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Overview
1.1

### Identified secondary metabolite regions using strictness 'relaxed'

BGC0001963 (Catenulispora sp)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1 | T1PKS,NRPS-like,NRPS | 1 | 154,666 | High | catenulisporolide A/catenulisporolide B/catenulisporolide C/catenulisporolide D | PKS:Type I

BGC0001963 - Region 1 - NRPS,NRPS-like,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
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Location: 1 - 154,666 nt. (total: 154,666 nt) Show pHMM detection rules used
Region on contig edge.
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
MIBiG
Tailoring
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
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Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
External annotation
This annotation was made externally by 'MIBiG' and not by antiSMASH

Name |  | MIBiG
Version |  | 4.0alpha

Type |  | Subregion
Location |  | 1 - 154,667
Label |  | BGC0001963

Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase oxygenase
AZF85917.1: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

AZF85924.1: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

AZF85937.1: dioxygenase, TauD/TfdA

smcogs
  SMCOG1121: dioxygenase, TauD/TfdA

Transferases: PPTase acylase aminotransferase glycosyltransferase
AZF85904.1: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1060: 4'-phosphopantetheinyl transferase

AZF85915.1: glycosyltransferase, MGT family

smcogs
  SMCOG1062: glycosyltransferase, MGT family

AZF85919.1: glycosyltransferase, MGT family

smcogs
  SMCOG1062: glycosyltransferase, MGT family

AZF85926.1: glycosyltransferase, MGT family

smcogs
  SMCOG1062: glycosyltransferase, MGT family

AZF85940.1: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

AZF85947.1: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: esterase
AZF85923.1: thioesterase

smcogs
  SMCOG1004: thioesterase

AZF85939.1: thioesterase

smcogs
  SMCOG1004: thioesterase

Lyases: dehydratase
AZF85899.1: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase synthase
AZF85912.1: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

AZF85929.1: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

AZF85930.1: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

AZF85933.1: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

AZF85934.1: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

AZF85941.1: Beta-ketoacyl synthase

smcogs
  SMCOG1093: Beta-ketoacyl synthase

AZF85942.1: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

AZF85944.1: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

AZF85945.1: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

AZF85946.1: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T1PKS | NRPS-like | T1PKS | NRPS | NRPS-like | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
BGC0001963.2 |  |  |  |  |  |  | 2.27 | PKS | catenulisporolide A, catenulisporolide B, catenulisporolide C, catenulisporolide D | Catenulispora sp.
BGC0001164.3 |  |  |  |  |  |  | 1.97 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001160.5 |  |  |  |  |  |  | 1.96 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001132.4 |  |  |  |  |  |  | 1.92 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001275.3 |  |  |  |  |  |  | 1.90 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0002286.3 |  |  |  |  |  |  | 1.86 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  |  |  |  |  |  | 1.85 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  |  |  |  |  |  | 1.83 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  |  |  |  |  |  | 1.79 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001135.5 |  |  |  |  |  |  | 1.79 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001963.2 |  | 0.99 | PKS | catenulisporolide A, catenulisporolide B, catenulisporolide C, catenulisporolide D | Catenulispora sp.
BGC0001275.3 |  | 0.77 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001273.3 |  | 0.77 | PKS | asperlactone | Aspergillus ochraceus
BGC0002075.3 |  | 0.76 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001244.3 |  | 0.76 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0001132.4 |  | 0.75 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002286.3 |  | 0.74 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.73 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  | 0.73 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 154666:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (ohmal - pk - ccmal) + (ccmal - ccmal - ohmal - ohmal) + (ohmal - pk - mal - ohmal - redmal) + (redmal) + (Asp) + (X - Asn) + (X) + (pk - Me-ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 31935:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (pk - Me-ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 13731 - 56824:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 29287 - 154666:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (ohmal - pk - ccmal) + (ccmal - ccmal - ohmal - ohmal) + (ohmal - pk - mal - ohmal - redmal) + (redmal) + (Asp) + (X - Asn) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 124814 - 154666:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (ohmal - pk - ccmal) + (ccmal - ccmal - ohmal - ohmal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
AZF85917.1: pk - mmal
PKS_AT (677..973): pk
ATSignature: Methylmalonyl-CoA

Top 3 matches:
  Methylmalonyl-CoA: 100.0%
  Malonyl-CoA: 91.7%
  Methoxymalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:
  Ethylmalonyl-CoA: 206.5
  Methylmalonyl-CoA: 202.9
  Methoxymalonyl-CoA: 160.6
  2-Methylbutyryl-CoA: 137.1
  trans-1,2-CPDA: 121.7
  Propionyl-CoA: 104.0
  Malonyl-CoA: 90.6
  CHC-CoA: 80.4
  Benzoyl-CoA: 80.4
  Isobutyryl-CoA: 72.9
  fatty_acid: 35.2
  Acetyl-CoA: 33.7
  3-Methylbutyryl-CoA: 30.3
  inactive: 26.5

