggg cccgcgtggc cggacgagga ggcccggccg gaggacgtgc
     6721 tgtgggccga cggcctggtg ctggcctctc ccacgtactt cggcaacgtc tccgcgccgt
     6781 tcaagcggtt cctggacggc acgacgaagc tgtggtggga cgggctgctg accgaccggg
     6841 tggtgacggg gatgacggcc tcgacctgcc cgcacggcgg ccgcgaggcc accttgctga
     6901 cgatgtatca gtcggctcac cactgggggg cctggaccgt cggggcgggc ccggccggcc
     6961 ccggtgatcc ggcggacccc gccggtcccg cccggcgcgg cgcgggcggc aatccgtacg
     7021 ggctggcggt caccgccctc cgcgacggcg gcgtcgcgga gcacgaccgg gacgcggcct
     7081 gggagctggg ccgccggctg gccggcgtgg ccgcccgggc gcggtccggc ggccctcccg
     7141 gcccggacgc cgcggcccgc agccgggtga cggtcgtcca ctgcgccgag gacgagacgg
     7201 tccggctgct ggcgcaggag tgcgcggccg gggcccggga gctcggtgcc gaggtgcggt
     7261 tgcgccggct gacggggccg ggcgtgcggc gggagtcggg gctgcccggc cgtgcgggcg
     7321 gggccccggc ggcggccgcc gtcgacccgg ccgacgtggc gtgggcggac tccgtggtct
     7381 tcggcacccc ggtgcgggcg ggcgccgtcg ccgcgccgct gctgggcttc ctgcagtcgc
     7441 tggagccccc ggccgggccg ggcccgctcg cgggcaagcc cgccagcggg ttcgtctcca
     7501 ccgcccggcc gcacgcgggc agcgagtcgg cgctcctctc cctccaccac gtgctgcatc
     7561 actgcggtgc ggtcgtggtg ccgccgggct acaccgatcc cgtggtgttc gaggccggcg
     7621 gcaatccgta cggcacgtcg cacgcccggt cggcgggggt cctgccgacc gtccaggcgc
     7681 tggcggccgc ccggcatcag ggcaggcgcg cagccctggc cggcgaccgg ctgcgcggcc
     7741 ggcccgttcc cggggccggc ctcctcgaca cccccctgga gaaggaactc acatgaccgt
     7801 gcagcagtac gacgacatcg gcgaggccta cgagggattc aagtcgctgc ccatggcccg
     7861 ctacccggag tcggacagct tcctgcggat gctcggggac ctgagcggca agtcggtcct
     7921 ggacctggcg tgcgggacgg gcttctacag ccggcaggcg aagctgctcg gcgccgcgga
     7981 ggtcctcggc gtcgacgtct ccgacaccat ggtggcggcc gcctggtcca tcgagaagcg
     8041 caacccgctg ggggtgcgct acctggtcgg cgacggcgcc gacctgcccc tgttcgaccg
     8101 gcacttcgac gtggcgacgg ccgtctacct cctcaactac gccgacgacg cggccacgat
     8161 ggagtggatg tgccggggcg tgcaccgcag cctgcggccg ggcggggagt tcttcgtcct
     8221 cacccaggcg ccggagttcc gcttcgacgg gccgcccacg gagaagtacg gcttccgcta
     8281 cgagcaggtg ggcgagggcg aggtgggacc gcgggtgcgg gtcacggcgc tgctcgactc
     8341 ccccgtcgag ttcgtgacca actacccgcg gcgcgaggtg tgcgagggcg cgctgtgggc
     8401 ggccggcttc cgggacgtca cgtgggtgcc gctgcaggtg cccgaggacg gggtcagcag
     8461 gtacggcgcg gagttctggg agaacttcct cgccaatccg ccgctggcga tgctgcgctg
     8521 cacggccggc tgacggccgg acccgcggcg cgccaccccg gcggcccggc ttcccctgcg
     8581 gctccggcgg ccatgacggc cccggcggcg gtcgtccgcc gccggggccg tcctgcgtgc
     8641 gcggtcagag cagccagggc cggaagtcgt ccgcgggcgg caggccggag gtctcccggg
     8701 cggccgcggc ggtgcggtgg atgtggaaca gcaggcggac ggccgcgccg gggtcgccga
     8761 aggcgacctg cccgtcgggc tcctcgcgca gggtccggtc gacgcgggcg acgacggtgc
