BGC0001972: toxoflavin biosynthetic gene cluster from Streptomyces hiroshimensis
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 32,436 nt. (total: 32,436 nt).
This entry is originally from NCBI GenBank MK256951.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001972
Short description toxoflavin biosynthetic gene cluster from Streptomyces hiroshimensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (other)
Loci
MK256951.1
via
Compounds
  • toxoflavin
  • fervenulin
Species Streptomyces hiroshimensis [taxonomy]
References
Chemical products information
toxoflavin Evidence:
Copy SMILES
C7H7N5O2
Chemical database entries
PubCHEM
fervenulin Evidence:
Copy SMILES
C7H7N5O2
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Shi4213
  • AZS52672.1
 268 - 1224 (+) F420-dependent LLM class oxidoreductase
    copy AA seq
    copy Nt seq
    • Shi4214
    • AZS52673.1
    		 1258 - 1809 (+) type 1 glutamine amidotransferase
      copy AA seq
      copy Nt seq
      • Shi4215
      • AZS52674.1
      		 1809 - 2492 (+) uracil-DNA glycosylase
        copy AA seq
        copy Nt seq
        • Shi4216
        • AZS52675.1
        		 2597 - 3667 (+) PE-PGRS family protein
          copy AA seq
          copy Nt seq
          • Shi4217
          • AZS52676.1
          		 3793 - 4212 (+) XRE family transcriptional regulator
            copy AA seq
            copy Nt seq
            • Shi4218
            • AZS52677.1
            		 4584 - 7469 (+) LuxR family transcriptional regulator
              copy AA seq
              copy Nt seq
              • Shi4219
              • AZS52678.1
              		 7497 - 8195 (-) GTP cyclohydrolase II
                copy AA seq
                copy Nt seq
                • Shi4220
                • AZS52679.1
                		 8278 - 9753 (-) putative multidrug resistance efflux protein
                  copy AA seq
                  copy Nt seq
                  • Shi4221
                  • AZS52680.1
                  		 9834 - 10139 (+) regulatory protein ArsR
                    copy AA seq
                    copy Nt seq
                    • Shi4222
                    • AZS52681.1
                    		 10192 - 10935 (-) class I SAM-dependent methyltransferase
                      copy AA seq
                      copy Nt seq
                      • Shi4223
                      • AZS52682.1
                      		 10932 - 12137 (-) XdhC/CoxI family protein
                        copy AA seq
                        copy Nt seq
                        • Shi4224
                        • AZS52683.1
                        		 12141 - 14414 (-) xanthine dehydrogenase subunit D
                          copy AA seq
                          copy Nt seq
                          • Shi4225
                          • AZS52684.1
                          		 14468 - 14950 (-) 2Fe-2S-binding protein
                            copy AA seq
                            copy Nt seq
                            • Shi4226
                            • AZS52685.1
                            		 14941 - 15852 (-) carbon monoxide dehydrogenase
                              copy AA seq
                              copy Nt seq
                              • Shi4227
                              • AZS52686.1
                              		 15849 - 16706 (-) class I SAM-dependent methyltransferase
                                copy AA seq
                                copy Nt seq
                                • Shi4228
                                • AZS52687.1
                                		 16829 - 19666 (-) TetR family transcriptional regulator
                                  copy AA seq
                                  copy Nt seq
                                  • Shi4229
                                  • AZS52688.1
                                  		 19769 - 20434 (-) TetR/AcrR family transcriptional regulator
                                    copy AA seq
                                    copy Nt seq
                                    • Shi4230
                                    • AZS52689.1
                                    		 20614 - 21981 (+) MFS transporter
                                      copy AA seq
                                      copy Nt seq
                                      • Shi4231
                                      • AZS52690.1
                                      		 22021 - 22623 (+) NADPH-dependent FMN reductase
                                        copy AA seq
                                        copy Nt seq
                                        • Shi4232
                                        • AZS52691.1
                                        		 22701 - 23441 (-) class I SAM-dependent methyltransferase
                                          copy AA seq
                                          copy Nt seq
                                          • Shi4233
                                          • AZS52692.1
                                          		 23438 - 24658 (-) flavodoxin family protein
                                            copy AA seq
                                            copy Nt seq
                                            • Shi4234
                                            • AZS52693.1
                                            		 24655 - 25785 (-) RibD-like protein
                                              copy AA seq
                                              copy Nt seq
                                              • Shi4235
                                              • AZS52694.1
                                              		 25782 - 26774 (-) formylglycine generating enzyme-like protein
                                                copy AA seq
                                                copy Nt seq
                                                • Shi4236
                                                • AZS52695.1
                                                		 26778 - 28076 (-) SGNH/GDSL hydrolase family protein
                                                  copy AA seq
                                                  copy Nt seq
                                                  • Shi4237
                                                  • AZS52696.1
                                                  		 28073 - 28798 (-) class I SAM-dependent methyltransferase
                                                    copy AA seq
                                                    copy Nt seq
                                                    • Shi4238
                                                    • AZS52697.1
                                                    		 28924 - 30612 (-) WD40-like protein
                                                      copy AA seq
                                                      copy Nt seq
                                                      • Shi4239
                                                      • AZS52698.1
                                                      		 30609 - 31307 (-) GTP cyclohydrolase II
                                                        copy AA seq
                                                        copy Nt seq
                                                        • Shi4240
                                                        • AZS52699.1
                                                        		 31755 - 32147 (+) hypothetical protein
                                                          copy AA seq
                                                          copy Nt seq
                                                          Biosynthesis information
                                                          Annotation changelog

                                                          Entry version: 3

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2022-10-07
                                                          Update chemical activity to schema version 2.11
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                          Entry version: 2

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2022-09-15
                                                          Cleaned up synonym list
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          2022-09-15
                                                          Fetch compound properties from PubChem
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          2022-09-15
                                                          Merged annotations from duplicate entry BGC0001973
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          2022-09-15
                                                          Updated bioactivity data
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                          Entry version: 1

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2019-10-16
                                                          Submitted
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          Similar known gene clusters from MIBiG 4.0
                                                          Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                          Click on reference genes to show details of similarities to genes within the current region.
                                                          Click on an accession to open that entry in the MiBIG database.