BGC0001972: toxoflavin biosynthetic gene cluster from Streptomyces hiroshimensis
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Location: 1 - 32,436 nt. (total: 32,436 nt).
This entry is originally from NCBI GenBank MK256951.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
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General information about the BGC
MIBiG accession BGC0001972
Short description toxoflavin biosynthetic gene cluster from Streptomyces hiroshimensis
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Other
Loci NCBI GenBank: MK256951.1
Compounds
  • toxoflavin
  • fervenulin
Species Streptomyces hiroshimensis [taxonomy]
References
Chemical products information
toxoflavin [synonyms: Xanthothricin, Toxoflavine, Xanthotricin, Xanthrothricin]
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C7H7N5O2
Chemical database entries
PubCHEM
fervenulin [synonyms: Planomycin, Fervenuline, Pulanomycin]
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C7H7N5O2
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Shi4213
  • AZS52672.1
 268 - 1224 (+) F420-dependent LLM class oxidoreductase
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  • Shi4214
  • AZS52673.1
 1258 - 1809 (+) type 1 glutamine amidotransferase
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  • Shi4215
  • AZS52674.1
 1809 - 2492 (+) uracil-DNA glycosylase
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  • Shi4216
  • AZS52675.1
 2597 - 3667 (+) PE-PGRS family protein
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  • Shi4217
  • AZS52676.1
 3793 - 4212 (+) XRE family transcriptional regulator
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  • Shi4218
  • AZS52677.1
 4584 - 7469 (+) LuxR family transcriptional regulator
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  • Shi4219
  • AZS52678.1
 7497 - 8195 (-) GTP cyclohydrolase II
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  • Shi4220
  • AZS52679.1
 8278 - 9753 (-) putative multidrug resistance efflux protein
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  • Shi4221
  • AZS52680.1
 9834 - 10139 (+) regulatory protein ArsR
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  • Shi4222
  • AZS52681.1
 10192 - 10935 (-) class I SAM-dependent methyltransferase
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  • Shi4223
  • AZS52682.1
 10932 - 12137 (-) XdhC/CoxI family protein
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  • Shi4224
  • AZS52683.1
 12141 - 14414 (-) xanthine dehydrogenase subunit D
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  • Shi4225
  • AZS52684.1
 14468 - 14950 (-) 2Fe-2S-binding protein
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  • Shi4226
  • AZS52685.1
 14941 - 15852 (-) carbon monoxide dehydrogenase
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  • Shi4227
  • AZS52686.1
 15849 - 16706 (-) class I SAM-dependent methyltransferase
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  • Shi4228
  • AZS52687.1
 16829 - 19666 (-) TetR family transcriptional regulator
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  • Shi4229
  • AZS52688.1
 19769 - 20434 (-) TetR/AcrR family transcriptional regulator
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  • Shi4230
  • AZS52689.1
 20614 - 21981 (+) MFS transporter
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  • Shi4231
  • AZS52690.1
 22021 - 22623 (+) NADPH-dependent FMN reductase
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  • Shi4232
  • AZS52691.1
 22701 - 23441 (-) class I SAM-dependent methyltransferase
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  • Shi4233
  • AZS52692.1
 23438 - 24658 (-) flavodoxin family protein
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  • Shi4234
  • AZS52693.1
 24655 - 25785 (-) RibD-like protein
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  • Shi4235
  • AZS52694.1
 25782 - 26774 (-) formylglycine generating enzyme-like protein
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  • Shi4236
  • AZS52695.1
 26778 - 28076 (-) SGNH/GDSL hydrolase family protein
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  • Shi4237
  • AZS52696.1
 28073 - 28798 (-) class I SAM-dependent methyltransferase
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  • Shi4238
  • AZS52697.1
 28924 - 30612 (-) WD40-like protein
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  • Shi4239
  • AZS52698.1
 30609 - 31307 (-) GTP cyclohydrolase II
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  • Shi4240
  • AZS52699.1
 31755 - 32147 (+) hypothetical protein
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Annotation changelog
MIBiG version Submitter Notes
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Cleaned up synonym list
  • Fetch compound properties from PubChem
  • Merged annotations from duplicate entry BGC0001973
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Similar known gene clusters
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