     8821 gcgggccgat gatggtggcg cctgcggaga agagcatccg ctcgacctcg cagtacggct
     8881 cgggctcggc cgcgggggcg gtggaggtgg tgatgaccgc gacgggcttg ccgatgagcg
     8941 gggagccttc ggtgggccac gtcagccagt tgaggagcgt gcgcagggag gtgggcggcg
     9001 cggcggccgt ctcgggggtc gtgatgacga tgccgtcggc gagcgaggcc atctggcgca
     9061 gggcgtcggc gacggggtgc gagggggcga tgatctcgct gccggcccgg gccagtacgg
     9121 acggcgccgt gctgacgacg agccgggtgc cggaggcacc gggggccgag agcgcgcgca
     9181 gcagcgggtc gccgtagggg tcgtcgtcgg ccggggcgct cagccccagc agcagtacgt
     9241 tctccacggt cggactcctt ccttgacgtg gtgcgtaggg ggcctcgggg tgctcaggcc
     9301 ttggggacgg gggccttggg ggaagagccc ccgcaggtgc gggtgaggtc gtgggggccg
     9361 gccggtcagc cggccggggc ggggcgcagg cgtctggaga gcagcacgcc tgccagggcg
     9421 agcgccgcgg tgagcgcgaa ggtgaacagg agcccggccc gggtggtcgc gccgtgccgg
     9481 tgggccgtgg cgaccgcggc gccgccgatg ccggagacca ggccggtggc gagggtctgg
     9541 gcgagctgca gggagccgct gacgaggccc tgccggccgg cgggggcctg ttcgagggtg
     9601 tcggtcgtgg cggcattgaa ggcgacgccc atgccgaagc cgcccacggc ccagcccgcg
     9661 acggcgacga gcgggggcac ggcctcggcg aggacggcgg cggccatgac ggcgagcccg
     9721 gcgagcagga cggcgaagcc gagggtgacg ctgccggtgc ggccctgtgc ccggccgtcg
     9781 cgccgggcct gccaggcgga gccggcgacc cacgtgatgg cgccggcgga caggccgagg
     9841 ccggccgggg aggcgtgcac gccgcgcagt tcctgcaggc cgagcgggag gaaggcctcg
     9901 ctgccgaagt agacgccgca cagcaggaag cggatgccga tgccggcgcc gactccggcc
     9961 cgtaggcgga gggttccggc gggggtgacc cggcgcaggg cgggcacggc gacggccggg
    10021 ccggcgaggg cgagcgggat cagcagggcg aggttgtcaa ggagcagcgc ctggaggaag
    10081 agtgcggtgc ccgcggtgag gaggatgctc gcggcgaggg ggctccgcca ccagggtccg
    10141 gcgggggtgg cggcgcaggc ggcggggcgg tcgaggcggc gcaggcccgg gagggtgagg
    10201 gcggcggcga cggcgatcag cggcagcatg agcaggaaca cgccgcgcca gcccgcgagg
    10261 tcggagagcg tgccggcgac gacggggccg atcagcgagg ggatggtcca ggccgaggag
    10321 aggagggcga acatgcgcgc cctgaggtgt tcggggtagg cgagcccgat cacggtgtag
    10381 gccatgctca tgacagctcc gacgccgagg ccctgcagcg cgcggccgag caggaacagc
    10441 ggccaggaga ccgccgcgcc cgccaccgcg cagccggcgg cgaagaccag cgtcccggcg
    10501 gccatggagc gcgcgggccc gccccggtcg gccgcgcgtc cggcgaccac cgtgccgacg
    10561 atgttggcga gcatcagggc cgacaggccc cagccgtagg cgccgagtcc gtgcaggtcg
    10621 tccgcgatgc cgggcaggac cgtggccacg cccagggatt cgaaggcgac catgctcacg
    10681 gacaggacga cgccgagggt cagcgcgcgg cgggccccgg agaagacgct ctccgccggg
    10741 ccctcccccg ccgtcggcga cggggagacg tccgcaccgg gcggcgcgag cgggccgccg
    10801 ggcccctcca ccgcctggtt cacctcctgc gacacgacga cctccagcac aacgtttcgt
    10861 tacgttccgg gacggaatca attgcagctt acctatactg gccgcatggt gaacaccccg
