BGC0001984: sarpeptin A biosynthetic gene cluster from Streptomyces sp.
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Location: 1 - 96,578 nt. (total: 96,578 nt).
This entry is originally from NCBI GenBank MN068049.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001984
Short description sarpeptin A biosynthetic gene cluster from Streptomyces sp.
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MN068049.1
via
Compounds
  • sarpeptin A
  • sarpeptin B
Species Streptomyces sp. [taxonomy]
References
Chemical products information
sarpeptin A Evidence:
(no structure information available)
sarpeptin B Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QED55413.1
  • speR
 9395 - 11188 (+) SARP transcriptional regulator
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    • QED55414.1
    • speH
    		 12052 - 12978 (-) alpha-ketoglutarate dependent oxygenase
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      • QED55415.1
      • speJ
      		 13326 - 13856 (+) flavin-dependent monooxygenase
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        • QED55416.1
        • speE
        		 16153 - 16434 (-) acyl carrier protein
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          • QED55417.1
          • speF
          		 16493 - 18175 (-) acyl-CoA dehydrogenase
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            • QED55418.1
            • speG
            		 18172 - 20004 (-) acyl-CoA dehydrogenase
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              • QED55419.1
              • speD
              		 20001 - 21782 (-) fatty-acyl AMP ligase
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                • QED55420.1
                • speI
                		 27998 - 28942 (-) alpha-ketoglutarate dependent oxygenase
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                  • QED55421.1
                  • speC
                  		 31375 - 42978 (-) nonribosomal peptide synthetase
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                    • QED55422.1
                    • speB
                    		 42975 - 55616 (-) nonribosomal peptide synthetase
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                      • QED55423.1
                      • speA
                      		 55618 - 76578 (-) nonribosomal peptide synthetase
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                        • QED55424.1
                        • speK
                        		 82006 - 83565 (-) alpha/beta hydrolase
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                          Biosynthesis information

                          Biosynthetic modules

                          Name
                          Unk01
                          Type
                          nrps-type1
                          Genes
                          speC
                          Substrates
                          glycine (evidence: Sequence-based prediction [2])
                          Integrated Monomers
                          Domains
                          adenylation
                          Name
                          Unk02
                          Type
                          nrps-type1
                          Genes
                          speC
                          Substrates
                          alanine (evidence: Sequence-based prediction [2])
                          Integrated Monomers
                          Domains
                          adenylation
                          Name
                          Unk03
                          Type
                          nrps-type1
                          Genes
                          speC
                          Substrates
                          glycine (evidence: Sequence-based prediction [2])
                          Integrated Monomers
                          Domains
                          adenylation
                          Name
                          Unk04
                          Type
                          nrps-type1
                          Genes
                          speB
                          Substrates
                          aspartic acid (evidence: Sequence-based prediction [2])
                          Integrated Monomers
                          Domains
                          adenylation
                          Name
                          Unk05
                          Type
                          nrps-type1
                          Genes
                          speB
                          Substrates
                          glycine (evidence: Sequence-based prediction [2])
                          Integrated Monomers
                          Domains
                          adenylation
                          Name
                          Unk06
                          Type
                          nrps-type1
                          Genes
                          speB
                          Substrates
                          proline (evidence: Sequence-based prediction [2])
                          Integrated Monomers
                          Domains
                          adenylation
                          Name
                          Unk07
                          Type
                          nrps-type1
                          Genes
                          speB
                          Substrates
                          glycine (evidence: Sequence-based prediction [2])
                          Integrated Monomers
                          Domains
                          adenylation
                          Name
                          Unk08
                          Type
                          nrps-type1
                          Genes
                          speA
                          Substrates
                          glycine (evidence: Structure-based inference, Sequence-based prediction)
                          Integrated Monomers
                          Domains
                          adenylation
                          Name
                          Unk09
                          Type
                          nrps-type1
                          Genes
                          speA
                          Substrates
                          aspartic acid (evidence: Structure-based inference, Sequence-based prediction)
                          Integrated Monomers
                          Domains
                          adenylation
                          Name
                          Unk10
                          Type
                          nrps-type1
                          Genes
                          speA
                          Substrates
                          tyrosine (evidence: Structure-based inference, Sequence-based prediction)
                          Integrated Monomers
                          Domains
                          adenylation
                          Name
                          Unk11
                          Type
                          nrps-type1
                          Genes
                          speA
                          Substrates
                          threonine (evidence: Structure-based inference, Sequence-based prediction)
                          Integrated Monomers
                          Domains
                          adenylation
                          Name
                          Unk12
                          Type
                          nrps-type1
                          Genes
                          speA
                          Substrates
                          leucine (evidence: Structure-based inference, Sequence-based prediction)
                          Integrated Monomers
                          Domains
                          adenylation
                          Annotation changelog

                          Entry version: 2

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-09-15
                          Fixed DOIs
                          • (ID: CUSGWVK3I4TVHJH7NHPFAP2L)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Added NRP substrate specificities
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 1

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2019-10-16
                          Submitted
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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