BGC0001968: cadaside A biosynthetic gene cluster from uncultured bacterium
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Location: 1 - 91,701 nt. (total: 91,701 nt).
This entry is originally from NCBI GenBank MK060022.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001968
Short description cadaside A biosynthetic gene cluster from uncultured bacterium
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MK060022.1
11462 - 81357
via
Compounds
  • cadaside A
  • cadaside B
Species uncultured bacterium [taxonomy]
References
Chemical products information
cadaside A Evidence:
(no structure information available)
cadaside B Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QBC75051.1
 10695 - 14465 (+) non-ribosomal peptide synthetase
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    • QBC75013.1
    • cdeA
    		 14462 - 15688 (+) cytochrome P450
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      • QBC75014.1
      • cdeB
      		 15709 - 16515 (+) alpha/beta hydrolase
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        • QBC75015.1
        • cdeC
        		 16538 - 17386 (-) ABC transporter permease
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          • QBC75016.1
          • cdeD
          		 17416 - 18354 (-) daunorubicin/doxorubicin resistance ABC transporter
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            • QBC75017.1
            • cdeE
            		 18851 - 20602 (+) acyl-CoA synthase
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              • QBC75018.1
              • cdeF
              		 20679 - 22382 (+) acyl-CoA dehydrogenase
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                • QBC75019.1
                • cdeG
                		 22379 - 24115 (+) acyl-CoA dehydrogenase
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                  • QBC75020.1
                  • cdeH
                  		 24203 - 24493 (+) acyl carrier protein
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                    • QBC75021.1
                    • cdeI
                    		 24502 - 46215 (+) non-ribosomal peptide synthetase
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                      • QBC75022.1
                      • cdeJ
                      		 46224 - 63350 (+) non-ribosomal peptide synthetase
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                        • QBC75023.1
                        • cdeK
                        		 63347 - 71701 (+) non-ribosomal peptide synthetase
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                          • QBC75024.1
                          • cdeL
                          		 71725 - 71946 (+) MbtH-like protein
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                            • QBC75025.1
                            • cdeM
                            		 72125 - 72856 (+) phosphatase PAP2 family protein
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                              • QBC75026.1
                              • cdeN
                              		 72898 - 73839 (+) alpha-ketoglutarate-dependent taurine dioxygenase
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                                • QBC75027.1
                                • cdeO
                                		 73894 - 74955 (-) branched-chain amino acid aminotransferase
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                                  • QBC75028.1
                                  • cdeP
                                  		 74974 - 75360 (-) ketosteroid isomerase
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                                    • QBC75029.1
                                    • cdeQ
                                    		 75544 - 76239 (+) phosphatase PAP2 family protein
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                                      • QBC75030.1
                                      • cdeR
                                      		 76625 - 78079 (+) sensor histidine kinase
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                                        • QBC75031.1
                                        • cdeS
                                        		 78172 - 78810 (+) DNA-binding response regulator
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                                          • QBC75032.1
                                          • cdeT
                                          		 79086 - 80216 (+) succinate-semialdehyde dehydrogenase
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                                            • QBC75033.1
                                            • cdeU
                                            		 80632 - 81357 (-) SDR family NAD(P)-dependent oxidoreductase
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                                              Biosynthesis information

                                              Biosynthetic modules

                                              Name
                                              Unk01
                                              Type
                                              nrps-type1
                                              Genes
                                              cdeI
                                              Substrates
                                              3R-aminoisobutyric acid (evidence: Structure-based inference [1])
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk02
                                              Type
                                              nrps-type1
                                              Genes
                                              cdeI
                                              Substrates
                                              glycine (evidence: Structure-based inference, Sequence-based prediction)
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk03
                                              Type
                                              nrps-type1
                                              Genes
                                              cdeI
                                              Substrates
                                              glutamic acid (evidence: Structure-based inference [1])
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk04
                                              Type
                                              nrps-type1
                                              Genes
                                              cdeI
                                              Substrates
                                              tyrosine (evidence: Structure-based inference, Sequence-based prediction)
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk05
                                              Type
                                              nrps-type1
                                              Genes
                                              cdeI
                                              Substrates
                                              threonine (evidence: Structure-based inference, Sequence-based prediction)
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk06
                                              Type
                                              nrps-type1
                                              Genes
                                              cdeI
                                              Substrates
                                              isoleucine (evidence: Structure-based inference, Sequence-based prediction)
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk07
                                              Type
                                              nrps-type1
                                              Genes
                                              cdeJ
                                              Substrates
                                              aspartic acid (evidence: Structure-based inference, Sequence-based prediction)
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk08
                                              Type
                                              nrps-type1
                                              Genes
                                              cdeJ
                                              Substrates
                                              aspartic acid (evidence: Structure-based inference, Sequence-based prediction)
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk09
                                              Type
                                              nrps-type1
                                              Genes
                                              cdeJ
                                              Substrates
                                              proline (evidence: Structure-based inference, Sequence-based prediction)
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk10
                                              Type
                                              nrps-type1
                                              Genes
                                              cdeJ
                                              Substrates
                                              glycine (evidence: Structure-based inference, Sequence-based prediction)
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk11
                                              Type
                                              nrps-type1
                                              Genes
                                              cdeJ
                                              Substrates
                                              glutamic acid (evidence: Structure-based inference [1])
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk12
                                              Type
                                              nrps-type1
                                              Genes
                                              cdeK
                                              Substrates
                                              glutamic acid (evidence: Structure-based inference [1])
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk13
                                              Type
                                              nrps-type1
                                              Genes
                                              cdeK
                                              Substrates
                                              glycine (evidence: Structure-based inference, Sequence-based prediction)
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Annotation changelog

                                              Entry version: 2

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2022-09-15
                                              Added NRP substrate specificities
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 1

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2019-10-16
                                              Submitted
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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