PKS_AT (2259..2556): mmal
ATSignature: Methylmalonyl-CoA

Top 3 matches:
  Methylmalonyl-CoA: 100.0%
  Methoxymalonyl-CoA: 95.8%
  Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:
  Methylmalonyl-CoA: 208.3
  Ethylmalonyl-CoA: 195.0
  Methoxymalonyl-CoA: 163.5
  2-Methylbutyryl-CoA: 133.6
  Propionyl-CoA: 102.3
  Malonyl-CoA: 96.9
  trans-1,2-CPDA: 94.8
  CHC-CoA: 85.1
  Isobutyryl-CoA: 79.1
  Benzoyl-CoA: 56.1
  Acetyl-CoA: 45.6
  inactive: 34.4
  fatty_acid: 27.2
  3-Methylbutyryl-CoA: 25.6

AZF85929.1: X
AMP-binding (415..807): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    DLTSVVMVGK
  Nearest Stachelhaus code(s):
    Asn DLTKVGEVGK (65% 8Å match)
  Stachelhaus code match:
    70% (weak)

AZF85930.1: X
AMP-binding (18..483): X
nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    DMTSLGCCYK
  Nearest Stachelhaus code(s):
    Pca DMGVLGCLMK (65% 8Å match)
    omeTyr DMGSHGCFCK (44% 8Å match)
    Ile DAMFLGCTYK (26% 8Å match)
  Stachelhaus code match:
    60% (weak)

AZF85932.1: mal
PKS_AT (636..933): mal
ATSignature: Malonyl-CoA, inactive

Top 3 matches:
  Malonyl-CoA: 79.2%
  inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 150.3
  inactive: 107.6
  Methoxymalonyl-CoA: 65.5
  Methylmalonyl-CoA: 61.6
  Isobutyryl-CoA: 44.5
  Propionyl-CoA: 40.2
  Benzoyl-CoA: 22.8
  Ethylmalonyl-CoA: 22.5
  CHC-CoA: 20.0
  2-Methylbutyryl-CoA: 15.4
  3-Methylbutyryl-CoA: 13.4
  fatty_acid: 12.8
  trans-1,2-CPDA: 9.9
  Acetyl-CoA: 8.9

AZF85933.1: X
AMP-binding (16..415): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    GFGCAGLNTK
  Nearest Stachelhaus code(s):
  Stachelhaus code match:
    0% (weak)

AZF85940.1: X - X - Asn
Search NORINE for peptide: strict or relaxed
AMP-binding (689..1098): X
nrpys: Glu, Gln

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    DPHQLGVIEK
  Nearest Stachelhaus code(s):
    Gly DILQLGVIWK (65% 8Å match)
  Stachelhaus code match:
    70% (weak)

AMP-binding (1748..2131): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    DADEAGTVTK
  Nearest Stachelhaus code(s):
    Lys DADDAGTVDK (59% 8Å match)
  Stachelhaus code match:
    80% (moderate)

AMP-binding (2798..3201): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    DFPKLGEVAK
  Nearest Stachelhaus code(s):
    Asn DGTKLGEVGK (68% 8Å match)
  Stachelhaus code match:
    70% (weak)

AZF85912.1: Asp
Search NORINE for peptide: strict or relaxed
AMP-binding (428..819): Asp
nrpys: Asp

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    DLTKVGHVGK
  Nearest Stachelhaus code(s):
    Asp DLTKVGHVGK (74% 8Å match)
  Stachelhaus code match:
    100% (strong)

AZF85941.1: mal - mal
PKS_AT (220..510): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 91.7%
  inactive: 83.3%
  Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 218.0
  inactive: 108.6
  Methoxymalonyl-CoA: 51.9
  Methylmalonyl-CoA: 43.1
  Propionyl-CoA: 26.2
  Benzoyl-CoA: 18.4
  Acetyl-CoA: 15.7
  fatty_acid: 14.9
  Isobutyryl-CoA: 14.9
  Ethylmalonyl-CoA: 13.4
  trans-1,2-CPDA: 9.1
  CHC-CoA: 5.5
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