    10921 aacggcgcgg tggccgaagc gcgggagacg cgcgaaggcg gccagcagcg cacaggcagg
    10981 ccacgggacg gccgcatcga cgcggccgtg cccgccgcgg tgatggagat cctcaacgag
    11041 tcgggctacg ggaacctgac gctcgaagcg gtggccgccc gtgcggggac gagcaagccg
    11101 gccctgcgcc ggcgctggca gtcccgccag cacctcgtcg tggacgcgct ggtcaccacc
    11161 gtgggcgcca ccccgacacc cgacaccggc tgcacccact gcgacctgat cgccggcatc
    11221 ggcacgctga gccaggcctt cggcaccacg ctggggcggc gcgtcctgcc cgccctcgtg
    11281 gccgacctcg ccgaccaccc cgagctggag agcctgttcc tggagcgctt cttccacacg
    11341 cgccgggcct cgacggccga ggcgctgcgc cgcggcatcc ggcgcgggga cctgcgcccc
    11401 gacgccgaca tcgacctgct gctcgacatg ctggcctcca ccacgtacta ccgggtgctc
    11461 ttcgggcacc tgccggtgac cgcgacgctc gcggaggacg tggtcgaggt cgtgctcaag
    11521 ggcgtcgcca ccgaggcctg gcgcgggcgc cacagccacg gggtgttcga cggcttctga
    11581 cgctcggggg cagcggaggc cgggcgccct gacggcccgg caggtacgag gggagggaga
    11641 gactgttgct cagccgcgac agcgaaatga cggccctgga cggggccttg tccgccgcgg
    11701 aggcgggcat gggggccagc ctgctgctgg agggcggcat cggcgccggc aagtcgcacc
    11761 tggtgcgcgc cgcgctgagg accgcccgca gcaagggctt cggaacggtc tccgcgcgcg
    11821 ccagacccgg cgagcgcgac cgcgcccacg gcgtcctgca ccagatccgc gaccagctga
    11881 ccggccctgc cggagagccc gggagcccgc ggggggcgga cggcacggac ggggccgggg
    11941 aggccgccgc ggtgcaccgc atgatcacgg ccgccacggc cggcgccccc ctgctgatcg
    12001 cgatcgacga cctgcagtgg acggacgccc cgtcgctgca ctggctcggc tacctgacgg
    12061 cccgcctgga gggcctgccc gtcgtcctgc tggccaccct cggcacggac cgccccgacc
    12121 tgacgggcga cggcgcgggc gggcagggct ccgagtccgc ggccggcgtc gcctccttct
    12181 tccaccgccg cgtggtgctg cagggcctca acgccgacag cgtcggctat ctgctgacgt
    12241 ccttcctcgg cgagcccgcg cacgaggacc tcacgcgcgc ctgccgcacg gccaccggcg
    12301 gcaacccgct gctgctccag gccctgctgc gcgaactgca ccgcaccggc ctcacctccg
    12361 gggacctctc cgccggccgt gtggcccggc tggcgccggt ggaggtcgcc gagaccctgc
    12421 tgacccggct cggcggctgc tcccccgagg tcggcgccgt cctcgacgcc gtctccatcg
    12481 tcgcgcccgg ggcgagcggc ccgctcgtct cccggctcgt cggcatcggc gccggcgagg
    12541 cggccgacgc cctctaccgg ctggtgcgcc ggggcatcct gacagagaac cacgacggca
    12601 tcggcttcgc ccagcccctg gtcatggcct ccttccgggc ccggatgccg cccagcgagc
    12661 gggcgcgcct gcacgccgag gccgccaagg ccctctacgc gggcagcgcc ccccgcgagc
    12721 gcatcaccgc acacctgctg cccggcgccc ccgtaggcga gcgctgggcg ctgcggctgc
    12781 tggtggacgc ggccgacgcg gcgctcgcgg gcggcgccct cgccgaggcc cgggtctgcc
    12841 tggagcgcgg ccttgccgag tgcgggccgg aggaggagcc ggggctgctg cgccggctcg
    12901 gccacatcga gctggccgac ggccccgagc ccgcggtcgc ccggctgcgc cgcaccgtcg
    12961 acctgatccg gggcgacacc gggcagcggg ccatggccct gctcgacctg gcccaggccg
