BGC0001980: lokisin biosynthetic gene cluster from Pseudomonas sp.
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Location: 1 - 50,122 nt. (total: 50,122 nt).
This entry is originally from NCBI GenBank MK534107.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001980
Short description lokisin biosynthetic gene cluster from Pseudomonas sp.
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MK534107.1
via
Compounds
  • lokisin
Species Pseudomonas sp. [taxonomy]
References
  • [1] . Omoboye OO et al., Front Plant Sci (2019) PMID:31354771
Chemical products information
lokisin Evidence:
Copy SMILES
C64H111N11O20
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QDF82256.1
 1699 - 1905 (-) hypothetical protein
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    • QDF82257.1
    		 2198 - 2569 (-) hypothetical protein
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      • QDF82258.1
      		 2936 - 3331 (-) hypothetical protein
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        • QDF82252.1
        • macB
        		 3391 - 5349 (-) macrolide export ATP-binding/permease protein
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          • QDF82253.1
          • macA
          		 5352 - 6500 (-) macrolide-specific efflux protein
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            • QDF82259.1
            • lokC
            		 6567 - 24389 (-) non-ribosomal peptide synthetase
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              • QDF82255.1
              • lokB
              		 24386 - 37399 (-) non-ribosomal peptide synthetase
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                • QDF82254.1
                • lokA
                		 37644 - 44033 (-) non-ribosomal peptide synthetase
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                  • QDF82260.1
                  • lokR
                  		 44546 - 45340 (+) transcriptional regulator, LuxR family
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                    • QDF82261.1
                    • lokT
                    		 45425 - 46831 (+) RND efflux system, outer membrane lipoprotein CmeC
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                      • QDF82262.1
                      		 46988 - 47593 (+) cytochrome oxidase biogenesis protein Sco1/SenC/PrrC, putative copper metallochaperone
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                        • QDF82263.1
                        		 47605 - 48072 (+) copper metallochaperone
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                          • QDF82264.1
                          		 48142 - 48636 (-) hypothetical protein
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                            • QDF82265.1
                            		 48764 - 49780 (-) ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components
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                              Biosynthesis information

                              Biosynthetic modules

                              Name
                              Unk01
                              Type
                              nrps-type1
                              Genes
                              lokA
                              Substrates
                              leucine (evidence: Structure-based inference [1])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk02
                              Type
                              nrps-type1
                              Genes
                              lokA
                              Substrates
                              aspartic acid (evidence: Structure-based inference [1])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk03
                              Type
                              nrps-type1
                              Genes
                              lokB
                              Substrates
                              threonine (evidence: Structure-based inference [1])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk04
                              Type
                              nrps-type1
                              Genes
                              lokB
                              Substrates
                              leucine (evidence: Structure-based inference [1])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk05
                              Type
                              nrps-type1
                              Genes
                              lokB
                              Substrates
                              leucine (evidence: Structure-based inference [1])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk06
                              Type
                              nrps-type1
                              Genes
                              lokB
                              Substrates
                              serine (evidence: Structure-based inference [1])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk07
                              Type
                              nrps-type1
                              Genes
                              lokC
                              Substrates
                              leucine (evidence: Structure-based inference [1])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk08
                              Type
                              nrps-type1
                              Genes
                              lokC
                              Substrates
                              serine (evidence: Structure-based inference [1])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk09
                              Type
                              nrps-type1
                              Genes
                              lokC
                              Substrates
                              leucine (evidence: Structure-based inference [1])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk10
                              Type
                              nrps-type1
                              Genes
                              lokC
                              Substrates
                              isoleucine (evidence: Structure-based inference [1])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk11
                              Type
                              nrps-type1
                              Genes
                              lokC
                              Substrates
                              aspartic acid (evidence: Structure-based inference [1])
                              Integrated Monomers
                              Domains
                              adenylation
                              Annotation changelog

                              Entry version: 2

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-09-15
                              Cleaned up synonym list
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Fetch compound properties from PubChem
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Added NRP substrate specificities
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 1

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2019-10-16
                              Submitted
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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