BGC0001970: malyngamide C acetate biosynthetic gene cluster from Okeania hirsuta
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 69,024 nt. (total: 69,024 nt).
This entry is originally from NCBI GenBank MK142792.1.

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC

MIBiG accession | BGC0001970
Short description | malyngamide C acetate biosynthetic gene cluster from Okeania hirsuta
Status | Quality: questionable The quality level of this entry. Status: active The status of this entry. Completeness: unknown Whether the entry covers everything needed for the pathway producing the compound(s)

Biosynthetic class(es)

- NRPS (Type I)
- PKS (Unknown)

Loci
MK142792.1
283 - 68730
via
Compounds

- malyngamide C acetate

Species Okeania hirsuta [taxonomy]
References

- [1] Ketoreductase Domain Dysfunction Expands Chemodiversity: Malyngamide Biosynthesis in the Cyanobacterium Okeania hirsuta. Moss NA et al., ACS Chem Biol (2018) PMID:30444349

Chemical products information
malyngamide C acetate Evidence:
Copy SMILES
C26H40Cl1N1O6
Chemical database entries
PubCHEM
List of genes involved in compound(s) production

Identifiers | Position | Product | Functions | Evidence | Extra
--- | --- | --- | --- | --- | ---
AZH23794.1 | 283 - 2622 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AZH23804.1 | 2888 - 3829 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AZH23807.1 | 4108 - 4857 (-) | MgcA |  |  | copy AA seq copy Nt seq
AZH23805.1 | 5263 - 6156 (-) | MgcB |  |  | copy AA seq copy Nt seq
AZH23809.1 | 6157 - 6711 (-) | MgcC |  |  | copy AA seq copy Nt seq
AZH23808.1 | 6871 - 7608 (+) | MgcD |  |  | copy AA seq copy Nt seq
AZH23815.1 | 8062 - 8325 (+) | MgcE |  |  | copy AA seq copy Nt seq
AZH23813.1 | 9004 - 9312 (+) | MgcF |  |  | copy AA seq copy Nt seq
AZH23790.1 | 9538 - 15249 (+) | MgcG |  |  | copy AA seq copy Nt seq
AZH23791.1 | 15500 - 20545 (+) | MgcH |  |  | copy AA seq copy Nt seq
AZH23789.1 | 20617 - 27171 (+) | MgcI |  |  | copy AA seq copy Nt seq
AZH23792.1 | 27150 - 31913 (+) | MgcJ |  |  | copy AA seq copy Nt seq
AZH23793.1 | 31998 - 35723 (+) | MgcK |  |  | copy AA seq copy Nt seq
AZH23816.1 | 35825 - 36073 (+) | MgcL |  |  | copy AA seq copy Nt seq
AZH23802.1 | 36115 - 37338 (+) | MgcM |  |  | copy AA seq copy Nt seq
AZH23801.1 | 37343 - 38602 (+) | MgcN |  |  | copy AA seq copy Nt seq
AZH23796.1 | 38767 - 40209 (+) | MgcO |  |  | copy AA seq copy Nt seq
AZH23806.1 | 40270 - 41037 (+) | MgcP |  |  | copy AA seq copy Nt seq
AZH23787.1 | 41025 - 49397 (+) | MgcQ |  |  | copy AA seq copy Nt seq
AZH23788.1 | 49445 - 57178 (+) | MgcR |  |  | copy AA seq copy Nt seq
AZH23810.1 | 57339 - 57848 (+) | MgcS |  |  | copy AA seq copy Nt seq
AZH23798.1 | 57954 - 59309 (+) | MgcT |  |  | copy AA seq copy Nt seq
AZH23797.1 | 59501 - 60901 (+) | MgcU |  |  | copy AA seq copy Nt seq
AZH23799.1 | 61321 - 62652 (+) | MgcV |  |  | copy AA seq copy Nt seq
AZH23803.1 | 62796 - 63830 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AZH23811.1 | 64040 - 64504 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AZH23812.1 | 64539 - 64913 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AZH23814.1 | 65153 - 65443 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AZH23800.1 | 65518 - 66822 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AZH23795.1 | 66943 - 68730 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq

Biosynthesis information

#### Biosynthetic modules

Name
Unk01
Type
nrps-type1
Genes
AZH23792.1
Substrates
glycine (evidence: Sequence-based prediction, Structure-based inference, Feeding study)
Integrated Monomers
Domains
adenylation
Annotation changelog

#### Entry version: 2

Date
Changes
Submitters
Reviewers
2022-09-15
Cleaned up synonym list

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

2022-09-15
Fetch compound properties from PubChem

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

2022-09-15
Added NRP substrate specificities

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

#### Entry version: 1

Date
Changes
Submitters
Reviewers
2019-10-16
Submitted

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains