BGC0001980: lokisin biosynthetic gene cluster from Pseudomonas sp.
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Location: 1 - 50,122 nt. (total: 50,122 nt).
This entry is originally from NCBI GenBank MK534107.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001980
Short description lokisin biosynthetic gene cluster from Pseudomonas sp.
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: MK534107.1
Compounds
  • lokisin
Species Pseudomonas sp. [taxonomy]
References
  • . Omoboye OO et al., Front Plant Sci (2019) PMID:31354771
Chemical products information
lokisin
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C64H111N11O20
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QDF82256.1
 1699 - 1905 (-) hypothetical protein
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  • QDF82257.1
 2198 - 2569 (-) hypothetical protein
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  • QDF82258.1
 2936 - 3331 (-) hypothetical protein
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  • QDF82252.1
  • macB
 3391 - 5349 (-) macrolide export ATP-binding/permease protein
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  • QDF82253.1
  • macA
 5352 - 6500 (-) macrolide-specific efflux protein
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  • QDF82259.1
  • lokC
 6567 - 24389 (-) non-ribosomal peptide synthetase
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  • QDF82255.1
  • lokB
 24386 - 37399 (-) non-ribosomal peptide synthetase
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  • QDF82254.1
  • lokA
 37644 - 44033 (-) non-ribosomal peptide synthetase
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  • QDF82260.1
  • lokR
 44546 - 45340 (+) transcriptional regulator, LuxR family
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  • QDF82261.1
  • lokT
 45425 - 46831 (+) RND efflux system, outer membrane lipoprotein CmeC
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  • QDF82262.1
 46988 - 47593 (+) cytochrome oxidase biogenesis protein Sco1/SenC/PrrC, putative copper metallochaperone
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  • QDF82263.1
 47605 - 48072 (+) copper metallochaperone
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  • QDF82264.1
 48142 - 48636 (-) hypothetical protein
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  • QDF82265.1
 48764 - 49780 (-) ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
lokA
Module ?
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: aspartic acid
Evidence for specificity:
  • Structure-based inference
lokB
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
lokC
Module ?
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: isoleucine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: aspartic acid
Evidence for specificity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Cleaned up synonym list
  • Fetch compound properties from PubChem
  • Added NRP substrate specificities
Detailed domain annotation
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