    13021 ccgccctgac cggcgacgtg ccggaagcgc tgcggatcgt ggaacaggag gcgggcgaac
    13081 tcgaccgcgc gggcgccccg aaggagctgc gggcgggctt ccgcgccgta cgcggcctgc
    13141 tcgaactcct cgaaggccgc ggcacgcacc aggcgccgcc ctcgacgccc tcccccgcgc
    13201 agctcagcga agtggcccgg agtccttggg tgcgccgggc cgaggccgcg ctggccgccg
    13261 tgggcgccca gtggagcggc acccggcggg ccgaggcgct ccagcaggcc cgcctggcgc
    13321 tcagcgaacc ggccgccacc gtcaacgacc acgccctgat gcggctgggc ctcgtcctcg
    13381 tcctggcccg ctcgggcgcc gaggaggagg ccctggacaa ctgcgcggcc ctgctgagcg
    13441 cggcgaccgc ggagggttcg cgcaccgtgg cggcgctcgc ccgggccgtg ctcgccgaat
    13501 gcacctaccg cgcgggccgg ctgacggagt gcctggacgc ggcgcacgag gtgctggagc
    13561 ggggccctga gcccgccgag cacgagtggc tgggctccgc catggcccgc ggctggctgg
    13621 gcagcgccct gtacgaatcc ggggacctgg accaggcgca gcgggtcctg ctggagcccg
    13681 gtctggaggg cgcggtgccg gcggtcacgc tgcccggcct gctgttccac cgcgggcggc
    13741 tgcaggtcgc cctggggcgg gtcggtcccg ggctggcgga cctggaggag tgcgggcggc
    13801 tgctgctgca ccggggctgg accaacccgg cgctgtggcc ctggcgttcc gaggcggccc
    13861 tggcgcacgc ccggctgggc gacgaggagg cggcccggcg gctggccggc gaggagctgg
    13921 ccctcgcgcg ggccttcggc gcgccccacg cggtgggggt cgccctgcgc gcggcggggc
    13981 tgctggctcc cggcgaggag cgggcggcgc tgctcaccga gtccgtcctg ctgctgcggg
    14041 aggcgggtgc ggcgctggac gaggcgcggg cgctgcgcga cctcgggcgc gagctgatgc
    14101 gcacccgcaa ggcgcgccag gcccgcgagc acctgcgggc cgcggccgcg ctggccgaga
    14161 agtgcgcggc gcacgtcctg gtgcaggagc tgcgccagga catggtcgag gcgggggcgc
    14221 gcccgcgccg cgacaccgag atcggccccg cctcgctcac ccccgccgag cgccggacgg
    14281 cgctgctcgc ggcggagggg ctcaccaaca aggagatagc cgggcggctg tacgtgaccc
    14341 ggcgcacggt ggagatgcac ctgagccggg tctaccggaa gctgtcgatc tccgaccgcc
    14401 gcgccctgcg gctggtgacg ggcgatcagc ggccgccgtc gccctccggt ccgcacccgc
    14461 agcacgaggc ggcggagtcc tgcgcgtgac ggcggcggcc ggtcaggggc ggacggcgac
    14521 cgcgtcgacc tcgaagagca tgcccggcag ggcgagcccg gcgacgccga gcagggtctg
    14581 cgccgggggc ttgtcgcccc agatccggcc tatgaccgcg accagggctt cgagcttggc
    14641 ctggtcgttg ccgacgatgt aggtgccgag gcgggcgacg tggctgtagt cgaggcccgc
    14701 ggcggccagg gcggtgccca ggtgggcgaa ggagagctcg acctgctcgg cgaagtcgcc
    14761 ggaggtcacg tggccgtcgg cgtcggaggc gtactgcccg gcgacgaaca cgaggtccgg
    14821 cgacggcgcg acggcgacgt ggctgtagcc gaagcccgtg gggtcgtgca gggcggcggg
    14881 gttgacgatg gtgtgggaca tggtcactct tcctctgtgc gctcgtgcgg gtctatgaac
    14941 gggtctgtga acgggtctgc gtacgcgtcc gcgtacaggt ctgcgtgcgg gtctgtgacg
    15001 gatccggtgg tcaggcgcgt gcttgcgcga accagcggcg ggtgcgttcg ggcacctcgg
    15061 ggacgtcccg ttccacgttc ttcttgacgt cggccagggt ctgcgcggcg agctccctgc
    15121 gccaggcgag ctcggcccgg cgcatggcct ggtcgatcag
//