PKS_AT (2314..2612): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 91.7%
  inactive: 83.3%
  Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 226.7
  inactive: 112.9
  Methoxymalonyl-CoA: 58.3
  Methylmalonyl-CoA: 49.4
  Propionyl-CoA: 37.4
  Isobutyryl-CoA: 20.8
  Benzoyl-CoA: 19.2
  Acetyl-CoA: 18.7
  fatty_acid: 17.0
  Ethylmalonyl-CoA: 16.8
  2-Methylbutyryl-CoA: 12.2
  CHC-CoA: 11.6
  trans-1,2-CPDA: 10.1
  3-Methylbutyryl-CoA: 0.0

AZF85947.1: mal - pk - mal - mal
PKS_AT (583..873): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 91.7%
  inactive: 83.3%
  Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 226.1
  inactive: 107.7
  Methylmalonyl-CoA: 51.4
  Methoxymalonyl-CoA: 51.1
  Propionyl-CoA: 37.2
  Benzoyl-CoA: 19.6
  Isobutyryl-CoA: 18.5
  Acetyl-CoA: 17.6
  fatty_acid: 15.2
  CHC-CoA: 11.4
  Ethylmalonyl-CoA: 10.0
  2-Methylbutyryl-CoA: 8.5
  trans-1,2-CPDA: 0.0
  3-Methylbutyryl-CoA: 0.0

PKS_AT (2040..2340): pk
ATSignature: Methylmalonyl-CoA

Top 3 matches:
  Methylmalonyl-CoA: 100.0%
  Methoxymalonyl-CoA: 95.8%
  Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:
  Ethylmalonyl-CoA: 203.9
  Methylmalonyl-CoA: 202.1
  Methoxymalonyl-CoA: 171.1
  2-Methylbutyryl-CoA: 136.4
  trans-1,2-CPDA: 123.3
  Propionyl-CoA: 109.0
  CHC-CoA: 96.9
  Malonyl-CoA: 93.1
  Isobutyryl-CoA: 73.6
  Benzoyl-CoA: 61.5
  3-Methylbutyryl-CoA: 42.9
  inactive: 36.2
  fatty_acid: 30.5
  Acetyl-CoA: 22.9

PKS_AT (3661..3943): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 91.7%
  inactive: 83.3%
  Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 228.8
  inactive: 120.8
  Methoxymalonyl-CoA: 59.0
  Methylmalonyl-CoA: 54.0
  Propionyl-CoA: 43.0
  Benzoyl-CoA: 26.3
  Isobutyryl-CoA: 23.9
  Ethylmalonyl-CoA: 22.9
  Acetyl-CoA: 22.7
  2-Methylbutyryl-CoA: 15.9
  CHC-CoA: 15.8
  fatty_acid: 11.4
  trans-1,2-CPDA: 8.3
  3-Methylbutyryl-CoA: 0.0

PKS_AT (4992..5280): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 91.7%
  inactive: 83.3%
  Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 230.1
  inactive: 121.7
  Methoxymalonyl-CoA: 64.6
  Methylmalonyl-CoA: 59.0
  Propionyl-CoA: 34.4
  Isobutyryl-CoA: 25.3
  Ethylmalonyl-CoA: 22.4
  CHC-CoA: 22.4
  Benzoyl-CoA: 22.3
  Acetyl-CoA: 20.7
  2-Methylbutyryl-CoA: 14.8
  fatty_acid: 14.2
  trans-1,2-CPDA: 11.5
  3-Methylbutyryl-CoA: 0.0

AZF85946.1: mal - mal - mal - mal
PKS_AT (579..871): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 91.7%
  inactive: 83.3%
  Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 224.8
  inactive: 111.0
  Methoxymalonyl-CoA: 57.5
  Methylmalonyl-CoA: 56.1
  Propionyl-CoA: 44.8
  Ethylmalonyl-CoA: 25.7
  Isobutyryl-CoA: 24.4
  Acetyl-CoA: 23.5
  Benzoyl-CoA: 22.3
  CHC-CoA: 18.6
  fatty_acid: 17.5
  2-Methylbutyryl-CoA: 12.9
  trans-1,2-CPDA: 10.0
  3-Methylbutyryl-CoA: 0.0

PKS_AT (2274..2563): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 91.7%
  inactive: 83.3%
  Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 222.0
  inactive: 113.1
  Methoxymalonyl-CoA: 57.3
  Methylmalonyl-CoA: 56.3
  Propionyl-CoA: 38.3
  Isobutyryl-CoA: 29.5
  Benzoyl-CoA: 24.5
  Acetyl-CoA: 20.3
  Ethylmalonyl-CoA: 19.9
  fatty_acid: 19.6
  2-Methylbutyryl-CoA: 15.5
  CHC-CoA: 15.0
  trans-1,2-CPDA: 12.6
  3-Methylbutyryl-CoA: 0.0

