BGC0001988 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001988 (Aspergillus novofumigatus IBT 16806)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	50,462	High	neosartorin	PKS

BGC0001988 - Region 1 - T1PKS

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Location: 1 - 50,462 nt. (total: 50,462 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 50,463
Label		BGC0001988

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

P174DRAFT_372675: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

P174DRAFT_421366: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

P174DRAFT_460884: Biaryl bond formation, Reduction

MITE: MITE0000160Biaryl bond formation, Reduction (identity: 88.10%)
smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: methyltransferase

P174DRAFT_512932: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Hydrolases: hydrolase

P174DRAFT_460891: Decarboxylation

MITE: MITE0000163Decarboxylation (identity: 75.70%)
smcogs: SMCOG1170: metallo-beta-lactamase family protein

Lyases: Dehydration hydrolase

P174DRAFT_451670: Dehydration

MITE: MITE0000159Dehydration (identity: 68.60%)

P174DRAFT_460891: Decarboxylation

MITE: MITE0000163Decarboxylation (identity: 75.70%)
smcogs: SMCOG1170: metallo-beta-lactamase family protein

Ligases: dehydrogenase synthase

P174DRAFT_460884: Biaryl bond formation, Reduction

MITE: MITE0000160Biaryl bond formation, Reduction (identity: 88.10%)
smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

P174DRAFT_487776: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001988.3	0.97	PKS	neosartorin	Aspergillus novofumigatus IBT 16806
BGC0001284.4	0.78	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001258.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002154.2	0.75	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.75	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.75	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001257.3	0.75	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001273.3	0.65	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.65	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.65	PKS	(-)-Mellein	Parastagonospora nodorum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001988.3	1.00	PKS	neosartorin	Aspergillus novofumigatus IBT 16806
BGC0001284.4	0.78	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001258.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002154.2	0.75	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.75	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.75	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001257.3	0.75	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001273.3	0.65	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.65	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.65	PKS	(-)-Mellein	Parastagonospora nodorum

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 4739 - 50462:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

P174DRAFT_487776: mal

PKS_AT (937..1236): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 98.8
inactive: 64.9
Methylmalonyl-CoA: 61.9
Methoxymalonyl-CoA: 59.2
Propionyl-CoA: 38.1
Benzoyl-CoA: 31.9
CHC-CoA: 25.9
Isobutyryl-CoA: 22.9
2-Methylbutyryl-CoA: 18.7
Acetyl-CoA: 17.4
fatty_acid: 17.2
Ethylmalonyl-CoA: 16.7
3-Methylbutyryl-CoA: 10.7
trans-1,2-CPDA: 7.7

Link to PARAS substrate predictor