BGC0001967: acyldepsipeptide 1 biosynthetic gene cluster from Streptomyces hawaiiensis
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Location: 1 - 36,600 nt. (total: 36,600 nt).
This entry is originally from NCBI GenBank MK047367.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001967
Short description acyldepsipeptide 1 biosynthetic gene cluster from Streptomyces hawaiiensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
MK047367.1
via
Compounds
  • acyldepsipeptide 1
Species Streptomyces hawaiiensis [taxonomy]
References
Chemical products information
acyldepsipeptide 1 Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QED88045.1
 297 - 1463 (-) putative regulator component
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    • QED88046.1
    		 1450 - 1971 (-) putative regulator component
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      • QED88047.1
      		 2211 - 2717 (-) putative XRE family transcriptional regulator
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        • QED88048.1
        • adeA
        		 3393 - 4217 (+) leucine hydroxylase
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          • QED88049.1
          • adeB
          		 4214 - 5329 (+) alcohol dehydrogenase
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            • QED88050.1
            • adeC
            		 5958 - 6218 (+) acyl carrier protein
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              • QED88051.1
              • adeD
              		 6258 - 7520 (+) 3-oxoacyl-ACP synthase alpha
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                • QED88052.1
                • adeE
                		 7517 - 8638 (+) 3-oxoacyl-ACP synthase beta
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                  • QED88053.1
                  • adeF
                  		 8635 - 9420 (+) 3-oxoacyl-ACP reductase
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                    • QED88054.1
                    • adeG
                    		 9456 - 23465 (+) nonribosomal peptide synthetase
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                      • QED88055.1
                      • adeH
                      		 23462 - 30604 (+) nonribosomal peptide synthetase
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                        • QED88056.1
                        • adeI
                        		 30635 - 30871 (+) MbtH-like protein
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                          • QED88057.1
                          		 30990 - 31676 (+) transposase
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                            • QED88058.1
                            		 31807 - 32076 (+) hypothetical protein
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                              • QED88059.1
                              		 32164 - 32742 (-) transposase
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                                • QED88060.1
                                		 33112 - 33627 (+) transposase
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                                  • QED88061.1
                                  		 34138 - 34443 (+) transposase
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                                    • QED88062.1
                                    		 34464 - 35069 (-) hypothetical protein
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                                      • QED88063.1
                                      • clpPADEP
                                      		 35713 - 36333 (+) ClpPADEP
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                                        Biosynthesis information

                                        Biosynthetic modules

                                        Name
                                        Unk01
                                        Type
                                        nrps-type1
                                        Genes
                                        adeG
                                        Substrates
                                        phenylalanine (evidence: Structure-based inference, Sequence-based prediction)
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk02
                                        Type
                                        nrps-type1
                                        Genes
                                        adeG
                                        Substrates
                                        serine (evidence: Structure-based inference, Sequence-based prediction)
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk03
                                        Type
                                        nrps-type1
                                        Genes
                                        adeG
                                        Substrates
                                        proline (evidence: Enzyme-coupled assay, Structure-based inference, Sequence-based prediction)
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk04
                                        Type
                                        nrps-type1
                                        Genes
                                        adeG
                                        Substrates
                                        alanine (evidence: Structure-based inference, Sequence-based prediction)
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk05
                                        Type
                                        nrps-type1
                                        Genes
                                        adeH
                                        Substrates
                                        alanine (evidence: Structure-based inference, Sequence-based prediction)
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk06
                                        Type
                                        nrps-type1
                                        Genes
                                        adeH
                                        Substrates
                                        proline, 4R-methylproline (evidence: Enzyme-coupled assay, Structure-based inference, Sequence-based prediction)
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Annotation changelog

                                        Entry version: 3

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2022-10-07
                                        Update chemical activity to schema version 2.11
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                        Entry version: 2

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2022-09-15
                                        Fixed DOIs
                                        • (ID: CUSGWVK3I4TVHJH7NHPFAP2L)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        2022-09-15
                                        Added missing polyketide class
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        2022-09-15
                                        Added polyene subclass
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        2022-09-15
                                        Use PubMed reference instead of DOI
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        2022-09-15
                                        Updated bioactivity data
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        2022-09-15
                                        Added NRP substrate specificities
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                        Entry version: 1

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2019-10-16
                                        Submitted
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        Detailed domain annotation
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