PKS_AT (3998..4287): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 91.7%
  inactive: 83.3%
  Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 216.8
  inactive: 109.3
  Methoxymalonyl-CoA: 51.8
  Methylmalonyl-CoA: 47.9
  Propionyl-CoA: 45.1
  Isobutyryl-CoA: 27.5
  Benzoyl-CoA: 23.5
  fatty_acid: 19.1
  2-Methylbutyryl-CoA: 17.5
  Acetyl-CoA: 17.0
  CHC-CoA: 13.0
  Ethylmalonyl-CoA: 10.8
  trans-1,2-CPDA: 9.7
  3-Methylbutyryl-CoA: 0.0

PKS_AT (5476..5766): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 91.7%
  inactive: 83.3%
  Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 231.9
  inactive: 112.2
  Methoxymalonyl-CoA: 64.0
  Methylmalonyl-CoA: 58.6
  Propionyl-CoA: 35.2
  Isobutyryl-CoA: 22.9
  Acetyl-CoA: 22.9
  Ethylmalonyl-CoA: 21.5
  Benzoyl-CoA: 19.9
  2-Methylbutyryl-CoA: 16.4
  CHC-CoA: 12.0
  fatty_acid: 11.8
  trans-1,2-CPDA: 9.8
  3-Methylbutyryl-CoA: 0.0

AZF85945.1: mal - pk - mal
PKS_AT (628..921): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 87.5%
  inactive: 75.0%
  2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 210.7
  inactive: 103.9
  Methoxymalonyl-CoA: 68.4
  Methylmalonyl-CoA: 65.9
  Propionyl-CoA: 38.8
  CHC-CoA: 25.3
  fatty_acid: 25.2
  Isobutyryl-CoA: 23.4
  Acetyl-CoA: 23.1
  2-Methylbutyryl-CoA: 22.1
  Ethylmalonyl-CoA: 18.8
  Benzoyl-CoA: 17.9
  trans-1,2-CPDA: 14.8
  3-Methylbutyryl-CoA: 0.0

PKS_AT (2131..2428): pk
ATSignature: Methylmalonyl-CoA

Top 3 matches:
  Methylmalonyl-CoA: 100.0%
  Malonyl-CoA: 87.5%
  Methoxymalonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:
  Ethylmalonyl-CoA: 205.6
  Methylmalonyl-CoA: 205.2
  Methoxymalonyl-CoA: 160.3
  2-Methylbutyryl-CoA: 127.0
  trans-1,2-CPDA: 124.5
  Propionyl-CoA: 95.3
  Malonyl-CoA: 89.5
  Isobutyryl-CoA: 73.9
  CHC-CoA: 71.6
  Benzoyl-CoA: 66.9
  Acetyl-CoA: 49.4
  3-Methylbutyryl-CoA: 26.8
  fatty_acid: 26.6
  inactive: 25.7

PKS_AT (3678..3968): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 91.7%
  inactive: 83.3%
  Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 218.8
  inactive: 106.6
  Methoxymalonyl-CoA: 53.0
  Methylmalonyl-CoA: 51.2
  Propionyl-CoA: 39.0
  Isobutyryl-CoA: 20.8
  Acetyl-CoA: 18.8
  Benzoyl-CoA: 16.4
  fatty_acid: 12.7
  CHC-CoA: 11.8
  Ethylmalonyl-CoA: 10.7
  2-Methylbutyryl-CoA: 9.5
  trans-1,2-CPDA: 9.1
  3-Methylbutyryl-CoA: 0.0

AZF85944.1: X
AMP-binding (448..840): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    DMTSLASIEK
  Nearest Stachelhaus code(s):
    Pro DMTFSAGIIK (59% 8Å match)
  Stachelhaus code match:
    60% (weak)

AZF85942.1: NH2
CAL_domain (45..484): NH2
minowa: NH2

Prediction, score:
  NH2: 114.9
  fatty_acid: 19.5
  AHBA: 1.5
  shikimic_acid: 0.0
  Acetyl-CoA: -3.1

AZF85914.1: pk
PKS_AT (23..264): pk
ATSignature: (unknown)
No matches above 50%
minowa: trans-1,2-CPDA

Prediction, score:
  trans-1,2-CPDA: 0.0
  inactive: 0.0
  fatty_acid: 0.0
  Propionyl-CoA: 0.0
  Methylmalonyl-CoA: 0.0
  Methoxymalonyl-CoA: 0.0
  Malonyl-CoA: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor